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ADP in Medical News

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

...hat will feature its investigational antiplatelet drug elinogrel, a P2Y(12) adp receptor antagonist currently in Phase II clinical development, and its ora... inhibitor is licensed to Merck & Co., Inc., and elinogrel, its P2Y(12) adp receptor antagonist and potential competitor for Plavix* (clopidogrel), is ...

Portola Pharmaceuticals to Host Conference Call at 11:00 a.m. Eastern Time Tomorrow to Discuss Betrixaban Partnership and Provide Corporate Update

...scular disease, inflammatory disease and cancer. Portola's two lead Phase 2 compounds, betrixaban, an oral Factor Xa inhibitor, and elinogrel, a P2Y12 adp receptor antagonist, target the global multi-billion dollar antithrombotic market. Both product candidates have best-in-class features versus current ...

Portola Pharmaceuticals Enters Worldwide License Agreement for Development and Commercialization of Novel Antiplatelet Drug Elinogrel

...vel, proprietary intravenous (i.v.) and oral P2Y12 adp receptor antagonist currently in Phase 2 clinical ...nly direct acting, reversible, i.v. and oral P2Y12 adp receptor antagonist in clinical development. Inhibiting the P2Y12 adp receptor on platelets has been proven to prevent t...

Ken Horowitz Joins North Star Health as Chief Executive Officer

...r. Horowitz served as President and Chief Operating Officer at Employease, Inc., the leader in SaaS based HR/Benefits solutions, which was acquired by adp in 2006. During his tenure, he led the company to exponential growth and built the company's client base to over 1500 customers. Prior to join...

Park Dental Doctor Group Settles Litigation With Service Provider

...ore than $130 million -- $88 million in compensatory damages and $42 million in punitive damages. The lawsuit involved claims by the dental group that adp and PDHC had overstepped their authority under Minnesota law and had improperly engaged in conduct constituting the practice of dentistry, which by la...

Florida Healthcare Agency Chooses Microsoft Technology to Heal Its Reporting Maladies

...purchasing habits to help monitor and control spending." The Microsoft Dynamics GP business management solution will be integrated into the agency's adp software and the CMHC/MIS clinical package, while replacing CMHC/MIS's general-ledger software. "With its Microsoft SQL Server platform, Microsoft D...

Prompt Diagnosis Could Be Life-Saving In Mini-Strokes

...of TIA, 149 patients were randomly assigned to the adp group or to an inpatient hospital bed. All patient..., and serial clinical evaluation) but those in the adp group received those tests more rapidly. The median length of stay for the adp group was 25 hours vs. 61 hours for the admitted p...
ADP in Medical Technology

Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study

...et activation without the liability of increased bleeding (when added to standard of care), a tendency associated with drugs that block thromboxane or adp pathways. Specifically, this compound is being investigated as an oral antiplatelet agent for patients with established vascular disease, with the int...

Portola Pharmaceuticals Initiates Phase II Trial of Novel IV and Oral Anti-Platelet Drug in Non-Urgent Percutaneous Coronary Intervention

...ical trial of PRT060128, the Company's novel P2Y12 adp receptor antagonist, in patients undergoing non-ur...is the only reversible, direct acting, IV and oral adp receptor antagonist in clinical development. Inhibiting the P2Y12 adp receptor on platelets has been proven to prevent t...

Portola Announces Data Showing Its Anti-Platelet Drug Inhibits Platelets in Clopidogrel (Plavix(R)) Non-Responders

...ug that directly and reversibly inhibits the P2Y12 adp receptor, overcomes high platelet reactivity (HPR)...versible, direct acting, intravenous (IV) and oral adp receptor antagonist in clinical development. Inhib...lopidogrel. Platelet aggregation was determined by adp and collagen-induced aggregation and pharmacodynam...

Portola Announces Data Presentations Relevant to Its Lead Phase II Antithrombotic Compounds at American Heart Association Scientific Sessions 2008

...ardiovascular and inflammatory diseases and cancer. Portola's two lead Phase II compounds, betrixaban, an oral Factor Xa inhibitor and PRT060128, an adp receptor antagonist, target the global multi- billion dollar antithrombotic market. Both product candidates have best-in- class features versus curren...

