Radioprotective effect of Heat Shock Proteins
...nished scarring, nuclear damage, and cell death (apoptosis), but HSP70i was slightly less effective. Finally, HSP25 and HSP70i preserved expression of aquaporin
5, which is important for water transport in salivary glands.
It is interesting to note that the results with HSP25 were similar to those observed...
Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
...TPase activating protein (GAP) that negatively regulates RAP1 and RAP2 GTPases. Human SIPA1 has recently been found to interact with the water channel aquaporin
2 (AQP2), by its PDZ domain, so the authors used AQP2 to see if the Alanine to threonine substitution affected this interaction.
Discovery of the cell's water gate may lead to new cancer drugs
... human cells in many respects, and Karin Lindkvist's research can have applications in cancer research and other fields.
"The structure of the yeast aquaporin
that we have determined can be used to create inhibitors for human aquaporins, and this may in the long term lead to drugs that slow the growth of a c...
Researchers develop better membranes for water treatment, drug delivery
...orporation of the functional water channel protein aquaporin
Z into a novel A-B-A triblock copolymer.
The expe...ile the polymer is assembling, the researchers add aquaporin
Z a protein found in Escherichia coli bacteria.
Z makes a hole in the membrane that only water can...
Scientists solve 30-year-old mystery of mutant mouse's kidney woes
...a research instructor at the Genome Sequencing Center at Washington University, Chen and his colleagues showed that the protein mutated in the mice is aquaporin
2 (aqp2), which belongs to an important family of proteins that channel water across membranes.
"We knew that the aqp2 protein is found in the pri...
Membrane research opens window to benefits for plants, humans
...at Lund University and Chalmers University of Technology, studying membrane proteins of spinach, solved the structure of a water-protein channel -- an aquaporin
that opens and closes a gate that regulates water movement in and out of cells.
Not only was the discovery the first for a plant-water channel, it ...
Cells direct membrane traffic by channel width
...f protein crystallography couldn't accomplish. Reporting in the August issue of Structure, they show that the main structural difference that makes an aquaporin
a glycerol channel is a channel that is just a hundred-millionth of a centimeter -- an angstrom -- wider than a normal water channel.
So even if gl...
Newly discovered genetic disease sheds light on body's water balance
Normally, when vasopressin binds to the V2R, it stimulates a chain of events inside the cell. Vesicles containing the water channel aquaporin
2 (AQP-2) are shuttled from the cytoplasm to the apical membrane of the collecting duct kidney cells. This process increases water permeability and di...