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Iron induces death in tumor cells

Rapid growth of cancer cells and their frequent divisions have their price: Cancer cells need considerably more energy than healthy cells. Their metabolism runs at full speed and requires large amounts of micronutrients, particularly iron. However, high levels of iron in the cell lead to the produ...

Common anesthetic induces Alzheimer's-associated changes in mouse brains

For the first time researchers have shown that a commonly used anesthetic can produce changes associated with Alzheimer's disease in the brains of living mammals, confirming previous laboratory studies. In their Annals of Neurology report, which has received early online release, a team of Mass...

High zinc status in lung cells slows growth and induces DNA damage-induced gene expression

Researchers at the University of Maryland at College Park have discovered that Normal Human Bronchial Epithelial (NHBE) cells cultured in medium with elevated zinc level, at the high end of plasma zinc attainable by oral supplementation, demonstrated inhibition of cell growth, up-regulation of gro...

Intra-arterial combination chemotherapy induces long-term survival for hepatocellular carcinoma

Portal venous tumor thrombus (PVTT) is a crucial factor that can worsen the prognosis of patients with hepatocellular carcinoma (HCC). It often leads to extensive spreading of the tumor throughout the liver, and can increase portal venous blood pressure, resulting in the fatal rupture of esophagea...

Monoclonal Antibody Induces Death in Liver Cancer Cells

Researchers at the University of Pittsburgh School of Medicine have found that a newly available monoclonal antibody has the potential to induce death in liver cancer cells. In a study, the monoclonal antibodies' use demonstrated significantly reduces tumour cell proliferation and surviva...

Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory

University of California scientists have found that cancer drug enhances long-term memory and strengthen neural connections in the brain. A protein complex called chromatin causes genomic DNA to compress much like a telephone cord shortens as it coils. When chromatin loosens, genes associa...

Fruit Crop Fungicide Induces Permanent Changes in Mating Behavior

Austin— Researchers from The University of Texas have discovered the intuitive ability of female rats, who simply give a cold shoulder to male rats// whose descent is contaminated by a common fruit crop fungicide; instead they showed a preference to male rats whose ancestors were untainted. ...

C-Reactive Protein Induces Hypertension

Researchers at UT Southwestern Medical Center have found that C-Reactive Protein plays a direct role// in inducing hypertension. "We have discovered that C-Reactive Protein (CRP) is not merely a marker of the risk of hypertension, it actually induces hypertension," said Dr. Wanpen Vongpatanas...

Aspirin induces Cancer Cells To Commit Suicide

Aspirin has already been hailed as a wonder drug that can take care of everything from Alzheimer's disease to heart attacks. It has now emerged that it can also induce cancer cells to commit suicide.// Researchers from the University of Pittsburgh report in the December 9 issue of the Journal o...

Plant based fake meat induces repulsive reaction

In a strongly worded news the Centre for Science in the Public Interest, has received more than 130 complaints from British and American consumers// to ban the sale of - the fake meat made from fungus that is sold under the brand name Quorn. It was found to induce vomiting and many people fell ill...

Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway

The Mycotoxin citrinin (CTN) is a secondary metabolite produced by several fungal species that belong mainly to the genus Penicillium and Monascus. It is widely considered as a hazard contaminant of foods// and feeds, including corn, wheat, rice, barley and nuts, and is known to be cytotoxic and ge...

High expression of interferon induces lupus disease

Scientists had been able to find a biomarker that will help in medical practitioners to diagnose lupus disease in their early state only for effective treatment.// Lupus is a condition that happens when the body’s tissues are affected by the body’s own immune system. Patients affected with lup...

UV Radiation induces Melanoma

Children who suffer sunburn very early in life are far more likely to suffer the most dangerous form of skin cancer, suggest researchers. In humans, melanocytes, the pigment-producing skin cells where melanoma develops, are on the surface of the skin. It is thought that some melanomas are the resul...

Antibiotic induces liver damage in children with E.COLI infections.

The strain of bacteria known as E. coli 0157:H7 causes some of the most serious digestive infections in both children and adults. Infections with this organism are often caused by eating undercooked meat. A major study shows using antibiotics to treat children with E. coli bacterial infection incre...

Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer

...85%) and very little on glycolysis (<7%) for energy production. Cancer cells depend largely on glycolysis (>85%) for energy production. Bezielle induces greater production of reactive oxygen species in cancer cells. This results in high levels of DNA damage and the hyperactivation of PARP. The resultin...

Researchers Identify New Method to Selectively Kill Metastatic Melanoma Cells

...g self-digestion that leads to programmed cell death specifically in melanoma cells. Fisher said that mda-5 is a key regulator of innate immunity that induces interferon beta production limiting replication of specific pathogenic viruses. This work was supported by grants from the National Institutes of...

Researchers identify new method to selectively kill metastatic melanoma cells

...g self-digestion that leads to programmed cell death specifically in melanoma cells. Fisher said that mda-5 is a key regulator of innate immunity that induces interferon beta production limiting replication of specific pathogenic viruses. ...

Immune responses to flu vaccine are diminished in lupus patients

...trol. Patients and controls were followed up at 28 days and three to four months following vaccination, at which time blood was drawn. Vaccination induces an influenza virus-specific immune response which is generally documented as the generation of antibodies specifically reacting with the virus. Howeve...

Millennium Pharmaceuticals Inc./Lymphoma Research Foundation funds lymphoma research

...und that higher expression of miR-17~92 is directly correlated with poorer patient survival. These findings indicate that higher miR-17~92 expression induces abnormal activation of a pathway in tumor cells that leads to increased resistance to standard chemotherapy. Dr. Fu will conduct a pre-clinical study...

Neuronal survival and axonal regrowth obtained in vitro

...maged neuron to prevent interference with the operation of the central nervous system. While the protection is initially useful, in the long run it induces formation of impermeable cicatricial tissue around the neuron, thus constituting impenetrable scarring hostile to axonal regeneration and hence to pro...

Vaxine Wins Line Honours With World's First Human Swine Flu Vaccine

...t is free of viral contaminants and is safe for people with egg allergies." This new swine flu vaccine includes Vaxine's Advax adjuvant that induces powerful influenza protection through anti-influenza antibodies, but also T-cells, key components of the body's defence against the influenza virus. ...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

...re the ones approaching death." In an early test of the probe, Bogyo and his colleagues gave mice a drug called dexamethosone, which preferentially induces apoptosis in certain immature immune cells residing primarily in the thymus. After systemically injecting a solution containing the probes, the invest...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

...o different receptors: insulin and IGF-1 (insulin-like growth factor-1) receptors. The former mainly causes glucose lowering whereas the latter mainly induces cell proliferation. Insulin binds much stronger (more than 500-fold) to the insulin receptor than to the IGF-1 receptor and it is if this binding prof...

Stroke Damage Is Less in Rats Given Opioids

...oscientist at the University of South Florida Center for Aging and Brain Repair, said in a news release about the study. "We've shown that a drug that induces hibernation can achieve similar results." Borlongan, along with colleagues at the U.S. National Institutes of Health, gave the rats a drug called [...

Novel light-sensitive compounds show promise for cancer therapy

...s attracted the attention of cancer researchers in recent years. According to Mascharak, one advantage of nitric oxide for cancer treatment is that it induces an orderly type of cell death known as apoptosis. Also known as "programmed cell death," apoptosis does not lead to the inflammation, pain, and swelli...

Nicotine Receptors Could Be Lung Cancer Treatment Target

...treated mice and 2.1-fold over untreated mice. "The results of this study show that α-CbT, a powerful, high-affinity α-7-nAChR inhibitor, induces antitumor activity against NSCLC by triggering apoptosis," wrote Patrizia Russo of the Lung Cancer Unit of the National Cancer Research Institute in G...

NIAID media availability: New strategy proposed for designing antibody-based HIV vaccine

...ting proteins called antibodies that either block infection or help eliminate the virus before it can cause disease. Attempts to create a vaccine that induces antibodies that prevent HIV infection or disease, however, have so far been unsuccessful. But several recent studies suggest promising new research di...

Quark Pharmaceuticals Announces the Presentation of Data Indicating Potential Utility of QPI-1002 in Chronic Kidney Disease at the RNA Interference Summit

...ted cells, allowing natural repair mechanisms to take over, thus preserving tissue integrity and function. In acute kidney injury (AKI), the p53 gene induces tubular cell death resulting in kidney dysfunction. In the context of AKI, RNA interference (RNAi) technology used to temporarily inhibit p53 exploit...

