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Heart Failure Patients With Normal Left Ventricular Ejection Fraction Don't Benefit From Treatment With Angiotensin II Receptor Blocker

Study highlights: -- The angiotensin system inhibitor irbesartan did not improve outcomes in heart failure patients with preserved left ventricular ejection fraction. -- There is not evidence-based therapy for this common condition that predominantly affects women and old...

MULTAQ(R) (dronedarone) for Atrial Fibrillation or Atrial Flutter Now Available in the United States

...ors (i.e., age >70, hypertension, diabetes, prior cerebrovascular accident, left atrial diameter greater than or equal to 50 mm or left ventricular ejection fraction [LVEF] <40%), who are in sinus rhythm or who will be cardioverted. MULTAQ was recently approved by the U.S. Food and Drug Adminis...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer

...tudy, 25 patients (8 percent) in the VELCADE for Injection arm and 42 patients (13 percent) in the VELCADE plus DOXIL arm experienced left ventricular ejection fraction decrease (defined as absolute decrease greater than or equal to 15 percent over baseline or a greater than or equal to 5 percent decrease bel...

FDA Approves Multaq(R) for Patients with Atrial Fibrillation or Atrial Flutter

...ude age over 70 years, hypertension, diabetes, prior cerebrovascular accident, left atrial diameter greater than or equal to 50 mm or left ventricular ejection fraction [LVEF] <40%. The FDA approval is based on five international, multi-center, randomized clinical trials involving nearly 6,300 patients. ...

Cell transplantation and cardiac repair

...ciency of cell delivery to the infarcted tissue." The research team also found that higher cell retention correlated with better changes in observed ejection fraction from baseline to a six-month follow-up. "Our data point toward a causal relationship between the total number of cells that participate in ...

Results from 8 late-breaking clinical trials presented at Heart Failure 2009

...(bisoprolol and carvedilol). Ex-DHF is an interesting study which looked at a neglected type of heart failure, diastolic HF (or HF with preserved ejection fraction). There are no proven treatments for this type of heart failure, and this study tested the value of exercise training. The results showed tha...

Anemia associated with greater risk of death in heart disease patients

...creased risk of death. The findings also show that anemia is associated with a poorer degree of left ventricular function and a lower left ventricular ejection fraction, an objective measure of cardiac function. Heart failure is a common and serious chronic illness. A large number of patients with heart fai...

Estrogen May Help Men's Hearts

...chronic heart failure and reduced left-ventricular ejection fraction, high and low concentrations of estradiol...f the men had heart failure and a left ventricular ejection fraction of 28 percent. ejection fraction is a measure of how well the heart is pum...

Schering-Plough Starts Patient Enrollment in Phase 3 Trial for Acadesine, an Investigational Agent Being Studied for Prevention of Complications From Cardiac Surgery

...p CABG. High-risk patients are defined as either female, or males with a previous history of CABG surgery, heart attack, stroke, low left ventricular ejection fraction, or diabetes mellitus. Patients will be randomized to either acadesine or placebo IV infusion started before anesthesia and continued for a ...

Sleep apnea may not be closely linked to heart failure severity

...ant advances in the management of these patients since this phenomenon was recognized. The study involved 218 heart failure patients with reduced ejection fraction (mean 24.7%) who underwent sleep studies between 1997 and 2004. Overall 47% had moderate to severe OSA or CSA. Both conditions were more pre...

Exercise Might Benefit Some With Heart Failure

...at abnormality called atrial fibrillation, ability to perform on a cardiopulmonary exercise test and the blood-pumping measure called left ventricular ejection fraction. After that adjustment, the researchers found that exercise reduced the incidence of hospitalization by 11 percent and cardiovascular deat...

GSK Submits TYVERB(R)/TYKERB(R) (lapatinib) for First-Line Treatment of Metastatic Breast Cancer in Europe, US

...function are severe, therapy with TYKERB should be discontinued and patients should not be re-treated with TYKERB. Decreased Left Ventricular ejection Fraction - TYKERB has been reported to decrease LVEF. Caution should be taken if TYKERB is to be administered to patients with preexisting cardiac ...

Siemens Demonstrates Workflow Efficiency in Echocardiography at ACC 2009

...ON X300 PE also offers advanced capabilities for comprehensive cardiac assessment, such as syngo (R) Auto Left Heart with expert-like measurements of ejection fraction and volumes of the left ventricle and atrium. Improved Stress Echo capabilities as well as compatibility with ACUSON AcuNav(TM) intracardiac ...

