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PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

...x is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in hoofed mammals and can also infect humans. Symptoms of disease vary depending on how the disease is contracted, but usually occur within seven days after exposure. The serious forms of ...

Corgenix, Tulane Announce Award of NIH Grant Extending Hemorrhagic Fever Virus Product Development Program

...ng upon their treatment and ultimately prevention." Lassa fever, a serious viral disease spread by contact with infected rodents, is estimated to infect 300,000 to 500,000 people per year across West Africa, with approximately 5,000 deaths. In some areas of Sierra Leone and Liberia, up to 16 percent of...

Clinical Update - Debio 025 in Hepatitis C

...ow accounts for 75% of all cases of liver disease around the world. HCV is considered by the World Health Organization as an epidemic. Because HCV can infect a patient for decades before being discovered, it is often called the "silent" epidemic. Studies suggest that in the US alone, nearly 4 million people...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

...x is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in hoofed mammals and can also infect humans. Symptoms of disease vary depending on how the disease is contracted, but usually occur within seven days after exposure. The serious forms of ...

Clinical Update - Debio 025 in Hepatitis C

...ow accounts for 75% of all cases of liver disease around the world. HCV is considered by the World Health Organization as an epidemic. Because HCV can infect a patient for decades before being discovered, it is often called the "silent" epidemic. Studies suggest that in the US alone, nearly 4 million people...

Jennerex Treats First Patients in Phase 2 JX-594 Trial for Liver Cancer

...X-594 multiplies selectively within cancer cells, leading to their destruction. These newly created copies of JX-594 are then released and are able to infect and eradicate other tumor cells both locally and in distant sites in the body. This cycle of JX-594 replication, cancer cell destruction, release and ...

Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay

...eir blood sample) and then uses it to make HIV particles containing the patient's virus envelope protein. The resultant HIV particles are then used to infect cells that contain the CCR5 co-receptor or the CXCR4 co-receptor on the cell surface. Once the virus infects the cell, it undergoes a single round of ...

Jennerex Completes the Treatment of First Patient Cohort in Phase 1 Trial With Intravenous Delivery of JX-594 Oncolytic Virus

...X-594 multiplies selectively within cancer cells, leading to their destruction. These newly created copies of JX-594 are then released and are able to infect and eradicate other tumor cells both locally and in distant sites in the body. This cycle of JX-594 replication, cancer cell destruction, release and ...

Copper Eliminates Resistant Hospital Germs in a Worldwide Field Test

... HAMBURG, Germany, August 22 /PRNewswire/ -- - Dangerous Bacteria infect Three Million People in Europe Every Year Sometimes something well-tried can also be innovative: already in Ancient Greece, copper was considered to...

Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus

...X-594 multiplies selectively within cancer cells, leading to their destruction. These newly created copies of JX-594 are then released and are able to infect and eradicate other tumor cells both locally and in distant sites in the body. This cycle of JX-594 replication, cancer cell destruction, release and ...

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells

...the DNA sequence encoding CCR5, a co-receptor that enables HIV to enter and infect cells of the immune system. Individuals carrying a naturally occurring muta...n permanent modification of the CCR5 protein such that HIV cannot enter and infect the cells. This approach could potentially enable the generation of a reser...

Kansas Invests Millions in Innovations to Improve Human Health and Launches Three National Bioscience Programs at BIO'08

...ide to create products that protect Americans from animal-borne diseases that could harm the food supply, disrupt the national agriculture economy, or infect humans. The Biosecurity Research Institute Training and Education Program at Kansas State University is going national with specialized training pro...

Promise of Vical's CMV Vaccine Noted by Independent Experts

...Pollard RB. A Cytomegalovirus Vaccine for Transplantation: Are We Closer? J infect Dis 2008; ( http://www.journals.uchicago.edu/toc/jid/current ) 197:1631-3. ...city of a Bivalent Cytomegalovirus DNA Vaccine in Healthy Adult Subjects. J infect Dis 2008; ( http://www.journals.uchicago.edu/toc/jid/current ) 197:1634-42....

Jennerex Publishes Promising Results from Cancer Clinical Trial of JX-594 in Lancet Oncology

...X-594 multiplies selectively within cancer cells, leading to their destruction. These newly created copies of JX-594 are then released and are able to infect and eradicate other tumor cells both locally and in distant sites in the body. This cycle of JX-594 replication, cancer cell destruction, release and ...

CERVARIX(R) Shown to Provide Longest Duration of Sustained Neutralizing Antibodies to Date

..., 2008 Tampa Convention Center. (13) Gravitt PE, Jamshidi R. Diagnosis and management of oncogenic cervical human papillomavirus infection. infect Dis Clin North Am, 2005; 19:439-458 (14) Munoz N, Bosch FX, de Sanjose S,et al. Epidemiologic classification of human papillomavirus types ...

Clinical Update - Debio 025 in Hepatitis C

... About HCV HCV is the most prevalent liver disease in the world and is considered by the World Health Organization as an epidemic. Because HCV can infect a patient for decades before being discovered, it is often called the "silent" epidemic. Studies suggest that over 200 million people worldwide are in...

