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Adenovirus in Medical News

Barr's BLA for Adenovirus Type 4 and 7 Live Oral Vaccines Accepted for Filing by FDA

MONTVALE, N.J., Dec. 11 /PRNewswire-FirstCall/ -- Barr Pharmaceuticals, Inc. (NYSE: BRL ) today announced that the U.S. Food and Drug Administration (FDA) has accepted for review Duramed Pharmaceuticals, Inc.'s Adenovirus Types 4 and 7 Live Oral Vaccines Biologics License Application (BLA). Thes...

PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach

...eld studies. Using Crucell's AdVac technology with two different vectorsthe adenovirus serotypes Ad35 and Ad26 as delivery mechanisms, this approach seeks to elic...am. Carter Diggs at the USAID MVDP said, "We are pleased to support this adenovirus approach, which could play a vital role in malaria vaccine development." ...

Eliminating Cell Receptor Prevents Infections in Animal Study

...st and Microbe , focused on the coxsackievirus and adenovirus receptor (CAR), which Bergelson discovered in 1997...eptors identified in cultured cells. For instance, adenovirus infects the liver, but it bypasses identified adenovirus receptors in that organ. Instead the virus engages...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

... pancreatic cancer cells such as the coxsackie and adenovirus receptor (CAR). Circumventing CAR-mediated entry t...igh affinity, was inserted into the HI loop of the adenovirus serotype 5 fiber knob. To further increase the spe...for native adenoviral receptors, the coxsackie and adenovirus receptor (CAR) and integrin, were ablated from the...

MicroRNA regulation of tumor-killing viruses avoids unwanted viral pathology

...sterdam, report that this approach can be used to regulate proliferation of adenovirus in a study published May 22 in the open-access journal PLoS Pathogens . adenovirus is a DNA virus widely used in cancer therapy but which causes hepatic disea...

Now we know what blocks the effects of a newly developed anticancer therapy

...mechanism by which CEACAM6 mediates its effects and indicated that knocking down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream protei...

JCI online early table of contents: May 1, 2009

... down expression of CEACAM6 markedly increased the anticancer effects of an adenovirus in mice harboring human tumor cells. The authors therefore suggest that ide... of more effective adenovirus-based therapies. TITLE: CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells AUTHOR CONTA...

TB vaccine developed at McMaster University in Canada

...that are resistant to every last one of the antibiotic defences. The McMaster researchers developed the new TB vaccine using a genetically modified adenovirus a virus responsible for the common cold. After removing a small portion of the gene, they inserted part of the TB gene responsible for immunity. "It ...

New Study Shows Probiotic Strain Effective in Boosting Immune Response

...key immune marker, versus control upon exposure to adenovirus and influenza A in healthy adults who consumed a d...changes in blood TNF-alpha levels upon exposure to adenovirus and influenza A in 10 healthy adults prior to and ...ts showed a 250% increase in TNF-alpha levels with adenovirus and a 1709% increase in TNF-alpha levels with infl...

Nose-spray vaccine against botulism effective in first tests

...d the virus to deliver BoNT/C Hc50 as a mucosal vaccine against botulism in a mouse model. A single dose of intranasal inoculation (nose spray) of the adenovirus vector brought about a high level of HC50-specific immune response as early as two weeks after vaccination. The response consisted of the activation ...
Adenovirus in Medical Technology

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

...tal scaffolds inside the carotid arteries of rats. adenovirus served as a gene therapy vector to carry genes for...tor when it can have the maximum benefit." The adenovirus vector carries genes that code for inducible nitri...l animals. Although this particular study used adenovirus vectors, said Levy, the synthetic formulation coul...

Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa

...echnology is specifically designed to manage the problem of pre-existing immunity in humans against the most commonly used recombinant vaccine vector, adenovirus serotype 5 (Ad5), without compromising large-scale production capabilities or the immunogenic properties of Ad5. AdVac(R) technology is based on adeno...

GeoVax Labs, Inc. Comments on Discontinuance of Merck's HIV Vaccine Trial

...y mobilize and then contract into a state called "central memory" from which they rapidly expand to fight the appearance of HIV. Merck's vaccines use adenovirus instead of poxvirus vectors. Adenovirus vectors provide more prolonged AIDS virus antigen exposure than the GeoVax poxvirus vectors. Prolonged antigen...

GenVec Announces New Research at AACR on Selectivity and Mechanism of Action of TNF-Based Anti-Cancer Therapy

...c researchers presented a poster entitled, "Selective delivery of tumor necrosis factor to disseminated tumors in the peritoneal cavity using targeted adenovirus vectors," (Abstract #3310) which confirmed the ability of its molecularly targeted adenovectors to selectively deliver genes to cancer cells in the pe...

