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JCI online early table of contents: May 1, 2009

EDITOR'S PICK: Now we know what blocks the effects of a newly developed anticancer therapy A new approach being developed to treat individuals with cancer that is resistant to standard therapy is the use of adenovirus-based therapies. Although promising clinical results have been obtained in ...

Dornier Reveals Urology Table with New Flat Panel Detector

CHICAGO, April 24 /PRNewswire/ -- In an unveiling held at the American Urological Association, Dornier increased their technology leadership of urology tables by revealing a flat panel detector for the Opus II UIMS. The international award-winning urology system, offers a 43 x 43 cm dynamic...

Landmark NBC News Nutrition Report: 'There Is Indeed Little Difference Between High Fructose Corn Syrup and Table Sugar'

Harvard Obesity Researcher: High fructose corn syrup 'misunderstood' WASHINGTON, April 23 /PRNewswire/ -- Last night, NBC Nightly News with Brian Williams ran a report, "The sweet truth about high fructose corn syrup," by Chief Science Correspondent Robert Bazell. In the report, Mr. Bazell ...

Millennials Push For Seat at the Table on Healthcare Reform

Conservative and Liberal Youth Advocacy Groups Join Together to Ask President Obama for a Greater Voice in the Healthcare Reform Debate. Nashville, TN (PRWEB) April 22, 2009 -- In recent days, both conservative and liberal youth advocacy groups, joined together to push...

JCI online early table of contents: April 13, 2009

EDITOR'S PICK: Enhancing the effects of the drug used to treat chronic myeloid leukemia Individuals with chronic myeloid leukemia (CML) are first treated with a drug known as imatinib mesylate. Although very effective, as the disease progresses it often becomes resistant to the drug. However,...

JCI online early table of contents: April 6, 2009

EDITOR'S PICK: Separating the beneficial effects of a drug from the adverse side effects Nicotinic acid is one of the most effective drugs for raising levels of "good" cholesterol and lowering levels of "bad" cholesterol and other lipids (fats), thereby reducing the risk of heart attack. Howe...

JCI table of contents: March 23, 2009

EDITOR'S PICK: Licorice extract blocks colorectal cancer in mice Non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, and drugs that selectively target a protein known as COX-2 prevent the development of intestinal polyps, the precursors of colorectal cancer. However...

JCI online early table of contents: March 9, 2009

EDITOR'S PICK: SOX9 renders melanomas sensitive to retinoic acid and stops tumor growth Melanomas are often resistant to standard cancer therapies such as radiotherapy, chemotherapy, and retinoic acid (RA). Given the lack of available treatments for melanoma, the prognosis for patients is oft...

JCI online early table of contents: Feb. 16, 2009

EDITOR'S PICK: Targeting the protein AEG1 impairs human liver cancer growth in mice Hepatocellular carcinoma (HCC) is a highly aggressive form of liver cancer and one of the 5 most common cancers worldwide. Devanand Sarkar and colleagues, at Virginia Commonwealth University School of Medicine...

JCI online early table of contents: Jan. 12, 2009

EDITOR'S PICK: Opiods provide relief from neuropathic pain The pain that is associated with injury to nerves, such as caused by the trauma of amputation, entrapment, and compression, is known as neuropathic pain. It can be extremely debilitating, and treatments show limited or no effectivenes...

JCI online early table of contents: Dec. 1, 2008

EDITOR'S PICK: Harnessing miRNA natural gene repressors for anticancer therapy Michel Sadelain and colleagues, at Memorial Sloan-Kettering Cancer Center, New York, have developed a new approach to modulate the expression of genes for therapeutic purposes, and used this to mediate effective a...

JCI online early table of contents: Nov. 6, 2008

EDITOR'S PICK: Visualizing asthma-causing immune cells at work Immune cells known as eosinophils have a central role in causing asthma. Now, a team of researchers at Massachusetts General Hospital, Boston, has developed approaches to noninvasively visualize in real-time eosinophil responses ...

JCI online early table of contents: Aug. 1, 2008

EDITOR'S PICK: Overcoming inhibitors of cell death improves cancer therapy efficacy Individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumor, have an extremely poor prognosis. Although pre-clinical studies indicated therapeutics inhibiting a group of pro...

