Man in Medical Technology

Astrocytes Help Separate Man From Mouse

ROCHESTER, N.Y., March 23 /PRNewswire-USNewswire/ -- A type of brain cell that was long overlooked by researchers embodies one of very few ways in which the human brain differs fundamentally from that of a mouse or rat, according to researchers who published their findings as the cover story in th...

Evotec's EVT 101 Shown to Penetrate the Brain in Man and to Modulate Brain Activity During the Performance of Cognitive Tasks

Single-Dose, Volunteer fMRI Study Completed and Reported Today Dosing in Four Week Higher Repeat Dose Study Completed HAMBURG, Germany and OXFORD, England, March 28 /PRNewswire-FirstCall/ -- Evotec (Frankfurt Stock Exchange: EVT) is pleased to announce the preliminary findings of ...

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

-- ARI-2243 is a highly potent DPP-4 inhibitor being developed for the treatment of Type II diabetes -- ARI-2243 produced a compelling 2.5% reduction in HbA1c in refractory diabetic animal model -- ARI-2243 is a first-in-class "soft drug" conferri...

Debiopharm Group and Mercury Therapeutics, Inc. Sign an Exclusive License Agreement for the Development and Commercialisation of Debio 0930

...efined advanced milestone payments during the development of the compound and a royalty based on net sales of commercialised product. First entry into man is expected for 2012. "We are very enthusiastic about our collaboration with an experienced innovative biotech company like Mercury. Diabetes i...

World's First Cardiac Adult Stem Cell Patient Receives Infusion

...a minimally-invasive cardiac catheterization procedure, which reaches the heart through an artery in the patient's leg. The 66-year-old, self-employed man continues to recover following the outpatient procedure. Mark Slaughter, M.D., Chief of the Division of Cardiothoracic Surgery at UofL and Di...

New Results From ARTEN Study of Nevirapine Plus Tenofovir and Emtricitabine (TDF/FTC) Versus Boosted Protease Inhibitor Regimen of Atazanavir/Ritonavir Plus TDF/FTC Revealed

..., but women and patients who have higher CD4+ counts when they begin VIRAMUNE treatment have a greater risk. A woman with CD4+ >250 cells/mm3, or a man with CD4+ >400 cells/mm3 should not begin taking VIRAMUNE unless they and their HCP have decided that the benefit of doing so outweighs the risk. W...

Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily

...4) and with substantial amounts of alcohol. CIALIS does not protect a man or his partner from sexually transmitted diseases, including HIV. Men shoul...ese events are related directly to the ED tablets or to other factors. If a man has a sudden decrease or loss of vision or hearing, he should stop taking a...

Study Reported Tadalafil Taken Once Daily Improved Erectile Function in Men with ED and Sexual Quality of Life in Couples

...4) and with substantial amounts of alcohol. Cialis does not protect a man or his partner from sexually transmitted diseases, including HIV. Men shoul...ese events are related directly to the ED tablets or to other factors. If a man has a sudden decrease or loss of vision or hearing, he should stop taking a...

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

...unwald E, Sabatine M, Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel. Circulation. 2009 May 19 (2) Myrand SP, Sekiguchi K, man MZ, Lin X, Tzeng RY, Teng CH, Hee B, Garrett M, Kikkawa H, Lin CY, Eddy SM, Dostalik J, Mount J, Azuma J, Fujio Y, Jang IJ, Shin SG, Bleavins MR, Will...

Isis and Collaborators Present New Research at the ATVB Annual Conference

...i-atherotic effect of lowering apoC-III, which we have seen in animals, suggests that lowering apoC-III could produce reductions in atherosclerosis in man as well." Finally, Isis and collaborators reported on the effects of antisense drugs targeting 11 beta-HSD1 and apoF. In a presentation titled ...

Study Results Present Paradigm Shift; REDUCE Trial Shows New Hope for the Risk Reduction of Prostate Cancer

...ction of prostate cancer," said Theresa Morrow of Women Against Prostate Cancer. "Just a little encouragement from a spouse or family member can get a man to the doctor for prostate screening." The REDUCE trial is the first step in a paradigm shift in the way prostate cancer is viewed, changing the ...

Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy

... Cancer Prostate cancer is the most common cancer, excluding skin cancers, and the second leading cause of cancer death in American men. About one man in six will be diagnosed with prostate cancer during his lifetime, and one in 35 will die of this disease.(4) Prostate cancer develops from cells in ...

A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations

...saged. In addition, in the long-term interests of the health of every man in the USA, and with health reform recognized as a national priority, we wi...ort in regard to their health. * We shall continue to encourage every man to discuss his individual risk for prostate cancer with his doctors, and to...