Introgen and Clinical Collaborators to Report New Results with Advanced-Stage Cancer Therapies at Upcoming Medical Meetings

...ASGT -- Role of the Immune System in Replicating adenovirus Using a Permissive Immune Competent Syrian Hamster...mmunity and Anti-Tumor Immunity on the Efficacy of adenovirus Vectors in Immunocompetent Syrian Hamster Model, A... of Medicine -- Anticancer Activity of Oncolytic adenovirus Vector Armed with IFN-alpha and ADP is Enhanced by...
Adenovirus in Medical Dictionary

Adenovirus

Genus Aviadenovirus; type species: Fowl adenovirus A ... Genus Mastadenovirus; type species: Human adenovirus C; others include AD-36 ... Adenovirus infections most commonly cause illness of the respiratory system; however, depending on the infecting serotype, they may also cause va...

Parainfluenza virus

...tenuation of bovine parainfluenza virus type 3 in nonhuman primates and its ... Serological studies of parainfluenza type 3 virus , bovine adenovirus type 3 and ... Overview: Parainfluenza viruses (PIVs) are paramyxoviruses. ... Human parainfluenza viruses (HPIVs) have been associated w...

Adenoviruses

... Recently, several adenoviruses , especially adenovirus 36 (AD-36), have been ... Although epidemiologic ... adenoviruses ... human adenoviruses . porcine adenovirus 3 ... ... human adenoviruses cause ... The ...erview: A nonenveloped double-stranded DNA virus, adenovirus was first ... Adenoviruses ... Adenoviruses ...
Adenovirus in Biological News

Live Recombinant Adenovirus Vaccine Technique Explored

Researchers at the Johns Hopkins Bloomberg School of Public Health are exploring ways to develop new vaccines for a variety of illnesses using genetically modified adenoviruses, a common cause of respiratory infections. Oral adenovirus vaccines have long been proven to be safe and effective. The re...

Penn-Wistar team gains insight into HIV vaccine failure

...V infection in at-risk individuals. It was noted that a subset of participants who had previous immunity in the form of neutralizing antibodies to the adenovirus 5 (Ad5) vector used to deliver the vaccine actually showed a trend toward an increased rate of HIV infection. Finding an explanation for this increase...

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

...wa Health Research Institute provide "Construction and Characterization of adenovirus Vectors," a set of detailed instructions for the generation, propagation, purification, and characterization of adenovirus vectors. This method is freely accessible on the website for Cold Spring ...

Gene therapy appears safe to regenerate gum tissue

...otable incident highlighting the safety concerns of gene therapy research and treatment occurred several years ago when a teenager died when given the adenovirus during a gene therapy clinical trial at the University of Pennsylvania. The U-M therapy also uses the adenovirus, Giannobile said, but the big dif...

Potential new herpes therapy studied

...ay that it can be active once inside is "the hard part" of these types of experiments. The University of Florida team packaged the enzyme inside an adenovirus the type of virus that causes the common cold and injected it into the mice. Afterward, the animals were infected with potentially lethal doses of t...

New vaccine developed for preventing 'uncommon cold' virus

...hat cold turned out to be something more? Human adenovirus type-3 is known as the "uncommon cold" because the...or Disease Control and Prevention (CDC), the human adenovirus was first seen in the 1950s and is associated with...tified, with even more expected to be isolated. adenovirus outbreaks are difficult to control because the vir...

New type of vaccines deliver stronger and faster immune response

...cids attached to a gene of the virus being vaccinated against. This genetic cocktail is then inserted into an incapacitated flu-like virus such as the adenovirus and injected into the body, where it triggers a broader and more aggressive immune response, enabling the immune system to quickly seek out and destro...

Gene therapy anti-cancer research featured in Scientific American

...s that make tumor cells more susceptible to existing chemotherapies. Curiel and Alvarez have been testing this concept with a virus compound called adenovirus in women with recurrent ovarian or other gynecological cancers. The clinical trial is still in the early stages, yet the compound has shown anti-tumor...

Tips from the Journals of the American Society for Microbiology

...s and proteins from all four dengue virus types as well as incorporating an adenovirus agent. Following intramuscular vaccination, rhesus macaques showed high an...g, K. Porter. 2008. A tetravalent dengue virus vaccine based on a complex adenovirus vector provides significant protection in rhesus monkeys against all four s...

New vaccine may give long-term defense against deadly bird flu and its variant forms

... system for important genes from two types of the H5N1 avian influenza. The adenovirus is incapable of multiplying and so cannot cause illness to people. By using the adenovirus vector technology, a couple of problems with existing vaccines used to figh...
Adenovirus in Biological Technology

Avian Adenovirus Genotyping Diagnostic Service

x-OvO Limited has developed a centralised genotyping diagnostic service to facilitate the identification of avian adenovirus from tissue samples taken from commercial poultry flocks. The test will allow the determination of the degree of association between two isolates and thus provide statisti...

