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Aldehyde in Medical News

Raptor Pharmaceuticals Corp. and TorreyPines Therapeutics, Inc. Announce Merger Agreement

...dates in clinical development to treat nephropathic cystinosis , non-alcoholic steatohepatitis ("NASH") , Huntington's Disease ("HD") , and aldehyde dehydrogenase ("ALDH2") deficiency . Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting plat...

Raptor Pharmaceuticals Corp. to Present at 2009 Cystinosis Research Network Family Conference

...dates in clinical development to treat nephropathic cystinosis , non-alcoholic steatohepatitis ("NASH") , Huntington's Disease ("HD") , and aldehyde dehydrogenase ("ALDH2") deficiency . Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting pl...

Raptor Pharmaceuticals to Collaborate with Roche on Therapeutic Delivery Across Blood-Brain Barrier

... product candidates in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("HD"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platform...

The Center for the Biology of Chronic Disease Highlights Anti-Cancer Activities of the Food Extracts Quercetin, EGCG, Glycyrrhizin, and Trans-Cinnamaldehyde

... Trans-Cinnamaldehyde (a compound found in the bark of cinnamon trees) 1. Cabello CM, et al. The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic Biol Med. 2009 Jan 15;46(2):220-31. For details on these studies,...

Flushing From Alcohol a Risk Factor for Esophageal Cancer

...hen drinking alcohol occurs in about a third of East Asians (Chinese, Japanese and Koreans), mainly due to an inherited deficiency in an enzyme called aldehyde dehydrogenase 2 (ALDH2). There is increasing evidence that people with this deficiency are at much higher risk for alcohol-related esophageal cancer (...

Alcohol 'flush' signals increased cancer risk among East Asians

...sk from alcohol. Dr. Brooks cites the high mortality from esophageal cancer and the large number of individuals with the deficient enzyme, known as aldehyde dehydrogenase 2 (ALDH2). "Cancer of the esophagus is particularly deadly, with five-year survival rates ranging from 12 to 31 percent throughout th...

Alcohol-induced flushing is a risk factor for esophageal cancer from alcohol consumption

...g, nausea, and an increased heart rate. This so-called "alcohol flushing response" is predominantly due to an inherited deficiency in an enzyme called aldehyde dehydrogenase 2 (ALDH2). Although clinicians and the East Asian public generally know about the alcohol flushing response, few are aware of the accumu...

New study shows how spikes in nitrite can have

...phenomenon shown to be caused by numerous pharmacological agents. "The proteins we have implicated include some key proteins, such as mitochondrial aldehyde dehydrogenase, that have been shown by others to be critical to cardiac protection afforded by other agents and triggers," added Perlman. "This is exc...

Variations in Gene DNA Boost Drinkers' Cancer Risk

...lymorphisms and cancer. Their analysis suggests that such variations, called gene polymorphisms, in two enzymes -- alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) -- involved in metabolizing alcohol significantly increase alcohol drinkers' risk of cancers of the head and neck and the esopha...

Raptor Pharmaceuticals Corp. to Present at Two Upcoming Healthcare Conferences

...e in nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease and Batten Disease, and its ConviviaTM product candidate in aldehyde dehydrogenase ("ALDH2") deficiency. In its preclinical programs Raptor bioengineers novel drug candidates and drug-targeting platforms derived from th...
Aldehyde in Medical Technology

Raptor Pharmaceuticals Receives Notices of Allowance for Two NeuroTrans(TM) Patent Applications

...andidates in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("Huntington's"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platform...

Raptor Pharmaceuticals Appoints Dr. Patrice P. Rioux as Chief Medical Officer

...e ("Huntington's"), as well as Convivia(TM), for the potential treatment of aldehyde dehydrogenase ("ALDH2") deficiency. Dr. Rioux has extensive experience...oholic steatohepatitis ("NASH"), Huntington's Disease ("Huntington's"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are...

Discovery of Marker for Colon Stem Cells Could Shed Light on What Drives Tumor Growth

...s doctors to identify, locate, and isolate normal and malignant colon stem cells, has been elusive. But the discovery by Dr. Boman and colleagues that aldehyde dehydrogenase 1 (ALDH1) is a marker for identifying and isolating colon stem cells is a potential breakthrough in the search for a key to what drives ...

Raptor Pharmaceuticals Announces Completion of Patient Enrollment in Phase 2a Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)

... product candidates in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("HD"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platform...

