Mechanism in Medical Technology

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

SEATTLE, July 21 /PRNewswire-FirstCall/ -- Cell Therapeutics (CTI) (Nasdaq and MTA: CTIC) announced today that researchers from the Laboratory of Molecular Pharmacology at the National Cancer Institute presented new preclinical research identifying unique anti-tumor mechanisms of br...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

ANNAPOLIS, Md., March 31 /PRNewswire-FirstCall/ --PharmAthene, Inc. (NYSE Amex: PIP ), a biodefense company developing medical countermeasures against biological and chemical threats, announced today that new mechanism of action data for Valortim(R) were presented at the Keystone Symposia on Mol...

Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease

SAN FRANCISCO, July 30 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN ) today announced new data showing that its investigational drug Dimebon continues to produce broad, clinically meaningful benefits in Alzheimer's disease patients after long-term dosing, and appears to operate th...

Genaera Corporation Presents Data on Mechanism of Inhibition of PTP-1B for Trodusquemine (MSI-1436) at Federation of American Societies for Experimental Biology (FASEB) Meeting

PLYMOUTH MEETING, Pa., July 14 /PRNewswire-FirstCall/ -- Genaera Corporation (Nasdaq: GENR ) announced today the presentation of new preclinical data on trodusquemine (MSI-1436), a novel inhibitor of PTP-1B and Genaera's lead drug candidate for the treatment of type 2 diabetes and obesity, du...

Anadys Pharmaceuticals Resumes Clinical Investigation of TLR7 Mechanism in HCV

Expanded HCV Development Presence Includes ANA598 and ANA773 Acting via Independent but Potentially Complementary Mechanisms Conference Call Today at 2:00 PM PDT SAN DIEGO, July 7 /PRNewswire-FirstCall/ -- Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today ...

DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin

REYKJAVIK, Iceland, June 30 /PRNewswire-FirstCall/ -- deCODE genetics (Nasdaq: DCGN ) today announced positive topline results from its latest clinical pharmacology study of DG041, the company's first-in-class antagonist of the EP3 receptor for prostaglandin E2, developed as a next-generation...

Bionovo Elucidates Mechanism of Breast Cancer Control by Estrogen Receptor Beta

- Results Presented at Endocrine Society's 90th Annual Meeting - SAN FRANCISCO and EMERYVILLE, Calif., June 16 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) today announced results on the role of estrogen receptor beta in breast cancer growth regulation. The data, which were pre...

Peregrine Researchers Present New Preclinical Data at AACR Annual Meeting Confirming Unique Anti-Tumor Mechanism of Bavituximab

- Bavituximab Causes Pro-Inflammatory Effects in the Tumor Microenvironment That May Contribute to Its Anti-Tumor Efficacy - - Studies Show Similar Results for a New Fully Human Version of the Antibody - SAN DIEGO and TUSTIN, Calif., April 15 /PRNewswire...

Bionovo Announces Publication of the Paper Detailing the Mechanism of Action of Its Cancer Drug BZL101

BZL101 selectively kills cancer cells but not normal cells EMERYVILLE, Calif., April 1 /PRNewswire-FirstCall/ -- Bionovo Inc. (Nasdaq: BNVI ) today announced the publication of a peer-reviewed article in the journal Cancer Biology and Therapy that elucidates the molecular mechanisms un...

Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers

Mechanism Described in Jan. 4 Issue of Science Explains How Neuronal Connections Continue To Strengthen After Repeated Stimulation PITTSBURGH, Jan. 3 /PRNewswire/ -- Practice makes perfect -- or at least that's what we're told as we struggle through endless rounds of multiplication table...

Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes

MONTVALE, N.J., Nov. 5 /PRNewswire-FirstCall/ -- Synvista Therapeutics, Inc. (Amex: SYI ) announced results of a series of preclinical studies designed to explain the mechanism underlying dysfunctional high density lipoprotein (HDL), that creates a defect in reverse cholesterol transport in p...

Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation

Findings Appear Online in the Journal Nature Medicine CLEVELAND, Aug. 27 /PRNewswire/ -- Researchers at Cleveland Clinic have identified the mechanism that accounts for platelet hyper-responsiveness during abnormal blood cholesterol levels, the major risk factor for fatal heart attack...

Sarasota's Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes

Findings Detailed in The Journal of Clinical Investigation SARASOTA, Fla., Aug 1 /PRNewswire/ -- The Roskamp Institute today released a study defining a mechanism for the development of obesity and the metabolic syndrome, which are the forerunners of type 2 diabetes. The study, led by R...

