Lymph in Medical Technology

Northern California Cancer Center's First-of-Its-Kind Research Reveals Low Socioeconomic Status Often Equals Poor Chance of Lymphoma Survival

... and women equally. The cancer involves the body's lymph nodes which fight infection and disease. It begins with an enlargement of the lymph nodes and symptoms can include fever, weight loss,...igue. It is called "follicular" lymphoma because lymph nodes seen under microscopes display unusual round...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

...in the cells of the lymphatic system, which is composed of lymphoid tissue, lymph vessels and lymph fluid that help the body filter out bacteria and fight disease. Since lymph...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

...was 67% and was as high as 98%. Two patients with leukemia cutis had complete or partial clearance of skin lesions. One patient had a 36% reduction in lymph node size, a 28% decrease in spleen size and a significant increase (44%) in hemoglobin. Mild grade 1 or 2 infusion toxicity was observed and there we...

Video: Phase III Study Data With Vandetanib (Zactima(TM)) in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Presented at American Society of Clinical Oncology

...ng cancer accounts for around 85% of all lung cancers(5). If lung cancer is detected at early stages, before it has spread to other organs or lymph nodes, around half of patients can survive for five years or more. However, few lung cancers are found at this early stage and it is normally diagnose...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

...cases and 23 cases were HER-2/neu positive. Scientists found that the increased expression of EZH-2 meant an increase in tumor size and an increase in lymph node metastasis. Dr. Nahleh said that increased identification of proteins in these aggressive forms of breast cancer is needed to develop bette...

BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting

...rapy treatment prior to surgery. Patients who present with tumor containing lymph nodes are particularly difficult to treat and approximately half of these p...ministered by direct injection, at three dose levels, into tumor containing lymph nodes in combination with standard first line chemo radiotherapy every thre...

Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis

...esence or absence of ulceration, and whether the melanoma has spread to the lymph nodes or other organs. For example, if a tumor is less than 1 mm in depth (...s deeper than 1 mm, Dr. Driscoll advised that a procedure known as sentinel lymph node mapping and biopsy should be considered. This procedure has not been s...

Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib

... In RCC, cancer cells develop in the lining of the kidney's tubes and grow into a tumor(8). If left untreated, the tumor can spread to neighboring lymph nodes and eventually other organs(9). RECORD-1 trial The FDA regulatory filing for Afinitor was based on data from RECORD-1 ( RE nal C ell ...

Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis

...usually progresses slowly over many years. In this disease, abnormal white blood cells called B-cells accumulate in the blood and the bone marrow. The lymph nodes, spleen, and other organs may also be affected. Although CLL is the most common form of leukemia in adults in Western countries, little is known...

Video: Zometa(R) Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports

...nter, Phase III study that enrolled 1,803 premenopausal women with estrogen receptor-positive Stage I or II breast cancer, with fewer than 10 axillary lymph nodes involved. Patients were recruited for the study after curative surgery and initiation of goserelin treatment for ovarian suppression, and random...

Three Clinical Studies of bioTheranostics Molecular Breast Cancer Diagnostics Presented at San Antonio Breast Cancer Symposium

...GI(SM) (Molecular Grade Index), two molecular biomarkers that refine and improve risk stratification in patients with estrogen receptor (ER)-positive, lymph node-negative breast cancer. Data presented at the San Antonio meeting this week provide further evidence that the Theros BCI is a valuable to...

RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial

...breast begin growing abnormally and divide more rapidly than healthy cells. The quick division of cells may cause spreading through the breast, to the lymph nodes or to other parts of the body. About RAD001 RAD001, an oral once-daily inhibitor of mTOR, is an investigational drug being studi...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

...ionally immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue and other organs. Roughly 90,000 people in the United States are liv...ionally immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue and other organs. Two types of lymphocytes are present in the blood,...

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

...inappropriate candidates for alemtuzumab due to bulky tumor masses in their lymph nodes (bulky fludarabine refractory; BFR). The primary endpoint of...inappropriate candidates for alemtuzumab due to bulky tumor masses in their lymph nodes. The study design calls for patients to receive eight weekly infusion...

Phase III Trial Results Show Elitek(R) (rasburicase) Significantly Reduced Plasma Uric Acid Levels versus Allopurinol in Adults with Hematologic Cancers at Risk for Tumor Lysis Syndrome

... on REAL classification plus one or more of the following criteria: LDH>2xULN (IU/I), Stage III-IV disease or Stage I-III disease with at least one lymph node/tumor >5 cm. Visit www.elitek.com for more information about Elitek(R). About sanofi-aventis Sanofi-aventis, a le...

