bind in Medical News

New understanding of how big molecules bind will lead to better drugs, synthetic organic materials

Biological and medical research is on the threshold of a new era based on better understanding of how large organic molecules bind together and recognise each other. There is great potential for exploiting the molecular docking processes that are commonplace in all organisms to develop new drugs t...

Mind in a Bind – Alternative Intervention

“The mind is its own place, and in itself, can make heaven of Hell, and a hell of Heaven” reflected John Milton three centuries ago. Though delicate as the most exquisite silk ever woven it is imbibed with a tensile strength// that can withstand the strongest forces in this universe. Yet when subje...

Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann

...iseases, including renal disease and cancer. Keryx is developing Zerenex((TM)) (ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

New microchip technology performs 1,000 chemical reactions at once

...ible to the eye. The chemical reactions were performed using in situ click chemistry, a technique often used to identify potential drug molecules that bind tightly to protein enzymes to either activate or inhibit an effect in a cell, and were analyzed using mass spectrometry. While traditionally o...

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

... diseases, including renal disease and cancer. Keryx is developing Zerenex(TM) (ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

Preventing toxic shock syndrome and other severe diseases

...ore than $9.55 million. "We are looking at how these superantigen toxins bind to proteins on the surface of white blood cells. This binding causes the o...use potent activation of the immune system, so if we could engineer them to bind only to cancer cells, we could get the immune system to destroy the cancer....

MEK4, genistein and invasion of human prostate cancer cells

...xpression and cell invasion in prostate cancer cells; decreased MEK4 expression had the opposite effect. Computer modeling showed that genistein could bind to the active site of MEK4, and an enzymatic assay showed that genistein inhibited MEK4 kinase activity. The MMP-2 transcript level was statistically ...

Scientists discover key event in prostate cancer progression

...ells of the prostate gland and other tissues. Male sex hormones androgens bind with these receptors to activate genes that control cell growth. The res...n a histone protein associated with that gene enabled androgen receptors to bind with and activate the gene in hormone-independent prostate cancer. Finall...

Eliminating Cell Receptor Prevents Infections in Animal Study

...eptor (CAR), which Bergelson discovered in 1997. He previously found that, in cell culture, Group B coxsackieviruses (CVBs) manipulate cell signals to bind to the CAR. CVBs are common in humans, usually causing minor, transient infections. However, this virus may at times cause potentially sever...

Notice Begins Announcing Pendency of a Class Action Regarding MetLife

... this notice because you may be a class member. In a class action, claims common to a group, called class members, are litigated together. The results bind all class members. Class members' rights will be affected by this lawsuit. You are a class member if you received in MetLife Co.'s demutual...

Small Molecule Might Play Big Part in Lung Cancer

...sis that miR-21 and EGFR may make attractive targets for therapy, the researchers tested two experimental compounds: an antisense molecule designed to bind to the RNA and essentially turn it off; and a compound called AG1478, which targets the cell's EGFR and tyrosine kinase pathway. The researchers f...

Scientists Reverse Muscular Dystrophy in Mice

..., which affects muscle control and other cellular functions. The original defects in the DNA translate into expanded repeats in the RNA which then bind up various cellular proteins. These include one called "muscleblind," thought to be a key factor in myotonic dystrophy. "Probably the main thing [...

K-State scientist receives grant from National Institutes of Health to research cataracts

...ssage of one type of protein. Over time, the protein concentrations in the chambers equalize, and if an interaction occurred, then the proteins should bind to one another. "This technique allows us to both detect and quantitate possible changes in these interactions for the first time, under true equil...

Peregrine Pharmaceuticals Reports Financial Results for Fiscal Year 2009

...patients co-infected with HIV. Was awarded a U.S. patent that includes broad claims covering anti-viral applications of antibodies that directly bind to aminophospholipids, including PS. Reported that the company's anti-PS technology was positively highlighted in scientific sessions at the AID...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

...s by affixing fluorescent "tags" to small molecules that were engineered to bind and stay bound almost exclusively to caspases, and only when the caspases...r own light, which can be imaged by a special detector. "Our probe can't bind to inactive caspases," Bogyo said. "It can go into cells, but it doesn't ge...

