Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results
...l patient population, which includes patients randomized either to olmesartan or placebo in addition to standard antihypertensive treatment (excluding ras
inhibition). After one year of treatment, 61 percent of patients in ROADMAP achieved the recommended BP goal of <130/80 mm Hg, a significant increa...
Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium
...ity, favorable pharmacokinetics and tumor distribution, efficacy in
EGFR- and HER2-expressing xenograft models, activity in tumors harboring
or inactivated LKB1 mutations and activation of AMPK pathways
in cardiac cells.
-- Tyrosine kinase inhibitors, such as TAK-285, GW572016 or SU1124...
Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
... two single-pill combinations of
commonly used high blood pressure medicines in reduction of cardiovascular events - ras
inhibition with an ACEI was the foundation of the combination
therapies in this study and exceptional blood pressure control rates were ...
Use of PressureWire(R) Yields a More Accurate Assessment of Translesion Pressure Gradients in Peripheral Vasculature, Two New Studies Report
...sessment of renal artery stenosis: side-by-side comparison
of angiography and duplex ultrasound with pressure gradient measurements,"
this study of 56 ras
patients reports that diagnoses based on renal
angiography and color duplex ultrasound overestimated the severity of RAS
by 38 percent and 55 percent ...
Prolexys Pharmaceuticals Initiates Phase 1 Study
...erived from tumors with dissimilar causative mutations, indicating potent
and selective activity against a wide variety of tumors, many with
pathway. The compound showed robust tumor regression in a
range of human tumor xenografts grown in immuno-compromised mice, including
models of pancre...
New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard
Therapy in Treatment of Hypertension
of research on renin. Renin is the key enzyme at the top of the
Renin Angiotensin System (RAS), one of the key regulators of blood
pressure. The ras
is a cascade, starting with renin, leading to
angiotensin I and finally to angiotensin II. Angiotensin-converting
enzyme inhibitors (ACE-Is) and angio...
Thallion Announces Publication of ECO-4601 Phase I/II Clinical Data
...l, McGill University in Montreal in
conjunction with Thallion Pharmaceuticals Inc. The abstract is
“Phase I study of ECO-4601, a novel ras
inhibitor.” Abstract No. 14128 by P. Kavan, D. Melnychuk, A.
Langleben, S. D. Baker, A. Bangash, C. Gauthier, M. Ranger, H.
Pharmexa A/S (DK) - Long lasting immune response and survival to
... Summary: Follow-up ras
data presented at ASCO
HORSOLM, Denmark, June 4,... with two different
peptide vaccines targeting the ras
mutation found in most instances
of pancreatic can...em in three of these patients
still remembered the ras
Prolexys Pharmaceuticals and Columbia University Researchers
Publish Study on Anti-Tumor Properties of a Selective Small
Molecule Anti-Tumor Agent With Novel Mechanism of Action
.... This process has a degree of selectivity for cells with
aberrantly active ras
pathway. In normal cells, ras
involved in growth and differentiation of cells; however the
Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure
Reduction During Important Early Morning Period When Most Adverse
Cardiovascular Events Occur
...eceptors and subsequent
narrowing of blood vessels should be decreased. The ras
been successfully targeted by three major classes of
pressure monitoring devices.
Angiotensin II: a molecule of the ras
inducing vasoconstriction of
blood vessels and other effects to raise blood...