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AKT in Medical News

Coming Soon: Lung-Cancer Spray?

...-terminal modulator protein (CTMP), which inhibits akt signaling. Previous research has shown 90 percent of non-small cell lung carcinomas involve the akt signaling pathway, according to the study. Res...lentivirus-mediated CTMP overexpression suppressed akt activity and inhibited tumor progression," Cho wro...

Vaporized viral vector shows promise in anti-cancer gene therapy

...t interest. Dr. Cho and colleagues targeted the akt signaling pathway, which has been shown to be an i...cinomas were associated with the activation of the akt signaling pathway. They chose a lentiviral vector,...the lentiviral vector with a negative regulator of akt signaling, carboxyl-terminal modulator protein (CT...

U-M researchers link pathway to breast cancer stem cells

...re of cancer will require killing these cancer stem cells. In the current study, researchers looked at a drug called perifosine, which inhibits the akt pathway. Tumors in mice were treated with perifosine or docetaxel, a standard chemotherapy drug. The docetaxel alone showed no effect on the number of...

Cellular target may prove useful in treating deadly brain tumors

...rs also showed that blocking NK1R activity reduced akt activity, which then led to greater cell death. ...h levels of phosphorylated or chemically altered akt did not respond to treatment, Kwatra said. "Th...the importance of discovering the origin of active akt in glioblastomas," he said. "We propose that the e...

Drugs From Vegetables May Target Melanoma Tumors

...e. "Selenium deficiency is common in cancer patients, including those diagnosed with metastatic melanoma. Besides, selenium is known to destabilize akt proteins in prostate cancer cells," Robertson said. When the researchers tested the combination drug on different human melanoma cell lines, they f...

Vegetable-based drug could inhibit melanoma

...c melanoma," explained Robertson, whose findings appear in the March edition of Clinical Cancer Research . "Besides, selenium is known to destabilize akt proteins in prostate cancer cells." To study the effectiveness of the new drug -- isoselenocyanate -- researchers injected mice with 10 million can...

An Achilles heel in cancer cells

...ublished in the Dec. 9 issue of Cancer Cell . akt is a signaling protein, called a kinase, that is h...companies have been trying to find ways to inhibit akt to improve cancer therapy, he said, but most candi...survival," Hay said. "Tumor cells with hyperactive akt are not only resistant to the external stresses th...

Keryx Biopharmaceuticals' KRX-0401 (Perifosine) Data Selected for Oral Presentation at the 50th Annual Meeting of the American Society of Hematology

...inal Results of a Phase II Trial of the Novel Oral akt Inhibitor Perifosine in Relapsed and/or Refractor...TITLE: Phenotypic and Functional Effects of Novel akt Inhibitor Perifosine on Immune System Session N...st-in-class, oral anti-cancer agent that modulates akt and a number of other key signal transduction path...

Arno Therapeutics Appoints William F. Hamilton to Board of Directors

...e PDK1 inhibitor that blocks the PI3K/Akt pathway undergoing IND-enabling studies. AR-42 is an orally available, targeted inhibitor of the Pan-DAC and akt pathways also undergoing IND-enabling studies. Arno is actively pursuing additional compounds to expand its portfolio. For more information on Arno pl...

How do Lactobacilli treat Helicobacter pylori-related diseases?

...optosis of intestinal epithelia treated with tumor necrosis factor α, interferon-γ or IL-1α and promoted cell growth through activating akt and blocking p38 mitogen-activated protein kinase and stress-activated protein kinase/c-Jun amino-terminal kinase signaling. So LBG-S in this experime...

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AKT in Medical Technology

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...ay is being fully funded by an external grant provided by a private organization. KRX-0401 is a novel, oral, anticancer agent that modulates akt and several other important signal transduction pathways. Keryx is currently in the process of finalizing late-stage protocols for Perifosine in the t...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

...ancer and aberrant PI3K pathway activity is observed with high frequency in a variety of tumor types. PI3K signaling through its downstream effectors akt and mTOR is also known to promote tumor cell survival, proliferation, and growth. Dysregulation of PI3K signaling is also thought to contribute resis...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

...ancer and aberrant PI3K pathway activity is observed with high frequency in a variety of tumor types. PI3K signaling through its downstream effectors akt and mTOR is also known to promote tumor cell survival, proliferation, and growth. Notably, dysregulation of PI3K signaling is thought to contribute t...

FDA Accepts Arno Therapeutics' IND for AR-12 a PDK1 Inhibitor That Blocks the PI3K/Akt Pathway

...ess pathway, that received FDA acceptance of its IND in the second quarter of 2009. AR-42, an orally available, targeted inhibitor of the Pan-DAC and akt pathways received FDA acceptance of its IND in the first quarter of 2009. For more information on Arno please visit www.arnothera.com . ...

