Antibody in Medical News

JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab

A novel anticancer agent, consisting of a monoclonal antibody linked to a chemotherapy drug, showed substantial antitumor activity in ovarian cancer cell lines and in mice, according to a study published online July 29 in the Journal of the National Cancer Institute . The agent, known as an im...

Bcl6 gene sculpts helper T cell to boost antibody production

HOUSTON - Expression of a single gene programs an immune system helper T cell that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune diseases and development of B cell lymphoma, scientists at The University of Texas M. D. Anderson Cancer Center r...

Caltech chemists say antibody surrogates are just a 'click' away

Chemists at the California Institute of Technology (Caltech) and the Scripps Research Institute have developed an innovative technique to create cheap but highly stable chemicals that have the potential to take the place of the antibodies used in many standard medical diagnostic tests. James R...

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1/2 Study of MM-111, a Bispecific Antibody to ErbB2/3

Merrimack Pharmaceuticals' second of five oncology pipeline candidates, MM-111, a bispecific antibody, has entered clinical development. Preclinical studies have demonstrated that the bispecific approach shows antitumor activity in a wide range of tumor types. The current Phase 1/2 study will eva...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

BETHESDA, Md., June 18 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, today announced the initiation of the first clinical trial for the anti-granulo...

Morphotek(R), Inc. Announces FDA Acceptance of Investigational New Drug Application for MORAb-004, a Monoclonal Antibody for the Treatment of Solid Tumors

Antibody Targets Endosialin, a Protein Widely Expressed on Tumors and Tumor Blood Vessel Cells EXTON, Pa., June 9 /PRNewswire/ -- Morphotek(R), Inc., a subsidiary of Eisai Corporation of North America, announced that the U.S. Food and Drug Administration (FDA) cleared its investigational new ...

BioMosaics' Glypican-3 Antibody (clone 1G12) Validated at PhenoPath Laboratories for Immunohistochemical Detection of Liver Cancer

BURLINGTON, Vt. and SEATTLE, March 26 /PRNewswire/ -- BioMosaics Inc., a cancer biomarker development company, announced today that its monoclonal antibody product (clone 1G12) for detection of Glypican-3 (GPC3) has been validated for use as an immunohistochemical test for diagnosis of Hepatocellu...

New Data Published in Immunobiology Describe Mode of Action of BiTE Antibody MT110

Study shows that very low amounts of Micromet's EpCAM-targeting BiTE antibody trigger the death of cancer cells BETHESDA, Md., Jan. 28 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, ...

UCSF Finds Potential New Antibody Treatment for Autoimmune Diseases

Scientists at UCSF have discovered an abnormality in a patient's immune system that may lead to safer therapies for autoimmune diseases such as rheumatoid arthritis and colitis, as well as potential new ways to treat transplant rejection. (Vocus) January 22, 2009 -- Sci...

Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus

PHILADELPHIA More drafts usually mean a better product and so it also seems to go with the human immune system. As B cells develop, genes rearrange to allow antibodies to recognize different foreign invaders or pathogens. But sometimes antibodies are created that recognize and attack the body's o...

EGFR-targeting antibody licensed to Abbott

The international Ludwig Institute for Cancer Research (LICR) announced today that one of its spin-off companies, Life Science Pharmaceuticals, has licensed its lead cancer therapy candidate, antibody 806, to pharmaceutical company Abbott. The 806 antibody targets the EGFR cell surface protein...

Intellect Neurosciences, Inc. Validates Pivotal European Patent for Alzheimer's Monoclonal Antibody Platform

Follows Option and Royalty-Bearing License Agreements with Top Tier Global Pharmaceutical Companies NEW YORK, Nov. 11 /PRNewswire-FirstCall/ -- Intellect Neurosciences, Inc. (OTC Bulletin Board: ILNS), a biopharmaceutical company focused on development of disease-modifying therapeutic agents...

Scripps Research Institute and IAVI launch world's first dedicated HIV neutralizing antibody center

LA JOLLA, CA, and NEW YORK, NY, September 30, 2008 The Scripps Research Institute, one of the world's largest independent, non-profit biomedical research organizations, and the International AIDS Vaccine Initiative (IAVI), the world's only global non-profit organization focused solely on AIDS vac...

Study sees need for standardized evaluation of antibody response to HIV-1

U.S. Military HIV Research Program (USMHRP) researcher Victoria R. Polonis, Ph.D., and colleagues released findings on a study of cross-clade neutralization patterns among HIV-1 strains from six major clades in the 5 Jun 2008 issue of Virology . Broadly neutralizing antibodies are likely to pl...

