Dissecting Diabetes - Is protein AKT2 the cause of type 2 diabetes?
"This is a big step forward in dissecting the pathways and mechanisms of diabetes. It is fascinating." Yes the researchers of Yale University have seen a break through in the identification of the missing protein in the adult onset Type II Diabetes mellitus.
They have discovered that...
Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma
...searchers found that mice bred to over-express the akt2
gene also over-expressed Dlx5. In fact, the resear...ined that the combined activation of both Dlx5 and akt2
could result in increased cell growth and prolifer...ival in both cancerous and non-cancerous cells, so akt2
is a potentially risky target for drug development...
Breakthrough in Type II Diabetes
...ice lacking a gene that produces the enzyme called akt2
or //Protein Kinase B are born without diabetes bu...ssue. Further studies showed that the liver of the akt2
knockout mice did not respond to insulin by loweri...ombined with the delayed onset, (it) suggests that akt2
might have a role in the diabetes. The researchers...
AKT2 in Biological News
Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
From this, Testa and Xu were able to gain a broader understanding of how cancers involving AKT2, DLX5 and MYC might develop. A mutation in akt2
may act as a "first hit" that makes the inversion on mouse chromosome 6, which contains the DLX5 gene, more likely. When the inversion happens, the ce...
UCSD researchers discover variants of natural tumor suppressor
...of glucose in the bloodstream. Therapies directed at inhibiting PHLPP1 could be used to treat diabetes; in essence, removing the 'brake' and allowing akt2
to be more functional and allow better insulin regulation. PHLPP2, on the other hand, controls the driver on Akt1, the path involved with cell surviv...
How mammals fuel milk production may have implications for cancer
...ch are expressed in the same areas of the mammary gland at distinct developmental stages. While Akt1 protein increases during pregnancy and lactation, akt2
Indeed, the researchers found that the mammary gland cells of Akt1-deficient mice failed to engage critical metabolic pathways d...
AKT2 in Biological Technology