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Suppressor in Medical News

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

Researchers have identified a new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples, according to a new study published online June 17 in the Journal of the National Cancer Institute . In the study, Manon van Engeland, Ph.D., of...

Gene helps protect tumor suppressor in breast cancer

HOUSTON - Scientists at The University of Texas M. D. Anderson Cancer Center have discovered a gene that protects PTEN, a major tumor-suppressor that is reduced but rarely mutated in about half of all breast cancers. The gene Rak helps protect and regulate PTEN, which also is important in sever...

Tumor suppressor may attenuate fibrotic disease

New research reveals a critical cellular signaling pathway that is responsible for generating excess connective tissue in multiple organs, similar to what is seen in human patients with scleroderma. The study, published by Cell Press in the February issue of the journal Developmental Cell , also ...

Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1

Scientists have uncovered an interesting connection between two important protein kinase signaling pathways that are associated with cancer. The research, published by Cell Press in the January 30th issue of the journal Molecular Cell , may direct new therapeutic strategies for multiple types of ...

Cell biologists identify new tumor suppressor for lung cancer

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. The study, led by Jorge Moscat, PhD, appears in the January 2009 issue of Molecular and Cellular Biol...

CSHL scientists trace causal link between a tumor suppressor gene and liver cancer

Scientists at Cold Spring Harbor Laboratory (CSHL) have taken the search for cancer-causing genes an important step forward. In a newly published paper, they confirm that a gene called DLC1 is a tumor suppressor. They have demonstrated in living mice that its deletion, inactivation or loss precipi...

Tumor suppressor genes speed up and slow down aging in engineered mouse

ROCHESTER, Minn. -- Mayo Clinic researchers have developed an animal model that can test the function of two prominent tumor suppressor genes, p16 and p19, in the aging process. Scientists knew that both these genes were expressed at increased levels as humans and mice age, but their role in the a...

Does 1q31.1-32.1 harbor a tumor suppressor gene related to Chinese SCC patients?

The LOH analysis on sporadic carcinoma by means of microsatellite markers has become an effective way to find allelic deletion regions and then to find candidate tumor suppressor genes. In a previous study, it was found that D1S413 (1q31.1-32.1, 9.8cM) exhibited higher LOH frequencies, which indic...

Gene found to play a suppressor role in skin cancer development

Researchers at the Burnham Institute for Medical Research (Burnham Institute) have provided genetic evidence that Activating Transcription Factor 2 (ATF2) plays a suppressor role in skin cancer development. ATF2 is a protein that regulates gene transcription, which is the first step in the transl...

Mutated Suppressor Gene Leads to a Type of Breast Cancer

Finding could lead to new treatments, researchers say MONDAY, Dec. 10 (HealthDay News) -- Scientists believe they've discovered how mutations in the cancer-susceptibility gene called BRCA1 can cause some breast cancers. Basal-like breast cancers (BBCs) represent 10 percent to 20 per...

Study details regulation of vital tumor suppressor gene p53

(PHILADELPHIA) So vital is the p53 tumor suppressor gene in controlling cancer that its dysfunction is linked to more than half of human cancers. At the same time, the genes capacity for shutting down cell growth, even causing cells to commit suicide if necessary, is so absolute that it must be t...

Carbohydrate acts as tumor suppressor

LA JOLLA, Calif., July 6, 2009 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These glycans play a critical role in cell adhesi...

Penn researchers identify natural tumor suppressor

PHILADELPHIA - Researchers from the University of Pennsylvania School of Medicine have identified a key step in the formation and suppression of esophageal cancers and perhaps carcinomas of the breast, head, and neck. By studying human tissue samples, they found that Fbx4, a naturally occurring ...

Protein thought to promote cancer instead functions as a tumor suppressor

DALLAS July 7, 2008 A protein previously thought to promote colorectal cancer instead suppresses the growth of human cancer cells in culture, researchers at UT Southwestern Medical Center have found. "This finding reshapes a fundamental model of how colorectal cancer arises," said Dr. Lawrenc...

Bacterial peptide provides new insight into common tumor suppressor

Scientists have identified a new antitumor drug that might prove useful in developing treatments for a multiple human cancers. The research, published by Cell Press in the July 8 issue of the journal Cancer Cell , advances the understanding of one of the most frequently disrupted tumor suppressor...

Regulatory Mechanism for Tumor Suppressor Protein Identified

A new mechanism has been identified by scientists from the Wistar Institute in Philadelphia and The Vienna Biocenter in Austria that is involved in normal repression of the p53 protein // which is the most important molecule for the control of cancer in humans. The new molecular pathway descr...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending// against cancer. Similarly, roughly 95 percent of cancer-causing mutations in the p53 protein occur in its DNA-binding core domain, pointin...

Tumor Suppressor p53's Contradictory Regulatory System

A new study appearing in the online open-access journal PLoS Biology examines the role played by the tumor suppressor protein called p53. It has been found that any mutations of p53 play a key role in the development of many human cancers. //This particular study was carried out by Min Hu, Yigong S...

Little Known DNA Repair Enzyme May Be A Tumor Suppressor Gene

Researchers at the University of Pittsburgh have demonstrated that loss of DNA // repair enzyme’s activity in mouse cells leads to dramatic chromosomal instability. The DNA in our cells is constantly subject to environmental, chemical and cellular impacts. Thanks to nature, our cells contain ...

Mathematical modeling predicts response to Herceptin

...hology at the University of Edinburgh, examined the role of PTEN protein expression on resistance to Herceptin. PTEN is a protein that acts as a tumor suppressor gene. "Herceptin has benefited thousands of women with HER2 positive breast cancer, but only a third to half of patients treated with this agent r...

