Scientists reveal structure of new botulism nerve toxin subtype
UPTON, NY Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have determined the atomic-level structure of a third subtype of botulinum neurotoxin a deadly toxin produced by certain bacteria that causes the disease botulism, and is also used in cosmetic and therap...Crystallography reveals the 3-D structure of mammalian sperm receptor
Scientists at the Swedish medical university Karolinska Institutet have determined the first 3D structure of ZP3, a protein essential for the interaction between the mammalian egg coat and sperm. The findings, presented in Nature , gives a first glimpse into the molecular architecture of animal e...Neuroscientists show insulin receptor signaling regulates structure of brain circuits
A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates both the structure and function of neural circuits. The finding suggests a significant role for thi...Performance Metrics -- Market Research Structure and Functions
CHAPEL HILL, N.C., May 19 /PRNewswire/ -- Integrate competitive intelligence skills into the overall market research function to forge deeper insights about the market and competition. More than 70% of market research organizations identify competitive intelligence as an important component of...Some like it hot! Structure of receptor for hot chili pepper and pain revealed
You can now not only feel the spicy kick of a jalapeno pepper, you can also see it in full 3D, thanks to researchers at Baylor College of Medicine in Houston. Using sophisticated equipment, the research team led by Dr Theodore G. Wensel, professor of biochemistry and molecular biology at BCM, g...LifeMasters Strengthens Capital Structure with $15 Million in Funding from Existing Investors
IRVINE, Calif., March 11 /PRNewswire/ -- LifeMasters Supported SelfCare, Inc., a national leading provider of health improvement programs and services, today announced it has received $15 million in financing from existing investors including VantagePoint Venture Partners, one of its earliest ...Measurement technique probes surface structure of gold nanocrystals
CHAMPAIGN, Ill. In the hands of jewelers, gold can be fashioned into rings and pendants of long-lasting beauty. But, when reduced in size to nanocrystals containing a few thousand atoms, this noble metal is a surprisingly good catalyst. Finding the key to golds chemical reactivity (or that of ...University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
PITTSBURGH, March 10 Using X-ray crystallography, researchers at the University of Pittsburgh School of Medicine led by structural biologist Joanne I. Yeh, Ph.D., have become the first to decipher the three-dimensional structure of a membrane-bound enzyme that plays a crucial role in glycerol met...Scientists determine structure of brain receptor implicated in epilepsy and PMT
Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have published new research in the journal Molecular Pharmacology identifying the structure of a receptor in the brain implicated in conditions such as epilepsy and pre-menstrual tension. The same receptor has ...U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1
MINNEAPOLIS / ST. PAUL (February 20, 2008) Understanding the structure of proteins involved in inhibiting HIV-1 infection could help in the battle against AIDS, and University of Minnesota researchers have taken a crucial step in that direction. Hiroshi Matsuo, Ph.D., and Reuben Harris, Ph.D., c...Enzyme structure reveals new drug targets for cancer and other diseases
If the genome is the parts list of the human cell, certain proteins are the production managers, activating and deactivating genes as needed. Scientists funded by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, now have a clearer understanding...Scientists solve structure of gene regulator that plays key role in cancer
(PHILADELPHIA) Scientists at The Wistar Institute have collaborated on a major advance in understanding a gene regulator that contributes to some of the deadliest cancers in humans. The culmination of 10 years work, their research paves the way for the development of new cancer therapies. Dur...Researchers solve first structure of a key to intact DNA inheritance
HOUSTON - Researchers have solved the structure of a DNA-protein complex that is crucial in the spread of antibiotic resistance among bacteria. Knowing this structure also provides fundamental insight into how cells successfully divide into two new cells with intact DNA The report in the Dec. ...Cell Structure Helps Direct Cancer Gene 'Switch'
The finding might help lead to new treatments, scientists say WEDNESDAY, Nov. 14 (HealthDay News) -- U.S. scientists say they've have uncovered a biological "switch" for key genes in cancer cells. They found that genes in cancer cells are silenced by distinct changes in the density of structu...Telomerase enzyme structure provides significant new target for anti-cancer therapies
(PHILADELPHIA) Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells seen in as many as 90 percent of all of human cancers. Since the mid-1990s, when telomerase was first identified in human tumors, scientists have eyed the enzyme as...Novel semiconductor structure bends light 'wrong' way -- the right direction for many applications