EntreMed Presents Mechanism Data for Its Three Lead Oncology Compounds

Multiple Mechanisms for Panzem NCD, MKC-1, and ENMD-1198 Highlighted at Oncology Drug Discovery Conference ROCKVILLE, Md., March 26, 2007 /PRNewswire-FirstCall/ -- EntreMed, Inc., a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases,...

DNA Therapeutics Reports a Novel Mechanism of Action and a Biomarker of its Lead Molecule Dbait That Open an Innovative Pathway-Targeting in Molecular Cancer Therapy

EVRY, France, April 12, 2007 /PRNewswire/ -- DNA Therapeutics S.A. an emerging pharmaceutical company specialized in innovative cancer therapy announces today the elucidation of a new mechanism of action and the identification of a biomarker of its first-in-class antitumoral lead molecule Dbait. I...

ZIOPHARM Presents Unique Mechanism Data for Indibulin at AACR

LOS ANGELES--(BUSINESS WIRE)--Apr 16, 2007 - ZIOPHARM Oncology, Inc. (NASDAQ: ZIOP) presented preclinical data yesterday on indibulin (ZIO-301) at the American Association of Cancer Research (AACR) meeting in Los Angeles. These data demonstrate that indibulin has distinct biologic and molecular pro...

Achillion Presents Positive Data on Novel Mechanism for Treating HCV at EASL Annual Meeting

-NS4A Antagonist Demonstrates Clinical Activity, a Novel Mechanism of Action and In Vitro Compatibility with other HCV Inhibitors- NEW HAVEN, Conn., April 16, 2007 /PRNewswire-FirstCall/ -- Achillion Pharmaceuticals, Inc. today announced the presentation of data validating the clinical antiviral a...

Othera Pharmaceuticals Announces Upcoming Presentation Based Upon Expanded Understanding of Lead Compound Mechanism of Action

EXTON, Pa.--(BUSINESS WIRE)--Apr 19, 2007 - Othera Pharmaceuticals, Inc. today announced that Dr. Shaker Mousa, Professor of Pharmacology and Executive Vice President and Chairman of the Pharmaceutical Research Institute at Albany College of Pharmacy, will present new preclinical data detailing the...

New Report Illuminates Ampligen's Unique Mechanism of Action

PHILADELPHIA--(BUSINESS WIRE)--Apr 30, 2007 - Hemispherx Biopharma, Inc. (AMEX: HEB) announced today the first scientific publication (Journal of Immunology, April 2007) that explains the unique therapeutic properties of its proprietary experimental therapeutic, Ampligen(R) (Poly I : Poly C(12)U), ...

Novel Mechanism Insights and Additional Data on CombinatoRx Drug Candidates to Be Presented at Upcoming EULAR Meeting

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 6, 2007 - CombinatoRx, Incorporated (NASDAQ: CRXX), today announced that data from its randomized, blinded, placebo-controlled phase 2 clinical trials of CRx-102 in patients with osteoarthritis (OA) and rheumatoid arthritis (RA) will be featured at the Europea...

Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action

SALT LAKE CITY, June 14, 2007 /PRNewswire/ -- Prolexys Pharmaceuticals and announced today a publication describing the properties of the selective small molecule anti-tumor agent, erastin. Prolexys and Columbia applied the company's chemi-proteomics technology to understand the mechanism of actio...

Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science

- Journal Article Also Demonstrates the Promise of Anacor's Boron-Based Chemistry in Developing Antibiotics - PALO ALTO, Calif., June 21, 2007 /PRNewswire/ -- Anacor Pharmaceuticals, a privately held pharmaceutical company, announced today that the journal Science will publish results of research ...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Mechanism of Action and Clinical Activity of Sulonex(TM) (sulodexide oral gelcap) at the Upcoming American Diabetes Association 67th Scientific Sessions in Chicago, Illinois

NEW YORK, June 22, 2007 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. today announced that abstracts related to Sulonex(TM) (sulodexide oral gelcap) have been selected for publication or presentation during the poster sessions scheduled to take place at the upcoming American Diabetes As...

CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa

-- New Preclinical Information May Correlate with Clinical HbA1c Reductions Observed in Phase 3 CARISA and MERLIN TIMI-36 Clinical Trials -- PALO ALTO, Calif., July 9, 2007 /PRNewswire-FirstCall/ -- CV Therapeutics, Inc. announced today that researchers have completed preliminary preclinical studi...

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

...rogression to leukemia. There remains a need for effective, well tolerated therapies for MDS having novel mechanisms of action. TELINTRA has a novel mechanism of action that inhibits a target enzyme called glutathione S- transferase P1-1 which in turn facilitates the activation of JNK kinase, a key regulator...

