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Aeruginosa in Medical News

AdvanDx Receives FDA 510(k) Clearance for EK/P. aeruginosa PNA FISH(R)

First Diagnostic Test for Identifying E. coli, K. pneumoniae and P. aeruginosa Directly from Positive Blood Cultures PNA FISH Provides Critical Results 24-48 Hours Sooner Than Conventional Methods to Help Clinicians Improve Care and Outcomes for 100,000 Patients with Gram-Negative Bloodstream...

A Broad-Spectrum Antibiotic with Activity Against MRSA and Pseudomonas Aeruginosa Would Earn a Higher Patient Share in the U.S. than in Europe for the Treatment of Hospital-Acquired Pneumonia

Merck's Drug Will Remain Decision Resources Gold Standard Through 2017, According to a New Report from Decision Resources WALTHAM, Mass., March 3 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that a b...

The Outbreak of Pseudomonas Aeruginosa In An LA Hospital, Makes 7 Children Sick

White Memorial Medical Center near downtown Los Angeles has shut its neonatal and pediatric intensive care units to new admissions after identifying an outbreak of a potentially// fatal bacterium Pseudomonas aeruginosa. Seven children are supposed to be infected with the virulent bacterium, includi...

AlphaRx Presents Positive Preclinical Data on Zysolin(TM) Inhalable Nanoparticles at Controlled Release Society Annual Meeting

...ve treatment in animal models of acute Pseudomonas aeruginosa pneumonia when compared to inhaled and injected co...d animals died within 24 hours after infection. P. aeruginosa is one of the most common and lethal pathogens res...ity against intracellular Klebsiella, Pseudomondas aeruginosa and Staphylococcus bacterial strains in pneumonia ...

Orlando Regional Medical Center (ORMC) Implements PNA FISH(R) Tests to Help Provide Better Care for Patients with Bloodstream Infections

...sts enable microbiology labs to provide rapid and accurate identification of bloodstream pathogens, including S. aureus , Enterococcus species, P. aeruginosa and Candida species, directly from positive blood cultures in hours instead of days. Clinical studies show that rapid identification of bloodstream...

Independent Laboratory Testing Shows BioNeutral's Hospital Grade Ygiene(TM) Eliminates Aspergillus Niger (Black Mold) Spores

...cult to kill antibiotic resistant forms including, Methicillan Resistant Staphylococcus Aureus often referred to as "MRSA", drug resistant Pseudomonas aeruginosa and the very difficult to eradicate pan resistant Klebsiella Pneumoniae. Obviously the new strain of H1N1 virus (Swine Flu) will not present any prob...

European researchers look for new ways to fight multi-drug-resistant bacterial infections

...On occasions, the choice narrows down to one drug such as the "last-resort" antibiotic colistin to treat infections caused by the bacteria Pseudomonas aeruginosa or Acinetobacter baumannii. At the same time, the lack of economic benefits has reduced the amount of research pharmaceutical companies dedicate to cr...

Derma Sciences Announces First Commercial Sales of BIOGUARD(TM) Barrier Dressings

...aureus 7.10 (>99.99999%) Escherichia coliform 7.10 (>99.99999%) Pseudomonas aeruginosa 7.22 (>99.99999%) Corynebacterium xerosis 5.68 (>99.999%) Micrococcus luteus ...

Zysolin(TM) Pre-clinical Data Supports Once-a-day Dosing in Humans

...delivery platform, and intended for the adjunctive treatment of Pseudomonas aeruginosa Pneumonia in intubated and mechanically-ventilated patients (VAP). In a r...g its antibacterial activity against intracellular Klebsiella, Pseudomondas aeruginosa and Staphylococcus bacterial strains in pneumonia patients. The active ingr...

BUSM researchers find gram-negative rods in two Philippine neonatal intensive care units

...d that 376 newborns became bacteremic with a total of 437 GNRs. The most common GNR species identified were Klebsiella, Acinetobacter, Pseudomonas aeruginosa and Enterobacter. A high proportion of colonization and bacteremia at the two NICUs was with non-intestinal GNRs. Factors significantly associated wit...
Aeruginosa in Medical Technology

Calixa Therapeutics Announces Initiation of Phase 2 Clinical Trial of Its Antibiotic, CXA-101, in Patients with Complicated Urinary Tract Infections

...iotic with excellent in vitro and in vivo activity against Pseudomonas aeruginosa , including drug resistant isolates. Calixa is investigating CXA-101 as a ...against increasingly resistant gram-negative pathogens such as Pseudomonas aeruginosa ," said Dr. Ian Friedland, chief medical officer of Calixa. "We are going...

