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Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

Scientists at Joslin Diabetes Center have discovered one reason why infants with low birth weight have a high potential of developing type 2 diabetes later in life. In studies of mice, the researchers found that poor prenatal nutrition impairs the pancreas's ability to later secrete enough insulin in response to blood glucose. "The bottom line is that if you don't have delivery of enough...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

Researchers at Duke University Medical Centerhave demonstrated for the first time what happens inside a cell when itis deprived of the essential nutrient iron. Iron is found abundantly inred meats, shellfish dried fruits, whole grains, spinach, seeds andother foods.Their study in yeast cells demonstrated that iron-starved cellspreserve the little iron they possess by shutting down the major...

Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers

A new study investigating the respiratory system of insects may have solved a mystery that has intrigued physiologists for decades: why insects routinely stop breathing for minutes at a time. Challenging previous theories, researchers at UC Irvine and Humboldt University propose that insects such as grasshoppers, moths, butterflies, some types of fruit flies, beetles and bugs close off th...

Research Gives Hope For Liver Damage

Millions of patients suffering from liverdamage (cirrhosis) and failure may benefit from research by theUniversities of Edinburgh and Southampton which may lead to newlife-saving treatments. There is currently no cure for liver cirrhosisand a patient's only hope of survival is to receive a liver transplant.The Edinburgh scientists from the University's Centre for InflammationResearch, in co...

How the environment could be damaging men's reproductive health

Two Scandinavian studies have provided further evidence that environmental factors could be affecting men's reproductive health. The studies, published online today (Thursday 28 April) in Europe's leading reproductive medicine journal Human Reproduction, suggest that environmental pollutants could be changing the ratio of sperm carrying the X or Y (sex determining) chromosomes and that th...

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AMA at Biology Products

AquaMax DW4 from Molecular Devices

Description:The AquaMax DW4 liquid handling system from Molecular Devices provides precise dispensing and thorough washing all in one instrument. The system handles a variety of plate formats for dispensing and plate washing96-, 384- and 1536-welland is the first to handle 1536-well microplate washing. AquaMax DW4 has been optimized to dispense from four different channels to accommodate up to four fluids.<P...
Company:Molecular Devices

AquaMax DW4 from Molecular Devices

Description:The AquaMax DW4 liquid handling system from Molecular Devices provides precise dispensing and thorough washing all in one instrument. The system handles a variety of plate formats for dispensing and plate washing96-, 384- and 1536-welland is the first to handle 1536-well microplate washing. AquaMax DW4 has been optimized to dispense from four different channels to accommodate up to four fluids.<P...
Company:Molecular Devices

Cell Line Nucleofector Kit V from amaxa biosystems

Description:For nucleofection of optimized cell lines in combination with the corresponding optimized protocol including the nucleofection parameters. Nucleofector Kits are only functional in combination with the Nucleofector Device. Different cell lines can be transfected with this kit. The corresponding efficiencies and viabilities are given in brackets in percent (Efficiency [%] / viability [%])....
Company:amaxa biosystems

Cell Line Nucleofector Kit T from amaxa biosystems

Description:For nucleofection of optimized cell lines in combination with the corresponding optimized protocol including the nucleofection parameters. Nucleofector Kits are only functional in combination with the Nucleofector Device. Different cell lines can be transfected with this kit. The corresponding efficiencies and viabilities are given in brackets in percent (Efficiency [%] / viability [%]). <...
Company:amaxa biosystems

Panorama Mouse/Rat Tissue Extract Protein Array Kit from Sigma-Aldrich

Description:Application: The Panorama Mouse/Rat Tissue Extract Protein Array Kit is designed for studying protein expression in various tissue extracts. The expression of a protein in an extract is detected using a protein specific antibody. When the antibody binds the protein, this binding is visualized by a sensitive chemiluminescent or fluorescent signal created by directly labeling the primary antibody w...
Company:Sigma-Aldrich

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AMA at Biology Technology

Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35)

Evelyn McGown, Ph.D. and Anna Lam, B.S. Molecular Devices Corporation, 8/99 Modern assays for proteolytic activity typically use synthetic chromogenic or flu-orogenic peptide substrates. Enzyme selectivity is obtained by choosing a peptide sequence uniquely recognized by the catalytic site of a particular enzy...

LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43)

Anne T. Ferguson, Ph.D. Molecular Devices Corporation This application note describes the use of the SPECTRAmax Viability/Cytoxicity Assay Kit for animal cells. This assay uses two fluorescent dyes, calcein AM (cal...

Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44)

1 GFP (Green Fluorescent Protein) is an extremely stable protein of 238 amino acids produced by the jellyfish that fluoresces in the lower green region of the visible spectrum....

Measurement of Molecular Beacons in the SpectraMax Gemini Spectrofluorometer (MaxLine Application Note #36)

October 1999 Molecular beacons are fluorogenic oligonucleotide probes developed by Kramerand associates to detect specific nucleic acids in homogeneous solutions. They are single-stranded oligonucleotides that exist in a hairpin shape because of thecomplementary arms at the ends which bind together to form a stem....

Using the NanoOrange protein kit in the Gemini XS, Gemini EM and SpectraMax M2 microplate readers (MaxLine Application Note #22)

By Yan Zhang, Molecular Devices Corporation, 1311 Orleans Dr., Sunnyvale, CA 94089. This application note describes how to use the NanoOrange Pro software from Mo...

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AMA at Biology Definition

Jean-Baptiste Lamarck

19...

AMA at Biology Dictionary

Environmental damage

A secondary product, a polymer synthesized by a side branch of a major metabolic pathway of s ont...

DNA damage

rearrangements. <a href="/ ?q=/ Biology-Dictionary/ site-speci...

AMA at Medicine News

Evidence Links Protein Damage to Neurodegenerative diseases like Parkinson's and Alzheimer's

Neurodegenerative diseases - including Parkinson's, Alzheimer's, Diffuse Lewy body disease, and Multiple System Arophy - are collectively called synucleinopathies. Most commonly they become symptomatic due to a deficiency of a specific neurotransmitter - in the case of Parkinson's it is dopamine. When the neurons that produce these chemicals die or become impaired, which occurs with oxida...

New drug to treat Heart Attack and damaged tissue

If a blood vessel in blocked the related tissue experiences ischemia, a state of low oxygen supply that slowly kills the tissue. They are referred as Ichemia / Reperfusion (IR) injury occurs during heart attacks. Understanding Ischemia / Reperfusion leads to the development of new drugs to save the damaged tissue and treat heart attack. During Ischemia / Reperfusion, Early growth respons...

Eating disorder in Diabetic girls lead to eyesight damage.

Diabetic girls were more likely to have an eating disorder when compared with non-diabetic girls. Some reported binge eating and used to take less than their prescribed dose of insulin in order to lose weight. Under dosing of insulin lead to early onset of diabetes related complications and are associated with increased risk of permanent eyesight damage. Intensive treatment to diabetes co...

Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre

The Consumer Education and Research Centre (CERC) in Ahmedabad has alerted the Drug Control General of India against the excessive use of paracetamol. CERC says that the commonly use drug might cause potential liver damage and might lead on to liver failure. CERC Secretary Ashwini Kumar warns that consumers must be aware of the potential hazards of paracetamol more so because it is bein...

The flip side of AIDS cocktails – HAART regime damages live

HIV infected patients on highly active antiretroviral therapy (HAART regime) are forced to stop the treatment because of the toxic side effects of the treatment, which causes liver damage. According to a study led by Dr. Raymond T. Chung, who presented the findings at Digestive Disease Week in Atlanta last week, severe liver toxicity forced almost one in every four patients to stop the t...

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AMA at Medicine Products

Ultramatic RX Master PHOROPTOR Refracting Instrument - Minus Cylinder Black

Description:The Ultramatic Rx Master is designed and constructed to provide years of reliable service and give the professional distinctive features that measurably improve procedures. It embodies the characteristics that doctors need and want most, including accuracy, speed, ease, patient comfort, and reliability....
Company:Reichert, Inc.

