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Perceptive Informatics Survey Results Reveal Top Barriers to Implementing Adaptive Trial Designs

BOSTON, May 4 /PRNewswire-FirstCall/ -- Perceptive Informatics, the industry's leading eClinical solutions provider and a subsidiary of PAREXEL International Corporation (Nasdaq: PRXL ), today announced the results of a survey conducted during its recent webinar entitled "Optimizing Adaptive Tri...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

- Tasigna front-line data demonstrating potential in newly diagnosed patients with a life-threatening type of leukemia to be featured in two oral sessions at ASH - Exjade results at ASH to show benefits for chronically transfused patients by significantly reducing toxic iron that can dama...

Scientists Reveal Roadmap to Brain Health That Can Be Passed Down to Future Generations: Exercise, Omega-3, Folic Acid, Vitamin B6, and Vitamin B12

GORDONSVILLE, Va., July 28 /PRNewswire/ -- New findings from a comprehensive analysis of more than 160 clinical studies have revealed the importance of routine exercise and a balanced diet on brain health that can be passed down through future generations. According to a recent press release*,...

VAP Cholesterol Test Helps Reveal Association Between Adiponectin Levels and Atherosclerosis

Detailed lipid profile helps clinicians identify risk in patients, including non-diabetics, despite normal LDL levels and statin therapy BIRMINGHAM, Ala., July 21 /PRNewswire/ -- Using the VAP Cholesterol Test from Atherotech, researchers have identified a link between adiponectin and he...

Studies of an Innovative Catheter Ablation System for Atrial Fibrillation Reveal Excellent Outcomes, Safety Profile and Fast Procedure Times

Presentations at Cardiostim World Congress Focus Attention on a New Ablation Technology CARLSBAD, Calif., June 24 /PRNewswire/ -- Ablation Frontiers, Inc. today announced that two studies reporting positive findings about its novel atrial fibrillation catheter ablati...

Cytel's Clinical Innovation Experts Cyrus Mehta and Judith Quinlan Reveal Latest Adaptive Trial Successes at 44th Annual DIA Meeting

Trial design and implementation pioneers from Cytel join peers in examining the rise of adaptive study approaches and overcoming the remaining challenges to wider adoption CAMBRIDGE, Mass., June 23 /PRNewswire/ -- Cytel's renowned adaptive trial design and implementation e...

PAREXEL Data Reveal A Record High Number of Clinical Trials Initiated

BOSTON, June 23 /PRNewswire-FirstCall/ -- According to new data from PAREXEL International Corporation (Nasdaq: PRXL ), a leading global biopharmaceutical services organization, the number of new industry-sponsored clinical trial initiations, or starts, surged another 12 percent to a record h...

Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat

QUEBEC CITY, Canada, April 29 /PRNewswire/ -- At a late breaking presentation made on April 29th during the Annual meeting of the European Atherosclerosis Society held in Istanbul, the investigators of ADAGIO-LIPIDS presented the key findings of a one year trial aiming at further studying the ...

Study Results Reveal alli(R) Patient Satisfaction Linked to Weight Loss Achieved; Not Treatment Effects

NEW ORLEANS and PITTSBURGH, Oct. 22 /PRNewswire-FirstCall/ -- Data presented at the 2007 Annual Scientific Meeting of NAASO, The Obesity Society, found that patient satisfaction with alli(R) (orlistat 60mg), the only FDA- approved, over-the-counter (OTC) weight loss product, was connected to t...

New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes

Lowest Dose of Estradiol Shown to Be Safe and Effective for Menopausal Women WEST PALM BEACH, Fla., Oct. 3 /PRNewswire/ -- A study presented today at the 2007 Annual Meeting of the North American Menopause Society (NAMS) revealed that Divigel(R) (estradiol gel)...

Neurocrine Biosciences Announces New Research Studies Presented at APSS Reveal Significant Under-Diagnosis of Insomnia

Data Highlights the Impact of Insomnia on Healthcare System and Worker Productivity SAN DIEGO, June 12, 2007 /PRNewswire-FirstCall/ -- Neurocrine Biosciences, Inc. announced today that results from several research studies on the impact of chronic primary and transient insomnia were presented this...

Urologist and Allergist Explore Link Between Allergies and Interstitial Cystitis

...nt, it's well worth the effort. It's one of the most rewarding patient care experiences I have ever had." Diet and IC Future research will reveal more about the role of food allergy in IC patients' symptoms. Meanwhile, whether patients have "true" allergies or sensitivity to foods, the treatment...

