JCI table of contents: Nov. 8, 2007
...IOVASCULAR DISEASE: Two heads are better than one: abca1
and ABCG1 combine to enable HDL to protect us from...as macrophage foam cells via two proteins known as abca1
and ABCG1. Previous studies examining the role of ...c effects of HDL. In this study, mice lacking both abca1
and ABCG1 were generated. When bone marrow from th...
Cholesterol mystery solved through research mice
...address these questions."
These specially developed mice have mutations in a gene (ABCA1) involved in HDL production. In one group of animals, the abca1
gene is selectively deleted in the liver – which means their livers cannot produce HDL. It was through studying these mice that the scientists were ab...
ABCA1 in Biological News
Dominant cholesterol-metabolism ideas challenged by new research
...n the on-line journal PLoS One.
A protein called abca1
is critical for producing "good" cholesterol:
pat...s at an early age. An important
question is what abca1
does that is so important for producing HDL.
T...uild-up of PS on the cell surface.
might activate or might actually be the enzyme,
ABCA1 in Biological Technology
RVX-208 Data Demonstrates Increase in Functional HDL Particles
...orresponding prebeta-HDL change
was 42% (P=0.007) in the actively treated group compared to control.
Furthermore, sera from subjects were assessed for abca1
cholesterol efflux as a predictive marker for reverse cholesterol
transport. Again, ABCA1-dependent cholesterol efflux change increased by
ABCA1 in Biological Products