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ATR in Medical News

Gene Mutation May Up Risks of Endometrial Cancer

...e in St. Louis, found that genetic mutation of the atr gene in tumors boosts the risk of cancer recurrenc...e known as endometrioid endometrial cancer. The atr gene directs cellular responses to DNA damage, the...noted. "Women whose endometrial cancers have an atr mutation have more than four times the risk of hav...

Caffeine May Offer Some Skin Cancer Protection

...ine interrupted a protein called ATR-Chk1, causing the damaged cells to self-destruct. "Caffeine has no effect on undamaged cells," Nghiem said. atr is essential to damaged cells that are growing rapidly, Nghiem said, and caffeine specifically targets damaged cells that can become cancerous. "Caffe...

Type of breast reconstruction impacts radiation therapy outcomes

... patients undergoing mastectomy for breast cancer: atr (autologous tissue reconstruction), which involves...d radiation treatments, and researchers found that atr is better tolerated by breast cancer patients beca...etter cosmetic results than TE/I. None of the 23 atr patients required surgical intervention, while 33 ...

Does HBV infection induce acute cellular DNA damage?

... in non-infected cells; immunofluorescence to show atr foci ands Chk1 phosphorylation foci formation; flo...at HBV infection induced increased steady state of atr protein and increased phosphorylation of multiple ...rgets including Chk1, p53 and H2AX. In contrast to atr and its target, the phosphorylated form of ATM at ...

A potential approach to treatment of hepatitis B virus infection

...endent DNA damage response, resulting in increased atr and Chk1 phosphorylation levels, however, atr checkpoint signaling was blocked downstream of the...cation or restore a response stalled by HBV in the atr DNA damage pathway. A research article to be pu...

Altarum Wins $7 Million Contract to Provide Technical Assistance to the Access to Recovery Program

...approach to recovery from substance use disorders. atr puts patients at the center, giving them the tools...m to live productive lives in the community." The atr program begins with the understanding that substan...ry," said SAMHSA Administrator Terry Cline, Ph.D. atr also fosters other systems-based change, including...

Chromatin remodeling complex connected to DNA damage control

...o regulate DNA repair and checkpoint pathways, Shen explains, by attaching phosphate groups to other proteins involved in damage control. When ATM and atr are themselves damaged, they cause genome instability and fuel cancer growth. "We found that one of the proteins phosphorylated was a unit of a ch...

Loss of Stem Cells Correlates With Premature Aging

...repair genes. When the researchers deleted atr in the tissues of adult mice, they noticed that th... that in the current study the mouse cells without atr had an overwhelming amount of DNA damage and could...heless, the 10 to 20 percent of cells that escaped atr deletion were able to reconstitute tissues in the ...

Scientists Develop Thought-Controlled Robotic Hands

...eal-time functional magnetic resonance imaging (fMRI) of their brain activity, reported the online edition of New Scientist. Researchers from the atr Computational Neuroscience Laboratories in Kyoto and from the Honda Research Institute in Saitama have previously shown that fMRI scanning can be used...

Japanese Scientists Develop Thought-Controlled Robotic Hands

...al-time functional magnetic resonance imaging (fMRI) of their brain activity, reported the online edition of New Scientist. Researchers from the atr Computational Neuroscience Laboratories in Kyoto and from the Honda Research Institute in Saitama have previously shown that fMRI scanning can be used...

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ATR in Biological Dictionary

Primase

...units and two primase subunits, which catalyzes the ... ... DnaB Helicase and Its Complex with a Domain of DnaG Primase [My Copy] ... posted to atr primase rad17 rfc rpa by DNAReplication on 2008-01-02 18:45:20 as ... The European ... DNA primase synthesizes the RNA primers for the Okazaki ...

MSH2

... MSH2 is a gene commonly associated with Hereditary nonpolyposis colorectal cancer. ... MSH2 and atr form a signaling module and regulate two branches of the damage ... ... homologs form two major heterodimers: Msh2 /Msh6 (MutSα) and Msh2 /M...

G2 phase

...ll transition through the G2 /M phase . ... promoter, and it is predominantly expressed in the G2 phase of the cell cycle. ... Activated atr phosphorylates CHK1 to initiate G2 - phase ... G2 - phase and then assaying for ... suggest that plants may regulate the G2 - phase checkpoint i...
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