Neurocrine Biosciences Presents Elagolix Data

...ate tissue. The animal model provided detailed information on changes in prostate size, weight, hormone levels and cell immunohistochemistry. The data reveal that transient inhibition of plasma testosterone and intra-prostatic androgens results in the reduction of prostate weight, a reduction in epithelial ...

Researchers Present Safety and Efficacy Results of 429 Patients Treated With Radiofrequency Ablation for Pre-Cancerous Barrett's Esophagus

...rtiary academic centers SUNNYVALE, Calif., June 1 /PRNewswire/ -- Clinical trial results presented at the Digestive Disease Week in Chicago today reveal that endoscopic radiofrequency ablation performed in a community practice setting is safe and effective for eradicating a pre-cancerous esophageal con...

Catalyst Pharmaceutical Partners Announces Top-Line Results of CPP-109 Phase II Trial for Cocaine Addiction

...bjects than placebo-treated subjects were cocaine-free during the last two weeks of the treatment period (Weeks 11 and 12). The clinical trial did not reveal any unexpected "serious" adverse events. Complete analyses of the clinical trial data (secondary clinical end-points and safety data) are ongoing...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...ta show that at eight weeks of treatment, Afinitor(R) stabilized or reduced tumor size in 61% of patients with advanced liver cancer - New data reveal postmenopausal women with breast cancer taking Femara(R) experience better cognitive function than those taking tamoxifen - Phase II data show ...

Study in the New England Journal of Medicine Shows Non-Surgical Treatment for Pre-Cancerous Condition of Esophagus is Effective and Reduces Risk for Cancer Development

...controlled trial SUNNYVALE, Calif., May 27 /PRNewswire/ -- Results from a clinical study published today in the New England Journal of Medicine reveal that ablative therapy using the HALO system (BARRX Medical, Inc.) is highly effective for complete eradication of a pre-cancerous condition of the eso...

Taking a Hard-Line Approach to Cardiovascular Risks in the Diabetes Patient

...y 18 /PRNewswire-USNewswire/ -- When treating the diabetes patient, doctors discussed how a "one size fits all" approach to testing is not enough to reveal an individual's risk for cardiovascular disease Saturday at the American Association of Clinical Endocrinologists (AACE) 18th Annual Meeting & Cli...

Methadone Frequently Causes Menopausal Symptoms in Young Women

...morphine and other opiate pain medications, seldom test or treat patients for hormonal deficiencies caused by these medications. Although studies reveal methadone and other opiate pain medications do not benefit fibromyalgia patients, physicians frequently prescribe opiate pain medications to fibromyal...

Men Treated for Localized Prostate Cancer Could Benefit From Pomegranate Juice Consumption

...f prostate cancer after unsuccessful treatment," said Christopher Amling, MD, an AUA spokesman. "This finding and other ongoing research might one day reveal that pomegranate juice is an effective prostate cancer preventative agent as well." Parts of this ongoing study suggest that some patients may be...

New, Published GELNIQUE Data Show Efficacy, Convenience and Excellent Tolerability

...orally administered oxybutynin. This unique dosing results in a low level of side effects, such as dry mouth and constipation. "The study data reveal that this innovative gel formulation provides the highly desired combination of efficacy and tolerability when utilized to treat symptoms of overactiv...

DaVita Abstracts Highlight Latest Research Developments at Annual Dialysis Conference

... Abstracts reveal Ground-breaking Information on Kidney Education and Modality Treatments EL SEGUNDO, Calif., March 10 /PRNewswire-FirstCall/ -- DaVita Inc., a l...

Scientists Discover Why Teeth Form in a Single Row

...the activation of a complete tooth developmental program outside of the normal tooth row in those mice. Finding out how the extra teeth developed will reveal how nature makes a tooth from scratch, which will guide tooth regeneration research." Why Extra Teeth Formed When we lose our baby teeth, t...

Applying Clinical Findings to the Practice of Medicine

...re suffered by millions of people. The molecular mechanisms of both conditions have not been identified, although this promising research attempts to reveal the molecular mechanism. The potential of this research may have the power to stop these bone and cartilage conditions before beginning. Ske...

Aching Back? Cholesterol Medication Might Help

...elated study, "Influences of Age-Related Degeneration on Regenerative Potential of Human Nucleus Pulposus Cells," at the same meeting. The two studies reveal the findings of a team of researchers from National Taiwan University Hospital. In one study, the researchers removed nucleus pulposus tissues f...

Heavy Marijuana Use May Damage Developing Brain in Teens, Young Adults

...hat the study is preliminary and does not demonstrate that marijuana use causes the brain abnormalities. However, "Studies of normal brain development reveal critical areas of the brain that develop during late adolescence, and our study shows that heavy cannabis use is associated with damage in those brain...

