gene in Medical Technology

Diabetes Gene Raises Odds of Lower Birth Weight

PHILADELPHIA, July 29 /PRNewswire-USNewswire/ -- Pediatric researchers have found that a gene previously shown to be involved in the development of type 2 diabetes also predisposes children to having a lower birth weight. The finding sheds light on a possible genetic influence on ...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

EMERYVILLE, Calif., July 17 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) announced today that a study of the gene regulation in multiple cell lines by several of their estrogen receptor beta (ERb) candidates will be published in Public Library of Science One. ...

More Gene Mutations Linked to Autism Risk

--Combination of Inherited and New Genetic Mutations Acting Together-- PHILADELPHIA, June 26 /PRNewswire-USNewswire/ -- More pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from The Children's Hospital of Philadelphia...

Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women

- Largest Genomic Study Comparing Gene Expression in Female and Male Patients Presented at ASCO Annual Meeting - ORLANDO, Fla., May 29 /PRNewswire-FirstCall/ -- Genomic Health, Inc. (Nasdaq: GHDX ) today announced results from a study which summarized the gene signatures identified by the O...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

Phase 1 Data Demonstrate Safety and Evidence of Biological Activity in 9 of 12 Patients; Phase 2 Study Currently Enrolling in 17 Leading U.S. Medical Centers SAN DIEGO, May 28 /PRNewswire/ -- Celladon Corporation presented today Phase 1 data from the Calcium Up-Regulation by Percutaneou...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

-Knowledge May Improve Diagnosis for Children with Cornelia deLange Syndrome- PHILADELPHIA, May 27 /PRNewswire-USNewswire/ -- An international team of scientists studying a rare genetic disease discovered that a bundle of proteins with the long-established function of keeping chromo...

Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy

Phase 1/2 Calcium Upregulation by Percutaneous Administration (CUPID) Data Highlight Safety Profile and Biological Effects of SERCA2a Enzyme Replacement SAN DIEGO, May 26 /PRNewswire/ -- Celladon Corporation today announced that results from its genetically targeted enzyme replacement therapy...

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

DENVER, April 19 /PRNewswire/ -- The search for the cause of an inherited form of a rare, aggressive childhood lung cancer has uncovered important information about how the cancer develops and potentially sheds light on the development of other cancers. The finding by researchers at Washing...

Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis

WALTHAM, Mass., April 1 /PRNewswire-FirstCall/ -- Interleukin Genetics, Inc. (NYSE Amex: ILI ), announced today that the company will present research findings from a large clinical study on the genetics of osteoporosis and vertebral fractures at the 8th International Symposium on Osteoporosis...

British Midlands University Announces Use of Gene Technology to Fight Lethal Hospital Acquired Infection

University of Nottingham Scientists Leading Major Study into Lethal 'Super' Strains of C.difficile CHICAGO, Jan. 28 /PRNewswire/ -- The British Midlands Development Corporation today announced that scientists at The University of Nottingham are leading a major European study to unravel the ...

St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment

Scan of thousands of inherited genetic changes reveal specific variations linked to treatment failure and the fate of chemotherapy drugs in the body for children with acute lymphoblastic leukemia MEMPHIS, Tenn., Jan. 27 /PRNewswire-USNewswire/ -- Scientists from St. Jude Children's Research H...

Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity

St. Jude study shows the Prox1 gene is a two-way switch that, if turned off, causes lymphatic endothelial cells to be reprogrammed so that they lose their identity and become more like blood endothelial cells MEMPHIS, Tenn., Dec. 1 /PRNewswire-USNewswire/ -- Scientists at St. Jude Childr...

AMT Obtains License to Amgen's GDNF Gene to Develop Treatment for Parkinson's Disease with AMT's Proprietary Gene Therapy Platform

AMSTERDAM, The Netherlands, September 18 /PRNewswire-FirstCall/ -- Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, today announced that it obtained a license from Amgen to use their GDNF gene for the development of a gene therapy treatment for Par...

More Findings on Gene Involved in Childhood Asthma

PHILADELPHIA, Sept. 15 /PRNewswire-USNewswire/ -- Asthma researchers have found that a gene variant known to raise the risk of childhood asthma in European children plays a similar role in white American children, but not in African American children. The most common chronic illness among ch...

Encouraging Gene Therapy Results in Genetic Form of Blindness

NEW ROCHELLE, N.Y., Sept. 8 /PRNewswire/ -- All three patients who received intraocular adeno-associated virus-based gene therapy to treat Leber congenital amaurosis (LCA), an incurable genetic disorder that results in blindness, had improved vision, according to a paper published online ahead...

