Gene Defects Determine Susceptibility to Cancer and Bone Marrow Failure
...rom a gene mutation, Dkc1, that affects ribosome function. Dyskeratosis congenita involves abnormal bone marrow leading to anemia, immune deficiency and infe...pproaches to study the Dkc1 mutation in cells from humans with dyskeratosis congenita and in a genetically altered mouse model. Ruggero had previously developed ...Telomerase Vital In Maintaining Ability of Stem Cell to Multiply
...eres are short, and having telomerase doesn't lengthen them right away." The condition in these altered mice bears a close resemblance to dyskeratosis congenita in humans where stem cells in the bone marrow as well as in the intestine are unable to multiply as required and consequently die early. The detai...