Immune exhaustion driven by antigen in chronic viral infection

A main reason why viruses such as HIV or hepatitis C persist despite a vigorous initial immune response is exhaustion. The T cells, or white blood cells, fighting a chronic infection eventually wear out. Researchers at Emory Vaccine Center have demonstrated that exhaustion is driven by how the...

AUA Counters Mainstream Recommendations with New Best Practice Statement on Prostate-Specific Antigen Testing

New guidance stresses that PSA testing should be individualized, men should get baseline reading at age 40 LINTHICUM, Md., April 27 /PRNewswire-USNewswire/ -- The American Urological Association (AUA) today issued new clinical guidance - which directly contrasts recent recommendations issue...

American Urological Association Statement in Support of Prostate-Specific Antigen Testing

LINTHICUM, Md., March 26 /PRNewswire-USNewswire/ -- The statement below is attributable to Dr. John Barry, president of the American Urological Association. This statement is being issued in response to two studies recently published in the New England Journal of Medicine about prostat...

When should prostate-specific antigen testing be stopped?

New York, NY, February 20, 2009 Although widespread Prostate-Specific-Antigen (PSA) testing has undoubtedly decreased prostate cancer mortality, is there a point of diminishing returns? In a study published in the April 2009 issue of The Journal of Urology , researchers found that in a subgroup ...

Prostate specific antigen testing may be unnecessary for some older men

Certain men age 75 to 80 are unlikely to benefit from routine prostate specific antigen (PSA) testing, according to a Johns Hopkins study published in the April 2009 issue of The Journal of Urology . The researchers found that men in this age group with PSA levels less than 3 nanograms per mi...

Statin use associated with reduction in prostate specific antigen levels

Use of cholesterol-lowering statins is associated with a statistically significant decline in prostate specific antigen (PSA) levels, according to a report in the October 28 online issue of the Journal of the National Cancer Institute . Previous studies examined whether statin use was associat...

ANTIGEN in Medical Technology

Inverness Medical Innovations Receives USDA Licensure of the BinaxNOW(R) Avian Influenza Virus Type A Antigen Test Kit

WALTHAM, Mass., Aug. 11 /PRNewswire-FirstCall/ -- Inverness Medical Innovations, Inc. (Amex: IMA ), a leading provider of near-patient diagnostics, monitoring and health management solutions, announced today that it has received licensure from the United States Department of Agriculture (USDA...

CEL-SCI's Cel-1000 Shown to Significantly Enhance Immune Response Against Hepatitis B Antigen in Animals

VIENNA, Va., May 01, 2007 /PRNewswire-FirstCall/ -- CEL-SCI CORPORATION announces that CEL-1000 alone increased the immune response against hepatitis B antigen, and that the combination of CEL-1000 with MAS-1, a proprietary water-in-oil adjuvant delivery system owned by Mercia Pharma, induced high...

CEL-SCI'S CEL-1000 Shown to Significantly Enhance Immune Response Against Avian Flu Antigen in Animals

VIENNA, Va., May 23, 2007 /PRNewswire-FirstCall/ -- CEL-SCI CORPORATION announces that CEL-1000 increased the immune response against H5 avian influenza antigen in combination with MAS-1, a water-in-oil adjuvant delivery system. These findings were presented on May 23, 2007 by Dr. Daniel Zimmerman...

Fast, Accurate Influenza A/B Antigen Detection

According to CDC data, influenza infections in this country cause more than 114,000 hospitalizations and 36,000 deaths annually. Among healthy adults, bronchitis and pneumonia are the most common complications. Together, influenza and pneumonia are the sixth leading cause of death in the United St...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

...t the annual American Society for Microbiology in Philadelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand Epitope antigen Presentation System) vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune responses that wo...

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

... protein component known as the anthrax Protective antigen (PA) of the lethal and edema toxin complexes produ...x(TM) - a second generation recombinant protective antigen (rPA) anthrax vaccine Valortim(R) - a full...rve agents RypVax(TM) - a recombinant dual antigen vaccine for plague A third generation rPA ...

ANTIGEN in Medical Products

VZV Antigen Detection and Culture

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

VZV Antigen Detection

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Soluble Liver Antigen Antibody, IgG

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Rotavirus Antigen by EIA

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Platelet Antigen Genotyping Panel

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Platelet Antigen 15 Genotyping (HPA-15)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

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ANTIGEN in Medical Dictionary

Antigen

Antibodies tutorial, Antigen tutorial and Antigen -Antibody interaction - The basic principle of any immunochemical technique is that a specific antibody will combine ... Immunoprecipitation and Antibody- Antigen precipitation - Success in an ... These include small scale antigen purifi...

VDRL

... online medical dictionary A-Z List ... VDRL antigen with Buffered Saline is recommended for use in the...rum, while ... BD - Diagnostic Systems: VDRL antigen 10 x 0.5 mL ... The likelihood of obtaining a reac...ase Research Laboratory A serologic nontreponemal antigen test for the detection of syphilitic reagin by me...

