Menopausal in Medical Technology

Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms

COLLEGEVILLE, Pa., July 27 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE ), announced the publication in Fertility and Sterility of data from a Phase 3 clinical study that showed that the investigational compound bazedoxifene/conjugated estrogens...

Methadone Frequently Causes Menopausal Symptoms in Young Women

TARPON SPRINGS, Fla., May 7 /PRNewswire/ -- Methadone medication frequently depresses estradiol, progesterone and testosterone hormone levels to menopausal levels, even in women less than thirty years old. Hormonal suppression, caused by methadone, can cause depression, anxiety, fatigue, weight g...

Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes

--Study will evaluate proof of concept for company's first-in-class SERM designed to relieve vasomotor symptoms without side effects associated with hormone therapy-- CAMBRIDGE, Mass., March 24 /PRNewswire/ -- Radius Health ("Radius") announced today that the first patient has been dosed in t...

Bionovo Announces Development Plans for Menopausal Hot Flash Drug Candidate, Menerba (MF101), Following FDA Meetings

EMERYVILLE, Calif., Dec. 3 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) today announced that the FDA has reviewed the company's manufacturing and control process descriptions (CMC), and has provided guidance on how Bionovo can move forward with the development of Menerba (formerly nam...

Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate

EMERYVILLE, Calif., Sept. 12 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) today announced the publishing of a paper in the journal for the American Society for Pharmacology and Experimental Therapeutics, Drug Metabolism and Disposition, entitled "Oxidative In Vitro Metabolism of Li...

Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation

- Results Presented at Endocrine Society 90th Annual Meeting - SAN FRANCISCO and EMERYVILLE, Calif., June 16 /PRNewswire-FirstCall/ -- Bionovo Inc. (Nasdaq: BNVI ) today announced results from in vitro studies in neurons of its drug candidate, MF101. The data were presented at the Endocr...

New Analysis of Data from WHI Provides Reassurance With Respect to Coronary Heart Disease For Newly Menopausal Women Considering Hormone Therapy

COLLEGEVILLE, Pa., April 03, 2007 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth , provides comment on a re- analysis of pooled data from both hormone therapy arms of the Women's Health Initiative (WHI) Study published today in the Journal of the American Medical Association....

Wyeth Presents Phase 3 Data for Pristiq, an Investigational Non-Hormonal Therapy for Menopausal Hot Flashes and Night Sweats

First Scientific Presentation for Pristiq Occurs at the 55th Annual Clinical Meeting of the American College of Obstetricians and Gynecologists COLLEGEVILLE, Pa., May 09, 2007 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth , presented results from the first Phase 3 studies ev...

TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men

...the American Society for Reproductive Medicine's menopausal Medicine , KLRI publications findings were twofold that there are certain benefits to menopausal hormone therapy (HT) in newly postmenopausal women... American Heart Association and other groups began menopausal HT use much later than in usual clinical practice-...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

...ve compounds could lead to safer, more attractive alternative therapies for menopausal symptoms," said Dr. Dale Leitman, the Principal Investigator of the study. ...igating the unique abilities of their drugs to safely and effectively treat menopausal symptoms. "It is essential that new drug candidates demonstrate dr...

When It Comes to Natural Remedies for Hormonal Balance, the Proof Is in the Clinical Research

...e. While natural products that promise relief from menopausal symptoms abound, few have success rates higher tha...of cells and organs, affecting much more than just menopausal symptoms. "Hormones are profoundly important to a ...rdingly. MacaLife(R) is formulated for relief of menopausal symptoms, while MacaPause(R) is focused on suppo...

Addrenex Pharmaceuticals Expands Product Pipeline by Licensing New Drug to Treat Narcolepsy

... of attention-deficit hyperactivity disorder (ADHD) and Sympres(R) for the treatment of hypertension. The company also plans to develop drugs to treat menopausal flushing and potentially pain, insomnia and migraines, all of which are impacted by the adrenergic system. "ADX-N05 represents a significant adva...