MacroChem Announces Presentation of Pexiganan Phase 3 Study Results for Topical Treatment of Diabetic Foot Infection

...es. It has antimicrobial activity against Gram positive (methicillin resistant staphylococcus aureus (MRSA)) and Gram negative organisms that commonly infect skin and soft tissue. It has a low potential for induction of resistance and no cross-resistance with existing therapeutic antibiotics as a consequenc...

GSK Cervical Cancer Candidate Vaccine CERVARIX (R) Demonstrates Long-Term Protection for More Than Six Years

...CR Medical Meeting. April 17, 2007 (9) Gravitt PE, Jamshidi R. Diagnosis and management of oncogenic cervical human papillomavirus infection. infect Dis Clin North Am, 2005; 19:439-458 (10) Munoz N, Bosch FX, de Sanjose S,et al. Epidemiologic classification of human papillomavirus typ...

DHHS Guidelines Support Use of Trofile(TM) Assay Prior to CCR5 Inhibitor Use

...eir blood sample) and then uses it to make HIV particles containing the patient's virus envelope protein. The resultant HIV particles are then used to infect cells that contain the CCR5 co-receptor or the CXCR4 co- receptor on the cell surface. Once the virus infects the cell, it undergoes a single round of...

MacroChem Acquires Rights to Pexiganan, a Novel Topical Anti-Infective for Treatment of Diabetic Foot Infections, From Genaera

...es. It has antimicrobial activity against Gram positive (methycillin resistant staphylococcus aureus (MRSA)) and Gram negative organisms that commonly infect skin and soft tissue. It has a low potential for induction of resistance and no cross-resistance with existing therapeutic antibiotics as a consequenc...

Monogram Provides Update on Trofile(TM) Co-Receptor Tropism Assay

...IV use the CCR5 co-receptor, the CXCR4 co-receptor or both co- receptors to infect healthy cells. This helps clinicians determine whether a CCR5 antagonist li...ic to that individual patient. The resultant HIV particles are then used to infect CCR5- and CXCR4- expressing cell lines. Once the virus infects the cell and...

Medicare Contractor Establishes Reimbursement Coding Guidance for Monogram's Trofile Assay

...patient's HIV genome (from their blood sample) to make HIV particles specific to that individual patient. The resultant HIV particles are then used to infect CCR5- and CXCR4- expressing cell lines. Once the virus infects the cell and undergoes its single round of replication, a reporter gene expresses its i...

Viral Enzyme Recruited in Fight Against Ear Infection

...enza virus infection paves the way. The investigators based their treatment on the ability of viruses called phages to break out of bacteria they infect by using a special enzyme to destroy the cell walls. The success of the new treatment, which uses a phage enzyme called lysin to kill S. pneumonia, ...

New Study Confirms Role for Pertussis Immunization of Entire Family in Reducing Infant Pertussis

... A. Transmission of Bordetella pertussis to young infants. Pediatr infect Dis J. April 2007. (2) Vitek CR, Pascual FB, Baughman AL, Murphy TV. ...is among young infants in the United States in the 1990's. Pediatr infect Dis J. 2003;22:628-34. (3) CDC. Outbreaks of Pertussis Associated wit...

Ace Biosciences, Ace393, the World's First Commercial Vaccine for Travellers' Diarrhoea Caused by Campylobacter Successfully Completes Phase I Clinical Trials

...s unique expertise in the extraction and analysis of the cell surface proteins used by pathogens (eg bacteria, viruses and fungi) to interact with and infect human host cells. ACE BioSciences aims to develop a portfolio of products independently and in collaboration with other companies. In addition to ACE3...

Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection

...x is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in hoofed mammals and can also infect humans. Symptoms of disease vary depending on how the disease was contracted, but usually occur within seven days after exposure. The serious forms of...

Anthrax Monoclonal Antibody Valortim(tm) Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection

...x is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Anthrax most commonly occurs in hoofed mammals and can also infect humans. Symptoms of disease vary depending on how the disease was contracted, but usually occur within seven days after exposure. The serious forms of...

Data on Telavancin and Micafungin Hold Promise of New Therapeutic Options in Fight Against Serious Infectious Disease

...(4) Kirkland KB et al. The impact of surgical-site infections in the 1990's: attributable mortality, excess length of hospitalization and extra costs. infect Contr Hosp Epidemiol,1999,20:725-730. (5) Wakefield DS et al. Cost of nosocomial infection: relative contributions of laboratory, antibiotic, and pe...

Clinical Update - Debio 025 Cyclophilin Inhibitor for the Treatment of HCV

... About HCV HCV is the most prevalent liver disease in the world and is considered by the World Health Organization as an epidemic. Because HCV can infect a patient for decades before being discovered, it is often called the "silent" epidemic. Studies suggest that over 200 million people worldwide are in...

AVI BioPharma Reports Positive Pre-Clinical Influenza Data

...e associated with widespread human disease (H1N1, H2N2 and H3N2). In addition, several subtypes of avian influenza virus -- H5N1, H7N7 and H9N2 -- can infect and cause disease in humans. The current influenza pandemic in birds throughout Asia, Eastern Europe and Turkey is caused by the H5N1 subtype. It is...
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