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APOBEC in Biological News

USC team reveals structure of APOBEC family protein

Researchers at the University of Southern California have provided the first 3-D view of a protein from an enzyme family that, through its ability to mutate genes, can both help and hinder human health. Reporting in the Dec. 24 online edition of Nature, a USC team led by Xiaojiang Chen revealed ...

Body's anti-HIV drug explained

...re born with it, and it's there waiting," Chen said. In addition to fighting HIV, APOBEC-3G can inhibit the Hepatitis B virus. Other members of the apobec family serve important roles in antibody maturation, fat metabolism and heart development. Mapping the structure of APOBEC-3G at the atomic level i...

HIV gets a makeover

...ng was required to get around the second obstacle: apobec proteins produced by a host normally cause invadin...ve, but HIV-1 uses a protein called Vif to destroy apobec and prevent the attack. Monkey apobec proteins, however, aren't susceptible to the human...
APOBEC in other areas

APOBEC3G - Wikipedia, the free encyclopedia

APOBEC3G is a human protein belonging to the APOBEC superfamily of proteins that interferes with the replication of HIV and other retroviruses. This family of proteins has been suggested to play an important role in innate anti-viral immunity.

Smith Lab research - APOBEC-1 editing of apolipoprotein B mRNA

Molecular cloning of apobec-1 complementation factor, a novel RNA-binding ... Identification of domains in apobec-1 complementation factor required for RNA ...

Cellular Resistance to HIV: The Vif-APOBEC Connection

... protein and the cellular enzyme, APOBEC, summarizing our knowledge of the unique ... Natural resistance to HIV infection: the Vif-APOBEC interaction. ...

IPR013158 APOBEC-like, N-terminal

The European Bioinformatics Institute ... The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while ... APOBEC-3 like members contain two ...

Hepatic secretion of small lipoprotein particles in apobec-1-/- mice is ...

... mice, but not WT, apobec-1–/–, or ldlr–/– mice, ... PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice ...

The APOBEC-2 crystal structure and functional implications for the ...

APOBEC-2 (APO2) belongs to the family of apolipoprotein B messenger RNA-editing ... Different APOBEC members use the same deamination activity to achieve diverse ...
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