A Princeton-led research team has created an easy-to-produce material from the stuff of computer chips that has the rare ability to bend light in the opposite direction from all naturally occurring materials. This startling property may contribute to significant advances in many areas, including hi...CRC Health Group Announces Acquisition of Durham's Structure House, Weight Loss Facility
CRC is Nation's Largest Behavioral/Educational Health Provider DURHAM, N.C. and CUPERTINO, Calif., Sept. 21 /PRNewswire-USNewswire/ -- Dr. Barry Karlin, Chairman and CEO of CRC Health Group, has announced the acquisition of Structure House, a residential, weight-loss facility for adults d...'Artificial Golgi' may provide new insight into key cell structure
Scientists in New York and North Carolina are reporting assembly of the first functioning prototype of an artificial Golgi organelle. That key structure inside cells helps process and package hormones, enzymes, and other substances that allow the body to function normally. The lab-on-a-chip device...Physical fitness improves spatial memory, increases size of brain structure
When it comes to the hippocampus, a brain structure vital to certain types of memory, size matters. Numerous studies have shown that bigger is usually better. Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than th...Sex difference on spatial skill test linked to brain structure
Men consistently outperform women on spatial tasks, including mental rotation, which is the ability to identify how a 3-D object would appear if rotated in space. Now, a University of Iowa study shows a connection between this sex-linked ability and the structure of the parietal lobe, the brain re...Pediatric obesity may alter thyroid function and structure
Chevy Chase, MDIn addition to its strong associations with hypertension, cardiovascular disease, and diabetes, pediatric obesity may induce alterations in thyroid function and structure, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology...Fetal Exposure to Substance Abuse Changes Brain Structure
Mom's use of tobacco, alcohol, drugs may affect kids into early adolescence, study shows MONDAY, April 7 (HealthDay News) -- Babies born to women who use cocaine, alcohol or tobacco during pregnancy may have brain structure changes that persist into early adolescence, a new U.S. study ...UIC chemists characterize Alzheimer's neurotoxin structure
Amyloid plaques, the hallmark of Alzheimer's disease, are clumps of fiber-like misfolded proteins which many experts think cause this devastating neurodegenerative disease. While effective treatment remains an elusive goal, new research by University of Illinois at Chicago chemists suggests a ...HIDA Calls for Scrutiny of Group Purchasing Organization Distributor Fee Structure
ALEXANDRIA, Va., Sept. 5 /PRNewswire-USNewswire/ -- The Health Industry Distributors Association (HIDA) announces the release of a position paper that examines the structure by which administrative fees charged by group purchasing organizations (GPOs) are paid by acute care medical products di...Translating Structure into Function
Scientists have perfected ways to determine the knot-like structure of enzymes, but theyve been stumped trying to translate the structure into an understanding of function what the enzyme actually does in the body. This puzzle has hindered drug discovery, since many of the most successful...Human Pain-controlling Molecule's Structure Identified
Boffins have unveiled the structure of a key molecule called 'P2X receptor' that control pain in humans . The research might lead to the development of painkillers for recurring migraine and backache. The study was conducted by a team of researchers including Dr Chris Thompson, Prof...Protein Structure of Pathogens Associated With CF and TB Solved
The structure of a novel protein in the bacterium that is the most persistent pathogen in cystic fibrosis (CF) patients has been solved . Hauptman-Woodward Institute scientists Dr. Andrew Gulick, Eric Drake and Dr. Manish Shah, in collaboration with researchers at the University at Buffalo and...Human Membranes Crystal Structure may Help Tailor Asthma Drugs
Scientists have managed to reveal the crystal structure of a human membrane protein, LTC4 synthase, which has a major influence on the development of asthma . LTC4 synthase is tremendously difficult to analyse, and previously only low-resolution information has been available on two...Individual Differences in Sleep Structure are Biologically Determined
Researchers have long observed significant differences in normal peoples sleep. Some are light sleepers, whereas others sleep deeply. Some fall asleep right away, while others take their time . Such sleeping pattern variability has long been attributed solely to differences in circumstance...Altered Protein Structure was Found in Autism Patients
A research team led by scientists at the University of California , has discovered how particular genetic mutations affect the structure of protein complex implicated in autism . These proteins contribute to the developmental abnormalities found in children with autism. By understanding the ...