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...sion) compared with those receiving Zometa (hazard ratio 0.84, 95 percent CI: 0.71-0.98), which is statisti... statistically superior compared to Zometa (hazard ratio 0.90, 95 percent CI: 0.77-1.04) (secondary endpoin...event-driven study were randomized in a one-to-one ratio to receive either 120 mg of denosumab subcutaneous...
... the compound's neurogenic properties," said Jim Schoeneck, chief executive officer of BrainCells Inc. "The platform was able to identify the pathway, ratio of drug and dosing that shaped the clinical trial protocol, directing the first rational approach to drug development in the area of psychiatry." ...
...e from baseline in HDL levels was 9.7 mg/dL among nevirapine patients and 3.9 mg/dL among ATV/r patients (p<0.0001). The mean total cholesterol/HDL ratio in patients receiving nevirapine decreased from baseline (-0.24) and increased in patients receiving ATV/r (+0.13) (p =0.0001). The mean triglyceride ...
...istered once daily; 30mg/N=244 or 60mg/N=180 administered twice daily), or warfarin (N=250) dose-adjusted locally to a target International Normalized ratio (INR) of 2.0-3.0 for 12 weeks. The INR was determined weekly for four weeks and every two weeks thereafter. Investigators, sponsors and study subjec...
...rgery to bone, or spinal cord compression) (hazard ratio 0.82, 95 percent CI: 0.71, 0.95), and delaying the time to the first-and-subsequent SREs (hazard ratio 0.77, 95 percent CI: 0.66, 0.89). Both results wer...olled in the study were randomized in a one-to-one ratio to receive either 120 mg of denosumab subcutaneous...
...ients (29%) in the orBec(R) group and 28 patients (42%) in the placebo group died within one year of randomization (46% reduction in mortality, hazard ratio 0.54, 95% CI: 0.30, 0.99, p=0.04, stratified log-rank test). In the Phase 2 study, the primary endpoint was the clinically relevant determinati...
... In the randomized, active-controlled, double-blind studies in focal dystonia NT 201 and one other Botulinum toxin (BTXCo) have been used with a dose ratio of 1:1. The results demonstrate equivalent efficacy between the NT 201 and BTXCo. Onset, waning, and duration of effect were comparable. These finding...
... statistically significant (p<0.0001). Finally, the AFRESA group had a statistically significant reduction in the incidence of mild/moderate (odds ratio [OR] 0.474, confidence interval [CI] 0.271, 0.831; p=0.0091) and total hypoglycemia (OR 0.488; CI 0.278, 0.856; p=0.0124). About Diabetes Di...
...lude any dose titration or run-in period. Patients were randomized in a 1:1 ratio to lorcaserin or placebo at baseline. At Week 52, 856 patients taking lorcaserin were re-randomized in a 2:1 ratio to continue lorcaserin or to switch to placebo, and 697 patients on placebo...
...ase 3 clinical trial of MDV3100 later this year. The primary endpoint of the trial will be overall survival. "We believe that the benefit-risk ratio for MDV3100 is highly favorable, and we are working diligently to initiate the Phase 3 clinical trial later this year," said David Hung, M.D., preside...
...ration of remission compared with the four patients who achieved a CRu with standard chemotherapy (7 months vs. 3.5 months, p=0.03, HR=0.279; a hazard ratio of less than one indicates a decreased risk of disease progression and a p-value of less than 0.05 indicates statistical significance). An analys...
...patient lives without their cancer growing (hazard ratio [HR] 0.79, 97.58% CI 0.70-0.90; P <0.001. Medi...statistical significance in the ZEAL study (hazard ratio [HR] 0.86, 97.58% CI 0.69-1.06; P =0.108. Median ... efficacy to erlotinib for PFS and OS (PFS: hazard ratio [HR] 0.98, 95.22% CI 0.87-1.10; P =0.721; OS: HR ...
...ain following bunionectomy studied the safety and efficacy of tapentadol IR for postoperative analgesia. Patients were randomly assigned in a 4:4:4:1 ratio to receive tapentadol IR 50-mg, tapentadol IR 75-mg, oxycodone HCl IR 10-mg, or placebo every four to six hours over a 72-hour period following surger...
