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Enzyme may be target for obesity drugs

An enzyme involved in hormone production may help explain why obese people who carry most of their extra weight around their waist have such a high risk of heart disease and other health problems. The findings may lead to new approaches to treat obesity and its complications. // It is no news that obesity increases the risk of health problems such as heart disease and diabetes, but wh...

Researchers trick Alzheimer's Enzyme

According to researchers in Scripps Research Institute, chemists have tricked an enzyme essential in Alzheimer's disease into blocking its own debilitating action.// A team led by Nobel laureate K. Barry Sharpless developed the chemical trick, called "click chemistry," to make a molecule that blocks neurotransmitter destruction caused by the brain enzyme acetylcholinesterase. The destr...

Enzyme stimulates growth of adult stem cells

According to researchers at the University of Texas, an enzyme has been found, that instigates the growth and maturation of stem cells lurking in bone marrow, causing the stem cells to step up production and replace lost blood and immune system cells.// It is possible the enzyme may also spur the growth of stem cells elsewhere in the body. This information may help researchers determin...

Enzyme may aid hold back disease

According to a new research it is found that an enzyme that rectifies mutations in genes could be a key factor in reducing a person's susceptibility to diseases such as hemophilia, cancer and cystic fibrosis. //Researchers from Cardiff University in Wales and the University of Edinburgh in Scotland have found the MBD4 enzyme could protect people from gene mutations that can lead to diseas...

Coenzyme Q10 may reduce risk of Parkinson's disease

The naturally occurring compound coenzyme Q10 is the first treatment to actually slow down Parkinson's disease, rather than just treating its symptoms. The current treatments for Parkinson's disease// can help alleviate the movement disorders that accompany the condition, but they do not actually stop the underlying brain damage. In Parkinson's, cells in the substantia nigra, at the base...

Enzyme help destroy cancer cell

Researchers have found that radiotherapy helps in natural tumor control process. They said radiotherapy attacks and destroys cancer cells directly. When experiments were conducted on mice researchers identified an cell suicide enzyme, getting activated when struck by radiation. This enzyme destroys tumor nourishing blood vessels to die. Tumors cannot survive without oxygen and nutrient su...

Key enzyme protects against Alzheimer's

An enzyme that helps brain cells function normally also protects against Alzheimer's, scientists said Wednesday in a finding that could lead to better treatments for the illness. Brain cells need the enzyme called Pin1 to stay healthy but researchers in the United States, who identified it in 1995, have discovered it can also prevent tangles of protein in the brain which are a characteri...

Enzyme Associated with Memory

Do you remember where you were when you heard about the World Trade Center attack? For many it is a memory they will never forget. But why? A new study finds lasting memories are formed with a process that involves the enzyme known as protein kinase C.// Researchers from Wake Forest University Baptist Medical Center reported on their study at the annual meeting of the Society of Neuros...

Enzyme Associated With Memory

Do you remember where you were when you heard about the World Trade Center attack? For many it is a memory they will never forget. But why? A new study finds lasting memories are formed with a process that involves the enzyme known as protein kinase C.// Researchers from Wake Forest University Baptist Medical Center reported on their study at the annual meeting of the Society of Neuros...

Brain Enzyme Found To Regulate Weight

Almost a third of American adults are obese, up from 14 percent a generation ago, according to government data. Only a few // prescription weight-control drugs are on the market, and they produce only modest weight loss, either by suppressing appetite or by preventing the body from digesting and absorbing fats. In a recent study Harvard researchers found in experiments with mice that whe...

New Enzyme Identified For Arthritis

Scientists of Murdoch Childrens Research Institute and University of Melbourne, Australia have identified a new enzyme // that causes arthritis. The enzyme called ADAMTS5 destroys the cartilage by degrading the aggrecan in the joints. The cartilage destruction leads to inflammations and the severe joint pains that are the symptoms of the disease called arthritis. Arthritis i...

Enzyme for treatment of arthritis

Scientists have identified an enzyme’s new role in aiding joint inflammations in conditions like // arthritis. An enzyme called cathepsin G can regulate the ability of the immune cells to secrete chemicals that will start the process of inflammatory conditions that can lead to arthritis. The enzyme cathepsin G attracts accumulation of immune cells that can lead to damage of the tissue...

New Study to look at the Beneficial Effects of Coenzyme Q10 on Parkinson’s disease

A recent article reviewing the research carried out so far into the effects// of CoQ10 on the progressive debilitating disease- Parkinson’s has revealed that a new phase III trial is scheduled to commence this year. In the past three years, demand for CoQ10 has escalated, causing soaring prices and reports of fake products entering the market. The increase in demand is thought to have bee...

An Enzyme That Turns a One –time Experience into a long-time Memor

Do you remember where you were when you heard about the World Trade Center attack? For many it is a memory they will never forget. But why? A new study finds lasting memories are formed with a process that involves the enzyme known as protein kinase C.// Researchers in New Orleans studied female mice and how they remembered their mating partner. They discovered that with only one expos...

