Navigation Links
Allele in Medical News

Link between Epsilon4 allele heterozygotes and Alzheimer’s diseas

Professor Mehul Trivedi and his colleagues from University of Wisconsin Medical School and William S. Middleton Memorial VA Hospital have reported that individuals with apolipoprotein E epsilon4 allele has been linked // to a reduced brain activity in the hippocampal region in these persons and pos...

Gene linked to increasingly common type of blood cancer

...titute. Researchers found that, for SNP rs6457327, the presence of the G allele a DNA letter that varies within the genome was protective against follicular lymphoma, while the presence of the A allele was predictive of an increased risk of developing follicular lymphoma. Dr. ...

Easy Baby or Fussy -- It May Be Out of Mom's Control

...hable and had more attention problems than the other children, according to the study. The findings "suggest that it is possible that the DRD4 long allele plays different roles (for better and for worse) in child temperament," the researchers said. They added that the pattern of frontal cortex activity m...

Risk of cancer

...n itself causes only a slightly increased risk of cancer. However, the risk allele is carried by 75% of people of European origin and by almost 100% of Africa...r the development of colorectal cancer. The scientists showed that the risk allele strengthens the binding of a regulatory factor in cancer cells, which activ...

Boys May Feel a Genetic Pull Toward Gangs

... and one Y-chromosome, possess only one copy of this gene, while females, who have two X-chromosomes, carry two," Beaver said. "Thus, if a male has an allele (variant) for the MAOA gene that is linked to violence, there isn't another copy to counteract it. Females, in contrast, have two copies, so even if t...

Study Refutes Depression Gene Finding

...on between stressful events and this gene mutation, either in men or women. "I was surprised by this [but] I haven't give up yet on this particular allele [mutation] as having an effect. It just may be that it's not as big an effect as we thought," said Young, who's also with the VA Center of Excellence ...
Allele in Medical Technology

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

... For the cultured cord blood cells, two patients received a five-out-of-six allele match and four patients received a four-out-of-six allele match. There was an average CD34+ increase of 160 (range 41 to 382), meanin...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

...syndrome (HES) and/or chronic eosinophilic leukemia (CEL) who have the FIP1L1-PDGFRa fusion kinase (mutational analysis or FISH demonstration of CHIC2 allele deletion) and for patients with HES and/or CEL who are FIP1L1-PDGFRa fusion kinase-negative or unknown; adult patients with unresectable, recurrent, a...

EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha-7 Nicotinic Agonist, EVP-6124, in Patients with Schizophrenia

...hizophrenia have decreased ability to suppress the response to a second stimulus. Sensory gating abnormalities in Schizophrenia have been linked to an allele on chromosome 15, the gene locus for the alpha-7 receptor. Alpha-7 nicotinic agonists have been recently shown to improve cognition and the P50 respon...

PTC Therapeutics Announces Publication of Preclinical Data in PNAS

...mber of genetic disorders. The paper entitled, "PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model," will be available in an advanced online publication of PNAS during the week of February 4, 2008 ( http://www.pnas.org/papbyrecen...

Not Only Lipids and Inflammation: Insight Into a New Cause of Heart Attack and Other Vascular Disease

...weden, Italy, Denmark and the UK - analyzed the association of the variant with several other cardiovascular conditions. The results show that the 'G' allele is suggestively but not definitively associated with conditions involving the buildup of atherosclerotic plaque, including peripheral artery disease a...
Allele in Medical Products

CEQ 8800 Genetic Analysis System

Features:...multaneous analysis of single nucleotide polymorphisms at multiple sites of a template (or different templates). Delivers precise DNA sizing, accurate allele assignment and automated data review. Important part of a comprehensive set of interrelated Genomelab solutions specifically designed to accelerate ge...
Company:Beckman Coulter, Inc.

CEQ 8000 Genetic Analysis System

Features:... De novo DNA Sequencing. Heterozygote detection. Confirmatory sequencing. Mutation analysis. allele identification. SNP scoring. Microsatellite instability. AFLP fingerprinting. Gene expression....
Company:Beckman Coulter, Inc.

