Nanoemulsion Kills Highly Resistant Bacteria Found in Patients With Cystic Fibrosis

ANN ARBOR, Mich., Jan. 29 /PRNewswire/ -- Scientists at NanoBio Corp. and the University of Michigan have demonstrated in the laboratory that their novel topical nanoemulsion kills the highly resistant strains of bacteria that cause chronic illness and death among individuals with cystic fib...

New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria

WASHINGTON, Oct. 27 /PRNewswire/ -- Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD), today announced new study results that demonstrate doripenem (DORIBAX(TM), doripenem for injection), a carbapenem antibiotic, was found to be more potent in vitro against certain strai...

Copper Eliminates Resistant Hospital Germs in a Worldwide Field Test

HAMBURG, Germany, August 22 /PRNewswire/ -- - Dangerous Bacteria Infect Three Million People in Europe Every Year Sometimes something well-tried can also be innovative: already in Ancient Greece, copper was considered to be very antimicrobial. This ability is now playing an important role ...

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells

Preclinical Animal Data Demonstrates Promising Therapeutic Strategy for HIV/AIDS RICHMOND, Calif., June 30 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO ) announced today the publication of data demonstrating that human immune system cells (C...

Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community- Associated Methicillin Resistant Staphylococcus Aureus (CA-MRSA)

CHICAGO, June 25 /PRNewswire-FirstCall/ -- Advanced Life Sciences Holdings, Inc. (Nasdaq: ADLS ), a biopharmaceutical company engaged in the discovery, development and commercialization of novel drugs in the therapeutic areas of infection, cancer and respiratory diseases, today announced that...

June 2008 Mayo Clinic Women's HealthSource Highlights Shingles Vaccine for Pain Prevention, Tips to Avoid Antibiotic Resistant Infections, and Benefits of Broad Genetic Testing

ROCHESTER, Minn., June 24 /PRNewswire-USNewswire/ -- Here are highlights from the June issue of Mayo Clinic Women's HealthSource. You may cite this publication as often as you wish. Mayo Clinic Women's HealthSource attribution is required. Reprinting is allowed for a fee. Include the following...

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

Findings suggest androgen production occurs within metastatic prostate tumors SEATTLE, June 2 /PRNewswire/ -- For the past 70 years the treatment of choice for advanced, metastatic prostate cancer has been androgen-deprivation therapy. That is, the suppression ...

Launch of Highly Targeted Cancer Treatment Tasigna(R) (nilotinib) Offers Potential Lifeline to Ph+ CML Patients Intolerant or Resistant to Existing Therapies, Including Glivec(R) (imatinib)

FRIMLEY, England, May 20 /PRNewswire-FirstCall/ -- - Tasigna(R) (nilotinib) Effective in 77% of Patients Resistant or Intolerant to Prior Treatment in the Chronic (Early) Phase of Chronic Myeloid Leukaemia (CML)(1) - Highly Targeted Nature of Tasigna(R) Tackles the Root Cause of CML Whilst...

Cepheid Launches New GeneXpert(R) Tests in Europe for Simultaneous, Rapid Detection of Staphylococcus Aureus and Methicillin Resistant Staphylococcus Aureus

Tests for Skin and Soft Tissue Infection and Blood Culture Extend European Product Line for Healthcare Acquired Infections SUNNYVALE, Calif., Dec. 4 /PRNewswire-FirstCall/ -- Cepheid (Nasdaq: CPHD) today announced the European release of Xpert(TM) MRSA/SA-Blood Cultures (BC) and Xper...

VA National Campaign Takes Aim at Resistant Staph Infections

VA Medical Facilities Leaders in Fight Against MRSA WASHINGTON, Oct. 18 /PRNewswire-USNewswire/ -- Building on the success of a pilot program that reduced a worrisome staph infection by 50 percent, the Department of Veterans Affairs (VA) has tough new screening requirements now in place in a...

Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria

CHICAGO, Sept. 19 /PRNewswire/ -- Targanta Therapeutics Corporation today released detailed data from completed studies comparing the in vitro activity of its lead antibiotic drug candidate, oritavancin, to that of other antibiotics against a variety of susceptible and resistant strains of gra...

MUSC Research Offers Hope for Those Resistant to Depression Treatment

CHARLESTON, S.C., March 23, 2007 /PRNewswire/ -- Researchers at the Medical University of South Carolina (MUSC) have announced the results of a two-year study, which tested the long-term antidepressant response to VNS (Vagus Nerve Stimulation) Therapy(TM) in patients with treatment-resistant depre...

