A new take on growth factor signaling in tamoxifen resistance
Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study, published in the open access journal BMC Medical Genomics , suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen
because of increased GF signaling...
Scientists Unravel Mystery of Tamoxifen Resistance
Some breast tumors produce a protein that defeats the drug
WEDNESDAY, Nov. 12 (HealthDay News) -- As many as 35 percent of women who take tamoxifen
to prevent the return of breast cancer do not respond to the drug -- and now scientists think they know why.
A battle between proteins ...
Research Reveals Why Tamoxifen Doesn't Always Work
Receptors on the surface of breast cancer cells may be the key, scientists say
THURSDAY, Oct. 30 (HealthDay News) -- Scientists have uncovered new clues to how breast cancer cells become resistant to the widely-used prevention and treatment drug tamoxifen.
The findings, from a team ...
Chemotherapy and tamoxifen reduce risk of second breast cancer
Among breast cancer patients, both chemotherapy and tamoxifen
independently reduced the risk of developing a second cancer in the other breast, according to a study published online December 25 in the Journal of the National Cancer Institute . The risk reduction persisted for at least 10 and 5 ye...
Data Show ARIMIDEX(R) (Anastrozole) Continues To Be Superior to Tamoxifen in Helping Reduce the Risk of Recurrence in Patients With Early Breast Cancer
Effectiveness Of ARIMIDEX Still Evident More Than Three Years After Treatment
SAN ANTONIO, Texas, Dec. 14 /PRNewswire-FirstCall/ -- Data released
today show a continued benefit of ARIMIDEX when compared to tamoxifen
treating postmenopausal women with hormone ...
Arimidex Beats Tamoxifen in Keeping Breast Cancer at Bay
After more than 8 years of follow-up, older women taking the newer drug fared better, study finds
FRIDAY, Dec. 14 (HealthDay News) -- The aromatase inhibitor drug Arimidex continues to outpace the old standard tamoxifen
when it comes to preventing recurrences of hormone-receptor-positi...
Technique May Let More Women Use Tamoxifen
30% of breast cancers currently don't respond to this type of estrogen-linked drug
MONDAY, Feb. 23 (HealthDay News) -- Researchers have found a way to "switch on" estrogen sensitivity in breast tumor cells, thereby making them vulnerable to the breast cancer drug tamoxifen.
Future hope for patients with breast cancers resistant to tamoxifen
Researchers have found a new family of therapeutic agents that interferes with the ability of estrogen to stimulate the growth of breast cancer cells. The results of the new study will be presented by Nicole Patterson at The Endocrine Society's 90th Annual Meeting in San Francisco.
Acupuncture relieves hot flushes in breast cancer patients taking tamoxifen
Berlin, Germany: Acupuncture provides effective relief from hot flushes in women who are being treated with the anti-oestrogen tamoxifen
following surgery for breast cancer, according to new research presented today (Friday) at the 6th European Breast Cancer Conference (EBCC-6) in Berlin.
Study Identifies Mechanism Which May Help Tamoxifen Work Better
The “crosstalk” between estrogen and a special protein responsible for cell development (Notch) helps breast cancer cells// proliferate and spread, a new study shows.
“Breast cancer cells respond to loss of estrogen, which is caused by commonly used hormonal therapy, by increasing the Notch s...
Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
Researchers have found that aromatase inhibitors like anastrozole are more effective in treating postmenopausal women with hormone receptor-positive early breast cancer// than tamoxifen
according to study published in the "The Lancet Oncology" journal.
Researchers followed more than 6,000 post...
Raloxifene Better Than Tamoxifen For Breast Cancer
The osteoporosis drug Evista is better than Tamoxifen
in preventing breast cancer in high risk post-menopausal women, new research// has suggested. Researchers said that both drugs reduce the risk of cancer by 50 percent. But the results of a 19,000-woman trial show that Eli Lilly and Co's Evista, ...
New Drug More Effective than Tamoxifen in Preventing Breast Cancer Relapse
New research appearing in the December 29 issue of the New England Journal of Medicine says that a new drug called as Femara is better than tamoxifen
fro preventing the chances // of a relapse of breast cancer. Femara is a drug manufactured by Novartis AG and is chemically letrozole.
Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence
Aromatase Inhibitors drug, Femara given after 5 years of Tamoxifen
therapy is found to give protection against occurrence of Breast cancer recurrence. Breast cancer is the second leading cause of cancer// in women. Breast cancer mostly occurs in post menopausal women and various risk factors are at...
