inhibit

Blood pressure control with ACE inhibitor or diuretic?

An Australian study published in The New England Journal of Medicine has challenged the American ALLHAT trial that showed diuretics were superior to ACE (angiotensin-converting enzyme) inhibitors and calcium channel blockers in controlling blood pressure. The Australian study included 6,083 people who were mostly white. Blood pressure reduction was the same in those who took a diuretic an...

Tomatoes Might Inhibit the Development Of Prostate Cancer

A new study finds that lycopene is not the only compound in tomatoes that could prevent prostate cancer.Lycopene is a carotenoid in tomatoes that gives //them that familiar red color. Research has suggested lycopene could reduce the risk of prostate cancer. But it is unclear if lycopene itself is responsible for the risk reduction. Researchers from the University of Illinois studied th...

Artificially made protein to inhibit angiogenesis

Researchers of Medical College of Georgia had successfully made a protein// that will stop the process of angiogenesis. Angiogenesis is the abnormal growth of blood vessels that may lead to obstructed vision or growth of a tumor. The new protein, when applied to animals suffering from corneal injury or skin cancer called melanoma, reduced the blood vessel proliferation by...

Identified Protein To Inhibit Cell Migration

Researchers from the University of North Carolina have identified a protein that may inhibit cellular movement, or migration. // The protein, CIB1, or calcium and integrin-binding protein 1, was originally discovered at UNC in 1997 as a blood platelet protein that may play a role in clotting. Cell migration belongs to the most rudimentary of cellular functions that allow processes su...

Phase 3 trials of two multi-kinase inhibitors against cancer

Sorafenib and stutent multi-kinase inhibitors against cancer is undergoing phase 3 trials// and these two drugs gained more appreciation in this years ASCO (American Society of Clinical Oncology) conference. This drug is gaining interest due to its multiple mechanism of action – known as Multi-kinase inhibitors. These drugs are in trial against different types of cancer and are found to b...

Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence

Aromatase Inhibitors drug, Femara given after 5 years of Tamoxifen therapy is found to give protection against occurrence of Breast cancer recurrence. Breast cancer is the second leading cause of cancer// in women. Breast cancer mostly occurs in post menopausal women and various risk factors are attributed for the occurrence of breast cancer. Treatment of breast cancer initially involve...

Omega 3 Fatty acids (fishy oil) Inhibits Breast Cancer Growth

Omega 3 fatty acids better known for their close association to fishes has been proven to inhibit growth of breast cancer cells. Dietary intake of omega 3 fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) // may curb the growth of breast cancer cells, according to a study published in the International Journal of Cancer. Min Wu and colleagues at M...

Macrophage Inhibitory Factor Causes Multiple Sclerosis Progression

Researchers have found that Migration/Macrophage Inhibitory factor (MIF) which is an immune cell responsible for progression of Multiple Sclerosis. This new pathway can be used in finding drugs which reduces the amount of MIF // in a way progression of Multiple Sclerosis is hindered. Multiple Sclerosis is an autoimmune disease which is caused by non-...

Inhibition of morphine tolerance by spinal melanocortin receptor blockade

Recent research suggests that the melanocortin system is an important component influencing the changes in the spinal neuronal plasticity observed after chronic morphine administration//. The chronic use of morphine is accompanied by the development of morphine tolerance, which is one of the major problems associated with opiate treatment. Possible modulation of opioid effects by melanoc...

Sugars Could Contain Key Cancer Inhibiting Compounds

An Association for International Cancer Research team has come out with the startling finding that a natural compound found in glucose blocks the development of tumors in mice. This discovery could be vital in fighting cancer and // related illnesses. The sugar molecules work by blocking the hormones that are essential for the growth of blood vessels in the tumor. In effect they strang...

Zyflamend inhibits 78 percent of prostate cancer cells

An article published in the October issue of the journal Nutrition and Cancer says that Zyflamend, an herbal extract from olive oil could end the search for a drug to beat prostate cancer.// It was found that this element caused the prostate cancer cells to commit "suicide." The researchers report that the drug had the ability to inhibit 78 percent of the cancer cell growth plus it also...

Garlic inhibits fungal growth and protects food

In a pilot study conducted it has been revealed that garlic extract can inhibit the growth of fungus. This study heralds a new chapter in food safety. Garlic extract can be used a inhibitory against fungal contamination // of food.The fungus on which the effect was seen was Aspergillus, a potent strain which spoils foods a lot. It is the commonest fungi to spoil foods and is a menace....

Rejuvenation of Stem cells by GSK-3 Inhibitor

Professor Mick Bhatia and his team from Robarts Research Institute have found that supplementation of GSK-3 Inhibitors with Cord blood regenerates the immune system to produce immune cells which fights against cancer cells.// Researchers have found that this drug GSK-3 which is used in the treatment of Alzheimer’s and diabetes to boost the immune cells without causing any toxicity or side...

