Aire

Autoimmune regulator

...une Regulator Identifiers Symbol aire Alt. Symbols AIRE1, APECED, APS1, APSI, PG...2.3 The Autoimmune Regulator, abbreviated aire , is a human gene which is expressed in the thymu...asis-Ectodermal Dystrophy (APECED). Disruption of aire results in the development of a range of autoimmu...

Central tolerance

...es. In the case of T cell central tolerance, additional sources of antigen are made available in the thymus by the action of the transcription factor aire . After exposure to self antigens, T cells and B cells become immunologically tolerant (non-reactive) in a number of ways : Negative selection ...

Thymocyte

...hymocytes reactive to peripheral organs, the gene aire drives the expression of multiple peripheral anti...Immunological Self-Shadow Within the Thymus by the aire Protein. Science 298 (5597), 1395-1401 ^ Liston, A. et al. (2003) aire regulates negative selection of organ-specific T c...

Aire in Biological News

Proteins anchor memories in our brain

...ork involving a protein in the cell nucleus called aire (for autoimmune regulator), which regulates the ex... in the thymus. Humans and mice lacking the normal aire gene suffer from multiple autoimmune diseases incl...olleagues there demonstrated that knocking out the aire gene in the mouse thymus led to failures of expres...

Autoimmune disease triggered if T cells miss a single protein early on

...ork involving a protein in the cell nucleus called aire (for autoimmune regulator), which regulates the ex... in the thymus. Humans and mice lacking the normal aire gene suffer from multiple autoimmune diseases incl...olleagues there demonstrated that knocking out the aire gene in the mouse thymus led to failures of expres...

New pathways for autoimmune treatment identified

...er cells in autoimmune disease. Mutation in the aire gene causes APS1, a disease causing two out of thr...e the status of these cells in a mouse missing the aire gene. That aire knockout is a good model for humans with APS1. ...