No Causality Found Between Black Cohosh and Liver Problems

...e-evaluation of Spontaneous Reports CHICAGO, May 5 /PRNewswire/ -- Black cohosh has been widely used in Europe and also in North America to treat menopausal symptoms including hot flashes, night sweats, occasional irritability and mood swings. While extensive research has been published on this botanical, ...

Addrenex Pharmaceuticals Reports Positive Results in Second Phase 3 Study of ADHD Medication

...alty pharmaceutical company is also developing drugs to treat hypertension, menopausal flushing and potentially insomnia, pain, and migraines. Based on the p... role in a host of adult conditions such as post-traumatic stress syndrome, menopausal flushing, hypertension, and migraines. About Addrenex Addrenex spe...

Staying One Step Ahead of Osteoporosis

...rthopaedic surgeon at Hadassah- Hebrew University Medical Center in Jerusalem, Israel, looked at improving the diagnosis rate of osteoporosis in post menopausal women, who fracture the distal radius bone, which is located in the lower arm, near the wrist. Dr. Kandel says these fractures are often the first cl...

New Mammography Technology Effective in Detecting Breast Cancer

...rica (RSNA). "The ability of PEM to detect cancer does not appear to be adversely affected by breast density, hormone replacement therapy or menopausal status," said lead researcher Kathy Schilling, M.D., director of breast imaging and intervention at the Center for Breast Care at Boca Raton Community...

Diagenic Announces Launch of First Breast Cancer Gene-Expression Blood Test

...nd US cohorts, also had similar good diagnostic and predictive performance in the Indian population. BCtect(TM) is not affected by ethnic variation or menopausal state of the patient, allowing for widespread use to diagnose breast cancer at an early stage." The TaqMan Array manufactured for DiaGenic by Applie...

New Analyses Indicate that Divigel(R) (estradiol gel) 0.1% Is a Valuable Option for Certain Postmenopausal Women With Hot Flashes

... - Transdermal Estrogen Analyses Continue to Show Benefits of Hormone Therapy Use in menopausal Women - MAPLE GROVE, Minn., Sept. 25 /PRNewswire/ -- Upsher-Smith Laboratories, Inc. today announced that clinical abstracts featuring Divigel(R) (e...

Bionovo's VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness

...ness is a very painful, day to day, quality of life concern for over 50% of menopausal women. The only available FDA-approved treatment for women is estrogen, whi...ravaginal drug designed for the treatment of vaginal atrophy and dryness in menopausal women. VG101 is a novel estrogen receptor beta selective agonist and unlike...

Bionovo's MF101 Shows Statistically Significant Improvement in Sleep Disturbance from Hot Flashes

...gs showing that MF101 can improve sleep quality in menopausal women are extremely exciting to the 40 million wom...ase 3 clinical trial of MF101 for the treatment of menopausal hot flashes, these additional beneficial results w...l." "Proving that MF101 significantly helps with menopausal sleep related symptoms further illustrates the pot...

Addrenex Pharmaceuticals Announces Positive Phase III Clinical Results for Clonicel to Treat ADHD

...drenex is currently developing a cadre of drugs focused on treating these and other conditions arising from adrenergic excess, including hypertension, menopausal flushing, pain and sleep disturbance. By mining a library of 400 adrenergic compounds at the University of Nebraska Medical Center, Addrenex scientist...

Addrenex Pharmaceuticals' New Hires Further Company Goal to Identify New Drugs for Adrenergic Regulation

... Gary Bream, Ph.D., as senior director of scientific affairs will strengthen Addrenex's ability to pursue additional drugs to treat conditions such as menopausal flushing, pain, addiction, aggression, and post traumatic stress disorder, said Moise Khayrallah, Ph.D., cofounder and chief executive officer of Addr...

Node-Negative Early Stage Breast Cancer Patients Benefit from Taxotere(R)-Based Chemotherapy

...e tumor) were enrolled in the study; 1047 patients were eligible. Patients from Spain as well as Germany and Poland were stratified by institution and menopausal status and randomized after surgery to receive either TAC (docetaxel 75 mg/m2, doxorubicin 50 mg/m2, cyclophosphamide 500 mg/m2) or FAC (5-fluorouraci...

