ADHD Genes Found; Known to Play Roles in Neurodevelopment
-- Missing DNA Segments May Suggest Future Drug Targets --
PHILADELPHIA , June 23 /PRNewswire-USNewswire/ -- Pediatric researchers have identified hundreds of gene variations that occur more frequently in children with attention-deficit hyperactivity disorder (ADHD) than in children without ...
Mutant Genes in High-Risk Childhood Leukemias Identified
Results of collaborative study could lead to development of new diagnostic tools and a new therapeutic target in high-risk disease
MEMPHIS, Tenn., May 19 /PRNewswire-USNewswire/ -- A research team has pinpointed a new class of gene mutations, which identify cases of childhood acute lymphoblas...
Autism Genes Discovered; Help Shape Connections Among Brain Cells
-Findings Suggest Biological Reasons for Altered Early Neural Development-
PHILADELPHIA, April 28 /PRNewswire-USNewswire/ -- A research team has connected more of the intricate pieces of the autism puzzle, with two studies that identify genes
with important contributions to the disorder. One ...
Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol
SAN DIMAS, Calif., Jan. 25 /PRNewswire/ -- A red wine resveratrol (rez-vair-ah-trawl) pill is edging closer to being confirmed as an anti-aging pill as researchers at LifeGen Technologies in Madison, Wisconsin, who were recently interviewed on CBS-TV's 60 MINUTES, reported this past September that...
Cepheid Announces CE IVD Release of First On-Demand Test for van A/van B Genes Most Associated With Hospital-Acquired VRE Infection
CE IVD Menu Expanded to Eight On-Demand Tests for Use on the GeneXpert(R) System
SUNNYVALE, Calif., Oct. 7 /PRNewswire-FirstCall/ -- Cepheid (Nasdaq:
CPHD) today announced the release of Xpert(TM) vanA/vanB as a European CE
IVD Mark product under the European Dir...
New Genes Found for Inflammatory Bowel Disease in Children
- Finding May Refine Drug Targets for Personalized Treatments -
PHILADELPHIA, Aug. 31 /PRNewswire-USNewswire/ -- Researchers have
discovered two new genes
that increase the risk of developing inflammatory
bowel disease (IBD) in childhood.
While further study is needed to identify the spe...
NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression
Free, Public Event Provides Findings That Include Important Clues
Toward the Development of Customized Treatment
GREAT NECK, N.Y., May 30 /PRNewswire-USNewswire/ -- New findings from
research supported by NARSAD, the world's leading charity dedicated to
mental health research, and conducted ...
Research Team Clones Genes Responsible for Amino Acid Absorption
MORGANTOWN, W.Va., May 23 /PRNewswire-USNewswire/ -- Researchers at the
West Virginia University School of Medicine have discovered ways to block
substances that interfere with absorption of nutrients in patients with
inflammatory bowel disease (IBD), according to Uma Sundaram, M.D., Section
Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines
OMAHA, Neb., April 30 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC
Bulletin Board: TBIO), a global genetic analysis and services company,
today announced the National Cancer Institute had approved a proposal to
perform mutational analysis and sequencing of the mitochondrial genes
Genomic Health Announces Identification of Genes Associated With Colon Cancer Recurrence Across Multiple Studies
- Studies Presented at ASCO GI: American Society of Clinical Oncology
Gastrointestinal Cancers Symposium to be Used in Selecting Final Genes
for Colon Cancer Test -
REDWOOD CITY, Calif., Jan. 28 /PRNewswire-FirstCall/ -- Genomic Health,
Inc. (Nasdaq: GHDX ) today an...
Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus
NEW YORK, Jan. 20 /PRNewswire-USNewswire/ -- A landmark genetic study
has identified multiple genes
linked to systemic lupus erythematosus (SLE),
or lupus, a debilitating autoimmune disease that affects an estimated 1.4
Lupus can affect the joints, kidneys, heart, lungs, b...
