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ACTOS in Medical News

New data showed Actos prevented progression of atherosclerotic plaque volume in patients

Chicago, IL, March 31, 2008 New data from a clinical trial using intravascular ultrasound (IVUS) technology found that in patients living with type 2 diabetes, ACTOS® (pioglitazone HCl) reduced the atherosclerotic burden in the coronary arteries compared to glimepiride, and prevented progress...

New research shows ACTOS is associated with a 38 percent lower risk of heart attack

Amsterdam, The Netherlands, Sept. 19, 2007 -- New research, including two studies presented this week at the 43rd Annual Meeting of the European Association for the Study of Diabetes (EASD), further support the cardiovascular safety of ACTOS (pioglitazone HCI) and its benefits regarding improved...

New research shows ACTOS is associated with a 38 percent lower risk of heart attack

Amsterdam, The Netherlands, Sept. 19, 2007 -- New research, including two studies presented this week at the 43rd Annual Meeting of the European Association for the Study of Diabetes (EASD), further support the cardiovascular safety of ACTOS (pioglitazone HCI) and its benefits regarding improved...

Takeda statement on ACTOS meta-analysis published in the Journal of the American Medical Association

Deerfield, IL, September 11, 2007 Takeda Pharmaceuticals North America, Inc. is aware of the review of ACTOS (pioglitazone HCl) data conducted by A. Michael Lincoff, M.D., and colleagues at the Cleveland Clinic, published in the Journal of the American Medical Association which concluded that ACT...

TGen and USC researchers find genetic markers to help fight diabetes

...6, a potassium inwardly-rectifying channel called KCNJ16, and the farnesoid X receptor (NR1H4). Together, these markers predicted both response to actos therapy and improvement in insulin sensitivity in the patients taking the drug. Dr. DiStefano said the next steps in this research will be to char...

New Diabetes Drug Shows Promise in Trial

...fe and effective, with less incidence of heart failure or edema than either actos or placebo; it produced less weight gain than actos when given at the 150-microgram dose. "The favorable balance in the safe...

Diabetes drug shows promise against multiple sclerosis

..., double-blinded clinical trial, patients with relapsing remitting multiple sclerosis were assigned to take pioglitazone (a drug commercially known as actos used to treat type-2 diabetes) or a placebo. Patients continued their normal course of therapy during the trial. Standard neurological tests were ...

The Launch and Uptake of More Than 20 Novel Drugs Over The Next 10 Years Will Drive $12.5 Billion Growth in the Type 2 Diabetes Market

...ss are higher than ever before." The report also finds that generic competition will weaken the market share of the PPAR-gamma agonists--Takeda's actos and GlaxoSmithKline's Avandia--reducing sales of these agents by more than 50 percent over the 2008 to 2018 study period. The PPAR-gamma agonists, alo...

FDA Approves ACTOplus met(R) XR (pioglitazone HCl and metformin HCl extended-release) Tablets for the Treatment of Type 2 Diabetes

...tformin or who have inadequate glycemic control on actos or metformin alone. ACTO plus met XR combines actos and metformin, two widely used medications in a single tablet. actos directly targets insulin resistance, a condition i...

Certain Diabetes Drugs May Pose Eye Risk

... Use of Avandia, actos tied to a retinal disorder, study finds TUESDAY, April 7 (HealthDay News) -- A class of diabetes drugs called glitazones are associated wi...
ACTOS in Medical Technology

Takeda Provides Update on the Investigational Fixed-Dose Combination of alogliptin and ACTOS(R) (pioglitazone HCl)

...9. The NDA for the FDC of alogliptin and actos was submitted in September 2008, following the NDA... 2008 FDA Guidance for alogliptin. About actos ((R)) (pioglitazone HCl) actos is a prescription medication used with diet and ex...

Takeda Submits a New Drug Application in the U.S. for Alogliptin (SYR-322) / ACTOS(R) (pioglitazone HCl) for the Treatment of Type 2 Diabetes

...one (TZD) class of oral anti-diabetes medications. actos is a TZD that directly targets insulin resistance,...ty Information About ACTOS(R) (pioglitazone HCl) actos works by directly targeting insulin resistance, a ...herapy with insulin, sulfonylureas or metformin. actos is not for everyone. Certain patients with heart f...

