OVA in Medical Technology

Nektar Therapeutics Reports Second Quarter 2009 Financial Results

...uct is being developed to treat opioid-induced constipation (OIC). NKTR-102, PEGylated irinotecan, is currently in Phase 2 clinical studies in ovarian, breast and colorectal cancer. NKTR-105, PEGylated docetaxel, is currently in a Phase 1 study in patients with refractory solid tumors. N...

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

...the treatment of cytopenias due to myelodysplastic syndrome or chemotherapy, and TELCYTA((R)), a tumor-activated prodrug for the treatment of advanced ovarian cancer and non-small cell lung cancer. Telik's product candidates were discovered using its proprietary drug discovery technology, TRAP((R)), wh...

Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program

...tions studies, and extend the safety database. Two ovarian cancer patients have been enrolled in the stu...s. Access recently announced data from a recurrent ovarian cancer trial that showed that ProLindac was m...ently in Phase 2 clinical testing of patients with ovarian cancer, and MuGard(TM) for the management...

Lilly and New York City Mayor Michael R. Bloomberg Announce Lilly Agrees to be First Tenant of East River Science Park; Issue Urgent Call for Healthcare Reform that Protects Innovation and Jobs

...studies of IMC-A12 are expected to begin in either late 2009 or early 2010; IMC-3G3 has recently moved into Phase II development with a study in ovarian cancer, and additional Phase II studies in other tumor types are planned; Phase II studies of IMC-1121B have been expanded to include colo...

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

...cular importance in patients with relapsed 'triple-negative' breast cancer, ovarian, or colorectal cancer following treatment with platinum containing reg...icin to prove safe and effective for treatment of solid tumors particularly ovarian or colon cancers, determinations by regulatory, patent, and administra...

Why Do African-Americans Fare Worse With Cancer? Access and Economics Are Only Part of the Story

... for the first time, that African-American breast, ovarian, and prostate cancer patients tend to die ear...ess of race. But this is not the case for breast, ovarian, and prostate cancers." Even with good t...hose with prostate cancer to a 61% higher risk for ovarian cancer patients. The elimination of trea...

Thiarabine Demonstrates a Reduction of Both Inflammatory and Erosive Disease Parameters in Rheumatoid Arthritis

...e treatment and supportive care of cancer patients. Access' products include ProLindac(TM), currently in Phase 2 clinical testing of patients with ovarian cancer, and MuGard(TM) for the management of patients with mucositis. The company also has other advanced drug delivery technologies including ...

New Data Supports Significant Economic and Clinical Value of MENOPUR(R) in IVF

...rtility management, it is believed that it will have a major implication on the decision-making process when choosing the appropriate gonadotropin for ovarian stimulation.[1] "I think the cost-effectiveness of treatments is a real issue for couples considering infertility treatment such as IVF to...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

...DNA-binding protein nuclease (ZFN) technology. Genentech scientists demonstrated the successful knockout of two preselected genes in a Chinese hamster ovary (CHO) cell line. The milestone achievement triggered a payment from Genentech to Sangamo. "Achievement of this milestone demonstrates the prog...

Alfacell Provides Shareholder Update

... this capacity Onconase can be widely used in therapy of different tumor types, including most common types such as cancer of breast, prostate, colon, ovary and lung." Another quote is provided by Harvey I. Pass. Director, New York University Medical Center, Division of Thoracic Surgery; Chief o...

New Bisphenol A Study Is of Very Limited Relevance to Human Health

...nd the National Institute of Environmental Health Sciences (NIEHS). The study, "Neonatal bisphenol A exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin releasing hormone neurons," was funded by NIEHS and published online June 17 by the journ...

Cancer Treatment Centers of America(R) Studies Treatment That Aims Chemotherapy Directly at Ovarian Cancer Cells

... research involving a treatment designed to target ovarian cancer cells otherwise resistant to standard ...ntly being studied in the treatment for women with ovarian cancer who develop a resistance to standard p...EDENT study, patients must have platinum-resistant ovarian cancer where the disease has progressed or re...

Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients

...0.2) and the most common cancer types were lung (133, 18%), breast (131, 17.8%), colorectal (97, 13.2%), pancreatic (86, 11.7%), prostate (44, 6%) and ovarian (38, 5.2%). Before the study, the researchers hypothesized that malnutrition could contribute to vitamin D deficiency and therefore expecte...

