U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1
...sity of Minnesota have determined the structure of apobec3g
a protein that inhibits the AIDS virus, HIV. This...each of which carries out a specific function. The apobec3g
machine is capable of modifying HIV DNA so that th...G.
The discovery will help researchers manipulate apobec3g
to make it effective in combating HIV. Current stu...
NIH doubles support for vital HIV/AIDS research center
... cohorts, assays and services.
CFAR has succeeded in stimulating several advances in HIV/AIDS research, including:
Delineating the biology of the apobec3g
protein in anti-viral immunity
Boosting thymic function
Changes in viral fitness as a result of antiretroviral drug resistance
APOBEC3G in Medical Technology
Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV
...el is exploring a
number of small molecule compounds aimed at modulating the
intracellular ubiquitin ligase signaling pathways utilized by Vif
so that apobec3g
will remain active in the presence of HIV and
impede the virus from replicating.
"Our approach focuses on restoring the body's natural ability to...
APOBEC3G in Biological News
Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone
... own, a viral protein called Vif, that can prevent apobec3g
from degrading HIV within infected cells. Dr. Gabu...s that can inhibit the interaction between Vif and apobec3g
and that might ultimately serve as the basis for a new drug to reinstate the ability of apobec3g
to degrade HIV.
Jing Jin, Ph.D./Mentor: Walthe...
Gladstone investigators identify a new protective action for the powerful anti-HIV factor, APOBEC3G
... Scientists at the Gladstone Institute of Virology and Immunology (GIVI) have identified a previously unknown function of apobec3g
(A3G), a protein that acts against HIV, a finding that may lead to new approaches for controlling HIV infection.
The work is published today, Oct....
Gladstone investigators discover how resting T cells avoid HIV infection
... T cells are not. The team discovered that a potent antiviral factor called apobec3g
(A3G) is the key.
The team, working in cell culture, found that A3G exis...ation for AIDS Research.
Other co-authors of the Nature paper, "Cellular apobec3g
restricts HIV-1 infection in resting CD4 T cells," at the Gladstone Institu...