...cal trials are identical multicenter, randomized, double-blind, placebo-controlled trials. Patients enrolled in the trials will be randomized in a 1:1 ratio (500 patients in each trial arm) to receive intravenous infusions of either placebo or 400 mg of solanezumab once every four weeks. Patients who are t...
...placebo. While the studies were not powered to demonstrate an effect on overall survival, a pre-specified exploratory endpoint, the pooled hazard ratio (pirfenidone: placebo) was 0.77 (p=0.326). ADDITIONAL EXPLORATORY EFFICACY RESULTS REPORTED AT ATS The ATS presentation highlighted new effi...
...Mean pramipexole extended release dosage increased from 2.63 to 2.75mg/d (a ratio of 1:1.05) and mean pramipexole immediate release dosage from 2.74 to 2.83mg/d (a ratio of 1:1.03); these data support a 1:1 switch from pramipexole immediate rele...
... 64.8 U in the NT-201 group. Pre-treated subjects were randomized in a 2:1 ratio to NT-201 or placebo. Subjects were followed-up for up to 20 weeks. The Ja...onia NT-201 and one other Botulinum toxin (BoNT) have been used with a dose ratio of 1:1. The results demonstrate equivalent efficacy between the two produc...
...th coronary artery disease for whom PCI was planned, and randomized to one of three oral loading doses of TRA (10mg, 20mg or 40mg) or placebo in a 3:1 ratio of active drug to placebo. The loading doses were increased in a sequential fashion based on a blinded review by a Safety Review Committee. Those pa...
...major response. However, the overall progression free survival (PFS) was significantly longer in the pixantrone arm (4.7 months vs. 2.6 months, hazard ratio = 0.6; p = 0.0074, pixantrone vs. standard chemotherapy). Thirty-two percent (32%) of pixantrone patients received all 6 cycles of therapy, with 84% r...
...gnificant improvement in median progression-free survival, compared with other single-agent chemotherapeutic agents (4.7 months vs. 2.6 months, hazard ratio = 0.6; p = 0.0074, pixantrone vs. standard chemotherapy) based on an intent to treat analysis. PFS, CR/CRu and ORR were determined by an independent ...
... hospitalization. Results found that 49.9 percent of patients studied were not optimally adherent to their medications and had a medication possession ratio (MPR) of less than 0.80. Across all patients, 41% were re-hospitalized at least once within the 12-month follow-up period; however, the highest rate o...
... delivery vehicle in order to maintain the desired ratio following administration. CPX-351 has been granted... to treat cancer. CombiPlex(R), the company's drug ratio technology platform, represents a novel approach t...l deliver a synergistic benefit, locks the desired ratio in a drug delivery vehicle that maintains the...
...nts treated with the DOXIL and docetaxel combination had a 35% risk reduction for developing disease progression compared with docetaxel alone (hazard ratio = 0.65; 95% confidence interval [0.55, 0.77]; p=0.000001). There is an almost three-month improvement in median TTP for patients treated with the comb...
...d by Professor San-Miguel, included: Thirty-six percent reduced risk of death in the VcMP arm, compared with the MP arm (hazard ratio =0.644, p=0.0032; median survival not yet reached in either arm). This OS advantage was maintained despite 43 percent of MP patients receiving...
...trial. After six months of treatment, 96% of patients had achieved CCyR(2). In addition, 74% of patients achieved MMR, defined as Bcr-Abl/Abl ratio < 0.1%. The percentage of patients achieving this level of response rapidly increased after one month of treatment. Adverse reactions were manageab...
...medications and even certain foods. For that reason, patients receiving warfarin require regular blood testing to monitor the international normalized ratio (INR) to ensure that an adequate yet safe dose of warfarin is given. A total of 1,146 patients with atrial fibrillation were randomized to re...
...istered once daily; 30mg/N=244 or 60mg/N=180 administered twice daily), or warfarin (N=250) dose-adjusted locally to a target International Normalized ratio (INR) of 2.0-3.0 for 12 weeks. The INR was determined weekly for four weeks and every two weeks thereafter. Investigators, sponsors and study subject...
...e eight times more likely to achieve an overall response of increased platelet counts of 50,000 to 400,000/microliters than those taking placebo (Odds ratio = 8.2; 99 percent CI [3.59, 18.73]; p < 0.001). In comparison to the placebo group, significantly fewer patients treated with PROMACTA had any blee...