Thrombocyte

...h from Academic Journals, Newspapers, and magazines at HighBeam.com. Free Trial, Credit Card Required. Quality Control of Thrombocyte Activation antigen Determinations by Flow Cytometry ... Problems of Clinical Thrombocyte Analysis: ... Platelet count - Overview, A platelet count is a test to m...

Rh factor

...rms Rhesus factor and Rh factor are equivalent and refer to the Rh D antigen only. If you just found out you're pregnant, one of the first tests ...rotein that is found on the covering of the red blood cells. ... An antigen found on the red blood cells of most people. Individuals with the Rh ...

PSA

... Prostate specific antigen ( PSA ) is a protein produced by the cells of the prostate gland. PSA...... Loading... 100% ... Information about use of the Prostate specific antigen ( PSA ) test for diagnosing prostate cancer anddifferentiating it from...

Lymphadenopathy

...erview: Lymph nodes, in conjunction with the spleen, tonsils, adenoids, and Peyer patches, are highly organized centers of immune cells that filter antigen from ... Thorax - Lymphadenopathy ... In most patients lymphadenopathy resolves spontaneously, but the lymph nodes may ... Hilar lymphaden...

ANTIGEN in Biological News

LSUHSC's Kolls awarded $1.8 million to improve vaccine strategies for P. carinii pneumonia

...anti-carbohydrate antibodies are part of the natural response repertoire to the Pneumocystis fungus, but also that when combined with a potent protein antigen called Kex1, these antibodies can regulate direct killing of the fungus and confer immunity. "Understanding these antibody responses will improve v...

Green tea may affect prostate cancer progression

... patients with prostate cancer. The biomarkers include hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and prostate specific antigen (PSA). HGF and VEGF are good prognostic indicators of metastatic disease. The study included 26 men, aged 41 to 72 years, diagnosed with prostate c...

Partnership to accelerate Trudeau Institute discoveries to patient care

...blished hundreds of patents and technology licenses that have resulted in the commercialization of medical advancements, such as the Prostate Specific antigen test ("PSA test"), HIV-1 co-receptor usage test, photodynamic cancer therapy, assistive communication devices for persons with spinal cord injuries, a...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...mokines. PGN632 also induced an increase in the expression of cell-surface molecules that are indicative of mature dendritic cells and that assist in antigen presentation functions, as well as in stimulating T-cell proliferation. Dr. Xianming Huang, assistant professor of pharmacology at UT Southwestern ...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

... cancers and a potential blood or urine screening tool that might eventually do for pancreatic cancer detection what biomarkers like prostate-specific antigen levels have done for prostate cancer. His presentation was part of the scientific program of the American Society for Investigative Pathology. Pers...

Burnham researchers present at 100th AACR Meeting

... Receptor-Mediated Apoptosis and Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NFκB Activation Induced by Protein Kinase C and antigen Receptors. Changming Fang, Ph.D., who will also present two papers: Ileal Bile Acid Binding Protein Mediates the Chemopreventative Effect of Ursodeox...

ANTIGEN in Biological Technology

Medicago succesfully expresses VLP antigen for A H1N1 strain

QUEBEC CITY, May 12 /PRNewswire-FirstCall/ - Medicago Inc. (TSX-V: MDG), a biotechnology company focused on developing highly effective and affordable vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), today announced that it has successfully expressed a new ...

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

LELYSTAD, The Netherlands, April 6 /PRNewswire/ -- Today, Pepscan reports that it has achieved a major scientific breakthrough through the use of its CLIPS-based synthetic peptide immunogen technology. By constructing synthetic 3D mimics of the ligand binding-site on CXCR7 it has induced funct...

PharmAthene Response to DHHS Request for Proposals for Recombinant Protective Antigen Anthrax Vaccine Deemed Technically Acceptable and Within Competitive Range for Procurement Consideration

ANNAPOLIS, Md., Sept. 15 /PRNewswire-FirstCall/ -- PharmAthene, Inc. (Amex: PIP ) a biodefense company specializing in the development and commercialization of medical countermeasures against chemical and biological threats, announced today that it has received notification from the Departmen...

U.S. Government Accepts $192 Million of sanofi pasteur H5N1 Bulk Vaccine Antigen for Pandemic Stockpile

- Vaccine for new strain of virus broadens government readiness program - SWIFTWATER, Pa. and LYON, France, April 28 /PRNewswire-FirstCall/ -- Sanofi Pasteur, the vaccines division of sanofi-aventis Group, announced today that the U.S. Department of Health and Human Services (HHS) has accepted ...

Dendreon Publishes Manuscript on CD54 as a Surrogate Marker of Antigen Presenting Cell Activation

SEATTLE, March 3 /PRNewswire-FirstCall/-- Dendreon Corporation (Nasdaq: DNDN) announced the publication of a manuscript titled, "CD54 is a surrogate marker of antigen presenting cell activation" in Cancer Immunology, Immunotherapy. The manuscript describes and supports the use of CD54 as a s...

Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis

Terry H. Landowski, Ibrahim Buyuksal, and William S. Dalton H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa FL 33612 Introduction Identifying of mutations within specific genes has...