St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment

... Scan of thousands of inherited genetic changes reveal specific variations linked to treatment failure and the fate of chemotherapy drugs in the body for children with acute lymphoblastic leukemia MEM...

Scientists Unmask Genetic Markers Associated With Psoriasis

... University of Michigan scientists reveal DNA 'hotspots' linked to psoriasis ANN ARBOR, Mich., Jan. 25 /PRNewsw...f Public Health and their collaborators have found DNA "hotspots" that may reveal how genetic differences among individuals result in psoriasis, an autoimmun...

Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting

...r in each treatment arm (50 percent versus 48 percent, respectively). Overall, the FCR combination showed a favorable risk-benefit profile and did not reveal any new or unexpected safety concerns. TET2 is a Novel Tumor Suppressor Gene Inact i vated in Myeloproliferative Neoplasms: Identif...

Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows

... Results reveal most respondents against expanding statin use broadly in wake of AHA-presented data LITTLE FALLS, N.J., Nov. 25 /PRNewswire/ -- JUPITER, a c...

New Insight Into the Controls on a Go-To Enzyme

... and traumatic brain injury. "Our basic findings on calpain regulation could add useful pieces to the puzzles of these disorders and perhaps reveal targets for drugs to treat them," said Douglas Green, Ph.D., chair of the St. Jude Department of Immunology. Calpains are triggered by calciu...

Parasites That Live Inside Cells Use Loophole to Thwart Immune System

...t mice genetically engineered to lack arginase only in their macrophages showed superior resistance to tuberculosis and toxoplasmosis. "Our findings reveal that these pathogens have evolved to exploit a biological loophole in the immune system," Murray said. "This discovery offers two important insights. ...

Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art of Aurora

...hesis whereby the anti-cancer activity exerted by the compound is mediated through inhibition of Aurora kinases. "Results obtained to date in humans reveal that PHA 739358 is a molecule with a good tolerability profile and promising hints of activity were seen," states Dr. Colotta. In Phase I trials, PHA ...

Prometheus Presents Findings From Development of PROMETHEUS(R) IBS Diagnostic, First Blood Test for IBS, at ACG Annual Scientific Meeting

...ent altered expression. The expression levels of these 16 biomarkers were then measured in a sample cohort of more than 1,700 patients and analyzed to reveal optimal IBS prediction with a final set of 10 biomarkers, including some that enable Prometheus' proprietary protection. These biomarkers are associat...

In Vivo Data on Taligen Therapeutics' Pipeline Candidates Presented at the XXII International Complement Workshop

...al animal models of complement-mediated diseases. "These highlighted presentations, as well as several in vitro studies presented at the conference, reveal the deep expertise and expanding knowledge base within the complement research community," said Michael Holers, M.D., chief scientific officer of Tali...

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

...in-RING changes when it wears the UBL accessory called NEDD8. The researcher's findings, published in the Sept. 19, 2008, issue of the journal Cell, reveal that NEDD8 changes the shape of cullin-RING to activate it to perform its function. The researchers found that when NEDD8 attaches, it transforms cull...

Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment

...a sub-analysis of Abbott's pivotal, 52-week study, reveal (The Randomized Controlled EValuation of Adalimuma...Waterloo, Ontario Canada. A separate analysis of reveal evaluated whether specific patient characteristics...soriasis and other therapeutic areas." About the reveal Trial The...

Southern Research Institute Wins $14.7 Million NIH Award to Participate in Molecular Libraries Probe Production Center Network

... improve health and therefore the quality of our lives." SRSBSC efforts should accelerate the discovery of targets for therapeutic intervention, and reveal biomarkers of infection that could be used for early diagnosis of viral infections. There are more than 300 human viruses that have no treatment, vacc...

Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)

...iabetic neuropathy have shown that the drug is well tolerated. Data from this clinical study and pre-clinical studies in animal models of nerve damage reveal positive effects of SB-509 on motor nerve function and muscle composition. Similar effects on motor nerves and muscles in these patients may slow the ...

Pooled-Analysis of 54 Clinical Studies Shows No Increased Risk of Heart Attack With Abacavir Therapy

... 1,000 people in the abacavir HAART and 1.4 per 1,000 people in the non-abacavir HAART. GSK's review of clinical and pre-clinical data to date did not reveal a plausible biologic mechanism for the results seen in the D:A:D study. Inflammatory biomarkers that may be associated with cardiac risk, hs-CRP and...
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