Calixa Therapeutics Announces Positive Phase 1 Results for CXA-101, a Novel Intravenous Cephalosporin Antibiotic with Excellent Anti-Pseudomonal Activity

...pport the further clinical development of this compound. " Pseudomonas aeruginosa is usually less susceptible to commonly used antibiotics, and infections c...ma Inc. in 2007. CXA-101's potent in vitro activity against Pseudomonas aeruginosa has the potential to address the unmet medical need posed by this very p...

Lytix Presents LTX-109 Anti-Microbial Data at ICAAC

...Streptococcus pyogenes than marketed gold standard drugs. In addition to this it has proven effective against a wide range of 110 European Pseudomonas aeruginosa clinical isolates, a problrmatic Gram (-) bacterium. According to Lytix Biopharma spokesperson Anders Fugelli, these are important studies: "T...

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis

...hat MP-376 has potent activity against Pseudomonas aeruginosa (P. aeruginosa) infection under a wide array of co...tients were required to be culture positive for P. aeruginosa at baseline. P. aeruginosa is a bacterial pathogen that is a leading cause of...

Intercell Announces Initiation of Further Phase II Clinical Trial of V710 an Investigational Vaccine to Prevent S. aureus Infection

...eus vaccine, based on an antigen identified by Intercell, Intercell is developing a vaccine against hospital-acquired infections caused by Pseudomonas aeruginosa (Phase II/III trial is expected to be initiated in 2008) and a Pneumococcus vaccine (Phase I trials planned for end 2008). Furthermore Intercell has o...

Mpex Initiates a Phase 2 Clinical Trial of Aerosol MP-376 in the Treatment of Chronic Bacterial Infections in Cystic Fibrosis Patients

...eatment of pulmonary infections due to Pseudomonas aeruginosa and other bacteria in patients with cystic fibrosi...ced a reduction in bacterial counts of Pseudomonas aeruginosa in sputum. The primary efficacy endpoint to be a...logical (change in bacterial counts of Pseudomonas aeruginosa in sputum) over 28 days of dosing. Additional endp...

PARI's eFlow Included in Gilead's NDA Submission for Aztreonam Lysine for Inhalation

...e for inhalation, delivered by eFlow, is an investigational therapy in development for people with cystic fibrosis (CF) who have pulmonary Pseudomonas aeruginosa (P. aeruginosa) infection. The NDA is supported by data from two Phase III clinical studies (AIR-CF1 and AIR-CF2) and interim data from an ongoing o...

Promising Data from Paratek Pharmaceuticals' MAR Inhibitor Program Presented in 'Late Breaker' Session at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... (ICAAC) taking place in Chicago. The findings demonstrated that small molecule agents which block the activity of ExsA (a MAR protein) in Pseudomonas aeruginosa significantly reduced bacterial virulence and were protective in an animal model from pneumonia. Lead authors on the research are Michael P. Draper, P...

New Data Show Ceftobiprole as Effective as Combination Therapy in Treating Patients With Complicated Skin Infections, Including MRSA

...e S. aureus (MSSA) (91% vs. 92%, respectively); MRSA (87% vs. 86%); S. pyogenes (90% vs. 100%); S. agalactiae (81% vs. 75%); E. coli (86% vs. 92%); P. aeruginosa (83% vs. 89%); and, Enterobacter spp., Klebsiella pneumoniae, and Proteus mirabilis (86% vs. 83%) from the site of infection. Other data from two, po...

New Data Show Doripenem as Effective as Commonly Used Therapies in Treating Hospital-Acquired Pneumonias

...doripenem, especially among strains of Pseudomonas aeruginosa and Klebsiella pneumoniae. A second study demonst... for imipenem. For those patients with Pseudomonas aeruginosa infection, doripenem demonstrated a 65% clinical c...r equal to 16 mcg/mL) in patients with Pseudomonas aeruginosa were 27% vs. 4%, respectively and in patients with...
Aeruginosa in Medical Dictionary

Skin infection

...k itch, ringworm, and yeast infections . The infection is usually caused by bacteria that normally live on the skin , such ... Pseudomonas aeruginosa skin ; soft tissue; and bone infections ... Candidiasis is by far the most common type of yeast infections in human skin . ... a-z list &g...