... gradual dose escalation, if the clinical benefit is expected to outweigh potential risks. Intermittent proteinuria (urine protein/creatinine ratio >0.6 mg/mg) occurred in 18.6% of Exjade-treated patients, compared to 7.2% of deferoxamine-treated patients in Study 1, and monthly monitoring is r...
... the compound's neurogenic properties," said Jim Schoeneck, chief executive officer of BrainCells Inc. "The platform was able to identify the pathway, ratio of drug and dosing that shaped the clinical trial protocol, directing the first rational approach to drug development in the area of psychiatry." ...
...e from baseline in HDL levels was 9.7 mg/dL among nevirapine patients and 3.9 mg/dL among ATV/r patients (p<0.0001). The mean total cholesterol/HDL ratio in patients receiving nevirapine decreased from baseline (-0.24) and increased in patients receiving ATV/r (+0.13) (p =0.0001). The mean triglyceride ...
...istered once daily; 30mg/N=244 or 60mg/N=180 administered twice daily), or warfarin (N=250) dose-adjusted locally to a target International Normalized ratio (INR) of 2.0-3.0 for 12 weeks. The INR was determined weekly for four weeks and every two weeks thereafter. Investigators, sponsors and study subjec...
...rgery to bone, or spinal cord compression) (hazard ratio 0.82, 95 percent CI: 0.71, 0.95), and delaying the time to the first-and-subsequent SREs (hazard ratio 0.77, 95 percent CI: 0.66, 0.89). Both results wer...olled in the study were randomized in a one-to-one ratio to receive either 120 mg of denosumab subcutaneous...
Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM)
...e formulated into small (0.3 micron), neutral liposomes that enable penetration of the biofilm and are highly efficient, with a very low lipid-to-drug ratio (0.65). ARIKACE can be delivered through nebulization, which enables the small aerosol droplet size (1 to 5 microns) to facilitate more effective di...Spherix Announces Positive Phase 2 Study Results
...reased serum LDL by an average -13 mg/dl by the end of the first month on therapy, while serum HDL was essentially unchanged (+0.9 mg/dl). The LDL:HDL ratio was improved for two of the three dose groups by an average of 0.3. "The results of this ongoing Phase 2 study are encouraging and reaffirm our b......ients (29%) in the orBec(R) group and 28 patients (42%) in the placebo group died within one year of randomization (46% reduction in mortality, hazard ratio 0.54, 95% CI: 0.30, 0.99, p=0.04, stratified log-rank test). In the Phase 2 study, the primary endpoint was the clinically relevant determinati...
... In the randomized, active-controlled, double-blind studies in focal dystonia NT 201 and one other Botulinum toxin (BTXCo) have been used with a dose ratio of 1:1. The results demonstrate equivalent efficacy between the NT 201 and BTXCo. Onset, waning, and duration of effect were comparable. These finding...
... statistically significant (p<0.0001). Finally, the AFRESA group had a statistically significant reduction in the incidence of mild/moderate (odds ratio [OR] 0.474, confidence interval [CI] 0.271, 0.831; p=0.0091) and total hypoglycemia (OR 0.488; CI 0.278, 0.856; p=0.0124). About Diabetes Di...
...lude any dose titration or run-in period. Patients were randomized in a 1:1 ratio to lorcaserin or placebo at baseline. At Week 52, 856 patients taking lorcaserin were re-randomized in a 2:1 ratio to continue lorcaserin or to switch to placebo, and 697 patients on placebo...
...ase 3 clinical trial of MDV3100 later this year. The primary endpoint of the trial will be overall survival. "We believe that the benefit-risk ratio for MDV3100 is highly favorable, and we are working diligently to initiate the Phase 3 clinical trial later this year," said David Hung, M.D., preside...
...ration of remission compared with the four patients who achieved a CRu with standard chemotherapy (7 months vs. 3.5 months, p=0.03, HR=0.279; a hazard ratio of less than one indicates a decreased risk of disease progression and a p-value of less than 0.05 indicates statistical significance). An analys...
