How to select anti-hepatitis B virus agents for drug-resistance patients?
...lls and antiviral susceptibility of lamivudine and adefovir
were analyzed in vitro model system. Furthermore, the antiviral susceptibility of adefovir
in vivo were observed subsequently.
Eight clini...ectively replicate and be expressed in Huh7 cells. adefovir
but not lamivudine inhibited HBV replication both ...
Annals of Internal Medicine tip sheet for Oct. 2
...nic hepatitis B virus (HBV) compared an older drug adefovir
dipivoxil and a newer drug, telbivudine. Researche...oup of patients who were switched at 24 weeks from adefovir
to telbivudine also showed reduced levels of the v...at 52 weeks compared to the group who continued on adefovir
for 52 weeks. Researchers say the study results su...
Adefovir in Medical Technology
BARACLUDE(R) (Entecavir) Treatment Resulted In Greater Viral Load Suppression Compared to Adefovir at 96 Weeks In Antiviral-Naive Adult Chronic Hepatitis B E-Antigen Positive Patients
MILAN, Italy, April 26 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb
Company (NYSE: BMY ) today announced new data from the E.A.R.L.Y. study
(ETV-079), in which treatment of antiviral-naive adult chronic hepatitis B
patients with BARACLUDE(R) (entecavir) resulted in greater long-term viral
Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load
Reduction Compared to Adefovir at 48 Weeks in Study of
Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients
WASHINGTON, May 21, 2007/PRNewswire-FirstCall/ -- Bristol-Myers
Squibb Company (NYSE: BMY) today announced new data from study
ETV-079, which showed that treatment with Baraclude (entecavir)
demonstrated greater viral load reduction than adefovir
at 48 weeks
-- a result that was also seen at weeks...
Pharmasset Voluntarily Halts Clinical Studies with Clevudine in Hepatitis B Infected Patients
...The QUASH studies are international, multi-center, randomized, double-blind clinical trials of 30mg once daily clevudine compared with 10mg once daily adefovir
for 96 weeks in patients with chronic hepatitis due to infection with e-antigen positive hepatitis B virus (QUASH 305) or e-antigen positive (QUASH 30...
Pharmasset Reports Fiscal Year End 2008 Financial Results
...ents. Data from one study suggested that
clevudine is as effective as entecavir (Baraclude(R)) and that it can be
effectively used in combination with adefovir
believes the unique attributes of clevudine will help to differentiate it in
the marketplace, including its potential to achi...
Idenix Announces Data Presentations at the 2007 Digestive Disease
...Pacific Medical Center, will present "A Randomized Trial
of Telbivudine vs. adefovir
for HBeAg-Positive Chronic Hepatitis B:
Efficacy Through Week 76, Predictor...
University of Toronto Western Hospital, will present "Salvage
Therapy with adefovir
for Virologic Breakthrough in
Telbivudine-Treated Patients from the GLOBE S...
Adefovir in Biological News
UCLA study assesses cost-effectiveness of Hepatitis B drugs
... at all 2) Interferon alone 3) Lamivudine alone 4) adefovir
alone 5) Beginning therapy with lamivudine, but changing to adefovir
if viral resistance is encountered.
Investigators found that the newest drug therapy -- adefovir
?was not cost-effective when taken alone. However,...
Adefovir in Biological Definition
...atitis B that can increase a person's chance of clearing the infection. Treatments are available in the form of antivirals such as lamivudine and adefovir
and immune system modulators such as interferon alpha . There are several other antivirals under investigation. Roughly, all of the currently availa...