New Data Showed ACTOS(R) (pioglitazone HCl) Prevented Progression of Atherosclerotic Plaque Volume in Patients With Type 2 Diabetes

...observational studies, have shown no evidence that actos is associated with an increased risk of heart atta...nge in coronary artery atheroma volume in favor of actos treatment compared to glimepiride treatment. The...sion of coronary atherosclerosis. In contrast, the actos arm showed no progression of coronary atherosclero...

Takeda Submits New Drug Application for Alogliptin (SYR-322) in the U.S.

...ollowed in recent years by the introduction of the actos family of products, with more than 75 million pres...of alogliptin, an investigational DPP-4 inhibitor. actos and alogliptin have distinct but complementary mec...y and combination therapy options. About ACTOS actos works by directly targeting insulin resistance, a ...

Data Presented at the American Heart Association Scientific Sessions 2007 Demonstrated Increased HDL with ACTOS(R) (pioglitazone HCl) Slowed the Progression of Carotid Intima-Media Thickness in Patients with Type 2 Diabetes

...s of the inner lining of a patient's carotid, with actos was associated with increased HDL cholesterol and .... Patients were treated with a 15 to 45 mg dose of actos or 1 to 4 mg dose of glimepiride for 72 weeks with...om 9:15 to 9:30 a.m. Eastern Standard Time About actos ...

ACTOS(R) (pioglitazone HCl) Demonstrates Reduced Risk of Ischemic Cardiovascular Disease in Patients with Type 2 Diabetes

...vascular disease in patients with type 2 diabetes. actos is an oral antidiabetic agent for type 2 diabetes ...tes showed that therapeutic regimens that included actos were associated with reductions in the risk for st...pies. The adjusted relative risk of stroke for the actos group was 20 percent lower than that for the group...

MEDIA ADVISORY: Subsets of Landmark Diabetes Trials Investigating MacroVascular Outcomes Presented at the American Diabetes Association 67th Scientific Sessions

.... -- Long-term cost-effectiveness analysis on actos for the USA from PROactive; Poster 1209-P ... 12-2 p.m. and 6:15-7:30 p.m. About actos actos works by directly targeting insulin resistance, a ...

Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures

...y practitioners and endocrinologists report they are reluctant to prescribe actos or any other product containing ACTOS (i.e., ACTOplus met). The GfK Marke...ns by responding to a survey that was self administered. Both Avandia and actos have been asked to add "black box" warnings on their labels while the FDA c...
ACTOS in Biological Technology

Surveyed Experts Indicate That Byetta LAR and Victoza Have Advantages Over Actos in the Treatment of Type 2 Diabetes

Byetta LAR Will Earn Decision Resources' Clinical Gold Standard Status for Type 2 Diabetes in 2012, According to a New Report from Decision Resources WALTHAM, Mass., March 24 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and heal...

Lilly Reports Solid First-Quarter Results

...he product in many countries outside the U.S. In the first quarter of 2008, actos generated $84.1 million of revenue for Lilly, the majority of which was outside the U.S. actos revenue decreased 2 percent versus the first quarter of 2007. Worldwide s...

New Data Published in Circulation Showed an Increase in HDL Cholesterol Levels with ACTOS(R) (pioglitazone HCl)

...tack and stroke. CHICAGO examined the effects of actos on measures of the atherosclerotic disease process.... Patients were treated with a 15 to 45 mg dose of actos or 1 to 4 mg dose of glimepiride for 72 weeks with...otic burden in people living with type 2 diabetes. actos studies, conducted over the past 10 years in more ...

Merck Will Obtain Blockbuster Antidiabetic Drug Sales in Type 2 Diabetes Market by 2011

... and GLP- 1 analogues (such as Eli Lilly/Amylin's Byetta). Nonetheless, the actos franchise will continue to gain uptake in the market due in part to the launch of a novel fixed-dose combination of actos with extended-release metformin. Furthermore, Takeda is developing a novel ...
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