Portola Completes $60 Million Financing to Advance Its Therapeutic Programs

...n patients with atrial fibrillation. The other Phase 2 drug candidate is PRT060128, an antiplatelet agent that is the only intravenous (IV) and oral adp receptor antagonist in clinical development. Portola believes that this compound may provide significant clinical benefit over clopidogrel and other a...

Arena Pharmaceuticals Announces Positive Phase 1b Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis

...n preclinical studies, Arena believes that APD791, by preventing only the amplification of platelet aggregation induced by primary aggregators such as adp and collagen, may allow sufficient platelet aggregation at therapeutic doses to avoid the bleeding risk associated with other anti-platelet agents whi...

Daiichi Sankyo/Eli Lilly's Effient and Astrazeneca's Ticagrelor May Offer Advantages in the Treatment of Post-Myocardial Infarction

...se more major bleeding than Plavix/Iscover and that ticagrelor must be twice-daily dosed, in comparison with Plavix/Iscover's once-daily dose. The new adp receptor antagonists Effient and ticagrelor will be launched in 2009 and 2011, respectively. However, with Plavix/Iscover's patent expiry in 2011, onl...

Arena Pharmaceuticals Announces Positive Phase 1a Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis and Initiates Phase 1b Clinical Trial

...n preclinical studies, Arena believes that APD791, by preventing only the amplification of platelet aggregation induced by primary aggregators such as adp and collagen, may allow sufficient platelet aggregation at therapeutic doses to avoid the bleeding risk associated with other anti-platelet agents whi...

SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients

...et activation without the liability of increased bleeding (when added to standard of care), a tendency associated with drugs that block thromboxane or adp pathways. Specifically, this compound is being investigated as an oral antiplatelet agent for patients with established vascular disease, with the int...

Portola Pharmaceuticals Presents Positive Phase I Data of Its ADP Receptor Antagonist at the American College of Cardiology

...harmaceuticals, Inc. presented Phase I data of its adp receptor antagonist at the of Cardiology's (ACC) 5...further study the differentiated properties of our adp receptor antagonist." Portola's adp Receptor Antagonist PRT060128 is an antiplatelet...
ADP in Medical Products

Plateletworks Combo-25 Kit

Description:... before and after intentional platelet activation, using either collagen or adp as the agonist. The procedure is simple and no special sample preparation i...st Reagent Tube. Both tubes are run on the Ichor analyzer. Kit includes 25 adp and 25 Collagen Agonist Reagent Tubes...
Company:Helena Laboratories

Ichor Hematology Analyzer

Description:...ount plus platelet aggregation within five minutes. The test is simple. A fresh whole blood sample is added to both an EDTA baseline and a Collagen or adp agonist tube. All tubes are run on the Ichor hematology analyzer. CBC, including platelet count, is available within minutes. Platelet aggregation is ...
Company:Helena Laboratories

Contact Wide Field Panoramic Viewing

Description:... As opposed to the BIOM, the CWF and autoclaveable adp contact lenses make contact with the eye and require a contact medium such as methyl cellulose. For those surgeons who have someone to hold a co...
Company:Oculus, Inc.
ADP in Biological News

Researchers find signal that switches on eye development -- could lead to 'eye in a dish'

...from the location where the eye will develop so that it can be converted to adp by E-NTPDase2, thereby providing the trigger for eye development. They wer...ick research shows that this short burst of ATP followed by accumulation of adp is a key signal for initiating expression of the EFTFs and hence the develo...

A human parasite with a streamlined mitochondrion

...be able to do far fewer jobs than our own mitochondria. Further experiments performed by the team reveal that the Entamoeba carrier can only transport adp and ATP, suggesting that it could fuel energy-requiring reactions within the mitosome but might not perform other functions. The work suggests that th...
ADP in Biological Technology

Portola Data on Its Novel Syk Inhibitors and Novel Universal Factor Xa Inhibitor Antidote to be Presented at 2008 American Society of Hematology (ASH) Meeting

...diovascular and inflammatory diseases and cancer. Portola's two lead Phase II compounds, betrixaban, an oral Factor Xa inhibitor and PRT060128, an adp receptor antagonist, target the global multi- billion dollar antithrombotic market. Both product candidates have best-in- class features versus curre...

Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation

...ardiovascular and inflammatory diseases and cancer. Portola's two lead Phase II compounds, betrixaban, an oral Factor Xa inhibitor and PRT060128, an adp receptor antagonist, target the global multi- billion dollar antithrombotic market. Both product candidates have best-in- class features versus curren...

Portola Pharmaceuticals Names William Lis Vice President of Business Development and Commercial Operations

...lation and for secondary prevention of myocardial infarction (MI) and stroke. Portola's other clinical compound, PRT060128, is an oral and intravenous adp receptor antagonist being developed for patients with acute coronary syndrome, for the prevention of cardiovascular events in patients undergoing perc...

Hsiao Dee Lieu, M.D., F.A.C.C. Named VP of Clinical Research of Nile Therapeutics

...to joining Nile, Dr. Lieu served as Director of Clinical Development for Portola Pharmaceuticals, Inc., where he led the global development of a large adp antagonist program in acute coronary syndrome. In this role, Dr. Lieu was responsible for the overall clinical development plan of intravenous and ora...

Gq-coupled Receptor Assays Using FLEXstation

...phate (2MT-ADP)>>ADP>ATP (1). The EC 50 value for adp was approximately 190 M as determined by phosphoin...lecular Devices, cat# R8041; Tel: 1-800-635-5577), adp (Sigma, cat# A2754; Tel: 1-800-325-3010), probenec...ell. 3. Prepare a fresh stock of 5 mM adp in 1X Reagent Buffer containing 2.5 mM probenecid...

DNA Quantitation in the LMax Microplate Luminometer (MaxLine Application Note #37)

...ation reaction is catalyzed by the enzyme nucleoside diphosphate kinase (NDPK). In this reaction, the terminal phosphate of the dNTP is transferred to adp to form ATP. The ATP is then measured using a luciferin/ luciferase reagent to produce light in proportion to the amount of ATP which, in turn, is pro...

Purification of Two Isoforms of Pyruvate Kinase from Nordic Krill Using an UNO Q1 Column, Rev A

...e glycolytic pathway in crustaceans. This enzyme catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate and the phosphorylation of adp to ATP. In addition to the role of PK in aerobic and anaerobic energy metabolism in invertebrates, regulation of PK activity in resp...

Translate High Yields of Biologically Active Proteins

... Adenylate kinase 1 (AK1): Activity was measured by a luciferase-based ATP bioluminescence assay (Sigma) in the presence of 1 mM adp [2]. Carbonic anhydrase 2 (CA2): Esterase activity of CA2 was monitored by the net increase in absorbance at 348 nm in a p-nitrophenyl ...

Simple Isolation of RNA from Tissue and Cultured Cells

...o the instructions provided. The presence of PCR products for high- (-actin), medium- (g-actin) and low- (protein phosphatase 1, adp ribosylation factors 1 and 3, and ornithine decarboxylase) abundance mRNA shows that a wide spectrum of RNA molecules is present...
ADP in Biological Definition

ADP

Automatic Data Processing . A Corporation providing Employer, Brokerage, Dealer & Claims Services. Aeroports de Paris adenosine diphosphate AOLserver Dynamic Pages , which are web server extensions designed to return dynamically created documents based on the TCL computer...

Actin

...redominantly bound to ATP , but can also bind to adp . An ATP-actin complex polymerizes faster and diss...ease in ADP-actin stimulates the exchange of bound adp for ATP, leading to more ATP-actin units. This rap...s this effect by stimulating the exchange of bound adp for ATP. In addition, ATP-actin units bound to pro...

Adenosine triphosphate

... 4 Other triphosphates 4.1 Reaction of adp with GTP 5 See also 6 External link ...process in aqueous solution . Reaction of adp with GTP adp + GTP ATP + GDP There is talk of using A...

ATP synthase

...iphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate by utilizing some form of energy. The overall reaction sequence is: adp + P i → ATP ATP synthase in E. coli These enzymes are of crucial importance in almost all organisms, because ATP is the co...

ATPase

...e (ATP). This enzyme works when a proton moves down the concentration gradient, giving the enzyme a spinning motion. This unique spinning motion bonds adp and P together to create ATP. ATP synthetase can also function in reverse; that is, use energy released by ATP hydrolysis to pump protons against thei...