National Jewish, Brigham and Women's Awarded $37 Million to Identify Genes and Other Risk Factors that Influence the Development of COPD
DENVER, Oct. 10 /PRNewswire-USNewswire/ -- Researchers from National
Jewish Medical and Research Center and Brigham and Women's Hospital have
been awarded a $37 million grant from the National Heart Lung and Blood
Institute (NHLBI) to lead the most comprehensive study of chronic
Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes
BOSTON, Oct. 30 /PRNewswire-USNewswire/ -- Four novel genes
significantly increase the risk of the most common form of late-onset
Alzheimer's have been identified by researchers at Massachusetts General
Hospital and Harvard Medical School, as reported in the November 7th issue
deCODE Launches a DNA-Based Test for Assessing Risk of Prostate Cancer on the Back of the Discovery of New Prostate Cancer Genes
New risk variants published today will also be folded into deCODEme(TM)
REYKJAVIK, Iceland, Feb. 10 /PRNewswire-FirstCall/ -- deCODE genetics
(Nasdaq: DCGN ) today announced the launch of deCODE PrCa(TM), a reference
laboratory test for common, single-letter variations in the human genome
NIDA Study Identifies Genes That Might Help Some People Abstain
Findings Move Science Closer to Targeted, Improved Therapies
BETHESDA, Md., April 2, 2007--Scientists supported by the
National Institute on Drug Abuse (NIDA), part of the National
Institutes of Health, have for the first time identified genes
might increase a person's ability to abstain fr...
NCI Researchers Discover Genes That Are Turned on at High Levels in
Tumor-associated Blood Vessels of Mice and Humans
BETHESDA, Md., June 11, 2007--A team of researchers at the
National Cancer Institute (NCI), part of the National Institutes of
Health (NIH), has uncovered a set of genes
that are turned on, or
expressed, at high levels only in the blood vessels that feed
tumors in mice and humans. These genes, and...
Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer
...ranted a conditional marketing authorization for Vectibix as monotherapy for the treatment of patients with EGFR-expressing mCRC with wild-type KRAS genes
after failure of standard chemotherapy regimens. Vectibix has been launched in over 20 countries, Switzerland, Australia and Canada. Applications in t...
Juvenile Diabetes Research Foundation, The Genomics Institute of the Novartis Research Foundation Announce Innovative Diabetes Drug Discovery and Development Partnership
...chnologies cut across the life sciences, and include genomics and proteomics tools, medicinal chemistry, cell-based ultra high throughput screening of genes
or compounds, structural genomics, and forward/reverse mammalian genetics.
The mission of the Institute is to exploit these technologies to ide...
Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
...echnique for 'knocking out,' or mutating, specific genes
to understand their function," said Howard Jacob, ...k out an inserted reporter gene and two native rat genes
without causing measurable effects on other genes....ly 90 percent of the rat's 25,000-30,000 estimated genes
are analogous to those in humans and mice, and the...
Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity
...which non-selectively regulates both ERa and ERb . The most significant finding in the study was that the ERb-selective compounds regulate a number of genes
differently than estradiol, a hormone therapy commonly used to treat women's health issues. This discovery indicates that ERb agonists might be safer ...
Ipsogen Reports Incorporation of the Genomic Grade in the 2009 St. Gallen International Consensus Meeting on the Primary Treatment of Early Breast Cancer
...d by proliferation.
MapQuantTM Genomic Grade is available to European oncologists and
pathologists. The genomic grade test analyzes a set of 97 genes
quantify the proliferation potential of the tumor, and has been validated in
several studies, covering more than 2 800 tumor samples. Map...
deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia
... development. Five of
the SNPs are located very closely together in the Major Histocompatibility
Complex, a region on chromosome 6 densely packed with genes
response. This lends support to previous research suggesting a possible
environmental link between schizophrenia immune response. It...
Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech
...strated the successful knockout of two preselected genes
in a Chinese hamster ovary (CHO) cell line. The mi...tandard technology for specifically editing target genes
in mammalian cells," stated Philip Gregory, D. Phi...e rapid generation of cell lines in which multiple genes
have been knocked out. Our proven ability to quic...
More Gene Mutations Linked to Autism Risk
...r extra copies of DNA segments - were found in the genes
of children with autism spectrum disorders (ASDs),... Philadelphia. This study also uncovered two novel genes
in which variations were found, BZRAP1 and MDGA...respectively. Interestingly, key variants of these genes
were transmitted in some, but not all, of the affe...
Gene Findings Unlocking Reasons for Neuroblastoma Risk
...ladelphia, found that an inherited CNV located at chromosome 1q21.1 is associated with neuroblastoma. The chromosome region contains a large family of genes
that are involved in the development of the nervous system, and the CNV they discovered changes how much of one particular gene is made within normal ...