InNexus Biotechnology Announces Third Antibody and Expands Pipeline of Anticancer Compounds

BRITISH COLUMBIA, Canada, Aug. 6 /PRNewswire-FirstCall/ -- InNexus Biotechnology Inc., (TSX VENTURE: IXS.V; OTC Bulletin Board: IXSBF) ( http://www.ixsbio.com ), a drug development company commercializing the next generation of monoclonal antibodies based on its Dynamic Cross Linking (DXL(TM))...

Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis

(PHILADELPHIA) Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have made a key discovery about the mechanism of breast cancer metastasis, the process by which cancer spreads. Focusing on a gene dubbed "Dachshund," or DACH1, they are beginning to pinpoint new t...

Core Informatics Deploys Core LIMS to Support Antibody Discovery at Fabrus

LA JOLLA, Calif., June 18 /PRNewswire/ -- Core Informatics, LLC. has deployed an installation of the Core LIMS to support Fabrus LLC, the first occupant of Pfizer's business incubator at the La Jolla Research and Development Center. Before Fabrus commenced laboratory operations, the company's ...

Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients

The ImmuKnow(R) and anti-HLA antibody assays both contribute to characterization of renal transplant patients being weaned off immunosuppression COLUMBIA, Md., June 1 /PRNewswire/ -- Data developed by Cylex in conjunction with the University of Pittsburgh Medi...

Phase 3 data Re: Anti-RSV antibody to be presented at Pediatric Academic Societies Annual Meeting

HONOLULU, HI, May 4, 2008 MedImmune today announced that researchers are currently presenting results from a MedImmune-sponsored Phase 3 study involving motavizumab, an investigational monoclonal antibody (MAb) that is being evaluated for its potential to prevent serious disease caused by respira...

Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?

There are a number of researchers who are searching for useful tumor markers to indicate cure. Antigens are being applied as an effective target in clinical therapy. Hb3 is an anti-colorectal cancer monoclonal antibody produced in the researchers laboratory, and whose sensitivity and specificity a...

Autism's origins: Mother's antibody production may affect fetal brain

The mothers of some autistic children may have made antibodies against their fetuses brain tissue during pregnancy that crossed the placenta and caused changes that led to autism, suggests research led by Johns Hopkins Childrens Center investigators and published in the February issue of the Journ...

EUSA Pharma Out-Licenses Preclinical-Stage Human Antibody to GlaxoSmithKline for up to $44 Million Plus Royalties

Out-Licensing Enhances EUSA's Strategic Focus on Late-Stage and Marketed Products DOYLESTOWN, Pennsylvania and OXFORD, England, February 18 /PRNewswire/ -- EUSA Pharma Inc ('EUSA'), a transatlantic specialty pharmaceutical company focused on oncology, pain contro...

Antibody Engineering Company f-star Appoints Three Pioneers in Antibody Engineering and Development to its Newly Established Scientific Advisory Board

VIENNA, Austria, December 12 /PRNewswire/ -- f-star, an antibody engineering company developing novel antibodies and antibody fragments based on its unique Modular Antibody Technology, announced today that it has established a Scientific Advisory Board and has appointed three outstanding scien...

Panacea Pharmaceuticals Announces Selection of PAN-622 - A Fully Human Sequence Monoclonal Antibody Against HAAH - As Its Lead Cancer Therapeutic Product

GAITHERSBURG, Md., Dec. 5 /PRNewswire/ -- Panacea Pharmaceuticals, Inc. announced today the selection of PAN-622 -- a fully human sequence monoclonal antibody against HAAH -- as its lead cancer therapeutic product. Developed in collaboration with the Massachusetts Institute of Technology, PAN-...

Micromet and MedImmune to Present New Clinical Data for Anti-CD19 BiTE(R) Antibody at American Society of Hematology Annual Meeting Showing Objective Clinical Responses in Relapsed Non-Hodgkin's Lymphoma Patients

BETHESDA and GAITHERSBURG, Md., Nov. 29 /PRNewswire-FirstCall/ -- Micromet, Inc. (Nasdaq: MITI ) and MedImmune, Inc. today announced that new data from an ongoing Phase 1 clinical trial of MT103 in patients with late- stage non-Hodgkin's lymphoma (NHL) will be presented at the 2007 Annual Mee...