JCI online early table of contents: July 10, 2008

EDITOR'S PICK: Why men are more at risk of diseases caused by blood clots than women Being male increases your risk of diseases caused by the inappropriate formation of a blood clot (a process known as thrombosis), such as heart attack and stroke, but the reasons for this are not completely u...

JCI online early table of contents: July 1, 2008

EDITOR'S PICK: Calpain inhibitors never forget: improving memory in Alzheimer disease mice Overactivation of proteins known as calpains, which are involved in memory formation, has been linked to Alzheimer disease. Ottavio Arancio and colleagues, at Columbia University, New York, have now sho...

Medline Announces Advanced Line of Therapeutic Mattresses, Operating Room Table Pads and Stretcher Pads

New support surface products to be included as part of company's comprehensive Pressure Ulcer Prevention Program to assist in reducing and preventing pressure ulcers MUNDELEIN, Ill., June 30 /PRNewswire/ -- Medline Industries, Inc. announced today an advanced line of...

JCI table of contents: June 20, 2008

EDITOR'S PICK: Smoking out the mediators of airway damage caused by pollutants New insight into how pollution and cigarette smoke damage airways has been provided by Pierangelo Geppetti and colleagues, at the University of Florence, Italy, who studied the effects of such chemicals on guinea ...

JCI online early table of contents: June 12, 2008

EDITOR'S PICK: New target to enhance anticancer drug sensitivity found in translation The development of resistance to anticancer chemotherapeutic agents remains a large problem. In some cases, such resistance is associated with altered control of a cellular process known as translation, whic...

JCI online early table of contents: June 5, 2008

EDITOR'S PICK: Finding the source: cells that initiate a common infant tumor identified Infantile hemangiomas, exemplified by the strawberry-like patches that appear on the skin of infants soon after birth, are benign tumors that develop in 5%-10% of Caucasian infants and usually disappear b...

JCI table of contents: May 22, 2008

EDITOR'S PICK: Anti-HIV drugs reduce the cause of some forms of vision loss A potential new therapeutic use for anti-HIV drugs known as protease inhibitors has been suggested by a team of researchers from Harvard Medical School, Boston, and Inserm U848, France, as a result of their work in a...

JCI online early table of contents: April 8, 2008

EDITOR'S PICK Too many gene copies stimulate tumor cell growth New data, generated by Peter Lichter and colleagues, at the German Cancer Research Center, Heidelberg, have characterized a molecular pathway underlying low-grade forms of a type of brain tumor known as an astrocytoma. The auth...

SaltWorks, Inc. Advises Table Salt Alternatives

Health risks of refined salt prompt consumers, food industry to consider benefits of natural sea salt WOODINVILLE, Wash., March 31 /PRNewswire/ -- No one would knowingly sprinkle chemicals over a dinner plate - yet that's exactly what millions of Americans unwittingly do e...

JCI table of contents: March 20, 2008

BACTERIOLOGY: Antibodies protect against bacteria in the blood In developed countries, infection with nontyphoidal strains of Salmonella bacteria (NTS) usually occurs through eating contaminated food and causes gastroenteritis. By contrast, in Africa, children under the age of 2 and HIV-infe...

JCI online early table of contents: March 13, 2008

EDITOR'S PICK: High levels of the molecule adenosine linked to priapism Priapism (prolonged penile erection in the absence of sexual interest) is common in male individuals with sickle cell disease (SCD), a blood disorder characterized by abnormally shaped red blood cells. Priapism is conside...

JCI online early table of contents: March 3, 2008

EDITOR'S PICK: How the drug isotretinoin zaps acne The most potent drug available for the treatment of acne is 13-cis retinoic acid (13-cis RA; also known as isotretinoin); however, little is known about the mechanism by which it acts. Insight into the mechanisms by which 13-cis RA combats a...

JCI table of contents: Feb. 21, 2008

EDITOR'S PICK: Deficiency in the protein MBL2 is linked to increased cystic fibrosis severity Cystic fibrosis (CF), a hereditary disorder causing thick mucous production and frequent lung infections, is associated with a high mortality rate primarily due to lung failure. Although it is known...