Genomic Health Announces Data Supporting Use of Oncotype DX(R) to Accurately Assess HER2 Gene Expression in Breast Cancer Patients

- Results Demonstrating 95 Percent or Greater Concordance Compared to FISH and IHC Presented at 2008 ASCO Breast - - Company to Include Reporting for HER2 Gene Expression in All Oncotype DX Reports by End of 2008 - REDWOOD CITY, Calif., Sept. 6 /PRNewswire...

Previous Claims of siRNA Therapeutic Effects Called into Question by Report in 'Human Gene Therapy'

NEW ROCHELLE, N.Y., Sept. 2 /PRNewswire/ -- The many recent reports documenting the therapeutic efficacy of short interfering RNAs (siRNAs) in animal models of human disease may actually be describing non-specific therapeutic effects related to the ability of siRNA to activate an immune respon...

Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies

Nutriceutical Shown To Affect 9-Fold More Longevity Genes Than Resveratrol Or A Limited-Calorie Diet Alone - Independent Laboratory Animal Study SAN DIMAS, Calif., July 30 /PRNewswire/ -- Researchers report that a proprietary nutriceutical matrix (Longevinex(R...

Pediatric Researchers Find Possible 'Master Switch' Gene in Juvenile Arthritis

PHILADELPHIA, July 1 /PRNewswire-USNewswire/ -- Researchers have found that a gene region known to play a role in some varieties of adult rheumatoid arthritis is also present in all types of childhood arthritis. The researchers say the responsible gene may be a "master switch" that helps turn ...

Avastin(R) Shows Unprecedented Benefits in Colorectal Cancer Patients, Irrespective of K-Ras Gene Mutation

- For Non-US Media Only - Avastin is the Only Biologic Proven to Extend Life in Patients With Normal K-Ras Gene BASEL, Switzerland, June 26 /PRNewswire/ -- Data presented today at the 10th World Congress on Gastrointestinal Cancer (WCGC) in ...

Pilot Therapeutics Announces Relaunch as Gene Smart(TM) Health

WINSTON-SALEM, N.C., June 18 /PRNewswire/ -- Pilot Therapeutics Holdings, Inc. today announced the relaunch of Pilot Therapeutics as Gene Smart(TM) Health. (Logo: http://www.newscom.com/cgi-bin/prnh/20080618/CLW006LOGO ) As an innovator in gene-based nutrition, Gene Smart(TM) Health uniq...

Orion Genomics Gains Exclusive Worldwide Rights to the IGF2 Gene for Colorectal Cancer Risk Testing Through Licensing Agreement With Johns Hopkins University

ST. LOUIS, June 11 /PRNewswire/ -- Orion Genomics announced today that the company entered into a worldwide exclusive license agreement with The Johns Hopkins University (JHU) to commercialize products that identify patients at risk for colorectal cancer. The license is based on a suite of iss...

Phase I/II Study of Targeted Gene Delivery In Vivo - Intravenous Infusions of REXIN-G - Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Patients With Progressive Chemo-Resistant Bone and Soft Tissue Sarcoma (ASCO 2008)

SAN MARINO, Calif., May 29 /PRNewswire/ -- Epeius Biotechnologies ( http://www.epeiusbiotech.com ) announced today the results of an on-going Phase I/II study of Rexin-G for metastatic bone and soft tissue sarcoma (J Clin Oncol 26: 14509, 2008). Rexin-G is the first and so far only targeted ge...

TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)

SAN MARINO, Calif., May 27 /PRNewswire/ -- Epeius Biotechnologies ( http://www.epeiusbiotech.com ) announced today that the results of a Phase I Feasibility Study of sequential targeted gene delivery -- using Rexin-G followed by Reximmune-C -- for cancer vaccination will be presented at the AS...

TARGETED GENE DELIVERY IN VIVO: Rexin-G Monotherapy Reveals Significant Biological Activity Without Toxicity in Chemo-Resistant Metastatic Breast Cancer (ASCO 2008)

SAN MARINO, Calif., May 22 /PRNewswire/ -- Epeius Biotechnologies announced today the promising results of an on-going United States-based Phase I/II study of Rexin-G for metastatic breast cancer that is refractory to conventional chemotherapy (J Clin Oncol 26:14509, 2008). This clinical trial...

New Gene Methylation Test for Prostate Cancer Available

RARITAN, N.J., May 16 /PRNewswire/ -- Veridex, LLC announced today that its licensing collaborator, Laboratory Corporation of America Holdings (LabCorp), has commercially launched a new gene methylation test for prostate cancer. The new assay uses the biological specificity of 'DNA methylation...

St. Jude Gene Study Reveals Basis of Anti-Cancer Drug Resistance in Childhood Leukemia

The findings provide new insights into genomic basis of methotrexate resistance and differences in methotrexate response MEMPHIS, Tenn., April 15 /PRNewswire-USNewswire/ -- The first analysis of the genetic determinants of resistance to the anti-cancer drug methotrexate in childhood acute ...