ANTIGEN in Biological Products

Anti-7H6 Antigen (tight-junction associated protein antigen) Monoclonal Antibody, Unconjugated, Clone 7H6 from Cell Sciences

Description: Anti 7H6 Antigen (tight-junction associated protein Antigen) Monoclonal Antibody 7H6...
Company:Cell Sciences

Mouse Anti-Ia Antigen Monoclonal Antibody, Biotin Conjugated, Clone CIa from Abcam

Description: Mouse monoclonal [CIa] to Ia Antigen (Biotin) ( Abpromise for all tested applications)....
Company:Abcam

Mouse Anti-Yersinia pestis Capsular F1 Antigen Monoclonal Antibody, Unconjugated, Clone YBF19 from QED Bioscience Inc.

Description: This monoclonal antibody specifically recognizes Y. pestiscapsular F1 antigen. It does not cross-react with Y. pseudotuberculosisor Y. enterocolitica....
Company:QED Bioscience Inc.

Mouse Anti-Yersinia pestis Capsular F1 Antigen Monoclonal Antibody, Unconjugated, Clone YBF19 from QED Bioscience Inc.

Description: This monoclonal antibody specifically recognizes Y. pestiscapsular F1 antigen. It does not cross-react with Y. pseudotuberculosisor Y. enterocolitica....
Company:QED Bioscience Inc.

SV40 Large T Antigen from Chimerx

Description: SV40 Large T antigen initiates replication from the SV40 origin of replication in the presence of the host proteins. This product can be used in conjunction with our SV40 DNA Replication Kit cat. no. 8050. For bulk purchases contact lloconne@molbiores.com....
Company:Chimerx

ELISA Kit for Hepatitis B Surface Antigen Using GoldMag-AS Microparticles from BioChain

Description: The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma....
Company:BioChain

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ANTIGEN in Biological Definition

Antigen

An antigen is any molecule that is recognized by antibodies . Usually, an antigen is a protein or a polysaccharide , but it can be any type of molecule, even small molecules if coupled to a large carrier ( haptens ). There are several kinds of antigens: Immunogen - Any substance t...

Affinity chromatography

...rom blood serum. If serum is known to contain antibodies against a specific antigen (for example if the serum comes from an organism immunised against the antigen concerned) then it can be used for the affinity purification of the antibod...

Antibody

...nd viruses . Each antibody recognizes a specific antigen unique to its target. Contents showTocTo...eavy and the light chain, which together shape the antigen binding site at the amino terminal end of the mo...ortant to note that to produce such a diversity of antigen binding sites with a separate gene for each poss...

Apoptosis

...g, say, from a malignant mutation) or with foreign antigen produced as a consequence of a viral infection. Af...random shapes of their receptors do not engage any antigen of significance), or dangerous to their own organi... and those that show high affinity to healthy self antigen are killed via apoptosis. Be aware that the abov...

B cell

...e antigen(s) encountered during the primary immune response; able to live for a long time, these cells can respond quickly upon second exposure to the antigen for which they are specific. Humoral immunity (the creation of antibodies that circulate in blood plasma and lymph ) involves B cell activati...

Cancer

...creened for by a digital rectal exam along with annual prostate specific antigen blood testing. Screening for cancer is controversial in cases when it is...e Medicine , National Cancer Institute Fact Sheet. The Prostate-Specific antigen (PSA) Test: Questions and Answers , National Cancer Institute Fact Sheet. ...

ANTIGEN in Biological Dictionary

Antigen

A antibody generator or antigen (Ag) is a substance that prompts the generation of antibodies and can cause an immune response. We now know that the immune system does not consist of only antibodies. The modern definition encompasses all substances that can be... antigen also antigene ...

T cell

...ology is intended as an introductory text for use in immunology courses for ... Naive T cells require a co-stimulatory signal from professional antigen ... T cell summary with 17 pages of encyclopedia entries, essays, summaries, research information, and more. ... Search " T cell " Get Motor...

Spleen

...to the spleen . ... The spleen is located between the fundus of the stomach and the diaphragm, while ... Here, the spleen processes foreign antigen and produces specific immunoglobulin ... Although people can survive without a spleen because other organs can take over... Conditions & Tre...

Somatic hypermutation

...IGH Somatic Hypermutation Assay - Gel Detection. Rearrangements of the antigen receptor genes occur during ontogeny in B and T lymphocytes. ... In...) ... Evolution and the molecular basis of somatic hypermutation of antigen receptor genes. ... to evolution immune somatic - hypermutation by t...

Semen

...yone know it came from seven different guys? ... Semen Detection, Sperm Detections, Saliva Detections for Infidelity or Rape by Prostate Specific antigen (PSA), Acid Phosphatase (AP), and microscopic inspection. More about Semen Analysis: Purpose Preparation Normal results Abnormal results Resource...

Rhesus factor

... Rh factor are equivalent and refer to the Rh D antigen only. The Rhesus Factor . GENOTYPING ... be...free online ... rhesus factor - a blood group antigen possessed by Rh-positive people; if an Rh ... ...rst discovered in the ... Landsteiner called this antigen the Rh ( Rhesus ) factor . ... The rhesus ...