RTA in Medical Technology

Positive Glufosfamide Results From a Phase 2 Clinical Trial Presented at European Cancer Conference (ECCO)

...ve patients (18%) had a glufosfamide-related serious adverse event (SAE), which included renal tubular acidosis (RTA) with renal failure (2 patients), rta alone, vomiting or nausea. Three patients died from an SAE unrelated to glufosfamide. Another patient developed an SAE of renal failure after hypotens...

Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer

...sity of Texas M.D. Anderson Cancer Center in 2004. rta 402, the lead agent from this series, has recently...e 1 study in cancer patients has demonstrated that rta 402 has potent single-agent anti-cancer activity i... has recently been confirmed in a Phase 1 study of rta 402 in cancer patients being conducted at the M.D....

RTA 402 Shown to Inhibit STAT3 in Animal Model and Holds Significant Promise for Treating Breast Cancer

...cer Center. The authors conducted two studies of rta 402 in the highly rigorous 4T1 mouse model of brea... body. In two separate experiments, treatment with rta 402 was found to have a profound effect in suppres... model mimicking the spread of metastatic disease, rta 402 completely blocked the development of metastas...

RTA 402 Shown to Protect Animals Against Toxicities of Standard Cancer Treatments

...lead anti-cancer agent, the Synthetic Triterpenoid rta 402, is effective at protecting against common tox...and collaborators presented data showing that when rta 402 is given in combination with radiation therapy...ol, a well-known expert on cancer supportive care. rta 402 is a novel, orally administered targeted thera...