Hormone shows promise in reversing Alzheimers disease and stroke
...d to be to work."
The therapy known as PACAP27 -- is a hormone produced by the body that is a general neuro-protectant. PACAP stands for pituitary adenylate
cyclase-activating polypeptide. "It is a general protector of the brain against many types of insult and injury," Banks says.
He compares a specif...
NuView Radiopharmaceuticals, Inc. Secures Exclusive Rights From Thomas Jefferson University for a Tumor-Specific Imaging Agent for the Diagnosis of Breast and Prostate Cancers
...human tumors over-express vasoactive intestinal peptide (VIP)
and pituitary adenylate
cyclase-activating peptide (PACAP) receptors known
as VPAC1, VPAC2 and PAC1...ing the binding of the small molecule peptide PACAP to vasoactive
cyclase (VPAC) receptors expressed in high density on
"The need f...
Caught in the act: The dynamic dance of enzymes
...f the biological world scientists had once thought, essentially passive until catalysis occurs. Rather, Kern and her team demonstrated that the enzyme adenylate
kinase, and presumably many more, engages in a dynamic dance even before its catalytic datethe substrate to which it bindsshows up.
If one of the ...
News Tips from the Journal of Neuroscience
...alcium currents and downregulation of potassium currents. Signaling through cAMP pathways downstream of calcium, including Ca 2+ /calmodulin-dependent adenylate
cyclase, appear to link the channel activity to more robust growth.
3. Cocaine, Serotonin, and Conditioned Place Preference
Thomas S. H...
Adenylate in Medical Technology
Adenylate in Medical Products
Description:... Acolytes core technology relates to the ultrasensitive measurement of adenylate
Kinase (AK), an enzyme found in all living cells. ATP produced by the AK reaction is measured using bioluminescence. By coupling AK Technology to m...
Company:Acolyte Biomedica Ltd
Adenylate in Biological Technology
Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells
Adrenergic receptors are linked to adenylate
cyclase via either inhibitory or stimulatory G pro...neration of cAMP. In response to receptor binding, adenylate
cyclase converts AMP to cAMP, which exerts its eff...ponse to stimulation by forskolin, an activator of adenylate
cyclase. The cells have responded in a dose depend...
The Bio-Rad Silver Stain, Rev E
...ins, Proc Natl Acad Sci USA
82, 52085212 (1985)
12. Coussen F et al., Identification of the catalytic subunit of brain
cyclase: a calmodulin binding protein of 135 kDa, Proc Natl
Acad Sci USA 82, 6736-6740 (1985)
13. Crooks AJ et al., The purificat...
Translate High Yields of Biologically Active Proteins
...ocol. The proteins
analyzed were dihydrofolate reductase (DHFR), adenylate
kinase 1 (AK1),
carbonic anhydrase 2 (CA2), caspase 3 (CASP3), a...successive decrease of absorbance of
NADPH at 340 nm at 30C . adenylate
kinase 1 (AK1): Activity was measured
by a luciferase-based ATP ...
TransMessenger Transfection Reagent Handbook
...ncorporated into an in vitro-transcribed RNA by adding an RNA cap-structure
analog to the transcription reaction. A poly-A tail, a stretch of adenylate
residues added 3' to the mRNA coding sequence, also stabilizes mRNA. A poly-A
tail can be incorporated into an in vitro-transcribed ...
In Vivo Signal Transduction Pathway Reporting Systems
be activated by ultraviolet irradiation, and the PathDetect CREB system
was activated by known PKA-activating agents such as the adenylate
toxin from Bordetella pertussis and forskolin (data not shown).
Applications of the PathDetect Systems
The PathDetect c-Jun...
Enzyme Immunoassay for Studying Intracellular Levels of cAMP
... Sensitive, nonradioactive cyclic-AMP detection kit and adenylate
Danny Q. Hoang
Stratagene Cloning Syste...AC Toxin for Increased Intracellular cAMP Levels
Stratagene is offering adenylate
cyclase (AC) toxin, a useful reagent for
increasing intracellular cAMP le...
Adenylate in Biological Products
Adenylate in Biological Definition
...h covalent bonds
The complete nomenclature can be browsed at http://www.chem.qmul.ac.uk/iubmb/enzyme/
Enzymes and classes of enzyme
cyclase : participate in signal transduction by converting ATP into cyclic AMP
Alcohol dehydrogenase : breaks down alcohols to aldehydes ...
Adenylate in Biological Dictionary
...zyme variation have revealed three ... The European Bioinformatics Institute ... This clade is found only in eukaryotes and includes human adenylate
kinase isozyme 1 (myokinase) ... Isozyme loci can be particularly useful for marking linkage groups (Tanksley and ... such as trees, may ...