Letrozole Beats Tamoxifen in Breast Cancer Therapy
Novartis' Femara (letrozole), one of a new class of breast cancer drugs, worked better than standard therapy with tamoxifen
in treating breast cancer in women// with advanced disease. Femara is a member of a new class of drugs called aromatase inhibitors, which work differently to prevent certain k...
Breast Cancer Drug May Beat Fungal Infection
... If proven effective, tamoxifen
could be new way to fight Candida ,,
...of Rochester Medical Center researchers found that tamoxifen
kills yeast in mice with Candida infections, whi...r chronic conditions.
At extremely high levels, tamoxifen
slashed yeast levels by 150-fold, causing most fun...
Breast cancer drug shows promise against serious infections
...tients with cancer. Some scientists suspected that tamoxifen
has antifungal properties; now new research from t...albicans blood stream infection is 20 percent.
is given to prevent breast cancer from returning. ...en for months at a time. Scientists had known that tamoxifen
has anti-fungal properties in test tubes, but it w...
June 2009 Mayo Clinic Health Letter Highlights Probiotics, Carotid Artery and Breast Cancer Treatments
...h early-stage cancer and no lymph node involvement.
Post-cancer treatment: For some breast tumors, patients typically take the estrogen blocker tamoxifen
after treatment. It reduces the risk of recurrence by about 50 percent. But this therapy doesn't work well for 8 to 10 percent of women -- those who h...
Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer
...mor cell survival.
Filardo says, "There has been a recent shift toward treating ER-positive breast tumor patients with aromatase inhibitors such as tamoxifen
that block estrogen biosynthesis. The thought is that this is yet another way to prevent estrogen from acting as its sole receptor, the ER." He conclu...
New Cancer Drug Fights Tumors in Those With BRCA Mutations
...over the cliff that would be only susceptible to a PARP inhibitor," he said.
In addition, "PARP inhibitors may be used for tumors that Herceptin or tamoxifen
are totally incapable of treating," he said. "That's true for ovarian cancer, too. There is nothing to treat that disease."
Two other trials of PAR...
VBI researchers develop new method for breast cancer biomarker discovery
...d the complex biochemical signaling pathways involved in the development of cancer. We hope this will also shed some light on the ways that drugs like tamoxifen
work to inhibit cell proliferation and to induce response to stress at the molecular level. This knowledge will help to advance our understanding of h...
Many breast cancer patients take high doses of antioxidants despite possible consequences
...during breast cancer treatment, which included chemotherapy, radiation, and tamoxifen
About seven in ten antioxidant users (69.3 per...ok high doses of antioxidants during treatment were more likely to be using tamoxifen
and to have a history of eating more fruits and vegetables, using herbal pr...
Some Antidepressants May Thwart Tamoxifen's Effect on Breast Cancer
...ors use to dampen the hot flashes caused by taking tamoxifen
may actually boost the odds of the disease's retur...N.C.
Many breast cancer survivors take the drug tamoxifen
to reduce their odds for recurrence. But tamoxifen
often causes hot flashes, a side effect that can b...
Compliance and cost: Bitter pills to swallow in the age of oral chemotherapy
... cancer "survivors" are taking adjuvant drugs to prevent a recurrence like tamoxifen
for breast cancer may simply tire of taking the drugs over the long term e...takes a toll in one study, women who filled fewer than 70 percent of their tamoxifen
prescriptions had an increased risk of death.
With more oral agents comi...
Mayo Clinic Researchers Say Agent Provides Treatment Option for Women with Hot Flashes
...nt of which was unknown to them.
In the study group, 34 percent were using anti-estrogen therapy -- either an aromatase inhibitor, raloxifene, or tamoxifen
-- to help prevent the recurrence of estrogen-sensitive breast cancer.
The researchers found that for the 163 patients for whom information was a...
Mayo Clinic researchers say agent provides treatment option for women with hot flashes
...content of which was unknown to them.
In the study group, 34 percent were using anti-estrogen therapy either an aromatase inhibitor, raloxifene, or tamoxifen
to help prevent the recurrence of estrogen-sensitive breast cancer.
The researchers found that for the 163 patients for whom information was availa...
New universal breast cancer marker predicts recurrence and clinical outcome
...rence and poor clinical outcome. As many as 40 percent of patients who take tamoxifen
in this setting relapse despite its significant effect on survival when used in the early stages of the disease.
"Resistance to tamoxifen
is thought to be an epithelial 'cancer cell' phenomenon, but we show here t...
M. D. Anderson study predicts dramatic growth in cancer rates among US elderly, minorities
...and should be strongly encouraged, said Smith. In the study, Smith and his team site: vaccinations for hepatitis B and HPV; the chemoprevention agents tamoxifen
and raloxifene; interventions for tobacco and alcohol; and removal of pre-malignant lesions, such as colon polyps.