FDA Issues Complete Response Letter for INTUNIV(TM) (guanfacine) Extended Release for the Treatment of ADHD in Children and Adolescents

...ory, reduce susceptibility to distraction, improve attention regulation, improve behavioral inhibition and enhance impulse control.(6-10) Although the mechanism of action of guanfacine in the treatment of ADHD is not fully understood, preclinical research suggests this selective alpha-2A agonist strengthens wo...

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

...ited by the fusion process. The efficient delivery and maximum release of tobramycin into the bacterial cell together with inhibition of the clearance mechanism indicate that Fluidosomes(TM)-tobramycin has a highly efficient therapeutic effect." About Axentis Pharma AG ( http://www.axentispharma.com ) ...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

...80-90 percent of treatment-naive patients have virus that uses the CCR5 co-receptor.(1) "CCR5 antagonists, such as vicriviroc, have a novel mechanism of action and may play a unique role as physicians seek to construct new HIV regimens to meet the specific needs of their patients," said Joseph C. Ga...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

...rget validation is an essential and historically underresourced phase of drug development in which researchers work to determine whether a molecule or mechanism of interest is a true drug target. While researchers have continued to identify novel targets in recent years through genetic, biochemical and epidemi...

CEL-SCI to Present Data from Multikine Clinical Trials at National Institutes of Health (NIH), National Cancer Institute (NCI) Seminar Series

...mmunotherapy for cancer work" . In the presentation, Dr. Talor will discuss Multikine's immunotherapy clinical program for cancer, the unique mechanism of action of Multikine (published in the Journal of Clinical Oncology) and the way Multikine imparts the patient's own immune response with the abilit...

Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis

...alogs of the same molecules used by white blood cells to destroy harmful microbes in the body, such as viruses and bacteria. Because of their natural mechanism of action, NovaBay believes that Aganocide(R) compounds have a low potential for generating microbial resistance, offering a potential solution to the...

King Pharmaceuticals Showcases Data From Pain Pipeline of Medicines Designed to Deter Common Methods of Non-Therapeutic Use

...mulation matrix is a prevalent safety concern. For extended-release opioids, there is an added concern that ethanol (EtOH) may disrupt the formulation mechanism leading to increased bioavailability of the opioid. Although the combination of EtOH and prescription opioids is frequently cited as having increased ...

Jazz Pharmaceuticals and UCB Announce Second Phase III Study of Sodium Oxybate in Patients With Fibromyalgia Meets Primary Endpoints

...Oxybate Sodium oxybate is the sodium salt form of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient ...

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

...ive support to the life sciences industry in the area of drug metabolism testing. Research has demonstrated that enterohepatic circulation is the mechanism that maintains quantitative whole body homeostasis of arachidonic acid. There is extensive research focused on blocking arachidonic acid metabolism al...

Gene Findings Unlocking Reasons for Neuroblastoma Risk

...1 is a susceptibility gene for neuroblastoma, and perhaps other cancers as well." Maris added that researchers are now working to understand the mechanism by which BARD1 gene variants act on developing nervous system cells to give rise to cancer during fetal or early childhood development. Maris's...

Alfacell Provides Shareholder Update

...r who has published numerous peer reviewed articles regarding the molecular mechanism of Onconase states the following: "We now have compelling evidence from num...veness by Onconase was shown to involve prevention of the induction defense mechanism which generally are triggered by the anticancer drugs and provide resistanc...

Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia

...m Oxybate Sodium oxybate is the sodium salt form of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient ...

Jennerex Therapeutic Research Collaboration With Ottawa Hospital Research Institute Selected for $10 Million Grant From Ontario Institute for Cancer Research

...s target, attack and eradicate cancers through a novel and potent oncolytic mechanism that is dependent on highly-specific replication of the company's poxviruse...taneously stimulate the body's immune response to the cancer. Of note, this mechanism of action and the results in patients to date put the company's product cla...

Research: Popular Diabetes Medications Associated with Increase in Bone Fractures

...ss than one-half of 1 percent (0.44 percent) experienced an episode of acute pancreatitis. Among the 2,143 patients taking sitagliptin, a drug with a mechanism of action related to that of exenatide, acute pancreatitis was identify in only 6 patients (0.28 percent). The rates of pancreatitis were comparable ...

Lupus Foundation of America Fosters the Next Generation of Lupus Researchers by Awarding Gina M. Finzi Memorial Student Summer Fellowships to Five Students

... "Cyclooxygenase 2 and Injury in Neonatal Lupus" Bruce Volpe, Winifred Masterson Burke Medical Research Institute (White Plains, NY) "Putative mechanism of NP-SLE: Toxicity of Anti-DNA Anti-NMDAR Antibody" Maggie Bromberg, Duke University Medical Center (Durham, NC ) "Psychological and Diseas...