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mice in Medical Technology

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

VIENNA, Va., June 5 /PRNewswire-FirstCall/ -- CEL-SCI Corporation (NYSE AMEX: CVM ) announced today that its collaborators at the University of Hawaii reported on data at the annual American Society for Microbiology in Philadelphia, PA. This data demonstrates that vaccines utilizing its L.E.A...

New Research on Pre-Eclampsia in Mice May Have Important Implications for Humans

Team Supported by March of Dimes Publishes Findings in Nature Medicine WHITE PLAINS, N.Y., July 28 /PRNewswire-USNewswire/ -- In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found r...

Senesco Announces H1N1 Influenza Survival Test Results in Mice

NEW BRUNSWICK, N.J., May 26 /PRNewswire-FirstCall/ -- Senesco Technologies, Inc. ("Senesco" or the "Company") (NYSE Amex: SNT ) today reported results of H1N1 mouse influenza survival studies that were conducted in Dr. William Scheld's lab at the University of Virginia School of Medic...

Molecular Therapy Succeeds in Preventing Craniofacial Birth Defect in Mice

Research by March of Dimes Grantee Offers Hope for Treatment of Children WHITE PLAINS, N.Y., Feb. 6 /PRNewswire-USNewswire/ -- A new gene-based technique has successfully prevented a rare craniofacial birth defect in mice and holds promise to help children with the same disorder, according...

New Drug Combination is Able to Eradicate Breast Metastases in Mice

SAN ANTONIO, Dec. 17 /PRNewswire/ -- A novel combination of drugs was able to completely eradicate human breast metastases growing in mice, and shows promise for the effective treatment of patients with advanced metastatic breast cancer. Dr. Sophia Ran from Southern Illinois University School ...

Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice

Positive Findings Support Preclinical Development of Intradigm's ICS-283 PALO ALTO, Calif., Oct. 24 /PRNewswire/ -- Intradigm Corporation, a leading developer of targeted, systemic RNA interference (RNAi) therapeutics, today announced study results that demonstrated the company's TargeTran(TM)...

ALS TDI Completes Gene Expression Profile of Lou Gehrig's Disease in Mice

Largest Target-Discovery Program Aimed at New Treatments for Fatal Disease CAMBRIDGE, Mass., Oct. 2 /PRNewswire/ -- The ALS Therapy Development Institute (ALS TDI) today announced that it has completed the first phase of a comprehensive gene-expression database for ALS with the profiling of the...

ProNAi Announces Preclinical Success for PNT2258 Therapeutic - Curative Events in Xenograft Mice for Difficult-to-Treat Non-Hodgkin's Lymphoma

LOS ANGELES--(BUSINESS WIRE)--Apr 17, 2007 - ProNAi Therapeutics, Inc., a biopharmaceutical company pioneering a new class of nucleic-acid drugs based on DNA interference (DNAi), today announced that its lead oncology therapeutic candidate, PNT2258, has successfully demonstrated preclinical in vivo...

Peramivir Protects Mice From Lethal H5N1 Infection

St. Jude study shows intramuscular injection of peramivir for eight days protected mice from lethal H5N1 influenza virus infection and inhibited virus replication, supporting the use of this drug to control influenza during a pandemic MEMPHIS, Tenn., May 01, 2007 /PRNewswire-USNewswire/ -- The ant...

Vision Deficit in Retinitis Pigmentosa Mice Corrected with DNA Nanoparticles

CLEVELAND--(BUSINESS WIRE)--Jun 4, 2007 - Copernicus Therapeutics, Inc. announced today that a research team at University of Oklahoma Health Sciences Center, led by Dr. Muna Naash, Professor of Cell Biology, demonstrated that Copernicus' DNA nanoparticles corrected vision defects in a mouse model ...

NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans

BETHESDA, Md., June 11, 2007--A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. These genes, and...

Researchers Use Poliovirus to Destroy Neuroblastoma Tumors in Mice

PHILADELPHIA, March 15, 2007-- The cause of one notorious childhood disease, poliovirus, could be used to treat the ongoing threat of another childhood disease, neuroblastoma. In the March 15 issue of Cancer Research, researchers from Stony Brook University report that an attenuated -- or non-viru...

Interferon Beta DNA Treatment Delivered with Ichor Technology Reduces Atherosclerosis Progression in Mice

Summary: Proprietary DNA delivery technology enables sustained Interferon-beta production from muscle cells - reduces atherosclerosis progression in mouse model of heart disease NEW ORLEANS--(BUSINESS WIRE)--Mar 26, 2007 - Research conducted at Cleveland Clinic and presented today at the American ...

Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

BETHESDA, Md., April 1, 2007--Rapamycin, an FDA-approved drug normally used to help prevent the body from rejecting organ and bone marrow transplants and also used to coat cardiac stents, was highly effective in preventing the development of tobacco-related lung tumors in mice. In a study publishe...

Opexa Advances Monocyte Derived Islet Technology to Proof of Principle in stz-induced NOD/SCID Mice

THE WOODLANDS, Texas--(BUSINESS WIRE)--Jun 27, 2007 - Opexa Therapeutics, Inc. (NASDAQ:OPXA), a company involved in the development and commercialization of cell therapies, presented poster presentations at the 5th International Society for Stem Cell Research Annual Meeting (ISSCR) in Cairns, Queen...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

...tage embryos and rapidly generate heritable, knockout mutations in a whole organism. Rats are physiologically more similar to humans than are mice for many traits and are ideal subjects for modeling human diseases. Extensive genetic characterization has revealed that approximately 90 percent of ...

Injection Reverses Heart-Attack Damage

...07. When the team injected NRG1 into the peritoneal cavity of live mice after a heart attack, once daily for 12 weeks, heart regeneration was incre...ardiograms) improved as compared with untreated controls. The NRG1-injected mice also lacked the left-ventricular dilation and cardiac hypertrophy that typi...

AlphaVax Announces Results from Initial Testing of Its H1N1 (Swine) Influenza Vaccine

... Officer. The studies performed at AlphaVax utilized the California 04/2009 HA sequence obtained from the WHO GISAID database on April 25th. mice inoculated with the AlphaVax H1N1 vaccine showed strong dose-dependent hemagglutination inhibition ("HI") antibody responses. After just a single dos...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...emonstrated that single agent perifosine not only induced tumor regression and delayed tumor growth, but that perifosine also improved the survival of mice bearing neuroblastoma tumors. Moreover, in a Phase 2 study conducted at Memorial Sloan-Kettering Cancer Center, perifosine induced responses and delay...

Spherix Announces Positive Phase 2 Study Results

...e in hypercholesterolemic mice. Obesity . 2009 Feb;17(2):269-75.). A novel finding in this study was that atherosclerotic lesions detected in TAG-fed mice were composed of increased collagen, indicative of a more stable plaque phenotype. The results suggest that, in addition to minimizing the extent of ...

Alfacell Provides Shareholder Update

...ns Biotechnology, to conduct a series of animal studies on immune deficient mice to see what effect Onconase would have on human tumors grafted onto these m...r, these data in cell lines are complemented by most recent animal study in mice bearing tumors of varying sensitivity to Cisplatin and Carbo Platinum. In ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

...n Improving Hyperglycemia and Insulin Sensitivity in Obese and Diabetic mice (Late-Breaking Poster) Authors: S.K. Pandey, S.F. Murray, S. Guo, L.M. ...in Sensitivity and Increases Heart Glucose Uptake in Diet-Induced Obese mice (Late-Breaking Poster) Authors: P. Manchem, S.F. Murray, S.L. Booten, X...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

...tinuing until June 9, 2009 in New Orleans, Louisiana. The presentation (#297-OR), entitled "Dose Ranging Studies of an Anti-CD3 Antibody in NOD mice to Determine Minimum Effective Dose," was part of an Oral Session on Antigen-Specific and Non-Specific Regulation of Type 1 Diabetes. In the session,...

Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

...ine combined with clofarabine provides much greater antitumor activity than achieved by either agent alone. In one colorectal cancer model, 66% of mice were cured of their tumors. The publication which will appear in the journal "Cancer Chemotherapy and Pharmacology," was based on work conducted b...

Autism Studies Presented at Mid-Atlantic Research Consortium Meeting

... animal studies that shed light on how autism operates in humans. By altering the flow of serotonin, a neurotransmitter in the brain, Blue showed that mice behaved less socially, had impairments in fine motor functions and increased repetitive behaviors. The changed animal behaviors, said Blue, shared sim...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... PI3K/Akt/mTOR pathway. Inhibitors of TORC2 may have beneficial effects without toxicity to normal tissues since loss of TORC2 in genetically altered mice does not appear to affect normal tissue. TORC1 antagonists such as rapamycin (Sirolimus) have shown activity in both animal models of ocular disease ...