Enzyme Responsible For Congenital Blindness

Researchers from UCLA had found out that a deficient gene that is also responsible for the presence of an enzyme in the vision cycle that causes congenital blindness in children. The researchers’ study regarding the congenital blinding disease // called Leber congenital amaurosis is published in the August issue of the journal Cell. Researchers suggest that replacement of RPE65, which...

Smoking Hazardous To The Enzymes System In Lungs

It has always been stated time and again that smoking is injurious to health. The maximum harm by smoking is on the respiratory system. The effects of smoking may be understood by the effect it has upon a key enzyme in the // lungs. Monoamine oxidase A (MAOA) is important in mood regulation and breaking down compounds that help to regulate blood pressure. In a new study, researchers at...

Urine testing for telomerase enzyme for bladder cancer diagnosis

Dr Maria Aurora Sanchini and her colleagues from Italy have found a new urine test which detects bladder cancer// in people with high-risk of cancer occurrence. The test which is proved to be 90% accurate is used to measure the level of the enzyme telomerase in urine of patients. The results of the study have been published in the Journal of the American Medical Association. The study wou...

Enzyme Linked To Spread Of Skin Cancer

A new study says that a key enzyme present in skin cancer cells might be responsible for the metastasis or triggering the spread of the cancer to other parts of the body. // The enzyme named focal adhesion kinase (FAK) is actually a critical component of the healthy cell and plays a vital role in many cellular activities. But this enzyme's less than helpful role in malignant melanoma o...

Excess Cdk5 Enzyme Can Harm Brain

A research conducted by the Howard Hughes Medical Institute, the National Institute of Mental Health and the Harvard Medical School has revealed that a brain enzyme plays a prominent role// in maintaining and developing learning and memory. If the enzyme is present in high levels, then it can have adverse effects on the brain. The tests were conducted on mice. The Cdk5 enzyme also plays a...

Streptococcus Bacterium Enzyme Identified

Professor Gary Black and his team from Newcastle University have found a triple stranded beta helix shaped enzyme which is responsible for the increased pathogenicity produced by Streptococcus bacterium. // Streptococcus is a gram positive bacterium which is the main cause of sore throat and is also responsible for causing Toxic shock syndrome, rheumatic fever, septicemia and necrotizing...

Little Known DNA Repair Enzyme May Be A Tumor Suppressor Gene

Researchers at the University of Pittsburgh have demonstrated that loss of DNA // repair enzyme’s activity in mouse cells leads to dramatic chromosomal instability. The DNA in our cells is constantly subject to environmental, chemical and cellular impacts. Thanks to nature, our cells contain several enzymes dedicated to detecting and repairing any damage caused by these impacts. Failu...

Bad Enzymes Found To Enable Brain Recovery Following Stroke

The same enzymes that cause brain damage following an acute attack of stroke could be beneficial some time later. This finding perhaps highlights that effective treatment // of stroke could be possible if administered few weeks following the stroke, instead of the treatment within couple of hours following stroke. Additionally, it could open avenues for the development of novel stroke tre...

Sepsis risk increased due to the absence of one key enzyme

The presence of caspase-12, touted as the wonder enzyme in sepsis increases the bodys vulnerability to bacterial infection and septic shock while a deficiency confers strong resistance to sepsis. // This enzyme appears to modulate inflammation and innate immunity in humans. "The results of the study make clear that caspase-12 plays a critical role in the elimination of bacteri...

New Role of COX Enzymes Discovered

Recent research has revealed that the COX enzymes interact physically in a biochemical partnership as well as function in the development of blood vessels. // The study was conducted by researchers at the University of Pennsylvania School of Medicine and Queen's University, Ontario, Canada and reported in the online edition of Nature Medicine. The COX enzymes are well-known for their c...

Enzyme Urokinase Better Option In Empyema For Kids

Researchers say that enzyme urokinase provides a better option as a treatment for empyema in children since it is 25 percent less costlier than another treatment// video-assisted thoracoscopic surgery. The researchers say both methods are equally effective. The study results appear in the second issue for July 2006 of the American Journal of Respiratory and Critical Care Medicine, pub...

Structure of DNA-modifying enzyme In Small Pox Determined

Researchers have determined the structure of DNA-modifying enzyme that could help fight the smallpox disease better. In a study published in the August 4 issue of Molecular Cell//, the researchers at the University of Pennsylvania School of Medicine have presented their findings on the structure of topoisomerase enzyme and how it binds to DNA. The findings could help in developing antiv...

Enzyme supply may improve Alzheimer’s condition.

A pioneering drug treatment has revealed that memory function can be restored in mice afflicted with Alzheimer’s disease.// Dr. Michael Shelanski, director of the Alzheimer's Research Center at Columbia University and his colleagues carried out this study. They treated mice whose brains were already clogged with the amyloid plaques. These plaques are responsible for the irreversible b...

