Study gives clues to how adrenal cancer forms
...ne in mice generally prone to develop cancer. The mice that also had dysfunctional telomeres were particularly prone to develop the usually ultra-rare adrenocortical cancer. This is the first mouse model to specifically address this rare but lethal type of cancer. "Usually when telomeres get short, they also see...Maternal depression and controlling behavior associated with increased stress response in infants
...ng-term effects: are these infants at increased risk for psychological or physical stress-related illnesses later in life. If so, why" Given that the adrenocortical system is known to be plastic and hence easily influenced in both positive and negative ways, we believe that it is very important to eventually ident...Genetic Link to Adrenal Tumor Revealed
...n conducting the study, the researchers used gene arrays to analyze the DNA of patients with a rare tumor of the adrenal glands, known as micronodular adrenocortical hyperplasia, explained the study's senior author, Constantine Stratakis, M.D., D(Med)Sc, Chief of NICHD's Section on Endocrinology and Genetics. The r...PRED FORTE* Ophthalmic Suspension
Description:... Prednisolone Acetate ophthalmic suspension USP, 1% is an adrenocortical steroid product prepared as a sterile ophthalmic suspension....Design of a compound that stabilizes the main natural suppressor of tumors
...ation of the entire protein with the consequent loss of activity. Two well documented examples of this kind of congenital predisposition are pediatric adrenocortical carcinoma and Li-Fraumeni syndrome. Therefore, the design of compounds with the capacity to stabilize the tetramerization domain of p53 represents a n...Lack of key enzyme associated with development of rare tumor
...n conducting the study, the researchers used gene arrays to analyze the DNA of patients with a rare tumor of the adrenal glands, known as micronodular adrenocortical hyperplasia, explained the study's senior author, Constantine Stratakis, M.D., D(Med)Sc, Chief of NICHD's Section on Endocrinology and Genetics. The ...