Wyeth Receives Approvable Letter From FDA for Bazedoxifene for the Treatment of Postmenopausal Osteoporosis

...f bone tissue, leading to bone fragility and an increased risk of fractures. According to the National Osteoporosis Foundation, the number of women of menopausal age who have osteoporosis or are at risk for developing the disease will increase from almost 30 million in 2002 to nearly 41 million in 2020. Up to 2...

Independent Physician Surveys Show if Approved, MF101 Could Become First-Line Treatment for Menopause Symptoms

...safe and new alternative drug for the treatment of menopausal symptoms," said Mary Tagliaferri, M.D., Bionovo's ...01 at the top of the list of treatment options for menopausal symptoms, physicians also reported the following: ...r women when considering treatment options for menopausal symptoms is the risk of cancer. -- Many women hav...

QuatRx Pharmaceuticals Announces Positive Phase 3 Results for Study of Ophena(TM) (ospemifene) to Treat Postmenopausal Vaginal Syndrome

... Novel non-estrogen oral therapy in development for menopausal symptoms ANN ARBOR, Mich., Jan. 3 /PRNewswire/ -- QuatRx Pharmaceuticals Company today announced positive results from a pivotal Phase 3 study of Op...

Wyeth Presents New Phase 3 Data and Updates Regulatory Timing for NDA Filing of Bazedoxifene/Conjugated Estrogens

...hat has the potential to change the way physicians and their patients treat menopausal symptoms and prevent postmenopausal osteoporosis," says Dr. Constantine. T...e U.S. Census Bureau, in 2006, there were approximately 20 million women of menopausal age (45-54 years) in the United States. As many as 50 percent to 90 percent...

New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes

... Lowest Dose of Estradiol Shown to Be Safe and Effective for menopausal Women WEST PALM BEACH, Fla., Oct. 3 /PRNewswire/ -- A study presented today at the 2007 Annual Meeting of the North ...

Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis

...th placebo, when both bazedoxifene doses were combined. About Osteoporosis According to the National Osteoporosis Foundation, the number of women of menopausal age who have osteoporosis or are at risk for developing the disease will increase from almost 30 million in 2002 to nearly 41 million by 2020. Osteopo...

Bionovo to Present Recent Findings of BZL101, Its Anti-cancer Agent, at the American Association of Cancer Research

...the treatment of advanced breast cancer. The company has an additional pipeline of drugs in development for breast cancer, pancreatic cancer and other menopausal symptoms with a total of 4 drug candidates expected to be in clinical trials by the end of 2007. The company is developing its products in close colla...

Bionovo's MF101 Shows Positive Safety, Tolerability and Efficacy in Phase 2 Trial

...ot only encouraging for discovering a safer therapy for hot flashes but also support the role of estrogen receptor beta as a novel target for treating menopausal symptoms." "Recent clinical trials, such as the HERS and the WHI, elucidated important safety concerns of postmenopausal hormone therapy and resulte...

New Analysis of WHI Data Shows Reduced Levels of Coronary Artery Calcification, a Predictor of Cardiovascular Events, in Women aged 50-59 taking Estrogen Therapy

...l of Medicine (NEJM). The study found that younger menopausal women (aged 50-59) who received a standard dose of... to show that in the newly diagnosed population of menopausal women, estrogen therapy does not increase cardiova... be limited to the treatment of moderate to severe menopausal symptoms, with the lowest effective dose used for ...

Arterial Plaque Significantly Reduced in Women Age 50-59 Taking Hormones, Says New Analysis of Women's Health Initiative Data

...udy (KEEPS), a randomized, controlled, double-blinded trial of 720 recently menopausal women at nine study centers across the United States. The KEEPS is designed to provide prospective data on the risks and benefits of early menopausal HT, particularly as it relates to the progression of atherosclerosis. "The ...