New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines

Study Results Published in Cancer Research TARRYTOWN, N.Y., June 15, 2007 /PRNewswire-FirstCall/ -- EpiCept Corporation today announced the results of scientific studies that (1) demonstrate that Azixa(TM) (MPC-6827) is effective in treating multiple types of human tumors in animal models, (2) rev...

Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine

- Phase II Results Published in the Journal of Clinical Oncology - NEW YORK, July 06, 2007 /PRNewswire-FirstCall/ -- Results from a Phase II study - which will be published in the August 10, 2007 issue of the Journal of Clinical Oncology (JCO) and are now available as an Early Release Article at <...

Controlling the Spread of Healthcare Associated Methicillin Resistant Staphylococcus aureus Requires Active Surveillance

Both methicillin sensitive and methicillin resistant Staphylococcus aureus (MSSA, MRSA) can cause invasive and life-threatening infections such as osteomyelitis, septicemia, endocarditis, and pneumonia. Healthcare associated MRSA is of particular clinical importance because it is not only predict...

Why Do African-Americans Fare Worse With Cancer? Access and Economics Are Only Part of the Story

...ans and Surgeons . "There may be differences in genetic factors by race that alter the metabolism of chemotherapy drugs or that make cancers more resistant or more aggressive," she adds. Hershman published a smaller study last month that found that, at least with breast cancer, disparities in surviva...

Leading Experts Endorse Bioheart's Muscle Stem Cell MyoCell Therapy

... failure and specifically to scar tissue (not living tissue) has shown that the cells survive, engraft and form new muscle and they do excrete fatigue resistant proteins similar to the heart muscle protein." Dr. HJ Duckers, Interventional Cardiologist, Thoraxcenter, Rotterdam discussed the history of the Bioh...

McCaughey Urges Use of First NYS Hospital Infection Report

...oss 25 states for this disclosure. Dr. McCaughey says the New York State infection report needs to be improved to include rates for methicillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile (C. diff). More critically, the public should not be misled by risk adjustment infection, but ...

UNT Health Science Center's Groundbreaking Research Applied to Protecting Brain After Traumatic Injury

...rth. Estrogens are made in large amounts by young women, but only in small amounts by men. Prior studies have suggested that young women are more resistant to brain trauma injury than are older, post-menopausal women and men. This apparent resistance of young women to brain trauma may be because of their ...

Calixa Therapeutics Announces Initiation of Phase 2 Clinical Trial of Its Antibiotic, CXA-101, in Patients with Complicated Urinary Tract Infections

...y against Pseudomonas aeruginosa , including drug resistant isolates. Calixa is investigating CXA-101 as a po...ge, including potent activity against increasingly resistant gram-negative pathogens such as Pseudomonas aerug... serious and life-threatening infections caused by resistant gram-negative bacteria and the paucity of new drug...

Alfacell Provides Shareholder Update

...nted synergistic effect in Cisplatin sensitive and resistant NSCLC. We are not surprised by these results and b...tin or Onconase alone, and in the tumor model most resistant to platinum, Onconase addition to platinum increas...ll lung cancer (NSCLC) in patients who have become resistant to platinum therapy. Dr. David Sidransky (Alfacell...

Cancer Treatment Centers of America(R) Studies Treatment That Aims Chemotherapy Directly at Ovarian Cancer Cells

... Therapy targets folate receptors found on cancer cells otherwise resistant to standard chemo ZION, Ill., June 17 /PRNewswire-USNewswire/ -- Can...rch involving a treatment designed to target ovarian cancer cells otherwise resistant to standard chemotherapy. (Logo: http://www.newscom.com/cgi-bin/pr...

Great Basin Scientific, Inc. Raises $3.6 Million in Bridge Funding to Prepare for Launch of First Product

...-clinical Study Completed As part of the preparation for an August clinical trial for its first test- a 50 minute diagnostic test for Methicillin resistant Staphylococcus aureus (MRSA) from a positive blood culture, Great Basin Scientific is leading several pre-clinical studies. The company conducted a su...

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

...clinically important, gram-positive, drug-resistant strains including those resistant to linezolid Activity against clinically important atypical and gra...y against drug-resistant, gram-positive bacterial pathogens including those resistant to linezolid, the only currently marketed antibacterial drug of the oxazoli...

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

... effects and non-compliance (3) lack of efficacy when administered late in the anthrax disease cycle, and (4) lack of effectiveness against multi-drug resistant or genetically engineered strains of anthrax. About PharmAthene, Inc. PharmAthene was formed to meet the critical needs of the United States ...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

... all kidney tumors, 85% are classified as renal cell carcinoma (RCC) and of all patients with RCC, 25% present with advanced disease. Advanced RCC is resistant to such standard treatments as radiation therapy and chemotherapy, and the initial treatment for most patients is surgical removal of the kidney. If t...