Neutrophil

...8 (IL-8) is location dependent. ... Neutrophil apoptosis is essential for the resolution of inflammation. ... Neutrophils (x106/g sputum) in P aeruginosa infected patients (Kruskal-Wallis p ... Human neutrophil defensins (alpha-defensins) belong together with the beta ... Activation of neutroph...
Aeruginosa in Biological News

A matter of density, not quantity

...etc. in hospitals in particular are often caused by bacteria called Pseudomonas aeruginosa. Once they reach a certain density, colonies of Pseudomonas aeruginosa produce virulence factors and can enter into a slimy state, a biofilm, which prevents antibiotics from penetrating. The process of quorum sensing, whi...

Research could lead to new non-antibiotic drugs to counter hospital infections

...rather than attempting to kill it. Pseudomonas aeruginosa is one of the most serious hospital-acquired path...procedure or immunosuppressive drugs, however, P. aeruginosa can cause infection, inflammation, sepsis and death. Why P. aeruginosa can suddenly turn on its host has eluded research...

No hiding place for infecting bacteria

...e body's own defence cells to prevent Pseudomonas aeruginosa bacteria from building a protective biofilm which...dy's defence cells, called neutrophils, attack P. aeruginosa , the cell contents - including a protein called F-actin and the cell's DNA are released. P. aeruginosa uses these cell proteins as a scaffold to build a...

Fowl soil additive breaks down crude oil

... their samples and identified 21 different microbial species known as aerobic heterotrophs. The team explains that Bacillus species and Pseudomonas aeruginosa were the best oil-munching microbes but of the 21 isolates 12 were capable of metabolizing components of crude oil. Other microbes included Proteus ...

Winter brings flu, summer brings bacterial infections

... There are several possible causes for the summertime increase in gram-negative bacterial infections, the researchers said, but none are proven. P. aeruginosa is an aquatic organism, and infections caused by it could be linked to more people swimming in lakes or pools during the summer. Cattle have higher ba...

Scientists build 'roach motel' for nasty bugs of the bacterial variety

... that bacterium sickens or kills patients suffering from burns, cancer, AIDS other serious conditions. The strain the researchers used was Pseudomonas aeruginosa PAO1, which is a close cousin but poses little health threat. While Schanze said further tests are needed to nail down the spheres' potency, initia...

New approach to treating cystic fibrosis lung infection shows promise

...ished in Proceedings of the National Academy of Science USA, this week. Communities of bacteria grow in the lungs of people with CF. Pseudomonas aeruginosa is a common bacterium found in these communities and is often associated with severe lung infections. Pseudomonas represents a constant and ever prese...

Rattlesnake-type poisons used by superbug bacteria to beat our defenses

...y's Autumn meeting being held this week at Trinity College, Dublin. The toxins are manufactured by communities of the hospital superbug Pseudomonas aeruginosa called biofilms, which are up to a thousand times more resistant to antibiotics than free-floating single bacterial cells. "This is the first time ...

American Society for Microbiology honors Marvin Whiteley

...ral discoveries that have impacted the understanding of chronic Pseudomonas aeruginosa infections. As a graduate student, Dr. Whiteley provided the first experimental evidence that quorum sensing is a global regulatory system in P. aeruginosa infection, responsible for modulating numerous processes aside from virulen...

Viruses evolve to play by host rules, according to University of Pennsylvania researchers

...Biologists at the University of Pennsylvania and Harvard University have examined the complete genomes of viruses that infect the bacteria E. coli, P. aeruginosa and L. lactis and have found that many of these viral genomes exhibit codon bias, the tendency to preferentially encode a protein with a particular sp...
Aeruginosa in Biological Technology

AdvanDx Receives FDA 510(k) Clearance for E. coli/P. aeruginosa PNA FISH(R)

First Diagnostic Test for Identifying E. coli and P. aeruginosa Directly from Positive Blood Cultures PNA FISH to Provide Critical Results 24-48 Hours Sooner Than Conventional Methods Helping Clinicians to Improve Care and Outcomes for 100,000 Patients with Bloodstream Infections WOBURN,...

