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Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City

PRINCETON, N.J., July 10 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX ) today provided a detailed overview of the company's strategy, strength in research discovery and antibody development, and the multiple opportunities Medarex is engaged in for creating long-term value. In additio...

Colorado Cancer Research Program Will Host Golf Event to 'Drive' the Message that Clinical Trials Play a Vital Role in the Quest to Find a Cure for Cancer

DENVER, April 28 /PRNewswire-USNewswire/ -- The Colorado Cancer Research Program (CCRP) invites golfers to participate in its second annual "Drive for a Cure" Golf Tournament on May 19 at the Valley Country Club, 14601 Country Club Drive, Aurora. The private club is one of Denver's premier gol...

Marketing of Diagnostics and deCODEme(TM), Recent Progress in Drug Development to be Highlighted at deCODE R&D Event

REYKJAVIK, Iceland, June 30 /PRNewswire-FirstCall/ -- At its annual R&D event being held today in New York, deCODE genetics (Nasdaq: DCGN ) will provide an update on progress in all aspects of its business, including the commercial potential and marketing rollout for its growing range of DNA-...

Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event

Recent clinical studies support the development of DG041 as an effective anti-platelet that does not increase bleeding risk REYKJAVIK, Iceland, June 25, 2007 /PRNewswire-FirstCall/ -- deCODE genetics today announced progress in the development of DG041, the company's Phase II developmental compoun...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...e the first prospective Phase 3 data to demonstrate the utility of KRAS mutational analysis as a predictive biomarker." Overall, the adverse event profile was as anticipated for an anti-EGFR antibody in combination with oxaliplatin-based chemotherapy, including known events such as skin toxicity,...

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

...e between discontinued operations and continuing operations in its Consolidated Statement of Operations. Since the sale of Ibis to AMI was a discrete event that occurred in the first quarter of 2009, the accounting rules required Isis to record the total amount of its estimated income tax expense for disc...

2,500 Cases Completed With the Magnetic Irrigated Catheter

...rigated catheter since its commercial release. The clinical performance of the catheter in these cases has been exceptional. The major adverse cardiac event rate for magnetic procedures remains at 0.1% "The irrigated tip is a great asset for creating deep lesions in patients with ventricular tachyca...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

...e cancer) or multiple myeloma. For the primary endpoint, patients treated with denosumab experienced a similar time to first skeletal-related event (SRE) (fracture, radiation to bone, surgery to bone, or spinal cord compression) compared with those receiving Zometa (hazard ratio 0.84, 95 percent C...

Lilly and New York City Mayor Michael R. Bloomberg Announce Lilly Agrees to be First Tenant of East River Science Park; Issue Urgent Call for Healthcare Reform that Protects Innovation and Jobs

... INDIANAPOLIS, July 22 /PRNewswire-FirstCall/ -- Eli Lilly and Company (NYSE: LLY ) announced today during a lease signing event that it has become the first tenant of New York City's new Alexandria Center for Science and Technology at East River Science Park, a development that...

R-Tech Ueno, Ltd. Completes Phase 1 Clinical Study on RK-023

...-day repeated-dose study. Since no serious adverse event occurred in each test, RK-023 seems to hardly caus... followed by UVA irradiation No adverse event occurred and the resulting irritation was negligib...y in the entire body and scalp. No serious adverse event occurred. After application of the drug, blood and...

New Results From ARTEN Study of Nevirapine Plus Tenofovir and Emtricitabine (TDF/FTC) Versus Boosted Protease Inhibitor Regimen of Atazanavir/Ritonavir Plus TDF/FTC Revealed

... efficacy of once-daily dosing have not been established Safety/Tolerability Data In the nevirapine group, the most common adverse event was rash/eruptions/exanthema (16.0 percent). Of the nevirapine-associated rashes that resulted in discontinuation, 76.2 percent (16 of 21) were identi...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

...t response rate at Week 52, compared with standard of care alone. Study results also showed that belimumab was generally well tolerated, with adverse event rates comparable between belimumab and placebo treatment groups. (Logo: http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO ) ...

BioCryst Pharmaceuticals Reports Positive Results of Shionogi & Co. Sponsored Phase 3 Studies of i.v. Peramivir for Influenza

...a. In 2008, Shionogi's rights were extended to include Taiwan. Under the terms of the agreement, BioCryst may receive future clinical and commercial event milestone payments up to $116 million, as well as double digit royalty payments on product sales of peramivir. BioCryst retains its rights to commerc...