Raptor Pharmaceuticals Corp. Announces Positive Phase IIa Clinical Study Results for Convivia(TM) Program

...ed ethanol metabolism with concomitant ethanol exposure. At the time of enrollment, study subjects also submitted to alcohol dehydrogenase ("ADH") and aldehyde dehydrogenase ("ALDH2") genotyping. The objectives of the study were to investigate the safety and efficacy of 4-MP as a potential treatment of sympto...

Raptor Pharmaceuticals Provides Update on Targeting Platforms

...the reach and benefit of existing therapeutics into underserved patient populations. The Company is currently running clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency, nephropathic cystinosis and non-alcoholic steatohepatitis ("NASH"). Raptor's preclinical programs are based upon b...

Raptor Pharmaceuticals Announces Phase 2a Clinical Trial Initiation in Non-Alcoholic Steatohepatitis (NASH)

...in nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease and Batten Disease, and its Convivia(TM) product candidate in aldehyde dehydrogenase ("ALDH2") deficiency. In its preclinical programs Raptor bioengineers novel drug candidates and drug-targeting platforms derived from th...

Raptor Pharmaceuticals Enters Collaboration Agreement with UC San Diego in Liver Disease

...ensed clinical-stage product candidates towards marketing approval and commercialization and is currently involved in clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency as part of Raptor's Convivia(TM) program and nephropathic cystinosis as part of Raptor's DR Cysteamine program. Rap...

Raptor Pharmaceuticals Corp. Initiates Phase IIa Clinical Study for Convivia(TM)

...tentially more effective or convenient treatments for their currently approved indications. Bennu's initial clinical programs include the treatment of aldehyde dehydrogenase ("ALDH2") deficiency and nephropathic cystinosis. For additional information, please visit http://www.raptorpharma.com . FORWARD LO...
Aldehyde in Medical Dictionary

Glucose

... the body's water with it, so you have to go to the ... Glucose , a simple monosaccharide sugar, is one of the most important ... Glucose is an aldehyde (contains a -CHO group) ... together, glucose and fructose ... Provides information on the benefits of physical activity ... activity cause ...
Aldehyde in Biological News

American Chemical Society's Weekly PressPac -- May 13, 2009

...eds from radio-contaminated environment. Interestingly, plants from contaminated fields produced one-third more of a protective protein called betaine aldehyde dehydrogenase the same protein known to protect human blood from radiation damage. ARTICLE #3 FOR IMMEDIATE RELEASE "Proteomic Analysis of Matur...

Tailor-made recombinant proteins in mammals

... be generalized or scaled up." Enter Bertozzi's aldehyde tag: the tag is an aldehyde group displayed as part of an amino acid side chai...no acids that normally make up a protein. When the aldehyde tag appears at a specific site on a given protein,...

Shape changes in aroma-producing molecules determine the fragrances we detect

...rants change their shape. They studied the odorant octanal, an eight-carbon aldehyde that occurs in many flowers and citrus fruits. Octanal is a structurally fl.... This work was done in Professor Firestein's laboratory at Columbia. The aldehyde molecules that could stretch to their greatest length triggered strong acti...

New organic molecule in space

...stellar molecules known to date have been found, including the most complex ones such as ethyl alcohol, formaldehyde, formic acid, acetic acid, glycol aldehyde (a basic sugar), and ethylene glycol. Starting from 1965, more than 140 molecular species have been detected in space, in interstellar clouds as we...

UM researchers find new marker to identify cancer stem cells

...d in the November issue of Cell Stem Cell, the researchers found that cells from normal and cancerous breast tissue that had high levels of the enzyme aldehyde dehydrogenase activity, or ALDH, acted like breast stem cells. Further, of 577 human breast cancer tissue samples studied, those that expressed the sp...

Skin oil -- ozone interactions worsen air quality in airplanes

...ed in real flights. Consistently, ozone in the cabin increased production of identifiable chemical byproducts including nonanal and decanal, a pair of aldehyde compounds associated with headaches, nasal irritation and with other symptoms of sick building syndrome. More than half of the byproducts were the ...

Measuring artery repair cells could become new heart disease test

...nsuming, the researchers said. As an indicator of EPC cell levels, the new method uses measurements of the amount of a detoxification enzyme, known as aldehyde dehydrogenase (ALDH), which is produced in high amounts by EPCs. "Our studies have shown that using ALDH activity to determine the numbers of EPCs ...
Aldehyde in Biological Technology

Raptor Pharmaceuticals Doses First Patient in Phase 2b Clinical Trial of DR Cysteamine for Cystinosis

... product candidates in clinical development to treat nephropathic cystinosis, non-alcoholic steatohepatitis ("NASH"), Huntington's Disease ("HD"), and aldehyde dehydrogenase ("ALDH2") deficiency. Raptor's preclinical programs are based upon bioengineered novel drug candidates and drug-targeting platform...

