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Alanine in Medical News

A new light on the mechanisms of early stage liver reperfusion injury

...g portal hepatitis, inflammation and the induction of apoptosis, were occurred. Biochemical analysis showed that the amounts of lactate dehydrogenase, alanine aminotransfrase and aspartate aminotransfrase, creatinine and urea were significantly increased in the serums obtained from the animals exposed to hep...

Varicella zoster infection causes severe autoimmune hepatitis

...oratory findings were as follows: hemoglobin 149 g/L, white blood cell count 9.9 109/L, platelets 512 109/L, erythrocyte sedimentation rate 39 mm/h, alanine aminotransferase (ALT) 1066 U/L, aspartate aminotransferase (AST) 755 U/L, alkaline phosphatase (ALP) 185 U/L, total bilirubin 425 μmol/L, direct...

Redesigned protein accelerates blood clotting

...rotein more likely to drive clotting. In 2005, he and Wakabayashi published work showing that swapping out a naturally occurring glutamic acid with an alanine at a specific spot in the calcium binding site on factor VIII doubled its ability to bind with factor IX and increased clotting. Factor VIII has on it...

Ortho Biotech Announces NDA Submission for Trabectedin for the Treatment of Relapsed Ovarian Cancer

... arm, but were generally reversible and not associated with evidence of chronic liver damage or other clinical consequences. These included increased alanine aminotransferase (55% versus 9%) and increased aspartate aminotransferase (40% versus 10%); and Fatigue (46% versus 36%). ...

Stem cells from umbilical cord used in the treatment of hepatic diseases

...splant carried out in rats caused an improvement both in the histological damage and in the hepatic function, as proved by the enzymatic activities of alanine transaminase, alkaline phosphatase, gama-glutamyl-transpherase and lactate dehydrogenase, as well as the concentrations of total and direct bilirubin....

Dads' Early-Onset Obesity Linked to Liver Disease in Kids

...am, Mass. The researchers found that people whose fathers were clinically obese at an early age were more likely to have increased liver enzyme (serum alanine aminotransferase -- ALT) levels, an indicator of liver disease. When the researchers conducted a secondary analysis that didn't include obese offsp...

Elevated liver enzymes associated with higher future mortality

... online at Wiley Interscience ( http://www.interscience.wiley.com/journal/hepatology ). Liver enzymes include aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and high concentrations in the blood tend to indicate liver disease. About 10 percent of Americans have an elevated liver enzy...

Scientists identify proteins that help bacteria put up a fight

...lysine has already been identified as a player in this modification, and is used by MprF2. Ibba and Roy found that MprF1, however, uses the amino acid alanine instead. This amino acid also contributes to cell membrane modification and seems to have additional functions that remain unknown. This is a new f...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

...has been reported rarely at all dosages (see ADVERSE REACTIONS). In AFCAPS/TexCAPS, the number of participants with consecutive elevations of either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) (> 3 times the upper limit of normal), over a median of 5.1 years of follow- up, was not si...

Statins may Help Treat Hepatitis C Patients

...ntiviral effect of fluvastatin (FLV) in vivo, in hepatitis C virus (HCV) patients who take statins, to see whether they experience any improvements in alanine transaminase (ALT, liver enzymes) levels. The researchers reported the total bilirubin (TB, yellow breakdown product) and ALT results and comp...
Alanine in Medical Technology

Raptor Pharmaceuticals Announces Completion of Patient Enrollment in Phase 2a Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)

...San Diego enrolled a total of 12 adolescent NASH patients receiving a twice daily oral dose of cysteamine and will measure possible reduction of blood alanine aminotransferase ("ALT") and aspartate aminotransferase ("AST") levels as a biomarker of cysteamine's efficacy for potentially treating NASH. Positive...

Peptimmune Announces Grant of United States Patent for PI-2301 Peptide Copolymer for Multiple Sclerosis

...other parts of the body is disrupted. The '790 patent claims "A linear random copolymer YFAK comprising amino acids tyrosine (Y), phenylalanine (F), alanine (A), and lysine (K)," )." which was licensed from Harvard University. The copolymer technology was developed in conjunction with Professor Jack L. Str...

