Elusive HIV shape change revealed; Key clue to how virus infects cells
Structural biologists at Children's Hospital Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine and treatment approaches. Researchers led...Timing is everything: First step in protein building revealed
Timing is everything, it seems, even inscience. A team led by Johns Hopkins scientists has unraveled the firststep in translating genetic information in order to build a protein,only to find that it's not one step but two.In a series of experiments, the scientists found that when yeast'sprotein-building machinery recognizes the starting line for a gene'sinstructions, it first alters its str...Male circumcision reduces risk of HIV transmission from women to men
The first study to examine the probability ofHIV infection per act of heterosexual sex among a population withmultiple sexual partners has found that uncircumcised men have morethan twice the risk of acquiring HIV than do circumcised men.In the study, published in the Feb. 15 issue of The Journal ofInfectious Diseases, now available online, Jared Baeten and colleaguesfrom the United States...Female sex hormones play a vital role in defense against sexually transmitted diseases
Two McMaster University studies, to be published in the Journal of Virology, show that sex hormones have a profound effect on susceptibility of female mice to the herpes simplex virus, type 2 (HSV-2 ), one of the most common sexually transmitted diseases. Charu Kaushic, assistant professor and supervisor of the studies, says the implication of this work is quite significant. "The research...Plasmid DNA Preparation (Small Scale) from Nature Technology Corporation
Description:Highly-purified, endotoxin-free plasmid DNA preparations are prepared from customers high-copy (pUC) plasmids in quantities from 1mg to multi-gram scales. Small-scale (1-100mg) as well as large-scale (100mg-multi-gram) preparations are made according to customer specifications. Each preparation is formulated according to customer needs, and glycerol stocks are maintained to facilitate future or...Plasmid DNA Preparation (Large Scale) from Nature Technology Corporation
Description:Highly-purified, endotoxin-free plasmid DNA preparations are prepared from customers high-copy (pUC) plasmids in quantities from 1mg to multi-gram scales. Each preparation is formulated according to customer needs, and glycerol stocks are maintained to facilitate future ordering. Transformation, clonal selection (Clonal selection includes screening colonies for super-coiled monomer prior...Angle Rotor with 323 Sealed Buckets, 4 50 ml from Thermo Scientific
Description:45° Fixed Angle Rotor for use in the IEC Centra CL2, Centra CL3CL3R, and Centra-MP4/MP4R. Perfect for rapid concentration of sputum samples and other difficult to separate infectious samples. Provides individual aerosol containment. Complete with rotor and 4 sealed shields....Biological sealed microtube rotor, 24 1.5 ml from Thermo Scientific
Description:The 891 45° Fixed Angle Rotor is designed to provide aerosol containment and can be removed from a centrifuge (seal entact) and opened under an environmental hood....Acetate Plate Sealers from Thermo Scientific
Description:Acetate Plate Sealers 100/Box...Ni-NTA Superflow Columns - automated large-scale purification of 6xHis-tagged proteins
Ni-NTA Superflow Columns enable up to 24 automated large-scale 6xHis-tagged protein preparations to be performed in parallel on the BioRobot 3000 workstation. Using cleared lysates from bacterial cultures as starting material, up to 15 mg protein per column can be purified under native or denaturing conditi...Purification of Recombinant Flavonone 3beta-Hydroxylase Using Bio-Scale CHT5-1 Hydroxyapatite Column
Flavanone 3b-hydroxylase (FHT), a typical 2-oxoglutaratedependent dioxygenase, catalyzes the 3b-hydroxylation of 2S-flavanones to 2R,3R-dihydroflavonols which are intermediates in the biosynthesis of flavanoids, catechins, proanthocyanidins, and anthocyanidins in plants. To understand the complex reaction mechanism,...Broadlook narrows search for sales leads with software
What's more, the founder and CEO of Pewaukee-based might have just the silver bullet to do it. Using Broadlook's primary software suite Profiler, Eclipse and Contact M...Sonic Foundry cuts losses as sales continue to rise
The boost came mostly from increased sales of the MediaSite video and presentation product, which increased by $1 million, the company said. Total revenue for the quarter wa...Bone Care marks solid quarter on Hectorol sales jump
Hectorol is a Vitamin D-based drug used to lower abnormally high levels of parathyroid hormone in patients with chronic kidney disease. Gross margins run about 75 percent....Inhaled Steroids Safe & Effective for Children with Asthma
A 5-year, 8-center study by "Childhood Asthma Management Program" (CAMP) has indicated that inhaled steroids are safe and effective for the long-term treatment of children with mild to moderate asthma. "Although asthma experts around the world have recognized the effectiveness of inhaled corticosteroids in treating asthma, their long term effects in children were not clear, and questions...Pesticide impairs male reproductive function
According to the May issue of the journal Epidemiology, high levels of DDT found in some Mexican workers suggest that pesticide can impair male reproductive function. The human body metabolises DDT to DDE. An international team of researchers took blood samples from 24 men aged 16 to 28 who had not been exposed to DDT in their work. In these men the high DDE levels correlated to low leve...New dimension in the treatment of female sexual dysfunction
Female sexual dysfunction is associated with loss of libido, low motivation and fatigue, most often occurring in women who have attained their menopause or whose ovaries had been removed surgically for some reason. Dehydroepiandosterone(DHEA), may serve as an effective treatment in such sexual dysfunction, according to a study released at the 96th annual meeting of the American Urologica...Researchers Scale to assess the Severity of Epilepsy in Kids
Epilepsy in kids is almost a nightmare to their respective parents, that too when it is resistant to the treatment. Researchers identified three factors that may increase a child's risk of having intractable epilepsy - a form of the disease that does not respond to commonly used drugs. Children who have their first epileptic seizure before their first birthday which is also called sympto...New point scale to ascertain the stroke recovery
Stroke is undoubtedly the most common neurological disorder and one of the leading causes of morbidity and mortality. Five million people die of stroke each year and more than 15 million suffer non-fatal strokes. But the question of the day is about the recovery - whether the patient would recover and if so how long would it take. Researchers at the National Institute of Neurological Dis...