DNA-damaged cells communicate with neighbors to let them know they're in trouble

...aid Rodier. He added that scientists were also surprised to discover that the damage-induced communication signaling pathway bypasses a powerful tumor suppressor gene known as p53. That finding gives scientists a target to shut down the inflammatory process without hampering the activity of p53, which is essent...

Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs

...has used the approach successfully in mice with skin grafts. The degradable microparticles deliver the most powerful known form of HLA-G, a natural suppressor of the immune response, straight to dendritic cells, which typically show the immune system what to attack. The microparticles are given right after a...

Lab Study Finds Protein That May Inhibit Cancer Spread

...ent longer than those who didn't receive prosaposin, the study reported. Further research revealed that prosaposin stimulated activity of the tumor suppressor p53 in connective tissue (stroma) surrounding the tumor, which then stimulated production of an inhibitor of blood vessel growth in the tumor stroma a...

Potent metastasis inhibitor identified

...ent longer than mice not receiving prosaposin. Watnick and colleagues also demonstrated that prosaposin stimulates activity of the well-known tumor suppressor p53 in the connective tissue (stroma) surrounding the tumor. This in turn stimulated production of thrombospondin-1, a natural inhibitor of blood vess...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

...suppression. By dissecting the mechanism by which lincRNAs influence tumor suppressor pathways, she hopes to identify new markers for cancer diagnosis as well as... insights into novel regulatory roles for noncoding RNAs in silencing tumor suppressor genes, while potentially revealing new therapeutic targets for the treatmen...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...t of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corpor...

Most common brain cancer may start in neural stem cells

... ANN ARBOR, Mich. University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more ef...

U-M researchers link pathway to breast cancer stem cells

... The study appears in the June issue of PLoS Biology , a journal from the Public Library of Science. PTEN is the most frequently inactivated tumor suppressor gene in several cancers, including breast cancer, where it is inactivated in about 40 percent of patients. PTEN is linked to poor outcomes and is asso...

Most common brain cancer may originate in neural stem cells

... ANN ARBOR, Mich. University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more ef...

Adult Glioblastoma: Best Approaches to a Challenging Diagnosis

...s a challenging diagnosis which carries a poor prognosis and appears to be associated with genetic alterations of several critical signaling and tumor suppressor pathways. While current treatment options are not curative, there is hope for improving outcomes for patients. In order to do this, healthcare profess...

A surprise 'spark' for pre-cancerous colon polyps

...earliest steps in tumor formation, as well as the downstream consequences." APC stands for adenomatous polyposis coli. It is classified as a tumor suppressor gene. Before the new study, scientists believed that following APC mutation, faulty cell communication caused by a particular protein known as beta-ca...

Novel gene predicts local recurrence in early onset breast cancer

...been implicated in other epithelial tumors, including colon and pancreatic cancers, and that the researchers suspected might harbor an important tumor suppressor gene. Finding that DEAR1 was mutated in breast cancer suggested that it could play a role in the initiation and progression of the disease. The res...

Novel gene predicts local recurrence in early-onset breast cancer

...been implicated in other epithelial tumors, including colon and pancreatic cancers, and that the researchers suspected might harbor an important tumor suppressor gene. Finding that DEAR1 was mutated in breast cancer suggested that it could play a role in the initiation and progression of the disease. The res...

Process controlling T cell growth and production identified

... infections. At the same time, they determined that expression of the tumor suppressor gene called KLF4 was reduced in these mice. "We discovered that ELF4 directly activates the tumor suppressor KLF4, which signals cell cycle arrest in nave CD8 T cells," Lacorazza said....

JNCI April 28 tip sheet

...ressofficers@mail.nih.gov , 301-496-6641 Clusterin Acts as a Tumor suppressor Gene in Mouse Models of Neuroblastoma Reduced expression of clusterin in ...ded, to our knowledge, the first evidence to show that clusterin is a tumor suppressor gene that is negatively regulated by the proto-oncogene MYCN," the authors ...

Tips from the American Journal of Pathology

...ation. Am J Pathol 2009, 174: 1745-1755 suppressor of Cytokine Signaling (SOCS)-1 Inhibits Prostate C...Rauch V, Brugger M, Hobisch A, Kenner L, Culig Z: suppressor of cytokine signaling (SOCS)-1 is expressed in hum...ournal of Pathology . TIP30 is a putative tumor suppressor with decreased expression in numerous cancers incl...

Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth

...aborators have focused their research on an enzyme known as lysine specific demethylase 1(LSD1), which contributes to the silencing of important tumor suppressor genes. They have successfully developed PG11144 that inhibits LSD1 and reactivates (expresses) the silenced genes that are inactivated in cancer. ...

Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells

...AD001 showed the same minimal effect, Dr. Gupta says. Panobinostat is a histone deacetylase (HDAC) inhibitor. In cancer, HDAC proteins "silence" tumor suppressor genes, so an HADC inhibitor restores expression of these beneficial genes. The agent is also believed to block angiogenesis - the growth of new blood ...

Reversing effects of altered enzyme may fight brain tumor growth

...mutation," Guan said. He added that IDH1 appears to function as a tumor suppressor gene that when altered and turned off can contribute to tumor formation t...e in normal human cells has two copies), which is different from most tumor suppressor genes. Most either have genetic material that is deleted or truncated not ...

Mayo researchers discover mechanism of cell type-specific signaling in tumor development

...f. "We found that a protein called Erbin, in cooperation with the NF2 tumor suppressor Merlin, controls the outcome." Erbin, the researchers found, controls the tumor suppressor gene Merlin. When Merlin is absent or mutated, the result is schwannoma, a ...
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