Defeating nicotine's double role in lung cancer

...ld over the no-treatment controls (p=0.0005). "The results of this study show that α-CbT, a powerful, high-affinity α-7-nAChR inhibitor, induces antitumor activity against NSCLC by triggering apoptosis," wrote Dr. Russo. "The prolonged survival of α-CbT-treated animals in our mouse model o...

American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications

... patients with immunodeficiency syndromes, among others. Cyclosporine Cyclosporine is one of the most effective treatments for psoriasis and induces immunosuppresion by inhibiting the first phase of T-cell activation. When the medication is used long-term (i.e., three to five years), a significant ...

AGA Institute presents cutting-edge research during DDW

... Prior Non-response, Viral Breakthrough or Relapse to Peginterferon-Alfa-2a/b and Ribavirin Therapy. A.M. Di Bisceglie et al. (3:00 p.m.)* Adalimumab induces and Maintains Mucosal Healing in Patients With Moderate to Severe Ileocolonic Crohn's Disease First Results of the EXTEND Trial. P. Rutgeerts, et al....

Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer

...than one-quarter of the women in a phase I/II trial had their tumors shrink on the combination therapy. "I think this is very promising. Neratinib induces clinically meaningful responses," says Ramona Swaby, M.D., a medical oncologist and attending physician at Fox Chase. Swaby will present the study res...

Cardium Presents Gene Activated Matrix Technology and Update on Excellarate Clinical Development Program at ASGT Annual Meeting

...the matrix, cells that have taken up the PDGF-B gene act as local bioreactors that produce PDGF-B protein. PDGF-B is a known cyto-attractant and thus induces repair cells to migrate from the normal wound margins into the wound bed. PDGF-B is also known for its ability to stimulate repair cell proliferation...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

...G-mediated cleavage occurs on one allele at a time at every stage of Igh and Igk recombination; introduction of a double-strand break on one lg allele induces repositioning of its homologous partner to pericentromeric heterochromatin (a repressive compartment of the nucleus). This repositioning, surprisingl...

Amgen Highlights Data to Be Presented at ASCO

...ptosis selectively in cancer cells, and dulanermin (rhApo2L/TRAIL), a recombinant human protein that targets death receptors 4 and 5 (DR4 and DR5) and induces apoptosis in preclinical models. Amgen is developing dulanermin in collaboration with Genentech. These molecules are being studied for their potential...

A new light on the mechanisms of early stage liver reperfusion injury

...n consisting of an early stage started upon reoxygenation and a delayed phase. It is thought that reactive oxygen species formation during reperfusion induces a cascade of series of cellular events that eventually leads to hepatocellur injury. However, the detailed mechanisms of cell death and the structural...

Five UCSF Scientists Elected to National Academy of Sciences

...ortex are refined through the action of mechanisms of neural plasticity in combination with specific molecular signals. In lab studies, Stryker's team induces brain plasticity through manipulations of genes or visual experience or by pharmacological or neurophysiological intervention in order to discover wh...

Cancer-obesity link discovery by MSU researchers could aid prevention efforts

...cell-derived hormone regulating body energy is higher in obese individuals. Fenton's study is the first to demonstrate that, at higher levels, leptin induces precancerous colon cells to produce more of a growth factor that can increase blood supply to early cancer cells promoting tumor growth and cancer pr...

New target for maintaining healthy blood pressure discovered

...is cleaved again to form angiotensin II, which stimulates blood vessels to narrow, thereby increasing blood pressure. At the same time, angiotensin II induces the release of the hormone aldosterone, which further elevates blood pressure by promoting retention of water and sodium in the kidneys. Many conv...

Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth

...pr 21, 2009, 8:00 AM -12:00 PM Location: Hall B-F, Poster Section 15 Abstract Number: LB-205 Presentation Title: PG11047, A Polyamine Analog, induces Potent Antitumor Activity in a Preclinical Model of Non-Small Cell Lung Cancer in Combination with Cisplatin. Presentation Start/End Time: Tuesday, ...
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