COX-2 inhibitors Lessen Breast Cancer Risk

Selective usage of COX-2 inhibitors like rofecoxib (Vioxx) and celecoxib (Celebrex) reduces breast cancer risk by 71%, according to a study. The Ohio State University College of Medicine and Public Health's Randall Harris led the // research which came to this conclusion. The nonsteroidal anti-inflammatory drugs (NSAIDs) play a prominent role in the prevention of breast cancer. The...

Anonymity Helps In Overcoming Inhibitions During Online Counseling

Online counseling through Internet is gaining momentum slowly but surely as anonymity assists the patient to chat freely with the practitioner// and discuss problems of any sort, as they do not come face to face with them. If the person being talked to is not visible, it is easier for the client to speak about terrible experiences or problems. "Psychotherapy is treatment fo...

LipB Protein Inhibitors Help To Fight Against TB

According to a recent study conducted by the researchers at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and the Max Planck Institute for //Infection Biology (MPIIB) has found the structural image of a protein needed for the TB bacteria to survive which could be targeted by the drug companies. Tuberculosis is one of the deadliest and the oldest disease. It i...

Birth Defects Link With ACE Inhibitor Use, FDA Reports

Taking ACE inhibitor, a common BP medication during first trimester of pregnancy have greater risk of developing birth defects in babies - The Food and Drug Administration reports from data collected by researchers at// Vanderbilt University Medical Center. The study, led by William Cooper, M.D., M.P.H., associate professor of Pediatrics at the Monroe Carell Jr. Children's Hospital at V...

Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer

Researchers have found that aromatase inhibitors like anastrozole are more effective in treating postmenopausal women with hormone receptor-positive early breast cancer// than tamoxifen according to study published in the "The Lancet Oncology" journal. Researchers followed more than 6,000 postmenopausal women with early breast cancer for more than 5 years and found that patients on ana...

ACE Inhibitors For Vascular Disease Patients

Researchers at the Laval University Heart and Lung Institute in Quebec have found that drugs used to treat heart failure also reduced the risk of death, heart attacks// and stroke in people with hardened arteries and hence should be considered in all vascular disease patients. ACE inhibitors are drugs that lower blood pressure by inhibiting the formation of a chemical that causes art...

Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax

A team of American and Canadian scientists from Rensselaer Polytechnic Institute in Troy, N.Y., and the University of Toronto have developed a new anthrax// inhibitor that blocks the host receptors where anthrax toxin attaches in the body. The researchers said that the inhibitor was able to bind to multiple sites on the host receptor making it much for potent than the inhibitors that b...

Reducing the Risk of Protease Inhibitor-Related Atherosclerosis

Physiologists may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors//, a class of drugs that has emerged as the most effective treatment against HIV and AIDS. Writing in the American Journal of Physiology–Cell Physiology, researchers from the University of Kentucky found that when mice were given a nucleoside re...

Antibiotic Inhibits Cancer Gene Activity

A little-known antibiotic shows early promise as an anti-cancer agent, inhibiting a gene found at higher-than-normal levels in most human tumors, // according to researchers at the University of Illinois at Chicago College of Medicine. Their findings appear in the Oct. 1 issue of Cancer Research. "We chose to target a gene believed to be over-expressed in cancer cells to sc...

Super Chow, Laced With Semi-Synthetic Vitamin E, Inhibited Spread of Cancer

A chemically altered form of vitamin E mixed into mouse chow dramatically reduced spread of aggressive mammary cancer in mice//, suggesting that the compound in pill form could be used to treat human metastatic cancer, according to a report in the October 1 issue of the journal Cancer Research. The study, by investigators at the University of Arizona, is the first to show that the synt...

Study IDs Protein That Inhibits HIV From Growing In Cell Cultures

How a harmless virus called GB Virus type C (GBV-C) protects against HIV infection is now better understood. Researchers at the Department of Veterans Affairs (VA) Iowa// City Health Care System and the University of Iowa have identified a protein segment that strongly inhibits HIV from growing in cell models. The team found that an 85-amino acid segment within a GBV-C viral protein c...

Inhibition of Colorectal tumor growth by Grape seed extract

Scientists have found marked inhibition of colorectal tumor growth by certain chemicals in grape juice in both cell cultures and in mice. The anti-cancer effects of this// extract in other types of tumor have previously been proven by these researchers. This study is included in the October 18 issue of Clinical Cancer Research. In this study, advanced colorectal tumors showed a reduct...

Inhibiting Blood to Save the Brain

A fibrous protein called fibrinogen, found in circulating blood and important in blood clotting, can promote multiple sclerosis (MS) when it //leaks from the blood into the brain, triggering inflammation that leads to MS-related nerve damage. Researchers at the University of California, San Diego (UCSD) School of Medicine have identified a fibrin-derived peptide that inhibits this specifi...