Alfacell Provides Shareholder Update
...wn that there are specific chemotherapy resistance genes
which not only are present in untreated mesothelio... reaction, measured the levels of the MDR and nfkB genes
after treatment with the drug. Striking decreases in all of these genes
in the mesothelioma cell lines were seen after tre...
Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women
...between the triple negative and hormone receptor positive groups, including genes
for which targeted agents are currently being evaluated in the clinical env...say for prediction of recurrence in stage II colon cancer: Selection of the genes
in 4 large studies and results of the independent, prospectively-designed Q...
New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer
...008, Maris led a study that was the first to identify the gene location at which neuroblastoma originates. His laboratory continues to investigate how genes
contribute to the disease, using that knowledge to devise new treatments.
Maris served as an oncologist for Alex Scott, the child with neuroblas...
Mayo Researchers Help Discover Genetic Cause for Primary Biliary Cirrhosis
...hat variants of two genes, interleukin 12A (IL12A) and interleukin 12RB2 (IL12RB2), were strongly associated with primary biliary cirrhosis. These two genes
constitute a pathway of the immune system. Potential therapeutic manipulation of this pathway provides new possibilities for more effective treatments...
In Rare Disorder, a Familiar Protein Disrupts Gene Function
...ogether also plays an important role in regulating genes
When gene regulation is disrupted...milies and patients, better knowledge of how those genes
perturb normal development may enable researchers ...wer, as the first study in human cells to identify genes
that are dysregulated when cohesin doesn't work pr...
Getting More From Whole-Transcript Microarrays
...hat are functionally distinct. Almost 90% of human genes
are now considered to exhibit alternative splicing...s. The approach can only be used in well-annotated genes
and can detect differential splicing involving mul...uggested that it should work particularly well for genes
containing few exons, since for these...
First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology
...tely 400 million base pairs in size, similar to the size of the rice genome. The teams are now working on annotating the genome to identify particular genes
of interest and to discover genetic variations for use in marker assisted breeding. The teams are also applying traditional breeding tools, as well as...
New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel
...at are responsible for converting prasugrel into its active form(2).
In the substudy, researchers examined how variation in cytochrome P450 (CYP) genes
affected the response to prasugrel. In prasugrel-treated patients with acute coronary syndromes (ACS) who underwent an artery-opening procedure known...
Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II
... complement activation can have destructive consequences. Over the past three years, multiple scientific publications have strongly linked variants of genes
encoding components of the complement system with a predisposition toward AMD.
POT-4 binds tightly to complement component C3, preventing its par...
Optherion Announces Issuance of Canadian Patents Covering Age-Related Macular Degeneration Diagnostics and Treatments
...the predisposition to AMD by screening for genetic modifications in several genes
including complement factor H (CFH), complement factor B (CFB), complement ...y technologies are based on landmark scientific discoveries linking certain genes
Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin
...it binds to the minor grooves located in the DNA double helix. To identify genes
associated with cellular response to brostallicin, a high-throughput RNA in...nd confirmed in breast cancer cell lines, wherein the knockdown of specific genes
involved in these concepts, mentioned above, resulted in an increased respo...
Pharmacyclics announces Global Strategic Alliance with Les Laboratoires Servier
...motherapy or radiation treatment, some patients' tumors may turn on certain genes
as a strategy by the tumor to adapt to the therapy and become resistant to ...NA-damaging chemotherapy or radiation, tumors will often turn on DNA repair genes
such as RAD51 as an adaptive strategy to help the tumor repair the DNA dama...
Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research
...ing colon-cancer prevention and inflammatory bowel disease. The company designed its powerful tkRNAi technology to deactivate specific disease-causing genes
safely and effectively, using non-pathogenic bacteria as an engine to produce and deliver RNAi directly into cells. It is based on ground-breaking sci...
Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis
...ated over 1,200 Korean and Japanese female subjects. Predisposition for vertebral fracture and elevated bone biomarkers were investigated in candidate genes
linked to osteoporosis, with statistical adjustments made for known risk factors such as age, body mass index and drug treatment. The research found K...
ExonHit Reports Proof-of-Concept in Breast Cancer Diagnostic Using its SpliceArray(TM) Platform
...an Genome Wide
SpliceArray(TM) biochips which profile close to 21,000 human genes
to 140,000 RNA splice events have been used in the Company's bio...logical functions. Current predictions
suggest that as many as 80% of human genes
exhibit some form of alternative
splicing. Given the large contribution of ...