Calvin cycle

.... The total sum of reactions in the Calvin cycle is the following: 6 CO 2 + 12 NADPH + 12 H 2 O + 18 ATP → C 6 H 12 O 6 + 12 NADP + + 18 adp + 18 P i Reactions in the Calvin Cycle Ribulose 1,5 bisphosphate (RuBP) + carbon dioxide → 3-phosphoroglycerate (catalysed by RubisCO...

Cellular respiration

... The overall reaction can be expressed this way: Glucose + 2 NAD + + 2 adp + 2 P i → 2 NADH + 2 pyruvate + 2 ATP + 2 H 2 O + 4 H + The ind... of glycerate-3-phosphate (3-phosphoglycerate), converting two molecules of adp to ATP. The two molecules of glycerate-3-phosphate again lose phosphate f...

Enzyme

... present in human saliva and also released by the pancreas Angiotensin converting enzyme ATPases : those enzymes that hydrolyze ATP into adp and inorganic phosphate in order to drive some other energetically unfavorable reaction ATP synthase : creates ATP from ADP, inorganic phosphat...

Glycolysis

... pyruvate , along with "reducing equivalents" in the form of the coenzyme NADH . The global reaction of glycolysis is: Glucose + 2 NAD + + 2 adp + 2 P i → 2 NADH + 2 pyruvate + 2 ATP + 2 H 2 O + 2 H + So, for simple fermentations, the metabolism of 1 molecule of glucose has a net yi...

Histone

...terminal tails, but also in their globular domains. Such modifications include methylation , acetylation , phosphorylation , ubiquitination , and adp -ribosylation. This effects their function of gene regulation (see functions). In general, genes that are active have less bound histone, while ...
ADP in Biological Dictionary

Urea

...us urea cycle n. The sequence of chemical reactions that takes place in the liver and that results in ... 3 ATP + 2 H2O urea + Fumarate + 2 adp + 4 Pi ... Describes forms and uses of fertilizer urea , how and when to apply it, and the ... Today, though, considerable urea is manufactured ...

Photophosphorylation

...ylation summary with 1 pages of encyclopedia entries, research information, and more. ... by light, this process is called photophosphorylation . adp + Pi -> ATP ... called noncyclic photophosphorylation because it produces ... Photophosphorylation ... photophosphorylation n. Phosphoryla...

Phosphodiester Bond

...ng the attacking 2' ... Definition and other additional information on Phosphodiester bonds from Biology-Online.org dictionary. ... its ATP and adp that have the phosphodiester bonds . ... Definition and other additional information on Phosphodiester bond from Biology-Online.org dictiona...

Phosphate group

...o increase our strength. ... After losing a phosphate group ATP becomes adp (Adenosine DiPhosphate) ... its own phosphate group to adp in ... two phosphate groups . c. ribose. d. adenine. Hint. 4. ... a t...

Mitochondrial membrane

...bs, lab registry, news, forum ... activity of the mitochondria occurs within the inner mitochondrial membrane (IMM) ... The transport of ATP, adp and phosphate across the mitochondrial membrane ... The mitochondrial membrane is permeable to small uncharged molecules such as O2, ... Ba...

Cyclic electron flow

... new window. Photosynthesis-Calvin Cycle and Cyclic Electron Flow ... photosynthesis Calvin Cycle cyclic electron flow NADPH adp Carbon Fixation AP ... There is little doubt that cyclic electron flow around PS I provides extra ATP ... B), indicating that the cyclic e...

Chloroplasts

...... Animal cells do not have chloroplasts . ... ... and orange, in the chloroplasts of plants; by absorbing wavelengths ... mechanism by which adp is phosphorylated to ATP in mitochondria and chloroplasts . ... The Cell - A Molecular Approach is a basic text that provides an accessible intr...

Chemiosmosis

... ATPase. ... Cristae (singular crista) are the internal compartments formed by the inner ... As a result, chemiosmosis occurs, producing ATP from adp and a phosphate group ... A plant that uses the Calvin cycle for the initial steps that incorporate CO2 ... The set of reactions by which some ...

Adenosine diphosphate

...phosphoric acid with the nucleoside adenosine . adp consists of the pyrophosphate group, the pentose s...hate (·deˑ·n·sēn dī·fsˑ·fāt) ... ... it yields adp ( adenosine diphosphate ), inorganic phosphorus,...dditional information on Adenosine Diphosphate adp from Biology-Online.org dictionary. ... Adenosine...
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