Caltech chemists say antibody surrogates are just a 'click' away

...roteins utilized by the immune system to identify, bind to, and remove particular foreign compounds, such ...lentswhat we call 'protein capture agents'that can bind to a particular protein with very high affinity an...r a protein can be created from blocks that do not bind to the protein all that well; the trick is to repe...

Stem Cells' "Suspended" State Preserved by Key Step, Scientists Report

...l technique of RNA interference, or RNAi, to screen this gene and 40 other candidate genes. (RNAi is a naturally occurring process in which small RNAs bind to other RNAs to increase or decrease their activity.) In this case, the scientists used the technique to silence Chd1. When they did so, embryonic st...

Physics research with atomic force microscope could lead to better health care

...arily to do such a screening would require a humongous amount of testing material and antibodies. If you could prepare a surface that will selectively bind only one or two molecules of a kind and then see if you have bound or not, then you would need only a few milliliters of blood, and you could test it ...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

...eic acids (DNA), they are copied into chains of messenger ribonucleic acids (mRNA) that are "read" by cellular machines that build proteins. microRNAs bind to messenger RNAs, usually targeting them for breakdown or rendering them unfit to serve as templates for protein production. The current study f...

Study shows PET can measure effectiveness of novel breast cancer treatment

...ody compound and allow researchers to visualize breast cancer tumors with HER2 protein in mice. These molecules can also be engineered to specifically bind to other targets for cancer diagnosis and therapy. The researchers implanted human breast cancer cellsexpressing either very high or high levels of...

Novo Nordisk Insulin Analogs Have Proven Safety Profiles

...ns that certain insulin analogs have a structure making them more likely to bind to the IGF-1 receptor which is known to be involved in promoting tumor grow...re on the same page. About insulin and IGF-1 receptors Insulin can bind to two different receptors: insulin and IGF-1 (insulin-like growth factor-1...

Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform

...rget for the vascular imaging of tumors and tumor metastases in patients with cancer. "PS-targeting antibodies such as bavituximab preferentially bind to tumor blood vessels, which makes them ideal vehicles for imaging the tumor vasculature," said Dr. Philip Thorpe, professor of pharmacology at UT So...

BRIT1 allows DNA repair teams access to damaged sites

...derived from primary microcephaly patients that BRIT1 dysfunction may specifically contribute to development of the neurological disease by failing to bind to SWI-SNF to relax chromatin. ...

Structures from the human immune system's oldest branch shed light on a range of diseases

...e called C3 convertase, initiating a cascade of immune and inflammatory reactions. In order to avoid self-attack, regulatory proteins such as factor H bind with C3b, a central component of C3, to help the immune system recognize the body's own tissue and keep complement in check. Researchers at the Uni...

Keryx Biopharmaceuticals Inc. Regains Compliance With NASDAQ Listing Requirements

...g diseases, including renal disease and cancer. Keryx is developing Zerenex(TM)(ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

UCF researcher's nanoparticles could someday lead to end of chemotherapy

...o can be engineered without the drug and used as imaging (contrast) agents for cancer. If there is no cancer, the biodegradable nanoparticles will not bind to the tissue and will be eliminated by the liver. The iron oxide core will be utilized as regular iron in the body. "What's unique about our work...

New approach for treating recurrent prostate cancer on the horizon

...t efficiently kills small tumors is needed. Because tumor cells readily bind with certain peptides, researchers have been able to develop highly specific radiopeptides that bind with tumor cells and treat them using specific therapeutic radioactive subs...