New Guidelines for Treating Heart Failure

...nd in the Heart Association journal Circulation The new guidelines "outline what has to happen in the initial evaluation, such as measurement of ejection fraction and whether the patient has coronary disease or not," Jessup said. "They describe what should be done each day to assess the patient and the ...

Older patients with 1 type of heart failure may receive little or no benefit from drugs

...ong elderly patients who have heart failure but an ejection fraction of at least 50 percent," said Cedars-Sina...warz, M.D., Ph.D., the article's senior author. ejection fraction is a measure of the pumping capacity of t...hamber of the heart. Heart failure with "preserved ejection fraction" a prevalent condition in the geriatric ...

Mount Sinai first in US to implant FDA-cleared ring for mitral valve repair

...s. The mitral valve lies between the left atrium and left ventricle of the heart. It prevents blood from leaking back into the left atrium during ejection (systole). Mitral valve regurgitation occurs when the valve does not close completely, and today the preferred treatment for such a condition is to re...

Data on VELCADE(R) (Bortezomib) for Injection Based Therapies to be Presented at the International Myeloma Workshop

...on of congestive heart failure, and new onset of decreased left ventricular ejection fraction has been reported, including reports in patients with no risk factors for decreased left ventricular ejection fraction. There have been reports of acute diffuse infiltrative pulmonary d...

CardioDynamics Reports Eighth Consecutive Quarterly Revenue Increase Over Prior Year and 12% Revenue Growth in 2008

... control rates at the American Society of Hypertension annual meeting; Announced two important clinical studies correlating BioZ ICG with ejection Fraction BioZ ICG technology featured in American College of Cardiology (ACC) audio series Sales & Marketing...

Cardiogenesis Announces Successful Educational Symposium at Society of Thoracic Surgeons Meeting in San Francisco

...ich plasma (PRP). The 6 month outcomes included a significant reduction in angina (82% of patients free of angina) and a trend towards improvement in ejection fraction. "This symposium outlines the Company's progress on developing breakthrough clinical tools in treating the increasing probl...

Stem Cells Poised to Grow Organs for Transplant : Zannos Grekos, MD Presents Clinical Data of Research with Adult Stem Cells to Physicians at International Regenerative Biomedicine Conference

...to illustrate his team's success with Adult Stem Cells. According to their findings, cardiac disease patients experience an average increase of 21% in ejection rates as well as measurable improvements in congestive heart failure class status, some in as little as one month post-treatment. "We are able to...

Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer

...cent of patients experienced a related serious adverse event of a decreased ejection fraction in the lapatinib plus letrozole group compared with 1% in the letr...hould not be re-treated with TYKERB. Decreased Left Ventricular ejection Fraction - TYKERB has been reported to decrease LVEF. Caution should be ...

Implantable monitor may help in managing diastolic heart failure

... HF leading to hospitalization, usually as a result of pulmonary congestion and rising blood pressure, is often more abrupt in patients with preserved ejection fraction. Hemodynamic monitoring may provide an early clue and facilitate relatively simple and effective interventions." ...

ICON Medical Imaging Launches New Cardiac Echocardiography Analysis Software

...inst the full motion image of the heart. This fine-tuning can optimise the accuracy of an important marker of heart performance - the left ventricular ejection fraction. MIRA-ECHO is a digital DICOM (Digital Imaging and Communications in Medicine) image viewer and analysis software module that is inte...

Exjade(R) Benefits Chronically Transfused Patients by Significantly Reducing Toxic Iron That Can Damage Key Organs, According to Landmark Trial

...jade had an improvement in T2* (>4% increase); there was no change in 14.3%; and worsening (>4% decrease) in 16.2% of patients. Left ventricular ejection fraction remained stable throughout the study. Additionally, LIC and SF levels (both indicators of total body iron) were significantly reduced from b...

Pulmonary Hypertension Treated with Stem Cells : International Medical Team Announces Patient Results in Adult Stem Cell Clinical Study for Pulmonary Hypertension

...ad consistent success in generating viable heart tissue and growing new vessels; with the increased circulation, healing of wounds, and improvement in ejection fractions, it seemed a natural progression to approach pulmonary hypertension in the same manner. I believe we have only begun to discover what Adult ...

Exercise improves quality of life for heart failure patients

...t 60 percent of that goal at one year. Participants had significant heart failure upon entering the study, measured by diminished left ventricular ejection fraction (mean, 25 percent). Ninety-five per cent of the patients were taking medications for heart failure, such as ACE-inhibitors or beta-blockers, ...

Exercise is safe, improves outcomes for patients with heart failure

...dering an intervention that should be covered. Participants in HF-ACTION had a significant degree of heart failure, determined by left ventricular ejection rate (LVEF), a measure of how vigorously the heart pumps blood throughout the body. The patients' mean LVEF was 25; a value less than 35 is considered...