CEQ™ 8000 Genetic Analysis System

Features:... De novo DNA Sequencing. Heterozygote detection. Confirmatory sequencing. Mutation analysis. allele identification. SNP scoring. Microsatellite instability. AFLP fingerprinting. Gene expression....
Company:Beckman Coulter, Inc.

CEQ™ 8800 Genetic Analysis System

Features:...multaneous analysis of single nucleotide polymorphisms at multiple sites of a template (or different templates). Delivers precise DNA sizing, accurate allele assignment and automated data review. Important part of a comprehensive set of interrelated Genomelab solutions specifically designed to accelerate ge...
Company:Beckman Coulter, Inc.
Allele in Medical Definition

Thymocyte

...s II undergo apoptosis . Some thymocytes are able to rescue failed positive selection by receptor editing (rearrangement of the other T cell receptor allele to produce a new T cell receptor). The double positive thymocytes undergo lineage commitment, maturing into a CD8+ T cell (recognising MHC class I) ...
Allele in Medical Dictionary

Sex-linked recessive

... Sex linkage is the phenotypic expression of an allele that is related to the chromosomal sex of the in...they have inherited the recessive sex - linked allele conferring insensitivity to ... sex linkage ...Question #5 --- sex - linked recessive ? If the allele is sex - linked rec. ... Therefore, the...

Sex-linked dominant

... Sex linkage is the phenotypic expression of an allele that is related to the chromosomal sex of the in... Question #5 --- sex - linked dominant ? If the allele is sex - linked dom. ... Therefore, the allele of interest isn't sex - linked dom. back to the ...

Genes

...f instructions, usually coding for a ... Different genes are activated in different cells, creating the specific proteins ... Gramene Gene and allele Database. Find: ... Gene Search or Browse Options. Home Page: Introduction and Quick search - Search the Gene database by keyword. ... Modifie...

Gene Therapy

...s the insertion of genes into an individual's cells and tissues to treat a disease, such as a hereditary disease in which a deleterious mutant allele is replaced with a functional one. Although the technology is... An overview of genomics and medicine highlighting the areas of gene testing, g...

Blood typing

...the most important factor in determining a healthy diet, and he promotes distinct diets for... A mother who is blood type O can only pass an O allele to her son or daughter. A father who is blood type AB could pass either an A ... Blood Type Calculator ... Features notes on human ABO mar...
Allele in Biological News

Mary had a lot of lambs: Researchers identify way to accelerate sheep breeding

...e of the unusual form of the gene, the so-called M allele that other researchers had suspected might be corr... student at OSU. Although the presence of the M allele has been definitively correlated with the ability ...y animals. The change in the DNA sequence of the M allele does not change the amino acid sequence of the pro...

UBC researchers find first-ever 'wanderlust gene' in tiny bony fish

...s . "Contrary to our assumption, the low-armour allele is not linked to a preference for fresh water, or ..., we found a strong association between having the allele and the fish's inclination to move into different ...ehavioural traits could explain why the low-armour allele keeps turning up during marine sticklebacks' 'inva...

Hush little baby... Linking genes, brain and behavior in children

...n of the DRD4 gene may act as a moderator of children's temperament. The authors note that the "results suggest that it is possible that the DRD4 long allele plays different roles (for better and for worse) in child temperament" depending on internal conditions (the environment inside their bodies) and conc...

The evolutionary foundation of genomic imprinting in lower vertebrates

...like mammalian imprinting gene DMR, the unmethylated DMR of maternal allele could not resist methylation reprogramming and started de novo methylation at the cleavage stage, while the paternal Igf2 allele appeared to maintain its paternal methylation imprints during embryogenesis...

