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Hormone in Medical Technology

TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men

PHOENIX, Aug. 3 /PRNewswire-USNewswire/ -- The Phoenix-based Kronos Longevity Research Institute (KLRI) has published two new publications on hormone therapies and their effects on reducing the risks of cardiovascular disease in older adults. Cardiovascular disease caused by ...

Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP

- Single Injection in Primates Containing 1,000-Times the Dosage Recommended for Humans Shows No Adverse Effects - - Half-Life and AUC Support the Potential for Weekly or Bi-Monthly Dosing Frequency - NES-ZIONA, Israel, Jan. 15 /PRNewswire-FirstCall/ -- Modigene Inc. (OTC Bulletin Board:...

Emisphere Technologies Announces the Launch of a Human Clinical Trial For Oral Parathyroid Hormone (PTH)

Phase I Study to Explore the Effects of Eligen(R) Delivery Technology on Healthy Postmenopausal Women CEDAR KNOLLS, N.J., June 30 /PRNewswire-FirstCall/ -- Emisphere Technologies, Inc. (Nasdaq: EMIS ) announced today that Novartis Pharma AG has launched a Phase I study in...

Poniard Announces Positive First-Line Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in Patients with Metastatic Hormone Refractory Prostate Cancer

- Poster Presented at ASCO Annual Meeting - SOUTH SAN FRANCISCO, Calif. and CHICAGO, May 31 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on oncology, today presented preliminary safety and efficacy data from its ong...

Medivation's MDV3100 Demonstrates Substantial PSA Reductions in First Patient Groups Treated in Phase 1-2 Hormone Refractory Prostate Cancer Trial

- Early study data from the two lowest dose groups show dose-dependent PSA declines to date in all patients - - Conference call to be held today at 8:30 A.M. Eastern time - SAN FRANCISCO, Nov. 5 /PRNewswire-FirstCall/ -- Medivation, Inc. (Nasdaq: MDVN ) today announced th...

Obesity-Related Hormone is Higher in Children with Down Syndrome

PHILADELPHIA, Oct. 26 /PRNewswire-USNewswire/ -- Children with Down syndrome are more likely than their unaffected siblings to have higher levels of a hormone associated with obesity, according to pediatric researchers. The hormone, leptin, may contribute to the known higher risk of obesity am...

Doctors Outraged Over Growth Hormone Controversy

Two anti-aging preventative medicine doctors say they are outraged over recent media coverage about their advocacy of prescribing human growth hormone to treat a hormone deficiency often associated with aging. DAYTONA BEACH, Fla., April 27, 2007 /PRNewswire/ -- The adult use of human growth hormon...

Debiopharm Group and Mercury Therapeutics, Inc. Sign an Exclusive License Agreement for the Development and Commercialisation of Debio 0930

...ction by Katan Associates. About Diabetes Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. The cause of diabetes continues to be a mystery, although ...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

...osed indications of treatment and prevention of osteoporosis in postmenopausal women, and treatment and prevention of bone loss in patients undergoing hormone ablation for prostate or breast cancer. The Prolia(TM) trade name is only for these indications and may not apply for other indications of denosumab. ...

Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

...u notice that you are gaining weight, please notify your doctor. INVEGA((R)) SUSTENNA(TM) and similar medicines can raise the blood levels of a hormone called prolactin and blood levels of prolactin remain high with continued use. This may result in some side effects including missed menstrual periods...

Is Your Hair Taking a Break?

...for male-pattern hair loss) for women of non-childbearing age only, and the anti-androgens spironolactone and flutamide that work by blocking the male hormone testosterone at the cellular level of the hair follicle. These oral medications also may be an option for women who may not want to spend time applyin...

Estrogen Getting Cool Reception From Dermatologists for Mixed Results in Improving Appearance of Skin

...July 29 /PRNewswire-USNewswire/ -- For many women, hormone replacement therapy (HRT) can alleviate the physic... and vaginal changes -- physicians often prescribe hormone replacement therapy (HRT) to boost the body's estr... For example, one study examined whether low-dose hormone therapy improved aging skin in 485 women who were ...

Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations

...sterone to the level of castration in adult men suffering from sexual deviations. Developed by Debiopharm, Moapar(R) contains a gonadotropin-releasing hormone (GnRH) agonist analogue. "We are very pleased that Swissmedic has recognised the potential of treatment of sexual deviations with Moapar(R)," s...

Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations

...sterone to the level of castration in adult men suffering from sexual deviations. Developed by Debiopharm, Moapar(R) contains a gonadotropin-releasing hormone (GnRH) agonist analogue. "We are very pleased that Swissmedic has recognised the potential of treatment of sexual deviations with Moapar(R)," s...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

...of ERb selective compounds compared to the natural hormone estradiol, which non-selectively regulates both ER...te a number of genes differently than estradiol, a hormone therapy commonly used to treat women's health issu...ists might be safer than current estrogens used in hormone therapy. The study also demonstrates the cell type...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

...osed indications of treatment and prevention of osteoporosis in postmenopausal women, and treatment and prevention of bone loss in patients undergoing hormone ablation for non-metastatic prostate or breast cancer, for which denosumab is administered twice yearly subcutaneously at a 60 mg dose. The Prolia(T...

New Data Supports Significant Economic and Clinical Value of MENOPUR(R) in IVF

...MG) offered considerable cost-savings over recombinant follicle stimulating hormone (rFSH).[1] The cost-effectiveness of HP-hMG compared with rFSH suggested by...afety of highly purified menotropin versus recombinant follicle-stimulating hormone in in vitro fertilization/intracytoplasmic sperm injection cycles: a random...

Vantia Therapeutics' Lead Candidate VA106483 Demonstrates Positive Anti-diuretic Effect in Phase IIa Trial in Nocturia

...ly 10% of these believed to be receiving any kind of treatment, it is a clear area of unmet medical need estimated to be worth in excess of $500m. The hormone vasopressin is involved in the regulation of the body's water content and as a vasopressin agonist VA106483 has been shown to act as an anti-diuretic....

Sanofi-aventis Stands Behind the Safety of Lantus(R)

...cientific experts. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the d...

Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

...central nervous system (CNS). Despite radiation's success in treating ALL, it produces side effects that include second cancers, stunted growth, hormone imbalances and cognitive deficits. Optimized use of anticancer drugs, especially those instilled directly into the spinal fluid, have enabled clinicia...

Salvacyl(R), Developed by Debiopharm, is Launched in two European Countries

...The effective commercial launch will take place in a couple of months. Salvacyl(R) contains the active substance triptorelin, a gonadotropin releasing hormone (GnRH) agonist analogue. The product will be prescribed for the reversible reduction of serum testosterone to the level of castration in order to lowe...

New Bisphenol A Study Is of Very Limited Relevance to Human Health

...tudy, "Neonatal bisphenol A exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin releasing hormone neurons," was funded by NIEHS and published online June 17 by the journal Biology of Reproduction. The study was co-authored by Heather B. Patisaul an...

Neurocrine Biosciences Presents Elagolix Data

...sciences. "An orally active gonadotropin releasing hormone antagonist with no long-term bone risk would be a ...orward in the treatment of endometriosis and other hormone dependent diseases. These safety results support s... to examine the impact of a gonadotropin releasing hormone (GnRH) antagonist on prostate tissue. The animal m...

When It Comes to Natural Remedies for Hormonal Balance, the Proof Is in the Clinical Research

... Femmenessence: Proven to Regulate hormone Levels in Women SAN FRANCISCO, June 12 /PRNew...pproaching and exiting menopause are in a bind. As hormone levels fluctuate and decline, they experience a ra...are limited. Researchers reported in 2002 that the hormone replacement therapy Prempro(R), which introduces f...

The Lancet Publishes Direct Comparison Study Between Liraglutide and Exenatide

...k has a leading position within areas such as hemostasis management, growth hormone therapy and hormone replacement therapy. Novo Nordisk manufactures and markets pharmaceutical ...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

... the first and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pan...

Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009

... the first and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pan...

Two-Year Data Show Investigational Drug Liraglutide More Effective at Lowering Blood Sugar Than Glimepiride: Oral 162

...k has a leading position within areas such as hemostasis management, growth hormone therapy and hormone replacement therapy. Novo Nordisk manufactures and markets pharmaceutical ...

Studies Show AFRESA(R) Controls Post-Meal Sugar Levels With Less Weight Gain and Hypoglycemia Risk for Diabetes Patients

....S., or 8 percent of the population, is characterized by the body's inability to properly regulate levels of blood glucose, or blood sugar. Insulin, a hormone produced by the pancreas, normally regulates the body's glucose levels, but in people with diabetes insufficient levels of insulin are produced (type ...

New Study Showed Lantus(R) Plus One, Two or Three Shots of Apidra(R) Lowered Patients' Blood Sugar

...reat population. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the d...

AFRESA(R) Phase 3 Pulmonary Function Safety Data in Patients with Diabetes Presented at ADA

....S., or 8 percent of the population, is characterized by the body's inability to properly regulate levels of blood glucose, or blood sugar. Insulin, a hormone produced by the pancreas, normally regulates the body's glucose levels, but in people with diabetes insufficient levels of insulin are produced (type ...

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

...nly a promising medication for men with CRPC, but that it may also be useful earlier in the disease state, for patients whose prostate cancer is still hormone sensitive." The data were presented by Dr. Scher in an oral session at the American Society of Clinical Oncology's (ASCO) 2009 Annual Meeting in ...

Results and Additional Analyses From Study Show That Corthera's Relaxin for Acute Heart Failure is the Strongest Predictor of Improved Longer-Term Outcomes Following Hospital Discharge When Compared to Other Variables

... agents have been associated with renal impairment, hypotension and adverse outcomes. About Relaxin Relaxin is a naturally occurring peptide hormone that acts as a systemic and renal vasodilator. Elevated levels of relaxin modulate increases in renal and cardiac function that meet the increased hem...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... a promising new therapeutic target for aggressive hormone receptor negative breast cancer tumors. (Logo...rget." Karmanos scientists tested 84 cases of hormone receptor negative human breast carcinomas and disc... EZH-2 was expressed in 74 percent of those cases. hormone receptor negative breast carcinoma is considered a...

Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women

... cancer patients had higher mean expression of the hormone receptor genes, likely due to the different hormon...res of triple-negative breast cancer compared with hormone receptor-positive disease, as well as the genotypi...in gene expression between the triple negative and hormone receptor positive groups, including genes for whic...

Results and Additional Analyses From Efficacy and Safety Study of Corthera's Relaxin in Acute Heart Failure to be Presented at Heart Failure Congress 2009

...HF study will also be presented from 8:30 a.m. to 12:30 p.m. CET on Monday, June 1. About Relaxin Relaxin is a naturally occurring peptide hormone that acts as a systemic and renal vasodilator. Elevated levels of relaxin modulate increases in renal and cardiac function that meet the increased hem...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...(R) [letrozole tablets] vs. tamoxifen) found that postmenopausal women with hormone receptor-positive early breast cancer taking adjuvant Femara had better ove...tion, octreotide substantially reduces and in many cases can control growth hormone and/or normalize IGF-1 levels in patients with acromegaly, a disease caused...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

...he bathroom a lot, or feeling weak or hungry, contact your doctor. RISPERDAL(R) CONSTA(R) and similar medications can raise the blood levels of a hormone known as prolactin, causing a condition known as hyperprolactinemia. Blood levels of prolactin remain elevated with continued use. Some side effects...

Type 2 Diabetes: An Epidemic Among America's Youth

...ysicians whose advanced, specialized training enables them to be experts in the care of endocrine diseases such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis, cholesterol disorders, hypertension and obesity. ...

Taking a Hard-Line Approach to Cardiovascular Risks in the Diabetes Patient

...hysicians whose advanced, specialized training enables them to be experts in the care of endocrine disease such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis, cholesterol disorders, hypertension and obesity. ...
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