Ultramatic RX Master PHOROPTOR Refracting Instrument - Plus Cylinder Black

Description:The Ultramatic Rx Master is designed and constructed to provide years of reliable service and give the professional distinctive features that measurably improve procedures. It embodies the characteristics that doctors need and want most, including accuracy, speed, ease, patient comfort, and reliability....
Company:Reichert, Inc.

Alabama University Utility Forceps

Description:Straight shafts with fitted v-grooved 15 mm platform. Serrated handle with polished finish....
Company:Bausch & Lomb Storz

OptimaMAX Ultracentrifuges 110 VAC 60 Hz

Description:Optima MAX has the highest g-force ever. But optimal productivity in the lab takes more than force. Optima MAX combines maximum force, capacity, and ease of operation to achieve benchtop performance that's worlds apart from any other system. With advanced rotor features, superior design, and enhanced efficiency, Optima takes productivity to the MAX. Optima MAX extends benchtop ultracentrifugation...
Company:Beckman Coulter, Inc.

OptimaMAX-E Ultracentrifuges 110 VAC 60 Hz

Description:Optima MAX has the highest g-force ever. But optimal productivity in the lab takes more than force. Optima MAX combines maximum force, capacity, and ease of operation to achieve benchtop performance that's worlds apart from any other system. With advanced rotor features, superior design, and enhanced efficiency, Optima takes productivity to the MAX. Optima MAX extends benchtop ultracentrifugation...
Company:Beckman Coulter, Inc.

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AMA at Medicine Technology

Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkin's Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy

Positive interim results prompt request for meeting with FDA SEATTLE, July 11, 2007 /PRNewswire-FirstCall/ -- CellTherapeutics, Inc. (CTI) announced today that interim results ofits phase II/III trial comparing CPOP-R, in which pixantrone issubstituted for doxorubicin in standard CHOP-R first-line treatmentof patients with aggressive non-Hodgkin's lymphoma (NHL), resultedin essentially al...

Samaritan's Alzheimer's Drug Caprospinol Suggests Brain May be Able to Heal From Alzheimer's Disease

Animal Study Confirms Caprospinol's (SP-233) Ability to Clear BrainPlaque and Empower Rat Brain Cells to Recover Memory Function In Vivo 'Proof of Concept' Study Proposes Direct CorrelationBetween Removing Beta Amyloid Plaque and Memory Recovery LAS VEGAS, July 10, 2007 (PRIME NEWSWIRE) -- SamaritanPharmaceuticals Inc. (AMEX:LIV), a developer of innovative drugs,is ple...

Labopharm to Present Poster on Dose Titration of Once-daily Tramadol at 3rd International Forum on Pain Medicine

- Article Discussing Pharmacokinetics and Dose Proportionality ofCompany's Once-Daily Tramadol to be Published in BiopharmaceuticsJournal - LAVAL, QC, June 29, 2007 /PRNewswire-FirstCall/ - Labopharm Inc.today announced that it will present a poster discussing the dosetitration of its once-daily formulation of tramadol at the 3rdInternational Forum on Pain Medicine to be held June 28 to J...

Obama Statement on Bush Veto of Stem Cell Bill

CHICAGO--(BUSINESS WIRE)--Jun 20, 2007 - Senator Obama todayreleased the following statement in response to President Bush'sveto of Stem Cell Bill: "By vetoing funding for stem cell research once again, thePresident is deferring the hopes of millions of Americans who donot have the time to keep waiting for the cure that may save orextend their lives. The promise that stem cells hold does...

PARI and Kamada Announce Positive Intermediate Phase I Results for Inhaled Alpha-1 Antitrypsin

MONTEREY, Calif., May 31, 2007 /PRNewswire-FirstCall/ -- Thefirst of two stages of the Phase I clinical trial show positiveresults for Kamada's Alpha-1 Antitrypsin (AAT) liquid drugcandidate for inhalation delivered with PARI's eFlow electronicnebulizer for the treatment of patients suffering from AATdeficiency. Dosage levels studied resulted in good safety profilesand patient tolerabili...

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AMA at Medicine Dictionary

Amaurosis fugax

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