Targeting a Single Gene Could Inhibit Bone Decay and Stimulate Bone Growth

Researchers at the University of Pennsylvania’s School of Medicine have found by targeting the function of a single gene that it is possible //to inhibit bone decay while simultaneously stimulating bone formation. This concept may lead to drug treatments for osteoporosis and other bone diseases. Senior author Yongwon Choi, PhD, professor of Pathology and Laboratory Medicine at the Univers...

Study Finds Astaxanthin Is Potent Inhibitor of Oxidation in Cell Membrane Model

A just-published research study by Dr. R Preston Mason and colleagues at Elucida Research has determined that astaxanthin, a relatively //unknown carotenoid found in nature, shows significant promise as a viable scaffold for a new therapy to treat cardiovascular disease based on its exceptional antioxidant properties in membrane models. Combined with published proof-of-concept, pre-cli...

New Protein Inhibitor Halts Growth Of Cancerous Cells

Researchers reporting their findings in the current Biology online on February 8, have developed a small-molecule inhibitor of a protein that plays// key roles in the control of cell division. The researchers show that the inhibitor can halt the growth of tumors in mice and cancer-derived cells growing in culture. The findings are reported in companion papers reported by two collabor...

Early Switch to an Aromatase Inhibitor Increases Survival

For breast cancer patients taking tamoxifen, switching to an aromatase inhibitor within three years significantly improves survival rates//, according to a new study. The study reveals that the clear survival benefit was also achieved without an increased risk of death from other causes – a significant risk associated with tamoxifen. Hormone modulating therapies have made a significa...

Green Tea and COX-2 Inhibitors Combine to Slow Growth of Prostate Cancer

Drinking a nice warm cup of green tea has long been touted for its healthful benefits, both real and anecdotal. But now researchers have found// that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of human prostate cancer. In the March 1 issue of Clinical Cancer Research, researchers from University of Wisconsin-Madison demonstrate that l...

Peptide Found in Human Blood Inhibits 60 Strains of HIV, Study Says

A peptide found in human blood inhibited 60 strains of HIV from infecting cells in laboratory tests, according to a study published Thursday in the journal Cell//, the San Francisco Chronicle reports. Researchers found the peptide can inhibit HIV strains that have developed resistance to existing medications --a discovery that could lead to the development of new HIV/AIDS drugs -- the Chr...

Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory

University of California scientists have found that cancer drug enhances long-term memory and strengthen neural connections in the brain. A protein complex called chromatin causes genomic DNA to compress much like a telephone cord shortens as it coils. When chromatin loosens, genes associated with memory can activate more easily. Previous studies have shown that the protein CBP cau...

Wheat Germ Extract Inhibits Breast Cancer in Study

CHICAGO, A fermented wheat germ extract inhibits estrogen positive and estrogen negative breast cancer tumors better than the world's best selling cancer drug, Tamoxifen, according to research published this past weekend at the 2007 meeting of the American Society of Clinical Oncology, ASCO. The compound, Avemar, has been extensively studied in many cell lines, animal tumor models,...

Glucosamine-like Supplement Inhibits Multiple Sclerosis, Type 1 Diabetes

A glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type 1 diabetes mellitus, according to University of California, Irvine health sciences researchers. In studies on mice, Dr. Michael Demetriou and colleagues with the UC Irvine Center for Immunology found that N-acetylglucosamine (GlcNAc), which is simil...

Targeting Sugar on Blood Vessels may Inhibit Cancer Growth

In a study that could point to novel therapies to prevent cancer spread, or metastasis, researchers at the University of California, San Diego (UCSD) School of Medicine have targeted a sugar that supports blood vessel growth in the tumor. Lung cancer is the most common cause of cancer death and an area where novel therapies to block metastasis are desperately needed, according to f...

Researchers Discover How Antibiotic Inhibits Bacterial Growth

Researchers at the University of Illinois at Chicago, in collaboration with research teams from Pharmacia & Upjohn and Pfizer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth. Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketplace in 30 years -- works by binding to ribosomes, the protein production factory...

Novel Method to Inhibit Prostate Cancer

A new method for combating prostate cancer was developed by researchers of Hebrew university. The student, Danny Goldstein, received the Barenholz Prize for Creativity and Originality in Applied Research for his work. The award, named for its donor, Yehezkel Barenholz, the Dr. Daniel G. Miller Professor of Cancer Research at the Hebrew University-Hadassah Medical School, was presen...

Src Inhibitors in Breast Cancer Therapy

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha . These ER-alphanegative cancers are more aggressive and have a worse prognosis than do ER-alphapositive breast cancers, and have been thought to be estrogen independent. In a study appearing online on...

Cell Toxin Inhibits Survival Protein in Cancer Cells

A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins in cancer cells. The research is a first step toward developing a molecularly-targeted drug that could eliminate cellular-level resistance to multiple types of chemotherapy and radiation therapy found in many type...