JCI online early table of contents: Feb. 7, 2008

EDITOR'S PICK: VEGF-B helps nerve cells cheat death without unwanted side effects The prototypical member of the VEGF family of proteins, VEGF, has recently been shown to protect cells in the nervous system from death and degeneration. However, its clinical utility in this regard is limited,...

JCI table of contents: Jan. 24, 2008

EDITOR'S PICK: TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data generated by Naofumi Mukaida and colleagues at Kanazawa University, Japan, id...

JCI online early table of contents: Jan. 10 2008

EDITOR'S PICK: A new way to boost red blood cell numbers A common treatment for anemia a deficiency in red blood cells (rbcs) caused by their insufficient production, excessive destruction, or excessive loss is administration of recombinant erythropoietin (Epo), a hormone that stimulates t...

Round Table Family Charities Raises $350,000 for Children's Miracle Network

CONCORD, Calif., Jan. 8 /PRNewswire/ -- In 2007, Round Table Family Charities raised $350,000 for Children's Miracle Network (CMN), an alliance of premiere children's hospitals throughout the United States. This is the second consecutive year Round Table Family Charities has devoted its effort...

JCI online early table of contents: Jan. 2, 2008

EDITOR'S PICK Il-22 gene delivers the goods and decreases intestinal inflammation There are two major types of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Conflicting reports have indicated that the soluble factor IL-22 can have both IBD promoting an...

JCI table of contents: Dec. 20, 2007

EDITOR'S PICK: You can teach an old dog new tricks: antimalarial prevents cancer in mice New data generated by a team of researchers from St Jude Childrens Research Hospital, Memphis, and Scripps Research Institute, Jupiter, have indicated that the antimalarial drug chloroquine effectively pr...

JCI online early table of contents: Dec. 6, 2007

EDITOR'S PICK: Anticancer drugs might be of benefit to sickle-cell patients Sickle cell disease (SCD) is an inherited blood disorder caused by a genetic mutation that leads to the generation of a mutant form of the beta-globin chain of hemoglobin (Hb). Red blood cells containing Hb with this ...

JCI table of contents: Nov. 21, 2007

EDITOR'S PICK: Pregnant women pass on the effects of smoking Smoking during pregnancy has many adverse effects on fetal development. A new study in mice by Andrea Jurisicova and colleagues at the University of Toronto, Canada, now adds the possibility that smoking before pregnancy or while...

JCI table of contents: Nov. 15, 2007

EDITOR'S PICK: CD200 stifles antitumor immunity The prognosis for individuals with metastatic melanoma (MM) is not good. Therapeutic strategies to enhance the immune response have some clinical benefit; however, most patients eventually succumb to progressive disease, in part because their i...

JCI table of contents: Nov. 8, 2007

EDITOR'S PICK: Atrogin breaks down the side effects of statins Statins are a popular class of drugs used to successfully combat high cholesterol. However, the rare, but serious, and poorly understood side effect of skeletal muscle breakdown (a process known as atrophy) prevents more prevalent...

JCI table of contents: Oct. 25, 2007

EDITOR'S PICK: Drug that lowers blood pressure might help prevent Alzheimer disease Alzheimer disease (AD), a neurodegenerative disease that is the most common form of dementia, is characterized by the formation in the brain of plaques containing misfolded beta-amyloid protein. Recent evidenc...

JCI table of contents: Oct. 18, 2007

EDITOR'S PICK: New links in the cystic fibrosis chain uncover potential therapeutics Cystic fibrosis (CF) is an inherited disease caused by mutations in the CFTR gene. Each mutation has number of effects on the cells of the lungs. New evidence generated in vitro by Vojo Deretic and colleague...

JCI table of contents: Sept. 4, 2007

EDITOR'S PICK: Immunosuppressive drugs are a double-edged sword to type 1 diabetics Type 1 diabetes is caused when immune cells attack and destroy the insulin producing beta-cells of the pancreas. Although insulin injections have changed the life of type I diabetics, they neither cure the ...

White House Health Reform Stakeholder Discussion Brings Palliative Care to the Table

Center to Advance Palliative Care Director, Diane E. Meier, MD, Points to Workforce and Non-Hospice Palliative Care NEW YORK, June 19 /PRNewswire-USNewswire/ -- Nancy-Ann DeParle, Director of the White House Office of Health Reform, held the third and last in a series of White House health ca...
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