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Ras in Medical Technology

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

...l patient population, which includes patients randomized either to olmesartan or placebo in addition to standard antihypertensive treatment (excluding ras inhibition). After one year of treatment, 61 percent of patients in ROADMAP achieved the recommended BP goal of <130/80 mm Hg, a significant increa...

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

...ity, favorable pharmacokinetics and tumor distribution, efficacy in EGFR- and HER2-expressing xenograft models, activity in tumors harboring activated ras or inactivated LKB1 mutations and activation of AMPK pathways in cardiac cells. -- Tyrosine kinase inhibitors, such as TAK-285, GW572016 or SU1124...

Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients

... two single-pill combinations of commonly used high blood pressure medicines in reduction of cardiovascular events - ras inhibition with an ACEI was the foundation of the combination therapies in this study and exceptional blood pressure control rates were ...

Use of PressureWire(R) Yields a More Accurate Assessment of Translesion Pressure Gradients in Peripheral Vasculature, Two New Studies Report

...sessment of renal artery stenosis: side-by-side comparison of angiography and duplex ultrasound with pressure gradient measurements," this study of 56 ras patients reports that diagnoses based on renal angiography and color duplex ultrasound overestimated the severity of RAS by 38 percent and 55 percent ...

Prolexys Pharmaceuticals Initiates Phase 1 Study

...erived from tumors with dissimilar causative mutations, indicating potent and selective activity against a wide variety of tumors, many with activated ras pathway. The compound showed robust tumor regression in a range of human tumor xenografts grown in immuno-compromised mice, including models of pancre...

New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard Therapy in Treatment of Hypertension

...years of research on renin. Renin is the key enzyme at the top of the Renin Angiotensin System (RAS), one of the key regulators of blood pressure. The ras is a cascade, starting with renin, leading to angiotensin I and finally to angiotensin II. Angiotensin-converting enzyme inhibitors (ACE-Is) and angio...

Thallion Announces Publication of ECO-4601 Phase I/II Clinical Data at ASCO

...l, McGill University in Montreal in conjunction with Thallion Pharmaceuticals Inc. The abstract is titled: “Phase I study of ECO-4601, a novel ras pathway inhibitor.” Abstract No. 14128 by P. Kavan, D. Melnychuk, A. Langleben, S. D. Baker, A. Bangash, C. Gauthier, M. Ranger, H. Gourdeau, M....

Pharmexa A/S (DK) - Long lasting immune response and survival to RAS vaccine

... Summary: Follow-up ras data presented at ASCO HORSOLM, Denmark, June 4,... with two different peptide vaccines targeting the ras mutation found in most instances of pancreatic can...em in three of these patients still remembered the ras vaccination. The...

Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action

.... This process has a degree of selectivity for cells with aberrantly active ras pathway. In normal cells, ras pathway is involved in growth and differentiation of cells; however the abe...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...eceptors and subsequent narrowing of blood vessels should be decreased. The ras has already been successfully targeted by three major classes of antihypert...atory blood pressure monitoring devices. Angiotensin II: a molecule of the ras inducing vasoconstriction of blood vessels and other effects to raise blood...
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