Further Clinical Testing of BZL101 in Advanced Breast Cancer Demonstrates Favorable Efficacy and Toxicity Profiles

...f prescribed doses. The most frequently reported BZL101-related adverse events were: diarrhea (40%), nausea (30%), headache (20%), and increased amino alanine transferase (20%). Twelve patients were evaluable for response according to RECIST. Five of the 12 patients had stable disease (SD) for >90 days (42...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008

... SVR 24 weeks after completion of therapy. Patients not achieving undetectable HCV RNA did not show significant reductions in viral load or alanine aminotransferase (ALT) levels. Patients responding to nitazoxanide treatment had lower viral loads at baseline. Adverse events were typicall...

Data to be presented at AAN Meeting -Study results of drug candidate for MS

...sea. FTY720 treatment was associated with initial dose-dependent decreases in heart rate and expiratory air flow. Clinically asymptomatic increases in alanine aminotransferase (liver enzyme) and an increase in blood pressure were also observed. No unexpected adverse events emerged in patients treated for up ...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

...well tolerated. All infusions were unproblematic and there were no signs of cytokine release or complement activation. Two patients had rises in serum alanine aminotransferase (ALT) following the last dose (i.e. after a total dose of 24mg/kg) which were transient and the patients recovered fully. Two cases o...

Prothrombin Time Comes in Small (CLIA-Waived) Packages

...lipid syndrome, hyperhomocystinemia, among others. Prothrombin levels are also monitored along with other tests (such as aspirate aminotransferase and alanine aminotransferase) to help evaluate liver function. Given the broad applicability of this test, it is helpful to many clinicians that several point-of-...
Alanine in Medical Products

Alanine Aminotransferase (ALT) GPT

Description:... The ALT method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of alanine aminotransferase activity in serum or plasma....
Company:Randox Laboratories Ltd.

Alanine Aminotransferase (ALT) Liquid

Description:... For the quantitative in vitro determination of alanine aminotransferase in serum or plasma....
Company:Randox Laboratories Ltd.

Alanine Aminotransferase (ALT)

Description:... For the quantitative in vitro determination of alanine Aminotransferase (ALT) in serum and plasma....
Company:Randox Laboratories Ltd.

ALT (SGPT) Reagent Set (UV-Kinetic Method)

Description:... For the quantitative determination of alanine aminotransferase in human serum....
Company:Teco Diagnostics

ALT (SGPT) Reagent (Colorimetric, Endpoint Method)

Description:... alanine Aminotransferase (ALT) reagent is used for the quantitative determination of alanine aminotransferase (Glutamate pyruvate transaminase, SGPT) in human serum....
Company:Teco Diagnostics

ALT (SGPT) Liquid Reagent (Kinetic Method)

Description:... For the quantitative determination of alanine aminotransferase in serum used in routine examination and monitoring of therapy and relapses....
Company:Teco Diagnostics

ALT (GPT) + Starter Reagent

Description:... Intended for the quantitative determination of alanine aminotransferase activity in serum or plasma. Two vials, dry powder reagents. Pyridoxal Phosphate tablets must be purchased separately for conformity ...
Company:Hemagen Diagnostics, Inc.

ALT (GPT) Liquidplus Reagent

Description:... Intended for the quantitative determination of alanine aminotransferase activity in serum or plasma. Liquid buffer and dry powder reagent. Pyridoxal Phosphate tablets must be purchased separately for confo...
Company:Hemagen Diagnostics, Inc.

ALT (GPT) Reagent

Description:... Intended for the quantitative determination of alanine aminotransferase activity in serum or plasma. Single vial, dry powder reagent. Pyridoxal Phosphate tablets must be purchased separately for conformity...
Company:Hemagen Diagnostics, Inc.

ALT-GPT

Description:... For the quantitative determination of alanine Aminotransferase in serum. Optimized IFCC without P-5'-P, Linearity: 500 IU/L at 37 C. Liquid Working Reagent prepared with simple 1:9 dilution....
Company:Horizon Diagnostics, Inc.

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Alanine in Medical Dictionary

AST

... transaminase ( AST ) also called serum glutamic oxaloacetic transaminase (SGOT) or aspartate aminotransferase (ASAT/AAT) (EC 2.6.1.1) is similar to alanine transaminase (ALT) in that it is another enzyme associated with liver parenchymal cells. Automotive diagnostic equipment, cooling system teste...