Vista Partners Updates Coverage on Raptor Pharmaceuticals Corp. (OTC Bulletin Board: RPTP)

...ensed clinical-stage product candidates towards marketing approval and commercialization and is currently involved in clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency as part of Raptor's Convivia(TM) program and nephropathic cystinosis as part of Raptor's DR Cysteamine program. Rap...

Raptor Pharmaceuticals Expands Board of Directors and Scientific Advisory Board

...-licensed clinical-stage product candidates towards marketing approval and commercialization and is currently running clinical trials in patients with aldehyde dehydrogenase ("ALDH2") deficiency and nephropathic cystinosis. Raptor's preclinical division bioengineers novel drug candidates and drug-targeting pl...

Raptor Pharmaceuticals Closes $10 Million Private Placement

...vances clinical-stage product candidates towards marketing approval and commercialization. Raptor's initial clinical programs include the treatment of aldehyde dehydrogenase ("ALDH2") deficiency, nephropathic cystinosis and non-alcoholic steatohepatitis ("NASH"). Raptor preclinical programs target cancer, n...

Raptor Pharmaceuticals Corp. Announces Presentation at 5th International Cystinosis Conference 2008

...vances clinical-stage product candidates towards marketing approval and commercialization. Raptor's initial clinical programs include the treatment of aldehyde dehydrogenase ("ALDH2") deficiency, nephropathic cystinosis and non-alcoholic steatohepatitis ("NASH"). Raptor preclinical programs target cancer, n...

Sangamo BioSciences Announces Presentation of Phase 1 Data of ZFP Therapeutic at International Society for Cellular Therapy (ISCT) Meeting

...pain scores, ulcer healing and amputation rates. aldehyde bright stem cells can be identified in the subject...ood or bone marrow by staining with a substrate of aldehyde dehydrogenase, an enzyme that is highly expressed ...generation and participate in the repair response. aldehyde bright stem cell populations of human bone marrow ...

Raptor Pharmaceuticals Corp. Enters Agreements to Advance Clinical Pipeline

...tentially more effective or convenient treatments for their currently approved indications. Bennu's initial clinical programs include the treatment of aldehyde dehydrogenase ("ALDH2") deficiency and nephropathic cystinosis. For additional information, please visit http://www.raptorpharma.com . About Path...

Raptor Pharmaceuticals Acquires Orphan Clinical Program

...tentially more effective or convenient treatments for their currently approved indications. Bennu's initial clinical programs include the treatment of aldehyde dehydrogenase ("ALDH2") deficiency and nephropathic cystinosis. For additional information, please visit http://www.raptorpharma.com . ...

Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers

... RESULTS ALLN inhibited proteasome activity in a dose-dependent manner, as expected (Figure 2a-2c). (ALLN is a peptide aldehyde that inhibits the proteasomes chymotrypsin activity and prevents the complex from degrading the ZsProsensor protein, thus allowing it to accumulate an...

Novel MicroRNA Array Technology for Sensitive miRNA Profiling

... functionally verified * The simple printing process is compatible with both epoxy and aldehyde slides * Data normalization is easy with provided 4 negative controls and one positive control. ...
Aldehyde in Biological Products

Mouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4 from Lab Vision

Description: In normal tissues this enzyme exists predominantly as XDH which converts hypoxanthine and xanthine to uric acid, a critical plasma antioxidant. During ischemia, XDH is reversibly converted to the oxygen radical producing XO by oxidation of essential sulfhydryl groups or irreversibly through limite...
Company:Lab Vision

UBC Fractions Extract from GeneTex

Description:...trate proteins such as lysozyme and beta-lactoglobulin. These conjugation fractions contain ubiquitin c-terminal hydrolases. The addition of ubiquitin aldehyde is recommended for the inhibition of UCHs and to improve overall conjugate yield. The supplied fractions do not contain 20S or 26S protein degradation...
Company:GeneTex

ALDEFLUOR, Stem Cell Identification, Kit from StemCell Technologies, Inc.

Description:... ALDEFLUOR Stem Cell Identification Kit. ALDEFLUORs proprietary technology comprises a substrate for the enzyme aldehyde dehydrogenase (ALDH) that is highly expressed in all viable stem cells, making ALDH an extremely useful marker for counting and isolating viable stem ...
Company:StemCell Technologies, Inc.
Aldehyde in Biological Definition

Alcohol

...propanol and 2-propanol. If a higher priority group is present (such as an aldehyde , ketone or carboxylic acid ), then it is necessary to use the prefix "h...(=O)-CH 3 + Cr 2 (SO 4 ) 3 + K 2 SO 4 + 7 H 2 O Frequently in aldehyde preparations these reagents cause a problem of over-oxidation to the carbox...