Bionovo Announces First Quarter 2009 Highlights and Financial Results

...as an active compound of BN108 that is responsible for BN108's selective cytotoxicity. BN108 and TspA3 induce apoptosis through rapid inactivation of akt and mTOR kinases in breast cancer cells but not in normal cells. Two additional members joined Bionovo's Scientific Advisory Board, Jan-Ake G...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

...inal Results of a Phase II Trial of the Novel Oral akt Inhibitor Perifosine in Relapsed and/or Refractory...st-in-class, oral anti-cancer agent that modulates akt and a number of other key signal transduction path...n and cell survival. The effects of perifosine on akt are of particular interest because of the importan...

SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines

... In vitro inhibition of the PI3K/AKT/mTOR pathway by SF1126 was demonstrated to impede the ability of angiogenic stimulants VEGF and Bv8 to activate akt in a dose dependant manner in two cancer cell lines (786-0 -- renal cell and PC3 prostate) and one endothelial cell line (HBEC -- human brain endothel...

Arno Therapeutics, Inc. Completes $18 Million Financing and Reverse Merger with Laurier International, Inc.

...ressive form of brain cancer. AR-12 is a PDK-1 inhibitor that targets the akt pathway while also possessing activity in the endoplasmic reticulum (ER) st...arceva(R) and tamoxifen. AR-42 is a targeted inhibitor of the Pan-DAC and akt pathways. In preclinical studies, AR-42 has demonstrated greater potency an...

Keryx Biopharmaceuticals, Inc. Announces Phase 2 Results on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Waldenstroms Macroglobulinemia at the 44th Annual Meeting of the American Society of Clinical Oncology

... Abstract 8546: A PHASE II TRIAL OF THE NOVEL ORAL akt INHIBITOR PERIFOSINE (KRX-0401) IN RELAPSED AND/OR...st-in-class, oral anti-cancer agent that modulates akt and a number of other key signal transduction path...on and cell survival. The effects of perifosine on akt are of particular interest because of the importan...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois

... Abstract 8546: A Phase 2 trial of the novel oral akt inhibitor perifosine in relapsed and/or refractory...CC): Abrogation of rapamycin-mediated induction of akt phosphorylation by perifosine. Investigators: W....st-in-class, oral anti-cancer agent that modulates akt and a number of other key signal transduction path...

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AKT in Biological News

JCI online early table of contents: Jan. 19, 2009

... benefit to individuals with prostate cancer. TITLE: Pim-1specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing akt phosphorylation, and activating apoptosis AUTHOR CONTACT: Pei Xiang Xing Burnet Institute Incorporating Austin Research Institute, Heidelberg, Vi...

Metastatic movements in 3-D

...tor 1 (EGFR1), which increased EGFR1's abundance at the membrane protrusions, as well as its autophosphorylation. Because EGFR1 is an activator of the akt pathway, hey presto, the cells took on some new moves. ...

How what and how much we eat (and drink) affects our risk of cancer

...cts signaling through downstream pathways, such as akt and mTOR. Negative energy balance inhibits, while...ietary energy balance alters signaling through the akt and mTOR pathways, both of which are related to TP...hanism for the effect of dietary energy balance on akt and mTOR signaling may be mediated, in part, by ch...

Mutant gene identified as villain in hardening of the arteries

...g" of the arteries is caused by plaque formation. In the vascular wall, akt plays an important role in regulating the development of endothelial cells,...One concern, he said, is that specific drugs are being developed to inhibit akt in cancer patients to reduce progression of tumors, and that these drugs ma...

UCSD researchers discover variants of natural tumor suppressor

... variants are important in cancer; the loss of a brake to any of the three akt pathways sends 'go, go, go' signals that promote the survival of tumor cell...rst author John Brognard. UCSD researchers had previously discovered that akt is hyperactivated, or elevated, in most cancers and PHLPP provides a mechan...

Molecular differences between early and advanced melanomas could provide new drug targets

... The cell-signaling molecule akt is a primary trigger that leads malignant melanoma... When the scientists introduced the gene for akt into radial growth melanoma cells, the cells expre...d cell growth. When melanoma cells overexpressing akt were introduced into immunocompromised (nude) mice...

How mammals fuel milk production may have implications for cancer

...d. The researchers found that one of three “isoforms?of the gene known as akt is specifically required for lactating mice to synthesize sufficient quanti... The findings may have important implications for cancer therapy, as the akt pathway is also one of the most commonly activated in cancer, Chodosh said....

Spelling out cancer on the nanoscale

...ing a decrease in oncoprotein levels. The new nano-fluidic system was also tested on human tumors by measuring the levels of MYC, BCL2, ERK, and akt proteins in the lymph nodes obtained from patients with Burkitt’s, mantle cell, or follicular lymphoma. The nano-fluidic system reported that MYC was ...

Protein's role in regulating cell death sets direction for cancer research

...cell death in response to other challenges, including some chemotherapeutic drugs. This study showed that calpain contributes to the activation of akt and JNK, two key players in the signaling pathways that control cellular responses to different death stimuli. These discoveries suggest that calpain ...

Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein

...h K17. Cell growth resulting from the manufacture of new proteins is in part controlled by several protein catalysts, or enzymes, including two called akt and mTOR. The researchers found that cells lacking K17 also have a less active Akt/mTOR pathway, suggesting that K17 somehow interacts with Akt/mTOR t...

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AKT in Biological Technology

FDA Accepts IND for Arno Therapeutics' Pan-DAC / Akt Inhibitor, AR-42

PARSIPPANY, N.J., March 17 /PRNewswire-FirstCall/ -- Arno Therapeutics, Inc. (OTC Bulletin Board: ARNI), a clinical-stage biopharmaceutical company focused on oncology therapeutics, today announced that the U.S. Food and Drug Administration ("FDA") accepted the Company's Investigational New Drug (...

Samtheo Announces License Agreement with Moffitt Cancer Center for Exclusive Rights to Novel Akt Inhibitor

Cancer Targeted Therapeutic for Samtheo's Personalized Medicine Portfolio NEW YORK, March 16 /PRNewswire/ -- Samtheo Biopharma LLC has entered into a license agreement, through its subsidiary, Lyndor Biosciences LLC, with Moffitt Cancer Center, gaining exclusive worldwide rights to a small mo...

Assay Designs(TM), Inc. Announces Release of First Available Product for Multiplex Analysis of Heat Shock Proteins

...haperones, the MultiBead(TM)* HSP/Chaperone 8-Plex Kit. The bead-based multiplex immunoassay enables measurement of HSP client proteins (Akt and akt phosphor-Ser473) and HSPs (Hsp27 phospho Ser15, Hsp27 phospho-Ser82, Hsp40, Hsp60, Hsp70 and Hsp90 alpha) in cell lysates. The assay utilizes monoclon...

Arno Therapeutics to Deregister its Common Stock under the Exchange Act

...PDK1 inhibitor that blocks the PI3K/Akt pathway, has completed IND-enabling studies. AR-42, an orally available, targeted inhibitor of the Pan-DAC and akt pathways received FDA acceptance of its IND in the first quarter of 2009. For more information on Arno please visit www.arnothera.com . ...

AEterna Zentaris Presents Two Posters on its PI3K Inhibitor Compound, AEZS-126, at AACR Annual Meeting

...rs on AEZS-126, a promising compound for clinical intervention of the PI3K/ akt pathway in human tumors. The posters were presented at the American Associa...its PI3Ka with an IC50 value of 10nM and proved to be a potent inhibitor of akt phosphorylation in cellular assays. Mode-of-action studies showed that AEZS...

Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research

...te that perifosine treatment induced inhibition of akt phosphorylation, and decreases of cell survival. ...s a single agent, perifosine targets activation of akt in neuroblastoma cells and xenografts, and signifi...ults by Cirstea et al. that dual inhibition of the akt pathway by rapamycin (ABI-009) and Perifosine indu...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

.... 2804 (Monday, April 20, 2009, 1:00 pm - 5:00 pm) -- AMG 479, a fully human anti-IGF-1R monoclonal antibody, inhibits rapamycin-induced akt activation in sarcoma cell lines Overview: Evaluated whether AMG 479 could inhibit this feedback-loop mechanism and thus increase the ...

Genstruct to Present Results of Collaboration with Top Pharmaceutical Company at American Association for Cancer Research's Annual Meeting

..., Ph.D., project lead/scientist II at Genstruct will be presenting a poster titled, "Causal Reasoning Identifies Mechanisms of Sensitivity for a Novel akt Kinase Inhibitor: GSK690693" on April 21 from 1:00 - 5:00 p.m. The poster will focus on how Genstruct and its partner evaluated the mechanisms for se...

Arno Therapeutics Reports 2008 Year-End Financial Results

...e PDK1 inhibitor that blocks the PI3K/Akt pathway undergoing IND-enabling studies. AR-42 is an orally available, targeted inhibitor of the Pan-DAC and akt pathways that received FDA acceptance of its IND in the first quarter of 2009. For more information on Arno please visit www.arnothera.com . ...

Arno Therapeutics to Present at the Rodman & Renshaw 10th Annual Healthcare Conference

...nhibitor that blocks the PI3K/Akt pathway that is undergoing IND-enabling studies. AR-42 is an orally available, targeted inhibitor of the Pan-DAC and akt pathways also undergoing IND-enabling studies. Arno is actively pursuing additional compounds to expand its portfolio. For more information on Arno pl...
AKT in Biological Dictionary

SiRNA

...; 14th, 2009. Flyer. Schedule ... SignalSilence<sup>®</sup > akt siRNA I from Cell Signaling Technology (CST) allows the researcher to specifically inhibit akt expression using RNA interference, a ... SignalSilence® MEK1 siRNA f...
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