Genes in Medical Technology

ADHD Genes Found; Known to Play Roles in Neurodevelopment

-- Missing DNA Segments May Suggest Future Drug Targets -- PHILADELPHIA , June 23 /PRNewswire-USNewswire/ -- Pediatric researchers have identified hundreds of gene variations that occur more frequently in children with attention-deficit hyperactivity disorder (ADHD) than in children without ...

Mutant Genes in High-Risk Childhood Leukemias Identified

Results of collaborative study could lead to development of new diagnostic tools and a new therapeutic target in high-risk disease MEMPHIS, Tenn., May 19 /PRNewswire-USNewswire/ -- A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblas...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

-Findings Suggest Biological Reasons for Altered Early Neural Development- PHILADELPHIA, April 28 /PRNewswire-USNewswire/ -- A research team has connected more of the intricate pieces of the autism puzzle, with two studies that identify genes with important contributions to the disorder. One ...

Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol

SAN DIMAS, Calif., Jan. 25 /PRNewswire/ -- A red wine resveratrol (rez-vair-ah-trawl) pill is edging closer to being confirmed as an anti-aging pill as researchers at LifeGen Technologies in Madison, Wisconsin, who were recently interviewed on CBS-TV's 60 MINUTES, reported this past September that...

Cepheid Announces CE IVD Release of First On-Demand Test for van A/van B Genes Most Associated With Hospital-Acquired VRE Infection

CE IVD Menu Expanded to Eight On-Demand Tests for Use on the GeneXpert(R) System SUNNYVALE, Calif., Oct. 7 /PRNewswire-FirstCall/ -- Cepheid (Nasdaq: CPHD) today announced the release of Xpert(TM) vanA/vanB as a European CE IVD Mark product under the European Dir...

New Genes Found for Inflammatory Bowel Disease in Children

- Finding May Refine Drug Targets for Personalized Treatments - PHILADELPHIA, Aug. 31 /PRNewswire-USNewswire/ -- Researchers have discovered two new genes that increase the risk of developing inflammatory bowel disease (IBD) in childhood. While further study is needed to identify the spe...

NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression

Free, Public Event Provides Findings That Include Important Clues Toward the Development of Customized Treatment GREAT NECK, N.Y., May 30 /PRNewswire-USNewswire/ -- New findings from research supported by NARSAD, the world's leading charity dedicated to mental health research, and conducted ...

Research Team Clones Genes Responsible for Amino Acid Absorption

MORGANTOWN, W.Va., May 23 /PRNewswire-USNewswire/ -- Researchers at the West Virginia University School of Medicine have discovered ways to block substances that interfere with absorption of nutrients in patients with inflammatory bowel disease (IBD), according to Uma Sundaram, M.D., Section C...

Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines

OMAHA, Neb., April 30 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO), a global genetic analysis and services company, today announced the National Cancer Institute had approved a proposal to perform mutational analysis and sequencing of the mitochondrial genes in the N...

Genomic Health Announces Identification of Genes Associated With Colon Cancer Recurrence Across Multiple Studies

- Studies Presented at ASCO GI: American Society of Clinical Oncology Gastrointestinal Cancers Symposium to be Used in Selecting Final Genes for Colon Cancer Test - REDWOOD CITY, Calif., Jan. 28 /PRNewswire-FirstCall/ -- Genomic Health, Inc. (Nasdaq: GHDX ) today an...

Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus

NEW YORK, Jan. 20 /PRNewswire-USNewswire/ -- A landmark genetic study has identified multiple genes linked to systemic lupus erythematosus (SLE), or lupus, a debilitating autoimmune disease that affects an estimated 1.4 million Americans. Lupus can affect the joints, kidneys, heart, lungs, b...

National Jewish, Brigham and Women's Awarded $37 Million to Identify Genes and Other Risk Factors that Influence the Development of COPD

DENVER, Oct. 10 /PRNewswire-USNewswire/ -- Researchers from National Jewish Medical and Research Center and Brigham and Women's Hospital have been awarded a $37 million grant from the National Heart Lung and Blood Institute (NHLBI) to lead the most comprehensive study of chronic obstructive pu...

Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes

BOSTON, Oct. 30 /PRNewswire-USNewswire/ -- Four novel genes that may significantly increase the risk of the most common form of late-onset Alzheimer's have been identified by researchers at Massachusetts General Hospital and Harvard Medical School, as reported in the November 7th issue of Amer...

deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes

New risk variants published today will also be folded into deCODEme(TM) REYKJAVIK, Iceland, Feb. 10 /PRNewswire-FirstCall/ -- deCODE genetics (Nasdaq: DCGN ) today announced the launch of deCODE PrCa(TM), a reference laboratory test for common, single-letter variations in the human genome (SN...

NIDA Study Identifies Genes That Might Help Some People Abstain from Smoking

Findings Move Science Closer to Targeted, Improved Therapies BETHESDA, Md., April 2, 2007--Scientists supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have for the first time identified genes that might increase a person's ability to abstain fr...

NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans

BETHESDA, Md., June 11, 2007--A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. These genes, and...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...ranted a conditional marketing authorization for Vectibix as monotherapy for the treatment of patients with EGFR-expressing mCRC with wild-type KRAS genes after failure of standard chemotherapy regimens. Vectibix has been launched in over 20 countries, Switzerland, Australia and Canada. Applications in t...

Juvenile Diabetes Research Foundation, The Genomics Institute of the Novartis Research Foundation Announce Innovative Diabetes Drug Discovery and Development Partnership

...chnologies cut across the life sciences, and include genomics and proteomics tools, medicinal chemistry, cell-based ultra high throughput screening of genes or compounds, structural genomics, and forward/reverse mammalian genetics. The mission of the Institute is to exploit these technologies to ide...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

...echnique for 'knocking out,' or mutating, specific genes to understand their function," said Howard Jacob, ...k out an inserted reporter gene and two native rat genes without causing measurable effects on other genes....ly 90 percent of the rat's 25,000-30,000 estimated genes are analogous to those in humans and mice, and the...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

...which non-selectively regulates both ERa and ERb . The most significant finding in the study was that the ERb-selective compounds regulate a number of genes differently than estradiol, a hormone therapy commonly used to treat women's health issues. This discovery indicates that ERb agonists might be safer ...

Ipsogen Reports Incorporation of the Genomic Grade in the 2009 St. Gallen International Consensus Meeting on the Primary Treatment of Early Breast Cancer

...d by proliferation. MapQuantTM Genomic Grade is available to European oncologists and pathologists. The genomic grade test analyzes a set of 97 genes to precisely quantify the proliferation potential of the tumor, and has been validated in several studies, covering more than 2 800 tumor samples. Map...

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

... development. Five of the SNPs are located very closely together in the Major Histocompatibility Complex, a region on chromosome 6 densely packed with genes regulating immune response. This lends support to previous research suggesting a possible environmental link between schizophrenia immune response. It...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

...strated the successful knockout of two preselected genes in a Chinese hamster ovary (CHO) cell line. The mi...tandard technology for specifically editing target genes in mammalian cells," stated Philip Gregory, D. Phi...e rapid generation of cell lines in which multiple genes have been knocked out. Our proven ability to quic...

More Gene Mutations Linked to Autism Risk

...r extra copies of DNA segments - were found in the genes of children with autism spectrum disorders (ASDs),... Philadelphia. This study also uncovered two novel genes in which variations were found, BZRAP1 and MDGA...respectively. Interestingly, key variants of these genes were transmitted in some, but not all, of the affe...

Gene Findings Unlocking Reasons for Neuroblastoma Risk

...ladelphia, found that an inherited CNV located at chromosome 1q21.1 is associated with neuroblastoma. The chromosome region contains a large family of genes that are involved in the development of the nervous system, and the CNV they discovered changes how much of one particular gene is made within normal ...

Alfacell Provides Shareholder Update

...wn that there are specific chemotherapy resistance genes which not only are present in untreated mesothelio... reaction, measured the levels of the MDR and nfkB genes after treatment with the drug. Striking decreases in all of these genes in the mesothelioma cell lines were seen after tre...

Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women

...between the triple negative and hormone receptor positive groups, including genes for which targeted agents are currently being evaluated in the clinical env...say for prediction of recurrence in stage II colon cancer: Selection of the genes in 4 large studies and results of the independent, prospectively-designed Q...

New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer

...008, Maris led a study that was the first to identify the gene location at which neuroblastoma originates. His laboratory continues to investigate how genes contribute to the disease, using that knowledge to devise new treatments. Maris served as an oncologist for Alex Scott, the child with neuroblas...

Mayo Researchers Help Discover Genetic Cause for Primary Biliary Cirrhosis

...hat variants of two genes, interleukin 12A (IL12A) and interleukin 12RB2 (IL12RB2), were strongly associated with primary biliary cirrhosis. These two genes constitute a pathway of the immune system. Potential therapeutic manipulation of this pathway provides new possibilities for more effective treatments...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

...ogether also plays an important role in regulating genes in humans. When gene regulation is disrupted...milies and patients, better knowledge of how those genes perturb normal development may enable researchers ...wer, as the first study in human cells to identify genes that are dysregulated when cohesin doesn't work pr...

Getting More From Whole-Transcript Microarrays

...hat are functionally distinct. Almost 90% of human genes are now considered to exhibit alternative splicing...s. The approach can only be used in well-annotated genes and can detect differential splicing involving mul...uggested that it should work particularly well for genes containing few exons, since for these...

First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology

...tely 400 million base pairs in size, similar to the size of the rice genome. The teams are now working on annotating the genome to identify particular genes of interest and to discover genetic variations for use in marker assisted breeding. The teams are also applying traditional breeding tools, as well as...

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

...at are responsible for converting prasugrel into its active form(2). In the substudy, researchers examined how variation in cytochrome P450 (CYP) genes affected the response to prasugrel. In prasugrel-treated patients with acute coronary syndromes (ACS) who underwent an artery-opening procedure known...

Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II

... complement activation can have destructive consequences. Over the past three years, multiple scientific publications have strongly linked variants of genes encoding components of the complement system with a predisposition toward AMD. POT-4 binds tightly to complement component C3, preventing its par...

Optherion Announces Issuance of Canadian Patents Covering Age-Related Macular Degeneration Diagnostics and Treatments

...the predisposition to AMD by screening for genetic modifications in several genes including complement factor H (CFH), complement factor B (CFB), complement ...y technologies are based on landmark scientific discoveries linking certain genes to AMD. ...

Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin

...it binds to the minor grooves located in the DNA double helix. To identify genes associated with cellular response to brostallicin, a high-throughput RNA in...nd confirmed in breast cancer cell lines, wherein the knockdown of specific genes involved in these concepts, mentioned above, resulted in an increased respo...

Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier

...motherapy or radiation treatment, some patients' tumors may turn on certain genes as a strategy by the tumor to adapt to the therapy and become resistant to ...NA-damaging chemotherapy or radiation, tumors will often turn on DNA repair genes such as RAD51 as an adaptive strategy to help the tumor repair the DNA dama...

Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research

...ing colon-cancer prevention and inflammatory bowel disease. The company designed its powerful tkRNAi technology to deactivate specific disease-causing genes safely and effectively, using non-pathogenic bacteria as an engine to produce and deliver RNAi directly into cells. It is based on ground-breaking sci...

Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis

...ated over 1,200 Korean and Japanese female subjects. Predisposition for vertebral fracture and elevated bone biomarkers were investigated in candidate genes linked to osteoporosis, with statistical adjustments made for known risk factors such as age, body mass index and drug treatment. The research found K...

ExonHit Reports Proof-of-Concept in Breast Cancer Diagnostic Using its SpliceArray(TM) Platform

...an Genome Wide SpliceArray(TM) biochips which profile close to 21,000 human genes associated to 140,000 RNA splice events have been used in the Company's bio...logical functions. Current predictions suggest that as many as 80% of human genes exhibit some form of alternative splicing. Given the large contribution of ...