Researchers Say More Aggressive Vitamin D Supplementation Needed in Obese Cancer Patients

...D = 6.7). The most common cancers were lung (134, 18.1%), breast (131, 17.7%), colorectal (97, 13.1%), pancreatic (86, 11.6%), prostate (45, 6.1%) and ovarian (39, 5.3%). The mean vitamin D (serum 25(OH)D) was 21.9 ng/ml (SD = 13.5). The study concluded that obese cancer patients (BMI >=30 kg/m2...

Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

...r the treatment and supportive care of cancer patients. Access' products include ProLindac(TM), currently in Phase 2 clinical testing of patients with ovarian cancer, and MuGard(TM) for the management of patients with mucositis. The company also has other advanced drug delivery technologies including Co...

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

...d in patients with a variety of tumor types including melanoma, renal cell, ovarian and colorectal cancer. ENMD-2076 was well-tolerated when administered ...with a variety of cancers as well as specifically those with colorectal and ovarian cancers. These additional data will guide our selection of the most p...

Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients

... cancer for whom surgery is not possible. GEMZAR is indicated in combination with carboplatin (another type of chemotherapy) for the patient with ovarian cancer that has returned at least 6 months after the patient had finished platinum-based therapy. GEMZAR is indicated as a single agent (giv...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

...t or advanced solid tumors. Enrolled patients are stratified according to disease type, including non-small cell lung cancer, small cell lung cancer, ovarian cancer and renal cancer. The open-label, multi-center clinical trial is a two-stage design, with pre-determined criteria for continuation after ...

Stand Up To Cancer Awards $73.6 Million for Novel, Groundbreaking Cancer Research

...act the diagnosis and treatment of a wide range of cancers in adults and children across ethnicities including, but not limited to pancreatic, breast, ovarian, cervical, uterine, brain, lung, prostate, rectal and colon, which represent two thirds of all U.S. cancer deaths. (562,340 people are expected ...

Telik Announces Presentation at ASCO Annual Meeting

... second-line therapy in platinum (P) refractory or resistant ovarian cancer (OC)." About Telik Telik, Inc. of Palo Alto, CA, i...erapy, and TELCYTA, a tumor-activated prodrug for the treatment of advanced ovarian cancer and non-small cell lung cancer. Telik's product candidates wer...

Type 2 Diabetes: An Epidemic Among America's Youth

...ed with type 2 diabetes, including obesity, hypertension, hyperlipidemia (elevated cholesterol), and potential risks of infertility such as Polycystic ovarian Syndrome. These youth also have an increased risk of developing long-term complications, including heart disease, stroke, kidney disease, and ne...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... -The First Presentation of Data on BIBF 1120 in ovarian Cancer- RIDGEFIELD, Conn., May 14 /PRNew...for BIBW 2992 and a Phase II study of BIBF 1120 in ovarian cancer patients will be presented. LU...irst Presentation of Phase II Data on BIBF 1120 in ovarian Cancer Data from a Phase II study of BIBF...

Moffitt Cancer Center Signs Licensing Agreement with Frantz BioMarkers, LLC

... Technology to improve accuracy of ovarian cancer diagnosis TAMPA, Fla., May 14 /PR... a license agreement on phospholipid biomarkers of ovarian cancer. Frantz BioMarkers, which has been gr... Moffitt and Frantz BioMarkers will collaborate on ovarian cancer biomarker research, combining use of t...

Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis

...row rapidly and spread due to the hormones associated with pregnancy. While we know that hormones may impact other types of cancer, such as breast and ovarian cancer, a review of the research on pregnancy and melanoma shows there is no evidence that pregnancy has an adverse influence either on the progn...

Two-Year Phase III Data Presented at AAN 61st Annual Meeting Show Positive Outcome of Cladribine Tablets in Patients With Multiple Sclerosis

...priately to treatment. In patients treated with Cladribine Tablets, four malignancies were reported during the study (cervical stage 0, melanoma, ovarian and pancreatic), and a case of choriocarcinoma was reported at week 14 of gestation in a cladribine-treated patient who became pregnant 6 months ...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...s, lymphomas, breast, lung, colon, pancreatic, and ovarian cancer. In preclinical studies, MDX-1338, a f...ssed on mesotheliomas and other cancers, including ovarian and lung cancer, and because of its limited e...an antibody-drug conjugate. In xenograft models of ovarian and lung cancer, MDX-1204, a fully human anti...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

...ical in vitro and in vivo studies of EP-100 in ovarian cancer cell lines and ovarian xenograft models were presented in a poster p...tled, "Targeted Oncolytic Peptide for Treatment of ovarian Cancers" at the American Association for Canc...

Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin

...llicin, a high-throughput RNA interference screen was performed in selected ovarian cancer cell lines. RNA interference is a cellular process that result...icin to prove safe and effective for treatment of solid tumors particularly ovarian or colon cancers, determinations by regulatory, patent, and administra...

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

... St. Louis. "Very recently, other research found that reduced DICER1 gene expression in tumor cells is associated with worse outcomes in patients with ovarian, lung, breast and prostate cancers. Now we've shown that mutations in the DICER1 gene are directly linked to the development of PPB." "For y...

EAU Position Statement on Screening for Prostate Cancer

...8 are needed to be treated in excess of the control group population to save one prostate cancer death. Results of the PLCO (Prostate, Lung, Colon and ovary) US randomized study of screening were also published in the same issue of the NEJM (Andriole et al, NEJM 2009) and to date show no significant eff...

Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research

...kRNAi against an important multidrug resistance mechanism seen in solid cancers such as gastric carcinoma, ovarian cancer, and others. About Cequent Pharmaceuticals, Inc. ( www.cequentpharma.com ) An early-stage biopharmaceutical company, Ceq...

Oasmia: FDA Grants Paclical(R) Orphan Drug Designation for Ovarian Cancer in the USA

...by the USA FDA of Paclical(R) for the treatment of ovarian cancer. Orphan Drug designation can entail ad...g the use of Paclical to Taxol(R) in patients with ovarian cancer. A safety objective is to show the sup... Aleksov, CEO of Oasmia in a comment. About ovarian cancer ...

Newly Published Phase III Study Shows Arzoxifene Significantly Increased Bone Mineral Density

...to break. Primary osteoporosis, which is deterioration of bone mass that is unassociated with other chronic illness, is related to aging and decreased ovarian function, including menopause. If not prevented, or if left untreated, osteoporosis can progress painlessly until a bone breaks. According to the...

New Report Shows Record Number of Medicines in Development to Treat Leading Causes of Cancer

...women; and 103 for prostate cancer, which this year is expected to kill 28,000 American men. Additional medicines target brain cancer, kidney cancer, ovarian cancer, pancreatic cancer, skin cancer, and others. The medicines represent many cutting-edge approaches, including a drug that delivers a s...

New Study Suggests Rx Estrogen Delivery Through the Skin May Show Safety Benefits as Opposed to Oral Delivery

...The Journal of the North American Menopause Society. Prescription transdermal estrogen therapy is bioidentical to estrogen produced by a woman's ovaries before menopause and delivered through the skin. Transdermal estrogen is available in a variety of formulations which have been quality controlle...

Leader in Prostate Health Urges Prostate Cancer Screening in Face of Contradicting Data

...ld be continued, based on new data from two studies, including the preliminary data from the prostate component of the Prostate, Lung, Colorectal, and ovarian (PLCO) study. Two studies featured in the March 26 issue of the New England Journal of Medicine present findings from the PLCO study and...

Cancer Research 'David' Hopes to Slay 'Cancer Goliath'

...outside the U.S. by Dr. Eric R. Brown on patients exhibiting lesions in one or more sites of the breast, skin, liver, lung, spine, pancreas, prostate, ovary, and stomach. In addition, some effectiveness was seen in an instance of lymphoid leukemia, and one of a glioma of the ocular nerve. These tests pr...

Access Pharmaceuticals Announces Positive ProLindac(TM) Phase 2 Ovarian Cancer Clinical Trial Results

...f ProLindac(TM) in late-stage, heavily pretreated ovarian cancer patients. In this monotherapy study 66... ProLindac as a monotherapy treatment for advanced ovarian cancer, to provide data on the monotherapy an... Ca-125, the established specific serum marker for ovarian cancer, were also observed in several patient...

Laser Burn Injuries in One Eye Can Disrupt Protective Immune Privilege in Both Eyes, Study Finds

...team made tiny laser burns in one of the retinas of 15 mice. They then injected either the burned or the unburned eyes of each mouse with the antigen, ovalbumin. Antigens are substances that the body perceives as foreign and against which it mounts a defense. They found that immune privilege was di...

Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis

...s in the nationwide Prostate, Lung, Colorectal and ovarian (PLCO) Cancer Screening Trial who were cancer...ference laboratory provider of the blood-based HE4 ovarian Cancer Monitoring test, which is FDA cleared ...nt or progressive disease in women with epithelial ovarian cancer. The company is also developing a mole...