"Dynamic Energy Landscape" of enzyme in Catalysis

Complex protein molecules called enzymes catalyze specific biochemical reactions in cells. The traditional theory is that dynamic fluctuations//protein conformation or structure play a major role in enzyme catalysis. However, recent findings reveal that it is the "dynamic energy landscape" of the enzyme that directs it to a specific pathway that reduces the number and dimension of the ene...

Naturally Occurring Enzyme Can Break Down Key Part of Alzheimer's Plaques

Scientists have identified a naturally occurring enzyme that can break down a key component of the brain plaques characteristic of Alzheimer's disease.// The finding may provide researchers with new opportunities to understand what goes wrong in the brains of Alzheimer's patients and could one day help them seek new therapies. Researchers at Washington University School of Medicine in...

Anti-Aging Powers of Enzyme Sirtuins

In the recent years, scientists discovered a family of enzymes called sirtuins, which can dramatically extend life in organisms// as diverse as yeast, worms, and flies. Now, a new study from scientists at The Wistar Institute points to another strategy for activating sirtuins to unleash their anti-aging powers. They may also be able to control age-associated metabolic disorders, inclu...

Enzyme to Boost Effect of Tumor Vaccine

The effects of tumor vaccines seem to get boosted by a 'super' form of an enzyme called Akt1. This enzyme is expected //to help extend the life of dendritic cells. These cells are also referred to as the main switch of the immune system that improves the way the T-cells respond to attack a tumor. This was divulged in a report that appears in an electronic media, online in the latest issue...

Run Amok Enzyme Causes Same Problems in Both Humans and Fruit Flies

An enzyme found at elevated levels in several human cancers has been linked to abnormal tumor growth in fruit flies//, a discovery that provides a new model for understanding the link between stem cell biology and cancer, according to researchers. Using fluorescent staining and laser-scanning microscopy, the eight-member research team studied various mutations in a gene called aurora-A...

Immune System Gears Up by Specific Enzymes

St. Jude study shows LAG-3 protein on activated T lymphocytes slows replication until // ADAM10 and ADAM17 enzymes cleave it off to allow these cells to reproduce rapidly. The complex task of launching a well-organized, effective immune system attack on specific targets is thrown into high gear when either of two specific enzymes chop a protein called LAG-3 off the immune cells leadin...

Suppression of Enzyme Delays a Type of Breast Cancer

Canadian researchers have disclosed that suppression of an enzyme called PTP1B stalls the advancement of a specific type of breast cancer//. This study was conducted on laboratory mice which were genetically modified to develop into a breast cancer condition of humans. This research headed by Michel L.Tremblay along with Sophie Julien of McGill cancer Center, Quebec delayed the advancem...

Sentry Enzyme Blocks Two Paths to Parkinson’s Diseas

The degeneration of brain cells that occurs in Parkinson’s disease may be caused by either externally provoked cell death or internally initiated //suicide when the molecule that normally prevents these fatal alternatives is missing, according to studies in mouse models by investigators at St. Jude Children's Research Hospital. Parkinson’s disease is a disease in which nerve cells in...

Enzyme Critical for Early Growth of Abdominal Aortic Aneurysms

Surgery is the only treatment for an abdominal aortic aneurysm, a weak spot in the body's main artery that dilates dangerously// over time. If the vessel ruptures suddenly before surgery to repair it, a quick death is virtually certain. Now, scientists say they have identified a key enzyme that triggers chronic inflammation in the aorta and promotes the growth of aneurysms. Their finding...

Fetal Heart-Cell Enzyme and Onset of Heart Failure

In almost all forms of heart failure, the heart begins to express genes that are normally only expressed in the fetal heart//. Researchers have known for years that this fetal-gene reactivation happens, yet not what regulates it. Now, investigators at the University of Pennsylvania School of Medicine have discovered that an enzyme important in fetal heart-cell development regulates the en...

Viral Enzyme Recruited in Fight Against Ear Infection

Parents might one day give their children a weekly treatment with a nasal spray of virus enzymes to prevent them from getting a severe middle //ear infection, based on results of a study. Such a treatment would kill the disease-causing bacteria without the use of antibiotics, thereby avoiding the problem of antibiotic resistance. Middle ear infection, also called acute otitis media, i...

Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals

Many HIV/hepatitis coinfected individuals on antiretroviral therapy (ART) experience liver enzyme elevation (LEE), and for that reason,// caution is generally advised when prescribing ART in this population. Results from the ICoNA (Italian Cohort of Na?ve for Antiretrovirals) study indicate that coinfection itself may be the major risk factor for LEE. The study investigated whether c...

A Shot in the Arm for Cancer Enzyme Research

Sydney- In what is being termed as a breakthrough in cancer research,// scientists from the Children's Medical Research Institute have cracked the composition of the cancer enzyme, telomerase, a constant in more than 85% of all cancers. This finding could pave the way for the design of precise drugs to target telomerase. This is not the first time that scientists have sought to study...
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