Innovative Oxidative Stress Management Protocol Safely and Effectively Enhances Body's Primary Antioxidant

...uble and water soluble areas of the body. Oxidative stress occurs when the body's supply of antioxidants, mainly glutathione, is insufficient to bind and remove potentially harmful free radicals. Free radicals have an unpaired electron that gives them the ability to oxidize cell membranes and cause ...

Protein Branded As Culprit in Mad Cow Disease

...s of the cell and that is when the trouble begins. Scientists at the National Institutes of Health (NIH) found that misfolded or mislocated PrP can bind with another protein called Mahogunin, which is thought to be vital to brain cells. The binding appears to reduce the effectiveness of Mahogunin, lead...

A real-time diagnosis for a treatable cancer

...y effective method for finding elusive colon cancer malignancies. The chip is essentially an electrochemical biosensor programmed to recognize and bind to colorectal cancer biomarkers with high specificity. "Following this bio-recognition event, the electrodes on the chip transduce the signal it recei...

New antibiotics could come from a DNA binding compound that kills bacteria in 2 minutes

... size as the parts of a protein that recognise and bind with particular sequences of DNA. The high positive charge of the compound enhances its ability to bind to DNA which is negatively charged. When the ir...coils the DNA so that it is no longer available to bind to anything else and is not able to drive biologic...

Keryx Biopharmaceuticals, Inc. Receives Extension for Nasdaq Listing Compliance

...g diseases, including renal disease and cancer. Keryx is developing Zerenex(TM)(ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

World first: Chinese scientists create pig stem cells

...can introduce this gene to the pig via pluripotent stem cells a process known as gene 'knock-in'. Alternatively, because the swine flu virus needs to bind with a receptor on the cell membrane of the pig to enter the cells and proliferate, we could knock out this receptor in the pig via gene targeting in ...

Peregrine Pharmaceuticals Reports Progress in Cotara(R) Brain Cancer Clinical Program

...t links a radioactive isotope to a targeted monoclonal antibody designed to bind to the DNA histone complex that is exposed by dead and dying cells found at the center of solid tumors. Cotara's targeting mechanism enables it to bind to the dying tumor cells, delivering its radioactive payload to the adjacen...

Scientists find shared genetic link between the dental disease periodontitis and heart attack

... mRNA, and is often carried by the reverse strand, the 'anti-sense' strand of the DNA double helix. This strand does not encode for a protein, but can bind specifically to the messenger RNA to form a duplex. Through this binding, the antisense strand inhibits the protein expression of the mRNA . Coro...

Why Chimps, Monkeys Don't Develop Alzheimer's

...ge Alzheimer's and three deceased older but healthy humans. "We were able to show that, similar to what has been seen in mouse brains, PIB does not bind with high affinity to plaque in monkey or ape brains," Rosen said. Another group of researchers at the Yerkes Center recently reported separately t...

Why do people with Down syndrome have less cancer?

... activates once it binds to cellular receptors; most existing anti-VEGF drugs work by simply binding to VEGF (like Avastin) or blocking its ability to bind to its cellular receptors. "We're now moving further downstream by going inside the cell," Ryeom says. "When we targeted calcineurin, we suppresse...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

...#946;arrestin2, androgen receptor expression and activity went down. βarrestin2 locks up an androgen receptor by binding to it, then the pair bind to yet another protein, ubiquitin ligase, which tags the receptor as waste and the trio make their way to the cell's garbage dump. "The neat thing abo...

The future of personalized cancer treatment: An entirely new direction for RNAi delivery

...cer tumor returns, because the tumor has mutated the target gene to avoid the drug binding," said Dowdy. "But since the synthetic siRNA is designed to bind to a single mutation and only that mutation on the genome, it can be easily and rapidly changed while maintaining the delivery system the PTD-DRBD fu...

Cocaine Spurs Long-Term Change in Brain Chemistry

...in the gene activity of mice that were injected with cocaine. The changes involve a shift in proteins called histones and transcription factors, which bind to DNA and regulate how the genetic information in a DNA strand is read to make a complementary sequence of RNA. A cell uses the information in the RN...