These findings also highlight tw...
V. Craig Jordan, Internationally Renowned Breast Cancer Scientist, Joins Georgetown's Lombardi Comprehensive Cancer Center
...blocks estrogen from fueling some breast cancers. tamoxifen
was the first in a class of drugs known as selecti... for women with some forms of breast cancer."
revolutionized breast cancer treatment when it bec...uvant therapy for the disease. Then, years later, tamoxifen
became the first drug approved to reduce the risk ...
Genomic Health Announces Study Confirming Prognostic Value of Oncotype DX(R) Recurrence Score(R) Result in Japanese Breast Cancer Patients
...proportion of breast cancer patients in Japan were identified by the Recurrence Score to have a low likelihood of distant recurrence when treated with tamoxifen
alone without chemotherapy.
About Onco type DX(R)
The Onco type DX breast cancer assay is the first and only multi-gene expression tes...
Mutation of BRCA gene influences women's views of preventive mastectomy
...a known deleterious mutation in either the BRCA1 or BRCA2 genes has included frequent screening with mammogram, breast MRI, and clinical breast exams, tamoxifen
therapy, and risk reduction surgeries including prophylactic mastectomy. To get a sense of women's opinions regarding those options, particularly freq...
Women with BRCA mutation, or worry, most likely to undergo prophylactic mastectomy
...ms, mammograms, or MRIs or prophylactic measures, such as medications like tamoxifen
In conducting the study, the researchers sent surveys to ...ngs on: the screening techniques mammograms and breast-self exams; the drug tamoxifen
and its known side effects, and prophylactic surgeries.
D&W Fresh Markets, Family Fare and VG's Expand Discounted Generic Drug Program
...s Pharmacies are also increasing the number of women's health medications they offer at the discounted price. These include prescription drugs such as tamoxifen
to treat breast cancer and pre-natal vitamins.
In-Store Pharmacy Program Specifics
The $4.00 - 30-day generic drug program and the 90-day $...
Goserelin improves long-term survival in premenopausal women with early breast cancer
...ook both drugs, the benefit of adding goserelin to tamoxifen
was smaller (2.8 fewer events per 100 patients) an...rs after starting treatment and is as effective as tamoxifen
when each are given for 2 years," the authors writ...that women who are unlikely to complete 5 years of tamoxifen
tablets may prefer 2 years of goserelin injections...
Menopause Drug Tied to Breast Cancer Recurrence
... tumors. The study authors also said the profile of future groups of breast cancer patients may differ from that of those in this study. For example, tamoxifen
use might not be as widespread or patients might be undergoing adjuvant systemic therapy.
Nevertheless, the study authors concluded, "There are ins...
Statins Don't Cut Cancer Risk
... of body weight to the animals, mixing it into their diet, but it showed no anti-cancer effect.
They also compared the use of the anti-cancer drugs tamoxifen
and bexarotene by themselves and with atorvastatin. The anti-cancer drugs reduced breast tumors in the animals, but adding the statin did not improve ...
NCCN Updates Breast Cancer and Breast Cancer Risk Reduction Guidelines
...tion include updates to two risk-reduction agents, tamoxifen
(Soltamox(TM), AstraZeneca) and raloxifine (Evista(R), Eli Lilly and Company). tamoxifen
is recommended for premenopausal women with a hist...ausal women, raloxifene is listed as equivalent to tamoxifen
in reducing the risk of developing invasive breast...
Federal Trade Commission Files Complaint Against Par Pharmaceutical Over Court-Approved AndroGel(R) Litigation Settlement
...enth Circuit's Schering-Plough decision has been followed by numerous federal circuit and district courts, including by the Second Circuit in In re tamoxifen
Citrate Antitrust Litigation , 466 F.3d 187 (2d Cir. 2006), and by the Federal Circuit in In re Ciprofloxacin Hydrochloride Antitrust Litigation , ...
Cancer Medicine Advances on Many Fronts
Women with breast cancer who have already taken tamoxifen
for five years and who take additional hormone the...rapy in the form of an aromatase inhibitor or more tamoxifen
may reduce even further the chances of the cancer ...sion of ovarian function and hormonal therapy with tamoxifen
or an aromatase inhibitor reduced the risk of recu...
US Oncology Research Network Presents Clinical Studies at San Antonio Breast Cancer Symposium
...menopausal early breast cancer," was to evaluate exemestane (E)
compared to tamoxifen
(T) as initial adjuvant endocrine therapy.
The analysis represents ...) at 2.75
years in 9,775 patients randomized to initial therapy with either tamoxifen
The analysis of DFS at 2.75 years demonstrated an 11 p...