FDA Advisory Panel Makes Favorable Recommendation for GlaxoSmithKline and Genmab's ARZERRA(TM) (ofatumumab)

...d following prior treatments, typically experience poorer clinical outcomes such as infections and death. Less than 25 percent of CLL patients who are resistant to current treatments respond to available therapies. "The positive vote by ODAC confirms that ofatumumab may offer a new treatment option for pa...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...accounts for 41,000 deaths worldwide each year(7)(8). While melanoma is curable when diagnosed and treated in early stages, advanced melanoma is often resistant to currently available treatments(9). New data from a Phase II study (abstract #9001) show the potential of Gleevec(R)(#) (imatinib mesylate) in ...

Stand Up To Cancer Awards $73.6 Million for Novel, Groundbreaking Cancer Research

... growing understanding of epigenetics to design targeted anticancer agents; and to explore new approaches to treating breast cancers, especially those resistant to current therapies. This unique translational research model focuses on the disease, drug targets and clinical development, combining research and ...

Ascenta Therapeutics Announces Multiple Presentations on AT-101 at 2009 ASCO Annual Meeting

...1 in combination with docetaxel (D) and prednisone (P) in men with castrate resistant prostate cancer (CRPC). Abstract #5062; Poster Board #17; Poster Discussio...(Bcl-2, Bcl-xL, and Mcl-1) currently in Phase 2 clinical trials in castrate resistant prostate cancer. The Company's preclinical pipeline includes the oral mult...

First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology

...developing new biological solutions to increase production and/or recovery rates of subsurface hydrocarbons and developing high-yielding, more disease resistant and economic feedstocks. For more information go to www.syntheticgenomics.com About Asiatic Development Berhad/ACGT Asiatic Developme...

Novexel to Present Four Posters at the 19th European Congress of Clinical Microbiology and Infectious Diseases in Helsinki

...s provides in vitro data showing that NXL103 was active against methicillin resistant Staphylococcus aureus (MRSA) and organisms responsible for lower respirator... has led to a clear need for novel drugs that are active against multi-drug resistant bacteria. Novexel's products are targeting the global hospital antibiotic m...

Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases

...a second generation oral and IV oxazolidinone antibiotic with potent activity against drug-resistant Gram-positive bacterial pathogens including those resistant to Zyvox(R), the only marketed antibacterial drug of the oxazolidinone class. Trius has recently completed Phase 2 testing of torezolid in a U.S. bas...

Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin

...neous determination of whether or not it is a drug resistant strain. Xpert MTB/RIF should be a breakthrough tec...en a significant factor in the development of drug resistant TB strains. Optimal management of the disease requ... earlier interruption of the transmission chain-of resistant strains, and promote appropriate accommodation of ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

...sides that, through virtue of binding at a different site than ANA598, display a resistance profile distinct from that of ANA598. Genotypic mutations resistant to ANA598 will be shown to be fully susceptible to interferon-alpha, telaprevir and PSI-6130. About ANA598 Anadys retains worldwide rights to...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

...oncology, including aggressive cancers known to be resistant to the current standards of care." Study re...ty in LHRH receptor over-expressing and multi-drug resistant ovarian cancer cells (OVCAR-3). As a negative cont...ely kill cancer cells, including cells known to be resistant to chemotherapeutic drugs, without harming normal ...

Elusys' Anthrax Anti-Toxin, Anthim(TM), Enters Second Phase I Clinical Study

...infection. Antibiotics target the bacteria, but can still fail to prevent death from the damaging effects of anthrax toxins. In addition, antibiotic resistant strains of anthrax could be used in a bioterror attack, making the medical need for anti-toxin therapy even more acute. Anthim Background An...

Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier

...ing chemotherapy or radiation treatment, some patients' tumors may turn on certain genes as a strategy by the tumor to adapt to the therapy and become resistant to cell death. One example of a genetic change that occurs in many cancers is the activation of the DNA repair gene RAD51. In response to treatment wi...

Rib-X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R&D Directions 100 Great Investigational Drugs of 2009

...nolones against Gram-positive bacteria, including isolates of MRSA that are resistant to other quinolones. The Company recently announced positive results from a...rogram is developing novel classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the Rx-02 discovery program is focused on develo...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... effects and non-compliance (3) lack of efficacy when administered late in the anthrax disease cycle, and (4) lack of effectiveness against multi-drug resistant or genetically engineered strains of anthrax. About PharmAthene, Inc. PharmAthene was formed to meet the critical needs of the United States ...