Native Americans descended from a single ancestral group, DNA study confirms

...sian (western) side of the Bering Strait. Yet this allele was absent in all 54 of the Eurasian, African and ... 908 people who were in the 44 groups in which the allele was found, more than one out of three had the vari...d explanation for the distribution of the 9-repeat allele was that all modern Native Americans, Greenlanders...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

...ck Huntington's, Zamore couldn't see a way. "I explained to him that you can't," Zamore said. The problem was that the disease gene and its healthy allele are almost identical, and Zamore told Aronin that he wouldn't be able to distinguish between the two forms of Huntingtin . "Then, as he was leaving ...
Allele in Biological Technology

Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System

Surekha Karudapuram, Ph.D. and David Batey Ph.D. MJ Research, Inc., South San Francisco, CA Abstract A two-color real-time quantitative PCR (qPCR) protocol was used on the MJ Research DNA Engine Opticon 2 system to genotype the CYP2D...

Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease

...d author on the Science article that described how risk for Alzheimer's disease multiplied according to the number of copies of the apolipoprotein E allele 4 inherited from parents. This finding has been replicated in hundreds of studies and remains the one established genetic risk factor for Alzheimer's ...

deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes

...omosome 9p21 affects the risk of myocardial infarction," Science (2007) 8;316 (5830):1491-3. 2. Brautbar, A, et al., "Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the A...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

...ry low concentration within the sample (less than 1% of the total wild type allele concentration). Cold-PCR protocols preferentially amplify heteroduplexes su...ontribute to Transgenomic's target of achieving a 1/10,000 mutant to normal allele ratio detection in a routine, cost-effective and high throughput protocol. ...

Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology

...ficantly reduced. Additionally, information is gained about the site of a mutation, allowing more accurate DNA sequence analysis when any given mutant allele is present at below 25% compared to the normal allele. SURVEYOR Nuclease's effectiveness in disease specific mutation discovery has been well document...

Gleevec Receives FDA Priority Review as First Therapy to Reduce Recurrence of Gastrointestinal Stromal Tumors After Surgery

...me (HES) and/or chronic eosinophilic leukemia (CEL) who have the FIP1L1- PDGFR alpha fusion kinase (mutational analysis or FISH demonstration of CHIC2 allele deletion) and for patients with HES and/or CEL who are FIP1L1-PDGFR alpha fusion kinase-negative or unknown; adult patients with unresectable, recurre...
Allele in Biological Products

Rat Anti-Mouse NKG2A / C/ E Monoclonal Antibody, Unconjugated, Clone 20d5 from Abcam

Description:...d5] to NKG2A + C+ E ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Mouse): CHO transfected cells expressing the B6 allele of NKG2A. Entrez Gene ID: 3821 Swiss Protein ID: P26715...
Company:Abcam

SagaGT Microsatellite Analysis Software (Server edition) from LI-COR Biosciences

Description:...vanced genotyping automation software available. SagaGT automates electrophoresis, lane finding, location of standards, calibration of band sizes, and allele scoring. Saga GT is second generation software developed by LI-COR. Saga 1.0 (Unix) was initially developed at the University of Washington and lic...
Company:LI-COR Biosciences

CEQ 8800 Genetic Analysis System from Beckman Coulter

Description:...th one gel, one array and one software platform, users can perform DNA sequencing, heterozygote detection, confirmatory sequencing, mutation analysis, allele identification, SNP (single nucleotide polymorphism) scoring, microsatellite instability and amplified fragment length polymorphism fingerprinting. T...
Company:Beckman Coulter
Allele in Biological Definition

Allele

An allele is any one of a number of alternative forms of the same gene occupying a given locus (position) on a chromosome . An example is the gene for blossom color in many species of flower - a single gene controls the color of the petals, but there may be several different versions of t...

Allele frequency

... allele frequency is a term of population genetics that..., or equivalently the richness of its gene pool . allele frequency is defined as follows: Given a) a part... sets of chromosomes) and finally d) a variant or allele of the gene, then the ...

Barr body

...osomes inactivated. This can be significant if different alleles of a gene are present on the different chromosomes; in some regions of the body one allele will be active, and in other regions the other will. This is what results in the coloration pattern of female calico cats ; pigmentation genes on the...