TNFerade(TM) Phase III Data Presented at ASCO
...so indicated a 25% reduction in the risk of death in the TNFerade plus standard-of-care (SOC) arm compared to the patients receiving SOC alone (Hazard ratio = 0.75; 95% Confidence Interval [0.494 - 1.15]). Dr. Mark Thornton, GenVec's Senior Vice President of Product Development commented on the poste......patient lives without their cancer growing (hazard ratio [HR] 0.79, 97.58% CI 0.70-0.90; P <0.001. Medi...statistical significance in the ZEAL study (hazard ratio [HR] 0.86, 97.58% CI 0.69-1.06; P =0.108. Median ... efficacy to erlotinib for PFS and OS (PFS: hazard ratio [HR] 0.98, 95.22% CI 0.87-1.10; P =0.721; OS: HR ...
...ain following bunionectomy studied the safety and efficacy of tapentadol IR for postoperative analgesia. Patients were randomly assigned in a 4:4:4:1 ratio to receive tapentadol IR 50-mg, tapentadol IR 75-mg, oxycodone HCl IR 10-mg, or placebo every four to six hours over a 72-hour period following surger...
...cal trials are identical multicenter, randomized, double-blind, placebo-controlled trials. Patients enrolled in the trials will be randomized in a 1:1 ratio (500 patients in each trial arm) to receive intravenous infusions of either placebo or 400 mg of solanezumab once every four weeks. Patients who are t...
...placebo. While the studies were not powered to demonstrate an effect on overall survival, a pre-specified exploratory endpoint, the pooled hazard ratio (pirfenidone: placebo) was 0.77 (p=0.326). ADDITIONAL EXPLORATORY EFFICACY RESULTS REPORTED AT ATS The ATS presentation highlighted new effi...
...Mean pramipexole extended release dosage increased from 2.63 to 2.75mg/d (a ratio of 1:1.05) and mean pramipexole immediate release dosage from 2.74 to 2.83mg/d (a ratio of 1:1.03); these data support a 1:1 switch from pramipexole immediate rele...
... 64.8 U in the NT-201 group. Pre-treated subjects were randomized in a 2:1 ratio to NT-201 or placebo. Subjects were followed-up for up to 20 weeks. The Ja...onia NT-201 and one other Botulinum toxin (BoNT) have been used with a dose ratio of 1:1. The results demonstrate equivalent efficacy between the two produc...
Pharmasset Voluntarily Halts Clinical Studies with Clevudine in Hepatitis B Infected Patients
...ASH trials was low and the severity was mild, more severe reports from other trials and post marketing surveillance led us to believe the risk benefit ratio for clevudine was insufficient to continue development. We would like to take this opportunity to thank patients and our investigators for their parti...Cynosure Announces Presentation of Favorable Results from Post-Marketing Studies of Smartlipo MPX
... and three months post-treatment. At one and three months, skin treated with Smartlipo MPX had a statistically significant higher skin shrinkage ratio than skin treated with liposuction only, Dr. DiBernardo reported. Of the nine patients who were fully evaluated, eight, or 89%, had an average of 54% ......th coronary artery disease for whom PCI was planned, and randomized to one of three oral loading doses of TRA (10mg, 20mg or 40mg) or placebo in a 3:1 ratio of active drug to placebo. The loading doses were increased in a sequential fashion based on a blinded review by a Safety Review Committee. Those pa...
Freezing Kidney Cancer: Hot Treatment Should Be New Gold Standard for Destroying Small Tumors
...or freezing) is a very effective option for patients who cannot or do not want to have surgery," noted Georgiades. Cryoablation's efficacy rate -- the ratio of how many patients' renal cell carcinoma was destroyed completely for localized tumors by size -- is 100 percent up to 4 centimeters (about 2 inches......major response. However, the overall progression free survival (PFS) was significantly longer in the pixantrone arm (4.7 months vs. 2.6 months, hazard ratio = 0.6; p = 0.0074, pixantrone vs. standard chemotherapy). Thirty-two percent (32%) of pixantrone patients received all 6 cycles of therapy, with 84% r...