The Leukemia & Lymphoma Society and Memgen Announce New Chronic Lymphocytic Leukemia Clinical Trial

... patients with high risk and treatment-resistant CLL. Most importantly, ISF35 was well-tolerated with only minimal side effects, reduced CLL cells and lymph nodes in nearly every patient, and when combined with chemotherapy produced complete or partial remissions in patients with 17p deleted CLL." ...

Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity

...e is also part of the immune system that traps and attacks invading organisms and is a primary route for malignant tumor dissemination to the regional lymph nodes. "The new finding adds to a growing body of evidence showing that some fully differentiated cell types can exhibit great plasticity an...

U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vical's Vaxfectin(R) Adjuvant

...agic fever is a more serious form of disease which can include all of the symptoms of classic dengue fever plus noticeable damage to blood vessels and lymph vessels, bleeding from the nose and gums, and conspicuous bruising under the skin. Dengue hemorrhagic fever can lead to death. The most severe form of...

Young Women Diagnosed with Early-Stage Breast Cancer More Likely to Die than Older Women

...argenthaler, MD, assistant professor of surgery, Washington University School of Medicine, St. Louis, MO, "These are women with similar size tumor and lymph node status. The characteristics of the tumor itself, however, portend a poorer prognosis. "We think we should devote much of our future research to...

Susan G. Komen for the Cure(R) Makes Unprecedented Research and Local Program Grants

...tudying the treatment of patients with advanced breast cancer. The majority of breast cancer deaths arise from the cancer spreading from the breast to lymph nodes and distant sites such as the lung and bone. Once the cancer spreads beyond the breast, the relative five-year survival rate drops from 98 to 26...

Photos: Sentara Joins 4 U.S. Hospitals in International 'TARGIT' Breast Cancer Trial

...ient to receive the single-dose radiation, they must be a candidate for the TARGIT Trial. Other considerations include type of cancer, tumor size, and lymph node involvement. To learn more, call 757-594- 1939 or visit http://www.sentara.com/cancer . ...

Radioactive Seed Therapy Shows Significant Reduction in Lung Cancer Recurrence

...sease, accounting for an estimated 85% of all cases. Stage I NSCLC is characterized by disease that is localized in the lung with no metastasis to the lymph node system. "The standard of care for patients with this particular disease is a lobectomy, or surgical removal of the entire lobe of the lung. Man...

Breast MRI Scan Could Determine Need for Radiation Therapy

... For women whose breast cancer has spread to their lymph nodes, a magnetic resonance imaging (MRI) scan cou...rgically based findings of cancer having spread to lymph nodes. This suggests that breast MRI could help de...rm the surgery to remove the cancer and sample the lymph nodes, you reduce your ability to know whether the...

Genomic Health Announces Data Supporting Use of Oncotype DX(R) to Accurately Assess HER2 Gene Expression in Breast Cancer Patients

...ent -- between central IHC and quantitative RT-PCR using Oncotype DX for determining HER2 status. The study analyzed 755 patients with 0 to 3 positive lymph nodes who were enrolled in Intergroup study E2197, a large adjuvant breast cancer trial evaluating two different chemotherapy regimens. The second s...

Alexion Secures U.S. Patent for ALXN6000, a First-In-Class Anti-CD200 Monoclonal Antibody

... body. (3) B-cell CLL is characterized by clonal expansion of abnormal B lymphocytes. Patients with CLL also may develop enlargement of the spleen and lymph nodes, and pancytopenia (depletion of red and white blood cells and platelets), ultimately resulting in hemorrhage, infection and death. (4) About A...

Genmab and GlaxoSmithKline Announce Positive Top-Line Results in Ofatumumab Chronic Lymphocytic Leukemia Pivotal Study

...idered inappropriate candidates for alemtuzumab due to bulky tumor in their lymph nodes. An objective response rate of 51% (p<0.0001) consisting of 30 partia...idered inappropriate candidates for alemtuzumab due to bulky tumor in their lymph nodes. All patients in the study receive 8 weekly infusions of ofatumumab, ...

Bioimpedance Spectroscopy is More Accurate and Reliable Than Other Methods of Subclinical Assessment of Lymphedema in Breast Cancer Patients, According to Paper Published in Journal of Clinical Oncology

...oximately 87 percent of the patients had undergone lymph node dissection, 70 percent had received radiation...nd lower extremities due to the build-up of excess lymph fluid. This can occur when the lymphatic system, w...ur after surgery, such as removal or biopsy of the lymph nodes, and/or radiation therapy. It is estimated t...

Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

...bservation only (n=629) within 70 days of regional lymph node dissection (intent-to-treat population). The ...unced in patients with a lower tumor burden in the lymph nodes based on predefined subgroups. For the subgr...atients with clinically non-palpable (microscopic) lymph node disease, the HR for RFS was 0.73 (99 percent ...

Results Published in the Journal 'Cancer' Demonstrate that Oral Talactoferrin Alfa is Active as Monotherapy in Previously Treated Patients with Metastatic Renal Cell Carcinoma

...e immune response mediated by anti-cancer Natural Killer (NK) cells, CD8+ lymphocytes and NK-T cells. This results in the activation of tumor-draining lymph nodes, cellular infiltration of distant tumors and tumor-cell death. Mounting the initial immune response in the GALT -- away from the primary tumor a...

The Leukemia & Lymphoma Society and Memgen Collaborate on CLL Clinical Trial

...rda, M.D., Ph.D., at The University of Texas M. D. Anderson Cancer Center, a single infusion of ISF35 resulted in the rapid decline in circulating and lymph node bound leukemic cells, induced long-term immune based responses against these cells and sensitized them to standard chemotherapies, even in severa...

Genetic Immunity to Present at 2008 BIO International Convention

...gy that includes disease-specific plasmid DNA encoded antigens. DermaPrep is the topical administration device that delivers NanoComp into a patient's lymph node dendritic cells to induce T cell mediated immune responses that can treat a broad spectrum of diseases. These two components together make up the...

Published Guidelines Further Support Use of Bioimpedance Measurement Technology for Early Assessment of Lymphedema

...t swelling of the upper and lower extremities due to the build-up of excess lymph fluid. This can occur when the lymphatic system, which is responsible for d...er patients, this can occur after surgery, such as removal or biopsy of the lymph nodes, and/or radiation therapy. It is estimated that 6 percent to 40 perce...

Preliminary Phase 2 Results of R788 in Lymphoma Show Benefit in Diffuse Large B-Cell and SLL/CLL

...ease. Diffuse large B-cell lymphoma is the most common type of NHL and is generally categorized as aggressive, marked by rapidly growing tumors in the lymph nodes, spleen, liver, bone marrow and other organs. A variety of treatment options exist, including chemotherapy and radiation, but the five-year su...

Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytren's Contracture

...d pain, swelling, bruising and pruritis at the injection site and transient lymph node swelling and pain. In over 2,000 XIAFLEX injections administered in ap...e pain, swelling, bruising and pruritis at the injection site and transient lymph node swelling and pain. These adverse events were consistent with previous ...

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

...elopment of better drugs to treat metastatic disease -- cancer that has spread beyond the prostate to distant sites throughout the body, such as bone, lymph nodes and internal organs. "So far we've targeted systemic, or circulating, androgens in men with advanced prostate cancer," Mostaghel said. "What t...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

...breast begin growing abnormally and divide more rapidly than healthy cells. The quick division of cells may cause spreading through the breast, to the lymph or to other parts of the body. About RAD001 RAD001, an oral inhibitor of mTOR, is an investigational drug being studied in multiple tumor types. I...

Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO

...sually appears at a younger age, while dietary iodine deficiency and radiation exposure are risk factors for the sporadic form. MTC may metastasize to lymph nodes or other organs before it is ever diagnosed. Additionally, MTC does not take up radioactive iodine, which is commonly used to treat other types ...

Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer

...nter, Phase III study that enrolled 1,803 premenopausal women with estrogen-receptor-positive Stage I or II breast cancer, with fewer than 10 axillary lymph nodes involved. Patients were recruited for the study after curative surgery and initiation of goserelin treatment for ovarian suppression, and random...

Long-Term Followup in Phase 3 CLL Trial Shows Genasense(R) is Associated with Significantly Increased Survival in All Responders

...that may progress over a period of years, ultimately producing a generalized depression of immunity, marked increases in the size of spleen, liver and lymph nodes, and impaired production of other normal blood cells. Eventually, these problems may cause life-threatening complications, such as overwhelming ...

TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)

...ed to the intervention. Immune-related reactions consisted of transient flu-like symptoms in two patients, redness and swelling of a tumor-infiltrated lymph node and one metastatic chest nodule, and acute flank pain in one patient with adrenal gland metastasis. Analysis of efficacy in biopsied tumor specim...