ALT

... alanine transaminase or ALT is a transaminase enzyme (...ed serum glutamic pyruvic transaminase (SGPT) or alanine aminotransferase (ALAT). The alt .* hierarchy...esigned Control- Alt -Escape to trigger ... An alanine aminotransferase ( ALT ) test measures the amount ...
Alanine in Biological News

Chemists make beds with soft landings

...ely of the amino acid alanine. Due to alanine's chemical nature, long chains of it naturally form so-called α helices. The researchers ended the alanine chain with the amino acid lysine, which stabilizes the helix and allows the coiled chain to be chemically attached to the surface. Working with a ...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...he cell's protein synthesis machinery -- an enzyme called alanyl tRNA synthetase. This enzyme is responsible for loading, or "charging" the amino acid alanine onto transfer RNAs (tRNAs). Transfer RNAs transport individual amino acids to the cell's protein synthesis machinery, where they are added to the grow...

Eliminate Data Analysis Bottlenecks in Drug Discovery

...ork as part of the School of Medicine's 28th annual Young Investigators' Day celebration.) "When there's no incoming food, muscles make lactate and alanine and send them to the liver to be converted into pyruvate and glucose," says Puigserver. "It appears, from our work, as though the pyruvate then trigge...

Computational verification of protein-protein interactions by orthologous co-expression

...ork as part of the School of Medicine's 28th annual Young Investigators' Day celebration.) "When there's no incoming food, muscles make lactate and alanine and send them to the liver to be converted into pyruvate and glucose," says Puigserver. "It appears, from our work, as though the pyruvate then trigge...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

...ork as part of the School of Medicine's 28th annual Young Investigators' Day celebration.) "When there's no incoming food, muscles make lactate and alanine and send them to the liver to be converted into pyruvate and glucose," says Puigserver. "It appears, from our work, as though the pyruvate then trigge...

Future diabetes drugs may target new protein interaction

...ork as part of the School of Medicine's 28th annual Young Investigators' Day celebration.) "When there's no incoming food, muscles make lactate and alanine and send them to the liver to be converted into pyruvate and glucose," says Puigserver. "It appears, from our work, as though the pyruvate then trigge...
Alanine in Biological Technology

Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

...variant by only two amino acids: aspartate-64 (Asp) and valine-118 (Val). These amino acids are substituted by glycine (Gly) and alanine (Ala) in the B variant. All variants contain five cysteine residues, four of which are involved in forming intrachain disulfide ...

In Vivo Signal Transduction Pathway Reporting Systems

...uld not be activated by overexpression of the MEKK protein. A mutated form of the c-Jun transactivator fusion protein, which had alanine residues substituted for serine 63 and 73 in c-Jun, could not be activated by MEKK (data not shown). In a similar fashion, the sp...
Alanine in Biological Definition

Amino acid

...otics (e.g. nisin or alamethicin ). Lanthionine is a sulfide-bridged alanine dimer which is found together with unsaturated amino acids in lantibioti...-COOH) pK 2 (α- + NH 3 ) pKr (R) Remarks A Ala alanine hydrophobic 89.09 6.11 2.35 9.87 C Cys ...

Genetic code

... (Val/V) Valine , Start 2 GCU (Ala/A) alanine GCC (Ala/A) alanine GCA (Ala/A) alanine GCG (Ala/A)...

Genetic code

... (Val/V) Valine , Start 2 GCU (Ala/A) alanine GCC (Ala/A) alanine GCA (Ala/A) alanine GCG (Ala/A)...

Neutral theory of molecular evolution

...etic code , according to which sequences of three nucleotides ( codons ) may differ and yet encode the same amino acid ( GCC and GCA both encode alanine , for example). Consequently, many potential single-nucleotide changes are in effect "silent" or "unexpressed" (see synonymous or silent substitution ...
Alanine in Biological Dictionary

Triplet repeat expansion

...e human genome, and these fall into two groups: (1) those that... ... dystrophy is caused by expansion of a GCG repeat that places additional alanine ... A second triplet repeat disorder that causes mental retardation was recently ... 1.1 Triplet Repeat Expansion ... The triplet repe...

Transfer RNA

...f link between the ... The answer: by means of transfer RNA molecules, each specific for one amino acid ... This image shows the structure of alanine transfer RNA (tRNAala) from yeast. ... What is transfer RNA ? Meaning of transfer RNA medical term. What does transfer RNA mean? ......

Alpha helix

...f ... Energetics of the structure of the four- alpha - helix bundle in proteins. ... Thermodynamics and mechanism of alpha helix initiation in alanine and valine peptides. ... Packing of alpha - helices : geometrical constraints and contact areas. J Mol Biol. ... Interactions between an alpha - ...
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