ViroPharma Announces Discontinuation of Maribavir Phase 3 Study in Liver Transplant Patients
...tive). Following transplantation, eligible subjects were randomized to receive maribavir 100mg BID or oral ganciclovir 1,000mg TID in a 1:1 allocation ratio for up to 14 weeks. If CMV disease, defined as symptomatic CMV infection or CMV organ disease, occurred during the study drug administration period, s......gnificant improvement in median progression-free survival, compared with other single-agent chemotherapeutic agents (4.7 months vs. 2.6 months, hazard ratio = 0.6; p = 0.0074, pixantrone vs. standard chemotherapy) based on an intent to treat analysis. PFS, CR/CRu and ORR were determined by an independent ...
... hospitalization. Results found that 49.9 percent of patients studied were not optimally adherent to their medications and had a medication possession ratio (MPR) of less than 0.80. Across all patients, 41% were re-hospitalized at least once within the 12-month follow-up period; however, the highest rate o...
... delivery vehicle in order to maintain the desired ratio following administration. CPX-351 has been granted... to treat cancer. CombiPlex(R), the company's drug ratio technology platform, represents a novel approach t...l deliver a synergistic benefit, locks the desired ratio in a drug delivery vehicle that maintains the...
...nts treated with the DOXIL and docetaxel combination had a 35% risk reduction for developing disease progression compared with docetaxel alone (hazard ratio = 0.65; 95% confidence interval [0.55, 0.77]; p=0.000001). There is an almost three-month improvement in median TTP for patients treated with the comb...
Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans
...fluenza virus. A dose response was apparent, as mice vaccinated with decreasing doses below a threshold level were afforded decreasing protection. The ratio of Vaxfectin(R) adjuvant to DNA in the vaccine also affected the protective efficacy of the vaccine. In separate tests, the use of alternative PCR pri......d by Professor San-Miguel, included: Thirty-six percent reduced risk of death in the VcMP arm, compared with the MP arm (hazard ratio =0.644, p=0.0032; median survival not yet reached in either arm). This OS advantage was maintained despite 43 percent of MP patients receiving...
...trial. After six months of treatment, 96% of patients had achieved CCyR(2). In addition, 74% of patients achieved MMR, defined as Bcr-Abl/Abl ratio < 0.1%. The percentage of patients achieving this level of response rapidly increased after one month of treatment. Adverse reactions were manageab...
...medications and even certain foods. For that reason, patients receiving warfarin require regular blood testing to monitor the international normalized ratio (INR) to ensure that an adequate yet safe dose of warfarin is given. A total of 1,146 patients with atrial fibrillation were randomized to re...
...istered once daily; 30mg/N=244 or 60mg/N=180 administered twice daily), or warfarin (N=250) dose-adjusted locally to a target International Normalized ratio (INR) of 2.0-3.0 for 12 weeks. The INR was determined weekly for four weeks and every two weeks thereafter. Investigators, sponsors and study subject...
...e eight times more likely to achieve an overall response of increased platelet counts of 50,000 to 400,000/microliters than those taking placebo (Odds ratio = 8.2; 99 percent CI [3.59, 18.73]; p < 0.001). In comparison to the placebo group, significantly fewer patients treated with PROMACTA had any blee...
... gradual dose escalation, if the clinical benefit is expected to outweigh potential risks. Intermittent proteinuria (urine protein/creatinine ratio >0.6 mg/mg) occurred in 18.6% of Exjade-treated patients, compared to 7.2% of deferoxamine-treated patients in Study 1, and monthly monitoring is r...
Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483
... safety and pharmacologic effect of PCI-27483. A single administration of PCI-27483 resulted in a linear dose response in the International Normalized ratio (INR), a routine laboratory test used to assess the level of anticoagulation (blood-thinning). "Single doses of PCI-27483 reliably and quickly...Celator(R) Pharmaceuticals Announces Enrollment of First Patient in Phase 2 Study with CPX-351
...tarabine and daunorubicin delivered in a 5:1 molar ratio shown in preclinical studies to represent a synergistic ratio for use in combination chemotherapy. CPX-351 repre...er (CPX-351) Containing a Synergistic, Fixed Molar ratio of Cytarabine (Ara-C) and Daunorubicin (DNR) in Ad...Young Women Diagnosed with Early-Stage Breast Cancer More Likely to Die than Older Women
...ted into the analysis, women under age 40 are 39 percent more likely to die from breast cancer than older women. This breakdown was based on a hazards ratio survival analysis, which is the standard analysis for this type of study. Dr. Margenthaler further explained that the tumors of women under 40 tende...Other TagsRVARVARVARVARVARVAMGBOther Contentsendotrachealendotrachealenemaepiglottitisenteromanometryenuresis
(Date:11/24/2009)... (November 24, 2009) -- The Wildlife Conservation ...hat the last remaining population of Siberian tige...sing tide of poaching and habitat loss. , ... officials of what needs to be done to protect rem... The report was released by the Siber...
