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Adipocyte in Medical News

Pluronic L-81 is a potential anti-diabetic drug?

... diabetic (db /db ) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db /db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mechanism, HepG2 cells were ...

Trimming the fat boosts blood recovery after marrow transplant

...ood cell progenitors that are known in mice as well as humans to be the most important in surviving the immediate post-transplant period. Several adipocyte inhibitors, such as PPAR-gamma inhibitors, are already being tested clinically against obesity, but might also serve as adjuvants to speed engraftment...

Total Health Center Using New Hgh Product to Destroy Fat Cells

...of most diets. But dieting only addresses one side of the body fat equation. The number of adipose, or fat, cells is an insuperable threshold, as each adipocyte has a minimal size. For long term success, use of Hgh , and a regular nutritional diet should reduce the size of each cell and destroy as many of the...

Researchers chart the genetic mechanisms behind the genesis of fat cells

... a limited number of direct targets for PPARg have been identified. Our findings provide a genome-wide map of PPARg binding sites during the course of adipocyte differentiation, said M. Sabry Hamza, Ph.D, a postdoctoral research fellow at the Genome Institute of Singapore, a division of Singapores Agency for S...

JCI table of contents: Oct. 18, 2007

...e, and increased energy expenditure, indicating a crucial role for LRP1 in translating a high-fat diet into obesity and glucose intolerance. TITLE: adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice AUTHOR CONTACT: David Y. Hui Uni...

Genaera Announces Formation of Scientific Advisory Board for Obesity Drug Candidate Trodusquemine (MSI-1436)

...ment, which often limits sustained weight loss during caloric restriction. Trodusquemine suppresses appetite, causes differential weight loss, reduces adipocyte size, reduces body fat (with no reduction of lean mass), and improves glucose tolerance via inhibition of a unique combination of signaling pathways i...
Adipocyte in Medical Technology

Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference

...ment, which often limits sustained weight loss during caloric restriction. Trodusquemine suppresses appetite, causes differential weight loss, reduces adipocyte size, reduces body fat (with no reduction of lean mass), and improves glucose tolerance via inhibition of a unique combination of signaling pathways i...

Elixir Pharmaceuticals Presents Additional Preclinical Data Demonstrating the Potential of Ghrelin Antagonism to Regulate Metabolism, Body Weight and Glycemic Control

...se tissue, isolated adipocytes from mice, and the mouse adipocyte cell-line. The results showed GhrR was detected in the isolated adipocytes and mouse adipocyte cell lines, suggesting ghrelin acts directly through its receptor on adipocytes to regulate energy homeostasis. Moreover, the reduction of insulin sig...

Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Association's Annual Meeting

... first examined ghrelin signaling by measuring insulin sensitivity in mouse adipocyte cell lines that were treated with ghrelin for four days. Scientists also as...f GhrR mRNA in adipose tissue, isolated adipocytes from mice, and the mouse adipocyte cell-line. The results showed GhrR was detected in the isolated adipocytes ...
Adipocyte in Medical Definition

Fat transfer

... ein Lipom. Zentralbl. Chir. 27: 72, 1895. ^ Shiffman, M.A., Mirrafati S. Fat Transfer Techniques: The Effect of Harvest and Transfer Methods of adipocyte Viability and Review of the Literature. Dermatologic Surgery 27 (9,) pp 819-826. (2001) ^ Mendieta, C.; Gluteoplasty. Aesthetic Surgery Journal,...
Adipocyte in Biological News

Empire State Stem Cell Board awards $12.7 million to Albert Einstein College of Medicine

... Judy R. & Alfred A. Rosenberg Professsor of Diabetes Research; director of the Diabetes Research and Training Center $1,080,000 Identification of adipocyte progenitor cells during adipose tissue turnover and obesity. Carl Schildkraut, Ph.D., professor of cell biology $1,080,000 Differential regulati...

Tips from the American Journal of Pathology

...dipose tissue isolated from mice after total body irradiation. They found that fat pads weighed significantly less post-irradiation and had decreased adipocyte size and a reduced number of mature adipocytes. Poglio et al also observed severe decreases in the number of proliferating cells and increases in the...

Medical College researchers find dinosaur clues in fat

...ns the surprising implication that the same lack of heat-generating tissue may have contributed to the extinction of dinosaurs. The paper, The brown adipocyte differentiation pathway in birds: an evolutionary road not taken, was written by Stuart A. Newman, Ph.D., professor of cell biology and anatomy, Nadej...

'Knocking out' cell receptor may help block fat deposits in tissues, prevent weight gain

...8 online edition and the November 2007 print issue of the Journal of Clinical Investigation, the findings about a specific cell receptor, known as the adipocyte LDL receptor-related protein 1 (LRP1), provide important clues about the underlying biological mechanisms that control fat transport in the body. U...

Story ideas from the Journal of Lipid Research

... The following article is the fourth in a series of reviews on adipocyte biology or the biology of fat tissue. The other articles in the series will... successful therapies in the future, the scientists conclude. Article: adipocyte stress: the endoplasmic reticulum and metabolic disease , by Margaret F. Gr...

Expanding waistlines triggered by your genes

...ion, was unaffected. Importantly, the research team also discovered that adipocyte differentiation in conventional two-dimensional (2-D) cell culture is diffe... cell biology and 3-D tissue function. These findings shed new light on adipocyte biology and possibly will provide novel therapeutics to prevent the progres...

UCSD study clarifies insulin's role in blocking release of energy in patients with type II diabetes

...ts can physically view the protein under a microscope and watch how the live cell activates PKA in real time. The PKA is normally activated inside the adipocyte cell, the major site of energy storage in the body where many aspects of metabolism are controlled. There, energy is stored in the form of triglycerid...
Adipocyte in Biological Technology

Stemgent, CellDesign Sign Co-Exclusive Marketing Agreement on Stem Cell-Based Adipocyte Research Products

- Stemgent to provide CellDesign's proprietary adipocyte differentiation kits - SAN DIEGO and NEW HAVEN, Conn., March 24 /PRNewswire/ -- Stemgent has signed a co-exclusive license to market CellDesign's AdipoDesign Starter Kit and AdipoDesign MaxiKit, which enable researchers to grow and stud...

ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System Target Validation and Identification of Novel Disease Indications

...n skeletal muscle from obese and/or diabetic patients as compared to non-obese and/or non-diabetic patients. It is known that ESR1 knock-out mice show adipocyte hyperplasia and hypertrophy (i.e. obesity), as well as insulin resistance (a feature of diabetes) (4). These mouse data, combined with the findings in...

QBT Fatty Acid Uptake Assay Kit datasheet

... throughput Fluorescence Activated Cell Sorter (FACS) instrumentation, or require cell washing, which can severely compromise the integrity of fragile adipocyte cells. OPTIMIZED ASSAY The QBT Fatty Acid Uptake Assay is a single-step homogeneous fluorescent assay that provides real-time upta...

Human Primary Preadipocytes and Differentiated Adipocytes

...pocytes that die within 24 hours. The study of adipocyte biology is important not only to understand metabo... energy balance. Previously, all research in adipocyte biology was conducted using rodent cells, mainly...assed for human systems in experiments involving adipocyte signal transduction pathways or gene regulation. ...
Adipocyte in Biological Dictionary

N Terminus

..... S terminus moved to exit 176, I-65, 5 miles N of Montgomery(1983) ... For example, the N terminus of PPAR confers the ability to promote adipocyte ... Swapping the DBD along with the N terminus (DBD-/ and DBD-/) has no additional ... Functional antagonists of sonic hedgehog reveal the impo...
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