Cancer Research 'David' Hopes to Slay 'Cancer Goliath'

... large animal appears to give the animal lifetime immunity to cancer). Protein-B(LPN) has shown effectiveness on a number of organ sites in both man and animals toward the conquest of cancer without the toxicity normally associated with today's modalities. Please see: www.chaifoundation.org ...

Freezing Prostate Cancer Does a Man's Body Good

...n men currently living with prostate cancer. Older age, African American race and a family history of the disease can all increase the likelihood of a man being diagnosed with the disease. As men increase in age, their risk of developing prostate cancer increases exponentially. An estimated 230,000 new c...

IlluminOss Medical Announces First Human Case Utilizing a Unique, New, Minimally Invasive Technology for Fracture Repair is Performed at Medical Hospital del Trabajadar in Santiago, Chile

...minOss Photodynamic Bone Stabilization System for orthopedic surgery. The IlluminOss Photodynamic Bone Stabilization System was used on a 21 year old man with a fracture of the 5th metacarpal. The metacarpals are the bones that extend from the base of the wrist to the base of each finger at the knuckle...

VIA Pharmaceuticals to Present at American Heart Association Scientific Sessions 2008

...: Cardiovascular Seminar: Translational Trials and Strategies: First in man Title: Three Months of Treatment with 5- Lipoxygenase Inhibitor VIA-2291...: Cardiovascular Seminar: Translational Trials and Strategies: First in man Title: Three Months of Treatment with 5-Lipoxygenase Inhibitor VIA- 2291...

Discharge of First U.S. DuraHeart(TM) Patient

... was discharged home on August 14th, from the University of Michigan Health System, 15 days after receiving the device. The patient is a 62-year-old man from Livonia, Michigan, who has been suffering from heart failure for nearly 20 years. He is the first U.S. patient to receive a ventricular assist sy...

Seventy Years Old and Going Strong With Down Syndrome and No Dementia: The Case of 'Mr. C' Causes Major Interest in the Scientific Community

...r research is published in the June 2008 issue of the journal, Intellectual and Developmental Disabilities. To read "Successful Aging in a 70-Year-Old man With Down Syndrome: A Case Study" by Sharon J. Krinsky-McHale et al., visit http://www.aaidd.org/Reading_Room/pdf/IDDMrCJune2008.pdf . "'Mr. C' pai...

Task Force Says Men Age 75 and Older Should Not Be Screened For Prostate Cancer

... test take years to affect health; most prostate cancers that grow serious enough to cause death take more than 10 years to do so. Since a 75-year-old man has an average life expectancy of about 10 years and is more likely to die from other causes such as heart disease or stroke, prostate cancer screenin...

The ED Conversation Dilemma: Forty Percent of Men with ED Don't Talk to Their Doctor, Survey Finds

...cussing ED ranked as the number one barrier to good communication between a man and his doctor -- mentioned by 74 percent of men with ED who participated i...y. "As a psychologist and sexual medicine specialist, I would encourage any man who thinks he might have ED to talk with a healthcare professional to learn...

Record 'Door-to-Balloon' Time at Presbyterian Hospital of Dallas

... DALLAS, July 15 /PRNewswire-USNewswire/ -- A man suffering a heart attack recently arrived at the Presbyterian Hospital of Dallas ER and was eventually treated with an angioplasty procedure in the ho...

Patient Receives vProtect(TM) Luminal Shield in First-Ever Vulnerable Plaque Clinical Trial

... Professor Patrick W. Serruys successfully placed a vProtect(TM) Luminal Shield in the left anterior descending (LAD) coronary artery of a 64-year-old man at Erasmus Medical Center in Rotterdam. This case marks the start of a pilot study, known as SECRITT I, designed to evaluate the vProtect(TM) Luminal ...

Patient's Own Infection-Fighting T Cells Put Late-Stage Melanoma Into Long-Term Remission - Without Chemotherapy or Radiation

...in the June 19 issue of the New England Journal of Medicine. Yee and colleagues removed CD4+ T cells, a type of white blood cell, from a 52-year-old man whose Stage 4 melanoma had spread to a groin lymph node and to a lung. T cells specific to targeting the melanoma were then expanded vastly in the lab...

Prostate Cancer Treatment Offers Results Without Side Effects

...ther invasive procedure where tiny 'seeds' are implanted that deliver a time-release dose of radiation. Side effects of these treatments often leave a man with impotence, incontinence, fatigue, hot flashes, rectal irritation or damage, diarrhea and blood in the stool. At least 40% of all surgery patients...

Preventing Prostate Cancer and BPH: Prostate-Health Expert Available (National Men's Health Week Is June 9-15)

...n of normal weight at the time of diagnosis. "If a man is obese at the time of diagnosis, he faces a... risk of dying as compared to a normal-weight man with the same diagnostic profile, regardless ...sk of developing BPH and prostate cancer. And if a man is diagnosed with prostate cancer, quitting smokin...