Doctors Urge Precaution to Shield Against Swine Flu

...ulting in improved health. The benefit of AHCC's NK Cell supporting effect, and its role in defense against influenza was explored in a study in mice conducted at Philadelphia's Drexel University and published in Journal of Nutrition, November 2006. Compared with animals exposed to the H1N1 virus...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

...the exact mechanisms by which these genetic variations cause autistic disorders. "For instance, we expect to manipulate similar cell-adhesion genes in mice to see if the animals show altered social behaviors that may correspond to human behaviors." In addition, other genes remain to be discovered. "A...

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

...gnificant number of untreated Morquio patients around the world," said Henry Fuchs, M.D., Chief Medical Officer of BioMarin. "GALNS has been shown in mice to reach important tissues including cartilage and different zones of the bone such as bone marrow, calcified bone and importantly, the growth plate. ...

Muscadine Grape Skin Dietary Supplement Protects against Cancer Therapy Radiation Side Effects

...scadine grape skin powder on irradiated mice. The mice consumed the powder two days before radiation and ...tly improved radiation protection when compared to mice that received no powder. Dr. Carsten also com...recede cancer of the blood cells seen in leukemia. mice fed Muscadine grape skin powder had protection aga...

Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels

...intain the health of the small blood vessels. In the current study, the team wanted to confirm that finding in animals. To do that, they injected mice with a virus that produces large quantities of soluble endoglin, a protein that would circulate, and then bind to and inhibit TGF-beta. When they exa...

Discovery of Marker for Colon Stem Cells Could Shed Light on What Drives Tumor Growth

...more specific marker for colon cancer stem cells than are other previously identified candidate markers. In the study, researchers implanted into mice colon stem cells from seven patients diagnosed with colon cancer, and found that the number of ALDH1 cells increased as the colon cancer progressed. ...

Astrocytes Help Separate Man From Mouse

...igger, faster, and much more complex than those in mice and rats. "There aren't many differences know...ompared the astrocytes in human brains to those in mice and rats. In addition to the findings above, the t...es in people signal five times as fast as those in mice and rats. Human astrocytes are organized i...

Cancer Research 'David' Hopes to Slay 'Cancer Goliath'

...ticular large animal. The serum causes the animal's system to create an immune-stimulating antibody which in turn is injected into a special strain of mice that has naturally occurring breast cancer. (The injected pre-treated serum into the large animal appears to give the animal lifetime immunity to canc...

Scientists Discover Why Teeth Form in a Single Row

...chers discovered that turning off a single gene in mice resulted in development of extra teeth, next to an... the current study, Jiang and colleagues generated mice that lacked the oddskipped related-2 (Osr2) gene, ...p. Secondly, and surprisingly, the Osr2 "knockout" mice developed teeth outside of the normal tooth row. J...

Research Finding Could Revolutionize Asthma Treatment

...igious scientific journal. The lead investigator, Dr. Richard Bond, and his colleagues demonstrated the absence of asthma-like symptoms in laboratory mice that do not have the very receptor that is inhibited by beta blockers. This finding was in agreement with earlier studies by Bond and his colleagues ...

Laser Burn Injuries in One Eye Can Disrupt Protective Immune Privilege in Both Eyes, Study Finds

...h eyes after six hours and continued to be disrupted even after 56 days. When they injected the same antigen into the eyes of a group of control mice without burns, they observed no inflammation. Since created in the 1960s, lasers have found their way onto the battlefield, into the operating r...

BN ImmunoTherapeutics Updates on Phase I/II Studies With Breast Cancer Vaccine

...re, it proved to be efficacious in additional tumour immunotherapy models in HER2 transgenic mice. The immunological situation regarding HER2 in those mice strongly resembles the situation in humans. Based on those encouraging data from both clinical and preclinical studies BN ImmunoTherapeutics de...

Novavax Reports Positive Preclinical Results for a Novel, Broadly Cross-Protective H5N1 Pandemic Influenza Virus-like Particle (VLP) Vaccine Candidate

...ng Kong through a collaboration with Novavax, Inc. showed 100% survival of mice immunized with this broadly protective H5N1 VLP vaccine candidate. The H5N...y, two injections of the VLP vaccine candidate resulted in 100% survival of mice that were challenged with lethal doses of three different H5N1 strains incl...

Inverseon's Founder and SAB Member Published in PNAS

...University of Maryland School of Medicine . "This work using knockout mice confirms prior results from Bond and collaborators using inverse agonists, a subset of beta blockers, in mice and patients (Callaerts-Vegh PNAS 2004; Nguyen AJRCMB 2008; Hanania 2008) t...
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