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

PHILADELPHIA, April 15 /PRNewswire-USNewswire/ -- Before gene therapy becomes practical for treating human diseases, researchers must master the details of safe and effective delivery. Cardiology researchers at The Children's Hospital of Philadelphia have advanced delivery techniques by cre...

New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit

Cancer drug development guided by genomics SAN DIEGO, April 14 /PRNewswire-FirstCall/ -- Systems Medicine LLC (SM), a wholly-owned subsidiary of Cell Therapeutics, Inc. (CTI) (Nasdaq and MTAX: CTIC), presented data from a preclinical study identifying the genetic markers in pati...

Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine

SAN MARINO, Calif., Dec. 18 /PRNewswire/ -- Epeius Biotechnologies Corporation announced today their appreciation of the accomplishments of their contemporaries in 2007, a truly remarkable year in terms of biomedical research, scholarship, and gonzo journalism. It was a year in which a definit...

PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients

MANHASSET, N.Y., Nov. 19 /PRNewswire-USNewswire/ -- Brain scans used to track changes in a dozen patients who received an experimental gene therapy show that the treatment normalizes brain function -- and the effects are still present a year later. Andrew Feigin, MD, and David Eidelberg, MD,...

BiPar Genomic Biomarker Data Demonstrate Overexpression of PARP-1 Gene in Multiple Cancer Types

SAN FRANCISCO, Oct. 25 /PRNewswire/ -- BiPar Sciences, Inc., a privately held biopharmaceutical company developing novel cancer therapies, today announced molecular biomarker data demonstrating the overexpression of the PARP (poly-ADP-ribose polymerase) protein in multiple cancers, including o...

One Shot of Gene Therapy Spreads Through Brain in Animal Study

- Method Has Potential for Correcting Devastating Genetic Diseases - PHILADELPHIA, Oct. 8 /PRNewswire-USNewswire/ -- By targeting a site in a mouse brain well connected to other areas, researchers successfully delivered a beneficial gene to the entire brain -- after one injection of gene the...

ALS TDI Completes Gene Expression Profile of Lou Gehrig's Disease in Mice

Largest Target-Discovery Program Aimed at New Treatments for Fatal Disease CAMBRIDGE, Mass., Oct. 2 /PRNewswire/ -- The ALS Therapy Development Institute (ALS TDI) today announced that it has completed the first phase of a comprehensive gene-expression database for ALS with the profiling of the...

New Risk Gene for Rheumatoid Arthritis and Lupus Opens Door to More Effective Treatments

MANHASSET, N.Y., Sept. 6 /PRNewswire-USNewswire/ -- Scientists at The Feinstein Institute for Medical Research have identified a critical gene that increases a person's risk for rheumatoid arthritis and systemic lupus erythematosus, and may be involved with other autoimmune diseases. The gene...

Diamyd Updates Gene Therapy Program and Outlines Plans for Phase I Clinical Trial for Treatment of Cancer Pain

Pre-IND Meeting Scheduled For August 29, 2007 STOCKHOLM, Sweden, and PITTSBURGH, Aug. 27 /PRNewswire-FirstCall/ -- Diamyd Medical AB (http://www.omxgroup.com, ticker: DIAM B; http://www.otcqx.com, ticker DMYDY)Diamyd Medical announced today that NP2, the company's first drug c...

Gene Hunters Fine-Tune Marker for Common Obesity Gene

- In Children's DNA, a Hint of a Mutation's Ancestral African Origin - PHILADELPHIA, March 12 /PRNewswire-USNewswire/ -- Genomics researchers, seeking to replicate another group's discovery of an important gene associated with obesity, have further refined the signal to a particular varian...

Major Gene Study Uncovers Secrets of Leukemia

St. Jude Study Scans 350,000 Locations Across the Genome From 242 Patients and Identifies New Mutations That Contribute to Acute Lymphoblastic Leukemia, Suggesting New Targets for Improved Therapy MEMPHIS, Tenn., March 07, 2007 /PRNewswire/ -- Investigators at St. Jude Children's Research Hospital...

ACC Presentation Indicates Interleukin-1 Gene Variants Determine Increased Risk for Coronary Artery Disease from Oxidized Phospholipids

WALTHAM, Mass.--(BUSINESS WIRE)--Mar 27, 2007 - Interleukin Genetics, Inc. (AMEX:ILI) and collaborators at the University of California San Diego today reported at the American College of Cardiology annual meeting that associations between coronary artery disease (CAD) and both oxidized phospholipi...

Researchers Discover a Common Variation in a Gene Segment that Increases the Risk for Prostate Cancer

BETHESDA, Md., April 1, 2007--Researchers report that a variation in a portion of DNA strongly predicts prostate cancer risk and that this common variation may be responsible for up to 20 percent of prostate cancer cases in white men in the United States. The research was conducted by investigator...