Exercise is Safe, Improves Outcomes for Heart Failure Patients

... government's encouragement for including populations that have traditionally been under represented in medical trials. The average left-ventricular ejection fraction (LVEF), a measure of the heart's function, in the study was 25 percent, indicating moderate heart failure. More than half of the participants...

Interferon Reduces, Eliminates Viral Infections in Heart Failure Patients

... in NYHA functional class; performance on a six-minute walk test; individual clinical symptoms; quality of life and echocardiographic left ventricular ejection fraction (LVEF) -- a measure of the heart's ability to pump blood -- both at rest and on exertion; and several other measures of heart function and in...

Zannos Grekos, MD to Present Clinical Results of Regenerative Stem Cell Treatments to the Dubai Congress on Anti-Aging and Aesthetic Medicine

...s Grekos. "With a minimally invasive treatment, the risks of which are equal to a cardiac catheterization, we are more than doubling cardiac patients' ejection fraction, improving kidney and pulmonary function, saving limbs from amputation by creating new circulation pathways and most recently reversing the l...

Angioplasty Scoring System Predicts Risk of Death

...ted that the MCRS provided "excellent" predictions overall and in specific groups of patients categorized by age, gender, diabetes, renal failure, low ejection fraction and multi-vessel disease. The researchers found that 97 percent of patients had a MCRS below 10, indicating low to intermediate risk. The ...

New method to overcome multiple drug resistant diseases developed by Stanford researchers

...resistant tuberculosis, or by drug resistant parasites such as malaria, as well as other types of cancer. The arginine transporter manages to avoid ejection by slipping through the membrane of the cell in between the pumps. The key is the ability of arginine to form weak, temporary bonds with some of the m...

Alzheimer's disease as a case of brake failure?

...he status quo, overrides the brake and unleashes a chain of events that ultimately leads to the death of the cells and the resulting dementia. "The ejection of Cdk5 out of the nucleus is probably related to the changed chemistry of the Alzheimer's brain and chronic inflammation that accompanies AD," Herrup...

FDA Approves VELCADE(R) (Bortezomib) for Injection for Patients with Previously Untreated Multiple Myeloma

...on of congestive heart failure, and new onset of decreased left ventricular ejection fraction has been reported, including reports in patients with no risk factors for decreased left ventricular ejection fraction. There have been reports of acute diffuse infiltrative pulmonary d...

Cardiogenesis Announces Preliminary Results Combining TMR + Platelet Rich Plasma (PRP)

...d a lower average angina score (0.4 vs 1.7, p=0.07) than the TMR alone group, and were more likely to be angina free (71% vs 23%, p=0.04). -- ejection fraction (EF) improved in the TMR + PRP group (+9.0% vs. -2.0%, p=0.07) compared to the TMR group. The authors conclude, "These preliminary resu...

Tim Russert's Death Provides Important Opportunity for News Media to Increase Public Awareness of How to Prevent Sudden Cardiac Arrest

...: Automated External Defibrillators: http://209.235.212.198/content/resources/fact_sheet-automated_external_ defibrillators.pdf SCAA Fact Sheet: ejection Fraction http://209.235.212.198/content/resources/fact_sheet-ejection_fraction_n umber.pdf CONTACT: Kristjen Renard 202-719-8909 ...

ECG Reading May Predict Death, Rehospitalization Risk

...ath or rehospitalization, U.S. researchers report. They analyzed data from 2,962 patients hospitalized for heart failure who had a left ventricular ejection fraction (LVEF -- a measure of how well the left ventricle of the heart pumps with each contraction) of 40 percent or less. Of those patients, 1,641 h...

Sorafenib Shows Promise for Heart-Lung Disease

...eir standard medications. Eight of the patients increased their ability to exercise, six showed significant improvements in their right ventricular ejection fraction (the ability of the heart to pump blood to the lungs), and four had a significant decrease in pulmonary artery pressures. The most common ...

Drug therapy for PKU reverses heart damage

...sequent therapy, researchers found that BH4-treated mice showed remarkable improvements, according to Kass, when compared to placebo-treated animals. ejection fraction measures of heart pumping function not only stabilized with BH4, but improved, from an average 87 percent before heart failure to roughly 48 ...

SEISMIC study issues glum report on cell therapy

...of scarring. At the beginning of the study, the average left ventricular ejection fractionor the portion of blood the heart is able to pump from the left ven...h contractionwas 41.5 percent. At six-month follow-up, the left ventricular ejection fraction was 29.2 percent in the cell-therapy group and 32.9 percent in the...
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