CureDM's Diabetes Therapy Achieves Major Development Milestone

...tide (HIP). CureDM has successfully stabilized HIP to improve its bioavailability with recent dose response studies indicating that the dosage used in man may be as much as 100-fold lower than the native form. HIP is a 14-amino acid human peptide derived from a specific human gene responsible for populat...

Idenix Pharmaceuticals Reports First Quarter 2008 Financial Results

... preclinical pharmacology and toxicology profile of IDX184 demonstrated to date, the company anticipates that the first-in- man clinical trial should be initiated in the second half of 2008. -- Idenix also reported positive preclinical data from its HCV ...

Mayo Clinic Study Identifies Potential Causes of Young-Onset Dementia

...p, age 27, was diagnosed with frontotemporal dementia in 2006. According to his parents, he was an energetic, thoughtful, caring and intelligent young man who graduated from college in 2004 with a double major in business and computers. His symptoms of dementia started around age 21, including withdrawal...

Diagnostic Center for Disease: Prostate Biopsy Spreads Prostate Cancer Cells

...better imaging enables an improved opportunity to diagnose disease while ensuring a better, more predictable outcome. A recent case of a 71-year-old man illustrates the benefit of the 3.0 Telsa MRI -S. In 1997, his PSA was measured at 3.7 ng/ml. Presumed to be normal, the PSA was not tested again until...

IDX899 Demonstrates Rapid and Profound Inhibition of HIV Replication in a Phase I/II Clinical Trial in Treatment-Naive HIV-Infected Patients

...2.01 log(10), or 99 percent, after seven days of treatment. Additionally, two posters detailing the in-vitro resistance and pharmacokinetic profile in man of IDX899 were presented at the 2008 Conference on Retroviruses and Opportunistic Infections (CROI) this week in Boston, MA. "New once-a-day NNRTIs ...

Looking Older? How Square is Your Jaw Line?

...ign of someone's age," said Joel Pessa, MD, ASPS Member Surgeon and study co-author. "Across the board in many cultures, the smaller and more curved a man or woman's jaw line, the younger looking they appear." The authors studied radiographic images of 16 patients (eight men and eight women) taken at...

LAP-BAND(R) System Weight-Loss Surgery Associated With More Than 70 Percent Reduced Risk of Death in People With Severe Obesity

... more for a woman of average height (5' 4") when ideal weight at this height is considered to be 140 pounds, and to a weight of 250 pounds or more for man who is six feet tall when ideal weight for this height is considered to be 177 pounds. About the LAP-BAND(R) System The LAP-BAND(R) System was app...

Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates

...lar, cytokine release, and ADCC tests with humanized Sphingomab were all negative at doses or concentrations well above those expected to be needed in man to provide an anti-angiogenic action. The panel of tests also included a pivotal multiple-dosing 28-day study in Cynomolgus monkeys. This study featu...

New Report Illuminates Ampligen's Unique Mechanism of Action

...pectrum defenses against many types of pathogens. New research shows that these receptors present in virtually all life forms, from mosquitoes to man (in scientific terms, they are remarkably "evolutionarily conserved"). This suggests that TLRs are critical to retaining healthy life in a constantly ...

Positive Final Data from HyCAMP Phase II Trial in Metastatic Colorectal

...eting of drug to the tumour, coupled with the ability of HyCAMP(TM) to deliver more doses due to lower toxicity, has been successfully translated into man with a greater therapeutic benefit to patients in this Phase II trial compared with Camptosar(R)." Dr Smith noted, "Commercially this result is very...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

...f SPC2996 in CLL is the first time an RNA targeted antisense drug containing the potent RNA analogue, Locked Nucleic Acid (LNA), has been evaluated in man for safety and efficacy. SPC2996 was well tolerated and infusions were unproblematic. Dr Henrik Orum, Santaris Pharma's Chief Scientific Officer, comm...

Karo Bio Announces Sucessfule Phase II Results of KB2115

... coating of KB2115 was effective in protecting the compound from chemical modification in the stomach.Thereby, a safety concern for longer exposure in man is removed. The specific results from the KB2115 phase II study will be presented at upcoming international conferences during the year. The phase I...

New Poll Shows Men, Women Incorrectly Blame Symptoms of Low Testosterone on Normal Aging

... The online survey of 2,008 women aged 30 or older (mean age 45.8 years) in a romantic relationship for at least three years (mean 19.8 years) with a man aged 35 to 65 (mean age 48.8 years) was conducted by Harris Interactive on behalf of Spirit of Women, a national coalition that inspires health and we...

PSA TestingHow Much is Too Much?

...logy and lead author of the study published in the October 2004 issue of the Journal of Urology. Our study raises a very serious question of whether a man should even use the PSA test for prostate cancer screening any more, Stamey said. The researchers opinion carries great influence, since it was Stamey...