Generate Adenovirus Vectors in E. coli by Homologous Recombination with the AdEasy Adenoviral Vector System

Efficient gene transfer and high-level protein expression within a variety of cells Tanya Hosfield Lisa Eldridge Stratagene Recombinant adenoviruses provide a versatile means of gene delivery and expression. We describe the AdEasy adenoviral vector system, ###,W ...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...derived Growth Factor-B Gene Delivery Sustains Gingival Fibroblast Signal Transduction, (Lin, et al., J Periodont Res , 2008; 43: 440-449); and (4) adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to Alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for Clinical...

Tips from the journals of the American Society for Microbiology

... animal viruses. When compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. "Bas...

Tips from the journals of the American Society for Microbiology

... animal viruses. When compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. "Bas...

Tips from the journals of the American Society for Microbiology

... animal viruses. When compared with a benchmark alcohol-based hand sanitizer, results showed higher levels of reduced infectivity of human rotavirus, adenovirus type 5, poliovirus type 1, and norovirus, as well as feline calicivirus and murine norovirus type 1 from the new ethanol-based sanitizer. "Bas...

Barr Reports First Quarter 2008 GAAP Earnings of $0.21 Per Share; Adjusted Earnings of $0.57 Per Share

... version of Allegra(R) tablets, and higher reimbursements under its Shire development agreement, which more than offset lower reimbursements under its adenovirus agreement with the Department of Defense, as the Company completed Phase III clinical trial for Adenovirus during the quarter. Other Revenue Other...

Oncolytics Biotech Inc. Announces Issuance of 26th U.S. Patent

...cancer cells that have an activated Ras pathway. "This patent expands our adenovirus portfolio both geographically and with respect to which adenovirus variants can be used," said Mary Ann Dillahunty, Vice President of Intellec...

Genzyme and Sunway to Collaborate on Gene Therapy Program in China

...nded in 1995. It is one of only two companies in the world to have successfully developed and commercialized a gene therapy product. Sunway's H101, an adenovirus agent for the treatment of head and neck cancer, was approved in China in 2005. With strong technical, regulatory, manufacturing and clinical expertis...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

...jection, Gendicine binds to the coxsakie adenovirus receptor (CAR) on tumor cells. Subsequen.... Therefore, Gendicine will not cause horizontal adenovirus infection or environmental contamination. More ...ious viruses, and level of replication-competent adenovirus (RCA). For example, our released final product h...
Adenovirus in Biological Products

293 cell line slides ( human: kidney; transformed with adenovirus 5 DNA ) from GeneTex

Description: Human 293 cells were cultured in Minimum Essential Medium (Eagle) with 2 mM L-glutamine and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each w...
Company:GeneTex

Mouse Anti-Adenovirus Type 7 hexon C11 Monoclonal Antibody, Unconjugated, Clone 1-N-14 from GeneTex

Description:... Mouse monoclonal [1-N-14] to adenovirus Type 7 hexon C11 Immunogen: Purified adenovirus type 7 Specificity: This antibody is specific for adenovirus type 7 hexon C11....
Company:GeneTex
Adenovirus in Biological Definition

Gene therapy

...ated when the cell is about to undergo cell division. So the descendants of that cell will not have the extra gene. This means that treatment with the adenovirus will require regular doses to add the missing gene every time new cells are produced without the gene. Adeno-associated viruses Adeno-associat...
Adenovirus in Biological Dictionary

Shuttle vector

...ast (a) a region ... Its use in Shuttle Vector Construction, 1989, Plasmid 22: 193-202. ... Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, ... GenScript's codon optimizatio...

RNA polymerase

...es of RNA polymerase are known, all catalyze the ... See also: Structure of RNA Polymerase , Interactions with Promoters, Initiation ... ... adenovirus type 5-infected cells, RNA polymerase III transcription of a gene ... Although the RNA polymerase III transcripts were present at signific...

Primary transcript

...icroRNA transcript (pri-miRNA) becomes a microRNA (miRNA) after processing. Researchers found that the primary RNA transcript produced by adenovirus type 2 ... The primary transcript of this gene contains an intron with two possible ... PLoS ONE: an inclusive, peer-reviewed, open-acc...

HnRNA

...nt of both ends ... ESTABLISHING A CELL CULTURE LAB AT MIT: pre-rRNA, hnRNA , AND POLYRIBOSOMAL mRNA ... CAPS AND POLY(A) IN LARGE hnRNA AND THE adenovirus MAJOR LATE TRANSCRIPT ... ... of hnRNA . ... hnRNA is the primary transcript that is subsequently spliced and processed to form ... measures o...

Encapsidation

... The present invention relates to a system for replication and encapsidation of recombinant DNA fragments into virus particles comprised of adenovirus associated ... HBV encapsidation signal. ... interaction, which leads to encapsidation of the pgRNA and ... The -apical loop is, however, requi...

Directional cloning

...rts into a ... for directional cloning into the supplied. topoisomerase-charged vectors. ... Efficient directional cloning of recombinant adenovirus vectors using DNA-protein complex. ... allows the directional cloning of genes into adenoviral ... Directional cloning was carried out ac...
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