Carbohydrate

...ccharides Monosaccharides may be divided into aldoses , which have an aldehyde group on the first carbon atom, and ketoses , which typically have a keto...ure described here is only one of the forms a monosaccharide may take. The aldehyde or ketone group may react with a hydroxyl group on a different carbon atom ...

Fehling's solution

...ehling's solution is a solution used to detect aldehyde functional groups . The substance to be tested i...recipitate indicates the presence of aldehydes or aldehyde groups. An example for its use is to screen for g... complexed with the tartrate ion. Contact with an aldehyde group reduces it to a cuprous ion, which then prec...

Glucose

...e) Glucose ( C 6 H 12 O 6 , molecular weight 180.18) is a hexose —a monosaccharide containing six carbon atoms . Glucose is an aldehyde (contains a -CHO group). Five of the carbons plus an oxygen atom form a loop called a "pyranose ring", the most stable form for six-carbon aldose...

Redox

...wavelengths of infrared light. In organic chemistry , stepwise oxidation of a hydrocarbon produces water and, successively, an alcohol , an aldehyde or a ketone , carboxylic acid , and then a peroxide . In inorganic chemistry terms, incompletely oxidized carbon takes the form of carbo...

Redox

...wavelengths of infrared light. In organic chemistry , stepwise oxidation of a hydrocarbon produces water and, successively, an alcohol , an aldehyde or a ketone , carboxylic acid , and then a peroxide . In inorganic chemistry terms, incompletely oxidized carbon takes the form of carbo...
Aldehyde in Biological Dictionary

Monosaccharides

...rbohydrates: The Monosaccharides . Carbohydrates: The Disaccharides and ... The monosaccharides are white, crystalline solids that contain a single aldehyde ... Our examples for that were in fact sugars; monosaccharide aldotetroses. ... Why are they monosaccharides when there is no ring? ... Mon...

Deoxyribose

... Deoxyribose , also known as D- Deoxyribose and 2- deoxyribose , is an aldopentose — a monosaccharide containing five carbon atoms, and including an aldehyde functional group in its linear structure. It is a deoxy sugar derived... The Molecular structure of Nucleic Acids: A Structure for Deoxyribose Nu...
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(Date:4/22/2014)... lung cancer are 70 years of age or older, ... not well represented in clinical trials. Therefore, the paucity ... evidence based clinical recommendations. , In 2010, the EORTC ... Group along with the International Society for Geriatric Oncology ... elderly patients with non-small cell lung cancer (NSCLC), and ...
(Date:4/22/2014)... to trauma, illness, alcohol or other drug abuse, these ... cells that can go awry and activate conditions such ... autism. , Until now, it has been unclear how ... developing brain. Past studies have shown that when an ... or she experiences some trauma or illness, her baby ...
(Date:4/22/2014)... (April 22, 2014) Cedars-Sinai stroke intervention researchers have ... and Stroke, part of the National Institutes of Health, ... multicenter Phase II clinical trial of an experimental drug ... used in combination with recombinant tissue plasminogen activator, or ... ischemic strokes shortly after onset. In laboratory rodent studies, ...
(Date:4/22/2014)... Based on results of a clinical trial ... Food and Drug Administration (FDA) approved a molecularly ... cancer that has progressed after standard chemotherapy has ... review was announced by the manufacturer, Lilly Oncology, ... name ramucirumab, it will be sold under the ...
(Date:4/22/2014)... of the University of Calgary,s Hotchkiss Brain Institute (HBI) ... cells as a means to restore connections after injury. ... key molecule that directly regulates nerve cell growth in ... the prestigious journal Nature Communications , with lead ... "We made the surprising discovery that a protein called ...
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(Date:4/22/2014)... the University of Kentucky has discovered new methods to ... , The research, led by Peixuan Guo, professor and ... UK College of Pharmacy and Markey Cancer Center, is ... Anionic Polymer Material To Build Robust Structures with Defined ... Daniel L. Jasinski. , The article, which will appear ...
(Date:4/22/2014)... a trip to Asia to coordinate with allies ... officials at the Office of Naval Research (ONR) ... (APTEP) as an example of strong and growing ... in the region. , The APTEP program, centered ... supports the development of alternative energy technologies. It ...
(Date:4/22/2014)... is another way of asking him or her to ... Certain cells of the immune system tend to misbehave ... Because these cells are known to misbehave similarly during ... immune cells to better understand how our immune systems ... Institute on Aging, part of the National Institutes of ...
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