Evolution

..."evolution" means a change in the frequency of an allele within a gene pool . This change may be caused b...netic drift Genetic drift describes changes in allele frequency that cannot be ascribed to selective pre...n to generation can be large. Such fluctuations in allele frequency between successive generations may resul...

Ewens's sampling formula

...in statistical equilibrium under mutation and genetic drift and the role of selection at the locus in question is negligible, and (3) every mutant allele is novel. This is a probability distribution on the set of all partitions of the integer n . Among probabilists and statisticians it is often ...

Gene

...ing more precisely, a biologist might refer to an allele or a mutation that has been implicated in or ...raits, for example eye color. A gene's most common allele is called the wild type allele, and rare alleles...al dominance relationships (more at genetics , allele ). Expression of molecular genes For vario...
Allele in Biological Dictionary

Allele

An allele , (US)) is one of a series of different forms of a gene. The word is a short from of allelomorph ('other form'), which was used in the early days of genetics to describe variant forms of a gene detected as different phenotypes. Alleles are now understood to be... In geneti...

Wild-type

... type was conceptualized as a product of the standard, "normal" allele at a locus, in contrast to that produced by a non-standard, "mutant&q...posed to the same rigid standards ... wild type - The most frequent allele or genotype found in nature, or a specified ... Science Magazine (subscr...

Wild type

... type was conceptualized as a product of the standard, "normal" allele at a locus, in contrast to that produced by a non-standard, "mutant&q...ght variations between each fish, ... wild type - The most frequent allele or genotype found in nature, or a specified ... Science Magazine (subscr...

True-breeding

... trying to create a true breeding strain, we are in fact trying to make all ... A true - breeding population is one that contains only one allele for the locus in ... act of selection will create a true - breeding pink population (Figure 9) ... Find Breeding's True Value and sear...

Transposable element

...st 8th, 2009 by ruth ... Transposable Genetic Elements WWW Links. Genetic Topics ... Thus, the presence of the transposable element in the allele changes the ... Transposable Elements in Peas. McClintock. Break-bridge-fusion cycle due to Ac-Ds ... The Ac transposable element is 4563 ...

Tandem repeat sequence

...nce -based typing ... Short Tandem Repeat database for genetic mapping and identity testing, ... Sequence Information (annotated) Variant allele Reports. Tri-Allelic Patterns ... Use of Short Tandem Repeat Sequences to Study Mycobacterium leprae in Leprosy ... Such variability makes sh...
Other Tags
(Date:12/17/2014)... Dr. Myo Nwe is the co-author of ... the Future” and co-founder of the Ace Medical Weight Loss ... takes a broad look at the industry of weight loss, ... scrutiny. On film and in television shows, however, she says ... social aspects and played for basic laughs, which she believes ...
(Date:12/17/2014)... December 17, 2014 A group of 127 ... Longevity, today, in reaction to a recent statement by the ... brain training and derogated the efficacy of all brain exercises. ... with the parts of the center’s statement critical of brain ... center had also overstated its case, in a document it ...
(Date:12/17/2014)... NY (PRWEB) December 17, 2014 Project ... who recently brought videos of MIT economist and Obamacare ... best-selling author James O’Keefe conducted the interview, which is ... stated that there was intentional mislabeling in the Affordable ... in the bill: A two-hundred-and-fifty billion dollar per year ...
(Date:12/17/2014)... TUESDAY, Dec. 16, 2014 (HealthDay News) -- Poor students get ... home, a new study finds. But, the opposite is ... that having fruits and vegetables at school may give a ... But, no matter what the family income level, students ... school, the study found. The study was published recently ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
Breaking Medicine News(10 mins):Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ... is the ultimate driver in long-term mass consumer adoption ...
(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:11/21/2014)... , November 18, 2014 According ... Market by Systems (Video, RFID, Access Control, Intrusion Detection, ... Hotels, Banks, Government), Component Service Geography - Global Forecasts ... Market is projected to be around $25 Billion in ... 2020, growing at a CAGR of 8.69%. ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
Other Contents