Iontophoretic Drug Delivery System (IDDS) Containing Lidocaine and Epinephrine is Effective in Reducing Pain Associated With Insertion of an Intravenous Catheter in a Phase 2 Clinical Trial

...Active group reported pain elimination and willingness to undergo IDDS treatment again. The IDDS treatment was well tolerated, with no serious adverse event reported in any subject. "This represents a major advancement for Dharma and the Transcu Group," said Paul R. Sleath, President and CEO of Dharma...

Landmark Study for GSK's Cervical Cancer Vaccine Published in The Lancet

...nd safety results from the interim analysis of the HPV 008 study were previously published in The Lancet . The data reported today are from the final event driven analysis, also published in The Lancet . Further to the final analysis, additional follow-up results will be forthcoming from the end of study...

Clay Walker's Band Against MS Foundation Donates $150,000 To Support Multiple Sclerosis Research

... tournament, players and guests were treated to special performances from Clay Walker and Friends and comedian Jeff Foxworthy at the tournament's Gala event on Tuesday, June 30. In total, the evening's live auction generated $56,000 to further the MS-related goals of BAMS. Band Against MS, Inc.,...

New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects

...dence indicating that tumor growth and metastasis formation are dependent on the formation of new blood vessels. Furthermore, angiogenesis is an early event in the development of tumors, being already switched on in pre-cancerous events and long before visible or clinically relevant tumor mass is present. ...

AcelRx Announces Positive Phase 2 Results from a Study of ARX-01 Sufentanil NanoTabs in Treating Post-Operative Pain

...ary endpoint, was also significantly different from placebo (p<0.001) for both treatment groups. ARX-01 was well tolerated; the most common adverse event reported was mild to moderate nausea with similar incidence between all treatment groups (including placebo). There were no serious adverse events rel...

King Pharmaceuticals Showcases Data From Pain Pipeline of Medicines Designed to Deter Common Methods of Non-Therapeutic Use

...very six hours for 48 hours after surgery. Both doses of ACUROX(R) Tablets demonstrated significant reduction in pain compared to placebo. The adverse event profile was similar to that seen with short-acting oxycodone, and ACUROX(R) was generally well tolerated. Evaluation of Plasma Naltrexone Conc...

Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial in 3rd Line Th

...02) with no patients in the standard chemotherapy arm achieving a confirmed complete remission while on study. The most common grade 3, 4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile ...

FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications

... prolactin levels, cognitive and motor impairment, body temperature elevation, and trouble swallowing. The most common treatment-emergent adverse event associated with Zyprexa use in adults in placebo-controlled, short-term schizophrenia and bipolar mania trials was somnolence. Other common events wer...

Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily

...with CIALIS. The most common side effects with CIALIS were headache, upset stomach, backache or muscle ache. As with any ED tablet, in the rare event of priapism (an erection lasting more than four hours), men should seek immediate medical attention to avoid long-term injury. In rare instances...

The Lancet Publishes Direct Comparison Study Between Liraglutide and Exenatide

... available. Both treatments led to a weight reduction of on average 3 kg during the 26-week study. Nausea was the most commonly reported adverse event with both treatments but the study results showed that there was less persistent nausea and fewer minor hypoglycemic events with liraglutide compared ...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

...52 weeks, the unadjusted rate at which patients experienced at least one CV event was 2.0 percent for BYETTA and 2.6 percent for the comparator group; the re...re, respectively. The unadjusted incidence of experiencing at least one CV event was 2.0 percent for BYETTA and 2.6 percent for pooled comparator; the relat...

Research: Popular Diabetes Medications Associated with Increase in Bone Fractures

...together experienced a 44 percent higher relative risk for a cardiovascular event than patients taking clopidogrel alone. Of those who took the medications together, nearly 27 percent experienced a major cardiovascular event within the first 12 months of taking the drugs together, compared to only 1...

Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009

... SBP [-3.0+/-1.0 mmHg for all participants and -9.4+/-1.5 mmHg for those with abnormal baselines]. Safety Profile Nausea was the most common event during the 30-week treatment period and decreased over time, occurring in 12 percent of patients during the 74-week assessment period when all patient...