ThromboGenics Begins Preclinical Development of Anti-VPAC Antibody for Thrombocytopenia

LEUVEN, Belgium, November 14 /PRNewswire/ -- - Key Research Findings Published in the Leading Medical Journal `Blood' Validate Drug Target ThromboGenics NV (Euronext Brussels: THR), a biotechnology company focused on vascular disease, announces today that it will progress with the developmen...

Medimmune announces phase 2 safety data for anti-RSV antibody and national RSV surveillance results

SAN DIEGO, October 4, 2007 MedImmune, Inc. today announced results from two important studies presented at the 2007 Infectious Diseases Society of America (IDSA) 45th Annual Meeting adding to the body of knowledge about respiratory syncytial virus (RSV). RSV is a viral pathogen that produces ann...

Ono and Medarex Announce Allowance of Investigational New Drug Application for Fully Human Anti-PD1 Antibody

Addition of Hepatitis C Treatment to Ongoing Oncology Program for MDX-1106 PRINCETON, N.J., Oct. 29 /PRNewswire-FirstCall/ -- Ono Pharmaceutical Co., Ltd. and Medarex, Inc. (Nasdaq: MEDX ) announced today the allowance of an investigational new drug application (IND) filed with the U.S. Food &...

A New Monoclonal Antibody Kills Cancer Cells

Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics. Using a newly available monoclonal antibody, they demonstrated significant redu...

Monoclonal Antibody Induces Death in Liver Cancer Cells

Researchers at the University of Pittsburgh School of Medicine have found that a newly available monoclonal antibody has the potential to induce death in liver cancer cells. In a study, the monoclonal antibodies' use demonstrated significantly reduces tumour cell proliferation and surviva...

Humanized Antibody Therapy Found Highly Effective in Easing RA Symptoms

Medical University of Vienna researchers have shown that nearly half of patients with rheumatoid arthritis (RA), who receive tocilizumab in addition to ongoing methotrexate therapy , showed a 50 per cent improvement in the symptoms at 24 weeks. Also one fifth of the patients achieved a 70 p...

J591- an Antibody Exclusively Targets Tumors

A clinical trial confirms that an antibody called J591 specifically targets an antigen found in high amounts in prostate tumors// and on blood vessels of all solid tumors. Researchers at NewYork-Presbyterian Hospital and Weill Cornell Medical Center conducted this study. Since the prost...

New Antibody for EGFR Causes Lung Cancer Regression

Mutant forms of the protein EGFR are important for the development of lung cancer in a substantial proportion of individuals with this disease. However, not all individuals// express the same mutant EGFR, for example, some have a mutation that affects the intracellular part of EGFR and some have a ...

Anti-rejection Therapy a Boon for Patients With "anti-donor" Antibody Levels

Soraya Kohanzadeh, 30, Muir Beach, CA, was living day-to-day, extremely ill, with no hope and expecting to live a shortened life dependent// on kidney dialysis. She needed a kidney transplant but because her “anti-donor” antibody levels were so high, her doctors believed that a transplant was not p...

Monoclonal Antibody Reduces Exacerbations in Asthmatics

Patients with symptomatic moderate asthma who were treated with anti-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced significantly// fewer disease exacerbations than individuals taking a placebo. This research appears in the first issue for October 2006 of th...

Monoclonal Antibody based system for Anthrax detection

According to Swiss Radio International report, a Swiss research team has developed a simple and highly sensitive testing system for anthrax detection, which is better than// the already existing ones.The report says that the new system can be used to detect anthrax spores that are used in biologica...

Single Sugar Enables Antibody to Treat Inflammation

For years, researchers have struggled to understand how IVIG worked. Its ability to treat autoimmune diseases seemed to be an apparent contradiction.// Intravenous immunoglobulin (IVIG) is a complex mixture of IgG antibodies made from human plasma that contains the pooled antibodies from tho...

Cancer killing antibody effective against prostate cancer

Researchers at the University of California, Los Angles have taken a major step forward in the war against cancer by identifying the mechanism, which blocks off the development of prostate cancer in animals//. The antibody that has been named 1G8 was discovered by UCLA scientists and according t...

Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs

New study has suggested that therapeutics based on monoclonal antibodies (mAbs) are fare more likely to be commercially successful than their small molecule predecessors. According to a study completed by // consultancy Propagate Pharma, about half the mAbs launched so fare appear to be profitable....

Human Antibody That Can Block SARS

SARS (severe acute respiratory syndrome) is a highly contagious and occasionally fatal illness that often progresses to pneumonia.// The virus killed nearly 800 people in a global outbreak last year. Researchers now say that they’ve discovered a human antibody that blocks infection caused by the...