(Date:11/24/2009)...le in Spanish . , The presence of increased...tory substances in the blood, hinders the loss and...h project of the University of Navarra conducted b...ool of Pharmacy. , The project, entitled "A nutr... control of body weight and inflammation," examine...
(Date:11/23/2009)...2009 - The time of day matters to forest trees dea...ed by a research team led by Professor Malcolm Cam...incipal for research and colleagues in the departm...campus. , Capitalizing on their previous work ...rch team examined how poplar trees use their 45,00...
Breaking Biology News(10 mins):Report shows dramatic decline in Siberian tigers 2It can be predicted the reaction obese patients will have to a diet 2Time of day matters to thirsty trees, U of T researcher discovers 2Ambry Genetics Announces Certified Service Provider Status for Agilent Microarrays 9944 1Ambry Genetics Announces Certified Service Provider Status for Agilent Microarrays 9944 2Forterus Inc Launches Updated Improved Web Site 57307 1Forterus Inc Launches Updated Improved Web Site 57307 2LA Daily News Readers 26apos 3B vote Dr Khanna as the Best LASIK Surgeon 57305 1LA Daily News Readers 26apos 3B vote Dr Khanna as the Best LASIK Surgeon 57305 2(Date:11/27/2009)... FRANCISCO, Nov. 27 The ...at Blair Lambert, CFO/COO, will present at the NAS...at the May Fair Hotel in London, England, on Wedne...o listen to a live broadcast of The Gymboree Corpo...g on to www.gymboree.com, click on "Our Company" a...
(Date:11/27/2009)... XenaCare Holdings has announced that i...oundation, one of the largest nonprofit organizati...lth education. , Delray B...dings, Inc. (OTCBB: XCHO), a company specializing ...er healthcare products, has announced today that i...
(Date:11/27/2009)... Voyant Health™ announced today t...icensed its TraumaCad Enterprise orthopedic templa...lution. , (PRWEB) Novembe... that Spectrum Health (Grand Rapids, Michigan) has...lating solution and its TraumaCad Extend workflow ...
(Date:11/26/2009)...W YORK, Nov. 27 With cold and flu ...mploy good practices to control the spread of infe...active not only to keep ourselves healthy, but to ...leen Finerty, RN, MS, CIC (certified in infection-...nd occupational health at Hospital for Special Sur...
(Date:11/26/2009)... too big or too heavy can lead to strains or worse...-- There may be nothing wrong with stuffing your t...do the same thing with your suitcase as you pack f...e treated in 2008 in U.S. hospital emergency rooms...lities for luggage-related injuries, such as muscl...
Breaking Medicine News(10 mins):Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 2Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 3Health News:XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation 4Health News:Voyant Health Announces: Spectrum Health Licenses TraumaCad Enterprise and TraumaCad Extend 2Health News:Voyant Health Announces: Spectrum Health Licenses TraumaCad Enterprise and TraumaCad Extend 3Health News:Infection-Control Strategies at Leading Hospital Can be Adapted for Everyday Use 2Health News:Infection-Control Strategies at Leading Hospital Can be Adapted for Everyday Use 3Health News:Infection-Control Strategies at Leading Hospital Can be Adapted for Everyday Use 4Health News:Pack Right for the Holidays to Avoid the ER 2[0] The Gymboree Corporation to Present at NASDAQ OMX 23rd Investor Program[0] XenaCare Holdings Announces National Sponsorship of the Arthritis Foundation [0] Voyant Health Announces: Spectrum Health Licenses TraumaCad Enterprise and TraumaCad Extend[1] Infection-Control Strategies at Leading Hospital Can be Adapted for Everyday Use[2] Pack Right for the Holidays to Avoid the ER
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