Arena Pharmaceuticals Announces Lorcaserin Data Demonstrating Highly Significant Categorical and Absolute Weight Loss and Improvements in Secondary Endpoints Associated with Cardiovascular Risk

... no increase in depression or suicidal ideation compared to placebo. Depression adverse events were measured using a Standard MedDRA Query for adverse event terms related to depression (e.g. depression, depressed mood, crying, decreased interest, etc.). Overall, the rate of depression-related events was lo...

Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment

...erapy arm, p=0.02) with no patients in the standard chemotherapy arm achieving a confirmed complete remission. The most common grade 3, 4 adverse event observed on the pixantrone arm was neutropenia in 41.2% of patients versus 19.4% on the comparator arm. However, the incidence of grade 3, 4 febrile ...

Researchers Present Safety and Efficacy Results of 429 Patients Treated With Radiofrequency Ablation for Pre-Cancerous Barrett's Esophagus

...reated with radiofrequency ablation using the HALO ablation system (BARRX Medical, Sunnyvale, CA) over the last 4 years. They report that the adverse event rate was favorable, with a low stricture risk (about 1%) and no serious adverse events. After an average of 2 ablation procedures and 20 month follow...

Horizon Therapeutics' HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain

... to moderate in severity. There were no significant differences in adverse event or serious adverse event profiles between the two treatment groups. One death occurred in the ibupr...

Shire Presented Results of a New Database Analysis on Lialda(R) (Mesalamine) and Other 5-ASAs for Ulcerative Colitis at Digestive Disease Week

... forward-looking statements. Such forward looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, the Company's results could be materially adversely affected. The risks and uncertainties include, but ...

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

...n monitoring in 35 pediatric renal transplant patients. "Among the 5 patients who became positive for EBV or BK virus," explained Dr. Imam, "each event was preceded by a deviation in baseline ImmuKnow status. Immunosuppression was adjusted in each case, accordingly, without evidence of graft loss or c...

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

...ed serious adverse events. The most common adverse event was diarrhea; however, there were no associated de...riod. Across both studies, the most common adverse event in the linaclotide-treated groups was diarrhea, and diarrhea was the most common adverse event leading to discontinuation. Linaclotide is a once ...

New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer

... CI, 55.9 percent to 69.4). In this preliminary analysis, the adverse event profile of the combination of neratinib (240 mg) plus paclitaxel (80 mg/m2)...penia, anemia, nausea, rash, fatigue and vomiting. The most common adverse event was diarrhea, observed in 89 percent of the 102 patients enrolled in part 2...

Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer

...cer." Analyst and Investor Briefing Poniard will host an investor event in Orlando on Sunday, May 31, 2009. Presentations will begin promptly at 6:00 p.m. Eastern Time. The event will feature presentations and discussion with expert oncologists, includin...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... forward-looking statements. Such forward-looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, the Company's results could be materially adversely affected. The risks and uncertainties include, but are no...

Siemens Corporate Research Develops RAPID2 System for Fast Discovery of Discriminative Pathogen Signatures

...es an efficient framework for quickly identifying new biomarkers based on the genomic sequence of a particular pathogen," says Dr. Wittenberg. "In the event of a pandemic, such as the recent H1N1 Flu outbreak, our system would enable a rapid response with the development of a strain-specific diagnostic tes...

Human Genome Sciences Submits Biologics License Application to FDA for ABthrax(TM)

... 2009. In January 2009, HGS began delivery of 20,000 doses of ABthrax(TM) (raxibacumab) to the U.S. Strategic National Stockpile for use in the event of an emergency for the treatment of inhalation anthrax. The Company also has several drugs in earlier stages of clinical development for the treatme...

Long Term Data Presented at EuroPCR 2009 from Randomized Study Attest to Durability of Results of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Compared to Drug-Eluting Stents

... risk of restenosis patients. However, the thrombosis rate for Taxus treated patients increased from one to two years from 4.2% to 5.3%, with another event occurring at 658 days in a patient who had previously presented with a subacute thrombosis and who was on dual antiplatelet therapy at the time of bot...

SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(R) Stent System More Cost Effective Than Bypass Surgery in Patients With Complex Coronary Artery Disease

...BG surgery. However, because of the increased need for repeat procedures, the overall 12-month MACCE (Major Adverse Cardiovascular or Cerebrovascular event rate, including all-cause death, stroke, MI and repeat revascularization) was higher for PCI. The safety and effectiveness of the TAXUS Express...
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