Ondine Announces Publication of Positive Results from Pseudomonas aeruginosa Eradication Study

VANCOUVER, Aug. 7 /PRNewswire-FirstCall/ - Ondine Biopharma Corporation (TSX: OBP; AIM: OBP), a medical technology company developing photodisinfection-based products, today announced that the results of a study using the Company's platform Photodisinfection technology to eliminate Pseudomonas...

Pseudomonas aeruginosa

Multiporator / Electroporator 2510 Transformation Protocol Protocol No. 4308 915.528 01/2002 ...

Pseudomonas aeruginosa

Multiporator / Electroporator 2510 Transformation Protocol Protocol No. 4308 915.528 01/2002 ...

Ondine Biopharma Announces Second Quarter 2008 Financial Results

...todisinfection technology to eliminate Pseudomonas aeruginosa would be published in the peer-reviewed journal Ph... "In Vitro Photodynamic Eradication of Pseudomonas aeruginosa in Planktonic and Biofilm Culture", Ondine researc... conclusively demonstrated rapid eradication of P. aeruginosa in both free-floating (planktonic) and the highly-...

GlaxoSmithKline and Mpex Pharmaceuticals Form Alliance to Develop Novel Efflux Pump Inhibitors for Use Against Serious Gram-Negative Infections

...o significantly improve the potency of a number of different antibiotic classes against drug- resistant gram-negative pathogens, including Pseudomonas aeruginosa and Klebsiella pneumoniae. About Mpex Pharmaceuticals Mpex Pharmaceuticals is a clinical stage biopharmaceutical company whose mission is to devel...

Nektar Receives Patent Covering Pulmonary Targeted Antibiotics

...secretion of thick, sticky mucus that supports bacteria growth. Pseudomonas aeruginosa is the most common bacterium causing lung infections in people with CF. By the age of 17, nearly 70 percent of people with CF have Pseudomonas aeruginosa in their lungs. Pseudomonas aeruginosa infections cause lung inflammation a...

Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients

...ndidate, ARIKACE(TM) (liposomal amikacin for inhalation), may have the ability to penetrate mucus and biofilms, and decrease the number of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis, according to results of a study published in the Journal of Antimicrobial Chemotherapy. Results of...

Mpex Candidate, MP-376, Granted U.S. Orphan Drug Status for the Treatment of Cystic Fibrosis

...lopment has granted Mpex orphan drug designation for levofloxacin solution for inhalation for the treatment of pulmonary infections due to Pseudomonas aeruginosa and other bacteria in patients with cystic fibrosis. Levofloxacin is the active pharmaceutical ingredient in MP-376, the company's proprietary levoflo...

Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007

...d to generate results using traditional culture-based methods. The collaboration's first MilliPROBE assay targets the bacterium Pseudomonas aeruginosa and is designed as an in-process, early warning system to provide faster, more effective detection of the bacterium in purified water used d...
Aeruginosa in Biological Dictionary

Transposon mapping

...n locations ... apply this method to mapping bacterial transposon insertion sites in a yeast ... ... the PA14 Non-Redundant Set of Pseunomas aeruginosa Transposon Insertion Mutants. ... MAR2xT7 Transposon Map [pdf] MAR2xT7 transposon map in PowerPoint format. ... Comprehensive transposon...

RecA protein

...tein filament whose ... However, RecA protein is also a dATPase; dATP supports RecA -RFP nucleoprotein ... The RecA protein of Pseudomonas aeruginosa (RecAPa) exhibits a more robust ... RecA protein , a central enzyme of homologous recombination and recombinational ... ...

Codominant

...heritance. ( 2009). In Medical. Retrieved August 10th, 2009, from www.yourdictionary.com/medical / codominant ... codominant algae Microcystis aeruginosa (Cyanophyceae) and Ceratium hirundinella ... present as codominant . algae within the late summer bloom of a eutrophic lake. ... Type of allelic...

Bioaugmentation

...ioaugmentation was further demonstrated when Comamonas testosteroni was ... ... nitrogen source) and/or bioaugmentation (addition of Pseudomonas aeruginosa ... improved bioremedation of HMW PAHs using biostimulation and/or Bioaugmentation . ... Bacteria are a skilled workforce in the task of decomposi...
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