Abatacept

Rheumatoid Arthritis Drug Might Fight Swine Flu

...th a group of lab mice that were treated with the rheumatoid arthritis drug abatacept (Orencia) after being given a lethal dose of influenza A virus, researchers...pproved for human use and effective in humans. As far as I know, the use of abatacept has not been tested for its effects in humans infected with the flu, which ...

Arthritis drug might prove effective in fighting the flu, study suggests

...luenza A. "We found that treating the mice with abatacept minimized tissue damage caused by the immune respo...tudy's senior author. "Moreover, treatment with abatacept significantly improved survival for mice infected ...ctive effects." The researchers are now testing abatacept in mice that have not previously been exposed to t...

Rheumatoid Arthritis Treatment Guidelines Updated

...ration RA, anti-TNF agents are recommended for patients who had failed to respond adequately to methotrexate therapy. Reserving the fusion protein abatacept and the B-cell antibody rituximab for patients with at least moderate disease activity and poor disease prognosis for whom methotrexate in combination...

Abatacept and infliximab improve clinical response over time in methotrexate-refractory RA patients

...t to methotrexate monotherapy improved when either abatacept or infliximab were added to their methotrexate tre...Efficacy and Safety in Treating RA) trial compared abatacept (~10mg/kg), a selective T cell co-stimulation modu...s who achieved an ACR20 response at six months (32 abatacept [ABA] and 27 infliximab [IFX] patients), over a qu...

American College of Rheumatology presents recommendations for rheumatoid arthritis therapy

...ation RA, anti-TNF agents were recommended for patients who had failed to respond adequately to methotrexate therapy. Reserving the fusion protein abatacept and the B-cell antibody(rituximab) for patients with at least moderate disease activity and poor disease prognosis for whom methotrexate in combinatio...

Drug Combos Effective Against Rheumatoid Arthritis

...tic DMARDs include hydroxychloroquine (Plaquenil), leflunomide (Arava), methotrexate (Trexall) and sulfasalazine (Azulfidine). Biologic DMARDs include abatacept (Orencia), adalimumab (Humira), anakinra (Kineret), etanercept (Enbrel), infliximab (Remicade) and rituximab (Rituxan). Corticosteroids include drugs ...

Drugs Can Ease Juvenile Rheumatoid Arthritis

...e results of this randomized double blind trial of abatacept were very encouraging for both efficacy and safety in these children with severe polyarticular JIA. abatacept was effective for many of the children who had alr...herapy. Because of its unique mechanism of action, abatacept is an important new treatment approach for childre...

New Drug for Rheumatoid Arthritis Looks Promising.

...n. Two other drugs rituximab (Rituxan), abatacept (Orencia) are already there to reduce signs and sy... prevails despite anti-TNF treatment, rituximab or abatacept constitute novel alternatives, although abatacept could be administered before use of a TNF inhibito...

Abatacept in Medical Technology

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... should be considered in patients with significant hematologic abnormalities. The concurrent administration of TNF-antagonists with anakinra or abatacept is not recommended. Concurrent administration has been associated with increased infections, including serious infections without increased clinical ...

Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment

...BV infection should be evaluated for prior evidence of HBV infection before initiating HUMIRA. The combination of HUMIRA and anakinra and HUMIRA and abatacept is not recommended. TNF antagonists, including HUMIRA, have been associated in rare cases with demyelinating disease including multiple sclerosis, G...

U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older

...Mothers: ORENCIA should be used during pregnancy only if clearly needed. The risk for development of autoimmune diseases in humans exposed in utero to abatacept has not been determined. Nursing mothers should be informed of the risk/benefit of continued breast-feeding or discontinuation of the drug. A pregnanc...

Three New Drugs Mark New Era in Rheumatoid Arthritis Treatment

...ncet Press pressoffice@lancet.com Telephone: +44 (0)20 7424 4949/4249 abatacept works by interfering in the T-cell activation response, viewed as vital in the mechanism of RA. A trial combining abatacept at 10 mg per kg bodyweight for patients with their existing methotrexate tr...